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Metastatic Prostate Adenocarcinoma

MedGen UID:
167835
•Concept ID:
C0862636
•
Neoplastic Process
Synonym: Metastatic Prostatic Adenocarcinoma

Definition

An adenocarcinoma that arises from the prostate gland and has spread to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Prostate Adenocarcinoma

Professional guidelines

PubMed

Novel therapeutic compounds for prostate adenocarcinoma treatment: An analysis using bioinformatic approaches and the CMap database.
Li K, Fan J, Qin X, Wei Q
Medicine (Baltimore) 2020 Dec 18;99(51):e23768. doi: 10.1097/MD.0000000000023768. PMID: 33371142Free PMC Article
Roles of Alternative RNA Splicing of the Bif-1 Gene by SRRM4 During the Development of Treatment-induced Neuroendocrine Prostate Cancer.
Gan Y, Li Y, Long Z, Lee AR, Xie N, Lovnicki JM, Tang Y, Chen X, Huang J, Dong X
EBioMedicine 2018 May;31:267-275. Epub 2018 May 16 doi: 10.1016/j.ebiom.2018.05.002. PMID: 29759485Free PMC Article

Recent clinical studies

Etiology

Metastatic prostate adenocarcinoma to the brain - a clinicopathologic analysis of 21 cases.
Ajmal N, Deng Y, Kenyon LC, Curtis MT, Dispagna M, Izes J, Li L
Diagn Pathol 2024 Oct 1;19(1):132. doi: 10.1186/s13000-024-01554-6. PMID: 39354583Free PMC Article
Immunogenomic Landscape of Neuroendocrine Prostate Cancer.
Bhinder B, Ferguson A, Sigouros M, Uppal M, Elsaeed AG, Bareja R, Alnajar H, Eng KW, Conteduca V, Sboner A, Mosquera JM, Elemento O, Beltran H
Clin Cancer Res 2023 Aug 1;29(15):2933-2943. doi: 10.1158/1078-0432.CCR-22-3743. PMID: 37223924Free PMC Article
Primary resection of oligometastatic recurrent prostatic carcinoma in the urethra.
Foo MA, Lim EJ, Cheng CWS, Ng LG
BMJ Case Rep 2022 Sep 21;15(9) doi: 10.1136/bcr-2022-250200. PMID: 36130819Free PMC Article
Abiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design.
Fizazi K, Foulon S, Carles J, Roubaud G, McDermott R, Fléchon A, Tombal B, Supiot S, Berthold D, Ronchin P, Kacso G, Gravis G, Calabro F, Berdah JF, Hasbini A, Silva M, Thiery-Vuillemin A, Latorzeff I, Mourey L, Laguerre B, Abadie-Lacourtoisie S, Martin E, El Kouri C, Escande A, Rosello A, Magne N, Schlurmann F, Priou F, Chand-Fouche ME, Freixa SV, Jamaluddin M, Rieger I, Bossi A; PEACE-1 investigators
Lancet 2022 Apr 30;399(10336):1695-1707. Epub 2022 Apr 8 doi: 10.1016/S0140-6736(22)00367-1. PMID: 35405085
Metastatic prostate adenocarcinoma to cervical lymph nodes: an unusual diagnosis on fine-needle aspiration biopsy.
Albadri ST, Salomão D
J Am Soc Cytopathol 2021 Mar-Apr;10(2):231-238. Epub 2020 Aug 25 doi: 10.1016/j.jasc.2020.08.009. PMID: 32950433

Diagnosis

Cerebrospinal Fluid Rhinorrhea as the First Symptom of Metastatic Prostate Adenocarcinoma.
Ostrowska M, Wróbel MJ
Ear Nose Throat J 2023 Sep;102(9):NP466-NP469. Epub 2021 May 26 doi: 10.1177/01455613211016710. PMID: 34037491
Cytological findings of metastatic poorly differentiated prostate adenocarcinoma to Virchow's node with immunohistochemical positivity for CD10 and negativity for PSA.
Kobayashi G, Sentani K, Uraoka N, Oue N, Sasaki N
Cytopathology 2022 Nov;33(6):749-753. Epub 2022 May 26 doi: 10.1111/cyt.13149. PMID: 35557476
Abiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design.
Fizazi K, Foulon S, Carles J, Roubaud G, McDermott R, Fléchon A, Tombal B, Supiot S, Berthold D, Ronchin P, Kacso G, Gravis G, Calabro F, Berdah JF, Hasbini A, Silva M, Thiery-Vuillemin A, Latorzeff I, Mourey L, Laguerre B, Abadie-Lacourtoisie S, Martin E, El Kouri C, Escande A, Rosello A, Magne N, Schlurmann F, Priou F, Chand-Fouche ME, Freixa SV, Jamaluddin M, Rieger I, Bossi A; PEACE-1 investigators
Lancet 2022 Apr 30;399(10336):1695-1707. Epub 2022 Apr 8 doi: 10.1016/S0140-6736(22)00367-1. PMID: 35405085
Metastatic prostate adenocarcinoma diagnosed in a colonic polyp.
Steevens CD, Abraham J, Bahadur S
J Clin Oncol 2012 Jun 20;30(18):e160-2. Epub 2012 May 14 doi: 10.1200/JCO.2011.39.7489. PMID: 22585688
Hypertrophic gastric folds caused by metastatic prostate adenocarcinoma.
Krones E, Stauber R, Vieth M, Langner C
Endoscopy 2012;44 Suppl 2 UCTN:E47-8. Epub 2012 Mar 6 doi: 10.1055/s-0031-1291524. PMID: 22396273

Therapy

Eruptive Papules as a Cutaneous Manifestation of Metastatic Prostate Adenocarcinoma.
Onalaja-Underwood AA, Sokumbi O
Am J Dermatopathol 2023 Dec 1;45(12):828-830. doi: 10.1097/DAD.0000000000002559. PMID: 37883967
Abiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design.
Fizazi K, Foulon S, Carles J, Roubaud G, McDermott R, Fléchon A, Tombal B, Supiot S, Berthold D, Ronchin P, Kacso G, Gravis G, Calabro F, Berdah JF, Hasbini A, Silva M, Thiery-Vuillemin A, Latorzeff I, Mourey L, Laguerre B, Abadie-Lacourtoisie S, Martin E, El Kouri C, Escande A, Rosello A, Magne N, Schlurmann F, Priou F, Chand-Fouche ME, Freixa SV, Jamaluddin M, Rieger I, Bossi A; PEACE-1 investigators
Lancet 2022 Apr 30;399(10336):1695-1707. Epub 2022 Apr 8 doi: 10.1016/S0140-6736(22)00367-1. PMID: 35405085
Novel therapeutic compounds for prostate adenocarcinoma treatment: An analysis using bioinformatic approaches and the CMap database.
Li K, Fan J, Qin X, Wei Q
Medicine (Baltimore) 2020 Dec 18;99(51):e23768. doi: 10.1097/MD.0000000000023768. PMID: 33371142Free PMC Article
Circulating tumor DNA profile recognizes transformation to castration-resistant neuroendocrine prostate cancer.
Beltran H, Romanel A, Conteduca V, Casiraghi N, Sigouros M, Franceschini GM, Orlando F, Fedrizzi T, Ku SY, Dann E, Alonso A, Mosquera JM, Sboner A, Xiang J, Elemento O, Nanus DM, Tagawa ST, Benelli M, Demichelis F
J Clin Invest 2020 Apr 1;130(4):1653-1668. doi: 10.1172/JCI131041. PMID: 32091413Free PMC Article
P450-dependent enzymes as targets for prostate cancer therapy.
De Coster R, Wouters W, Bruynseels J
J Steroid Biochem Mol Biol 1996 Jan;56(1-6 Spec No):133-43. doi: 10.1016/0960-0760(95)00230-8. PMID: 8603034

Prognosis

Metastatic prostate adenocarcinoma to the brain - a clinicopathologic analysis of 21 cases.
Ajmal N, Deng Y, Kenyon LC, Curtis MT, Dispagna M, Izes J, Li L
Diagn Pathol 2024 Oct 1;19(1):132. doi: 10.1186/s13000-024-01554-6. PMID: 39354583Free PMC Article
Metastatic Prostate Adenocarcinoma of the Mandible Diagnosed With Oral Manifestations.
Ayranci F, Omezli MM, Torul D, Ay M
J Craniofac Surg 2020 May/Jun;31(3):e220-e222. doi: 10.1097/SCS.0000000000006025. PMID: 31688259
The U Shape of Prostate-specific Antigen and Prostate Cancer-specific Mortality in High-grade Metastatic Prostate Adenocarcinoma.
Wang J, Abudurexiti M, Shao N, Wei Y, Zhu Y, Ye DW
Eur Urol Focus 2020 Jan 15;6(1):53-62. Epub 2018 Sep 11 doi: 10.1016/j.euf.2018.08.024. PMID: 30217630
Metastatic prostate adenocarcinoma to the penis: a series of 29 cases with predilection for ductal adenocarcinoma.
Ellis CL, Epstein JI
Am J Surg Pathol 2015 Jan;39(1):67-74. doi: 10.1097/PAS.0000000000000289. PMID: 25025445
Multiple cranial neuropathy as the initial presentation of metastatic prostate adenocarcinoma: case report and review of literature.
Kolias AG, Derham C, Mankad K, Hasegawa H, O'Kane R, Ismail A, Phillips NI
Acta Neurochir (Wien) 2010 Jul;152(7):1251-5. Epub 2010 Apr 9 doi: 10.1007/s00701-010-0630-9. PMID: 20379748

Clinical prediction guides

Circulating tumor DNA profile recognizes transformation to castration-resistant neuroendocrine prostate cancer.
Beltran H, Romanel A, Conteduca V, Casiraghi N, Sigouros M, Franceschini GM, Orlando F, Fedrizzi T, Ku SY, Dann E, Alonso A, Mosquera JM, Sboner A, Xiang J, Elemento O, Nanus DM, Tagawa ST, Benelli M, Demichelis F
J Clin Invest 2020 Apr 1;130(4):1653-1668. doi: 10.1172/JCI131041. PMID: 32091413Free PMC Article
The U Shape of Prostate-specific Antigen and Prostate Cancer-specific Mortality in High-grade Metastatic Prostate Adenocarcinoma.
Wang J, Abudurexiti M, Shao N, Wei Y, Zhu Y, Ye DW
Eur Urol Focus 2020 Jan 15;6(1):53-62. Epub 2018 Sep 11 doi: 10.1016/j.euf.2018.08.024. PMID: 30217630
Metastatic prostate adenocarcinoma to the penis: a series of 29 cases with predilection for ductal adenocarcinoma.
Ellis CL, Epstein JI
Am J Surg Pathol 2015 Jan;39(1):67-74. doi: 10.1097/PAS.0000000000000289. PMID: 25025445
Clinical outcome of Taiwanese men with metastatic prostate cancer compared with other ethnic groups.
Chen CH, Tzai TS, Huang SP, Wu HC, Tai HC, Chang YH, Pu YS
Urology 2008 Dec;72(6):1287-92. Epub 2008 Apr 18 doi: 10.1016/j.urology.2008.01.026. PMID: 18372020
P450-dependent enzymes as targets for prostate cancer therapy.
De Coster R, Wouters W, Bruynseels J
J Steroid Biochem Mol Biol 1996 Jan;56(1-6 Spec No):133-43. doi: 10.1016/0960-0760(95)00230-8. PMID: 8603034

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