U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Bladder Large Cell Neuroendocrine Carcinoma

MedGen UID:
1677587
•Concept ID:
C2111710
•
Neoplastic Process

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the bladder. It is characterized by the presence of malignant large cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBladder Large Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Comparative Effectiveness Analysis of Treatment Strategies for Surgically Resectable Neuroendocrine Carcinoma of the Urinary Tract.
Alhalabi O, Wilson N, Xiao L, Lin Y, Khandelwal J, Moussa MJ, Msaouel P, Navai N, Gao J, Kamat AM, Pilie P, Shah AY, Goswami S, Matin S, Kovitz C, Holla V, Guo C, Czerniak B, Logothetis C, Corn PG, Dinney CPN, Campbell MT, Hansel DE, Tannir NM, Siefker-Radtke AO
Eur Urol Oncol 2023 Dec;6(6):611-620. Epub 2023 Oct 11 doi: 10.1016/j.euo.2023.09.004. PMID: 37833193
Unusual histomorphological spectrum of urinary bladder cancers and their treatment modalities revisited: Our experience with series of five cases.
Mohanty P, Mohapatra AS, Sabat D, Nayak J
J Cancer Res Ther 2023 Apr-Jun;19(3):617-623. doi: 10.4103/jcrt.jcrt_134_21. PMID: 37470584
What Is the Prognostic and Clinical Importance of Urothelial and Nonurothelial Histological Variants of Bladder Cancer in Predicting Oncological Outcomes in Patients with Muscle-invasive and Metastatic Bladder Cancer? A European Association of Urology Muscle Invasive and Metastatic Bladder Cancer Guidelines Panel Systematic Review.
Veskimäe E, Espinos EL, Bruins HM, Yuan Y, Sylvester R, Kamat AM, Shariat SF, Witjes JA, Compérat EM
Eur Urol Oncol 2019 Nov;2(6):625-642. Epub 2019 Oct 8 doi: 10.1016/j.euo.2019.09.003. PMID: 31601522

Recent clinical studies

Etiology

Associations of TACSTD2/TROP2 and NECTIN-4/NECTIN-4 with molecular subtypes, PD-L1 expression, and FGFR3 mutational status in two advanced urothelial bladder cancer cohorts.
Bahlinger V, Branz A, Strissel PL, Strick R, Lange F, Geppert CI, Klümper N, Hölzel M, Wach S, Taubert H, Sikic D, Wullich B, Angeloni M, Ferrazzi F, Diehl L, Kovalenko M, Elboudwarej E, Jürgensmeier JM, Hartmann A, Eckstein M
Histopathology 2024 Apr;84(5):863-876. Epub 2024 Jan 9 doi: 10.1111/his.15130. PMID: 38196202
Classifying Pulmonary and Urinary High-grade Neuroendocrine Carcinoma by CK7 Immunohistochemistry.
Fan J, Li H, Zhou C, Xiong W, Villamil C, Ionescu D, Oo HZ, Contreras-Sanz A, Black PC, Wang G
Appl Immunohistochem Mol Morphol 2022 Jul 1;30(6):459-468. Epub 2022 May 24 doi: 10.1097/PAI.0000000000001036. PMID: 35603802
Urinary Large Cell Neuroendocrine Carcinoma: A Clinicopathologic Analysis of 22 Cases.
Wang G, Yuan R, Zhou C, Guo C, Villamil C, Hayes M, Eigl BJ, Black P
Am J Surg Pathol 2021 Oct 1;45(10):1399-1408. doi: 10.1097/PAS.0000000000001740. PMID: 34074810Free PMC Article
The Colorful Palette of Neuroendocrine Neoplasms in the Genitourinary Tract.
Pósfai B, Kuthi L, Varga L, Laczó I, Révész J, Kránicz R, Maráz A
Anticancer Res 2018 Jun;38(6):3243-3254. doi: 10.21873/anticanres.12589. PMID: 29848671
Neuroendocrine Carcinoma of Gall Bladder: A Series of 19 Cases with Review of Literature.
Kamboj M, Gandhi JS, Gupta G, Sharma A, Pasricha S, Mehta A, Chandragouda D, Sinha R
J Gastrointest Cancer 2015 Dec;46(4):356-64. doi: 10.1007/s12029-015-9745-9. PMID: 26208508

Diagnosis

Urinary Tract Large Cell Neuroendocrine Carcinoma: Diagnostic, Prognostic and Therapeutic Issues.
Sanguedolce F, Calò B, Chirico M, Tortorella S, Carrieri G, Cormio L
Anticancer Res 2020 May;40(5):2439-2447. doi: 10.21873/anticanres.14213. PMID: 32366387
Large Cell Neuroendocrine Carcinoma of the Prostate: A Systematic Review and Pooled Analysis.
Tu X, Chang T, Nie L, Qiu S, Xu H, Huang Y, Bao Y, Liu Z, Yang L, Wei Q
Urol Int 2019;103(4):383-390. Epub 2019 Apr 9 doi: 10.1159/000499883. PMID: 30965328
Primary "Pure" Large Cell Neuroendocrine Carcinoma of the Urinary Bladder: A Case Report and Review of the Literature.
Radović N, Turner R, Bacalja J
Clin Genitourin Cancer 2015 Oct;13(5):e375-7. Epub 2015 Mar 30 doi: 10.1016/j.clgc.2015.03.005. PMID: 25936587
A rare case of large cell neuroendocrine carcinoma of the urinary bladder evaluated by ¹⁸F-FDG-PET/CT.
Treglia G, Paone G, Flores B, Venzi G, Ceriani L, Giovanella L
Rev Esp Med Nucl Imagen Mol 2014 Sep-Oct;33(5):312-3. Epub 2014 Jan 16 doi: 10.1016/j.remn.2013.10.007. PMID: 24440201
Large cell neuroendocrine carcinoma of the urinary bladder. Bibliographic review.
Martín IJ, Vilar DG, Aguado JM, Perelló CG, Aliaga MR, Argente VG, Ferreres LA, Gómez JG
Arch Esp Urol 2011 Mar;64(2):105-13. PMID: 21399243

Therapy

Comparative Effectiveness Analysis of Treatment Strategies for Surgically Resectable Neuroendocrine Carcinoma of the Urinary Tract.
Alhalabi O, Wilson N, Xiao L, Lin Y, Khandelwal J, Moussa MJ, Msaouel P, Navai N, Gao J, Kamat AM, Pilie P, Shah AY, Goswami S, Matin S, Kovitz C, Holla V, Guo C, Czerniak B, Logothetis C, Corn PG, Dinney CPN, Campbell MT, Hansel DE, Tannir NM, Siefker-Radtke AO
Eur Urol Oncol 2023 Dec;6(6):611-620. Epub 2023 Oct 11 doi: 10.1016/j.euo.2023.09.004. PMID: 37833193
Primary MiNEN of the urinary bladder: an hitherto undescribed entity composed of large cell neuroendocrine carcinoma and adenocarcinoma with a distinct clinical behavior : Description of a case and review of the pertinent literature.
Pini GM, Uccella S, Corinti M, Colecchia M, Pelosi G, Patriarca C
Virchows Arch 2021 Jul;479(1):69-78. Epub 2021 Jan 17 doi: 10.1007/s00428-021-03023-7. PMID: 33454836Free PMC Article
Neuroendocrine Carcinoma of the Urinary Bladder: A Large, Retrospective Study From the French Genito-Urinary Tumor Group.
Sroussi M, Elaidi R, Fléchon A, Lorcet M, Borchiellini D, Tardy MP, Gravis G, Guérin M, Laguerre B, Estrade F, Delva R, Barthélémy P, Loriot Y, Lavaud P, Lebret T, Neuzillet Y, Penel N, Houede N, Pouessel D, Rousseau B, Mussat E, Gross-Goupil M, Culine S, Gauthier H, Gobert A, Roupret M, Huillard O, Tartas S, Radulescu C, Allory Y, Oudard S
Clin Genitourin Cancer 2020 Aug;18(4):295-303.e3. Epub 2019 Dec 5 doi: 10.1016/j.clgc.2019.11.014. PMID: 31882335
What Is the Prognostic and Clinical Importance of Urothelial and Nonurothelial Histological Variants of Bladder Cancer in Predicting Oncological Outcomes in Patients with Muscle-invasive and Metastatic Bladder Cancer? A European Association of Urology Muscle Invasive and Metastatic Bladder Cancer Guidelines Panel Systematic Review.
Veskimäe E, Espinos EL, Bruins HM, Yuan Y, Sylvester R, Kamat AM, Shariat SF, Witjes JA, Compérat EM
Eur Urol Oncol 2019 Nov;2(6):625-642. Epub 2019 Oct 8 doi: 10.1016/j.euo.2019.09.003. PMID: 31601522
Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder: a case report.
Colarossi C, Pino P, Giuffrida D, Aiello E, Costanzo R, Martinetti D, Memeo L
Diagn Pathol 2013 Feb 4;8:19. doi: 10.1186/1746-1596-8-19. PMID: 23379295Free PMC Article

Prognosis

Urinary Large Cell Neuroendocrine Carcinoma: A Clinicopathologic Analysis of 22 Cases.
Wang G, Yuan R, Zhou C, Guo C, Villamil C, Hayes M, Eigl BJ, Black P
Am J Surg Pathol 2021 Oct 1;45(10):1399-1408. doi: 10.1097/PAS.0000000000001740. PMID: 34074810Free PMC Article
Urinary Tract Large Cell Neuroendocrine Carcinoma: Diagnostic, Prognostic and Therapeutic Issues.
Sanguedolce F, Calò B, Chirico M, Tortorella S, Carrieri G, Cormio L
Anticancer Res 2020 May;40(5):2439-2447. doi: 10.21873/anticanres.14213. PMID: 32366387
Large Cell Neuroendocrine Carcinoma of the Prostate: A Systematic Review and Pooled Analysis.
Tu X, Chang T, Nie L, Qiu S, Xu H, Huang Y, Bao Y, Liu Z, Yang L, Wei Q
Urol Int 2019;103(4):383-390. Epub 2019 Apr 9 doi: 10.1159/000499883. PMID: 30965328
Primary "Pure" Large Cell Neuroendocrine Carcinoma of the Urinary Bladder: A Case Report and Review of the Literature.
Radović N, Turner R, Bacalja J
Clin Genitourin Cancer 2015 Oct;13(5):e375-7. Epub 2015 Mar 30 doi: 10.1016/j.clgc.2015.03.005. PMID: 25936587
Large cell neuroendocrine carcinoma of the urinary bladder. Bibliographic review.
Martín IJ, Vilar DG, Aguado JM, Perelló CG, Aliaga MR, Argente VG, Ferreres LA, Gómez JG
Arch Esp Urol 2011 Mar;64(2):105-13. PMID: 21399243

Clinical prediction guides

Associations of TACSTD2/TROP2 and NECTIN-4/NECTIN-4 with molecular subtypes, PD-L1 expression, and FGFR3 mutational status in two advanced urothelial bladder cancer cohorts.
Bahlinger V, Branz A, Strissel PL, Strick R, Lange F, Geppert CI, Klümper N, Hölzel M, Wach S, Taubert H, Sikic D, Wullich B, Angeloni M, Ferrazzi F, Diehl L, Kovalenko M, Elboudwarej E, Jürgensmeier JM, Hartmann A, Eckstein M
Histopathology 2024 Apr;84(5):863-876. Epub 2024 Jan 9 doi: 10.1111/his.15130. PMID: 38196202
Primary MiNEN of the urinary bladder: an hitherto undescribed entity composed of large cell neuroendocrine carcinoma and adenocarcinoma with a distinct clinical behavior : Description of a case and review of the pertinent literature.
Pini GM, Uccella S, Corinti M, Colecchia M, Pelosi G, Patriarca C
Virchows Arch 2021 Jul;479(1):69-78. Epub 2021 Jan 17 doi: 10.1007/s00428-021-03023-7. PMID: 33454836Free PMC Article
Neuroendocrine Carcinoma of the Urinary Bladder: A Large, Retrospective Study From the French Genito-Urinary Tumor Group.
Sroussi M, Elaidi R, Fléchon A, Lorcet M, Borchiellini D, Tardy MP, Gravis G, Guérin M, Laguerre B, Estrade F, Delva R, Barthélémy P, Loriot Y, Lavaud P, Lebret T, Neuzillet Y, Penel N, Houede N, Pouessel D, Rousseau B, Mussat E, Gross-Goupil M, Culine S, Gauthier H, Gobert A, Roupret M, Huillard O, Tartas S, Radulescu C, Allory Y, Oudard S
Clin Genitourin Cancer 2020 Aug;18(4):295-303.e3. Epub 2019 Dec 5 doi: 10.1016/j.clgc.2019.11.014. PMID: 31882335
Small cell carcinoma of the urinary bladder: a clinicopathological and immunohistochemical analysis of 81 cases.
Wang G, Xiao L, Zhang M, Kamat AM, Siefker-Radtke A, Dinney CP, Czerniak B, Guo CC
Hum Pathol 2018 Sep;79:57-65. Epub 2018 May 12 doi: 10.1016/j.humpath.2018.05.005. PMID: 29763719Free PMC Article
Updates in the Pathologic Diagnosis and Classification of Epithelial Neoplasms of Urachal Origin.
Paner GP, Lopez-Beltran A, Sirohi D, Amin MB
Adv Anat Pathol 2016 Mar;23(2):71-83. doi: 10.1097/PAP.0000000000000110. PMID: 26849813

Recent systematic reviews

What Is the Prognostic and Clinical Importance of Urothelial and Nonurothelial Histological Variants of Bladder Cancer in Predicting Oncological Outcomes in Patients with Muscle-invasive and Metastatic Bladder Cancer? A European Association of Urology Muscle Invasive and Metastatic Bladder Cancer Guidelines Panel Systematic Review.
Veskimäe E, Espinos EL, Bruins HM, Yuan Y, Sylvester R, Kamat AM, Shariat SF, Witjes JA, Compérat EM
Eur Urol Oncol 2019 Nov;2(6):625-642. Epub 2019 Oct 8 doi: 10.1016/j.euo.2019.09.003. PMID: 31601522
Large Cell Neuroendocrine Carcinoma of the Prostate: A Systematic Review and Pooled Analysis.
Tu X, Chang T, Nie L, Qiu S, Xu H, Huang Y, Bao Y, Liu Z, Yang L, Wei Q
Urol Int 2019;103(4):383-390. Epub 2019 Apr 9 doi: 10.1159/000499883. PMID: 30965328

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...