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Overactive bladder

MedGen UID:
168058
•Concept ID:
C0878773
•
Disease or Syndrome
Synonym: Overactive bladder (disease)
SNOMED CT: Instability of bladder (786457000); Bladder instability (786457000); Overactive bladder (786457000); Hyperactive bladder (786457000); Overactive urinary bladder (786457000)
 
Monarch Initiative: MONDO:0006624

Definition

A urinary voiding disorder that includes urinary urgency, with or without incontinence, nocturia, and urinary frequency. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOveractive bladder

Professional guidelines

PubMed

Pelvic-floor function, dysfunction, and treatment.
Quaghebeur J, Petros P, Wyndaele JJ, De Wachter S
Eur J Obstet Gynecol Reprod Biol 2021 Oct;265:143-149. Epub 2021 Aug 28 doi: 10.1016/j.ejogrb.2021.08.026. PMID: 34492609
Overactive bladder syndrome: Management and treatment options.
Hutchinson A, Nesbitt A, Joshi A, Clubb A, Perera M
Aust J Gen Pract 2020 Sep;49(9):593-598. doi: 10.31128/AJGP-11-19-5142. PMID: 32864677
Primary and Secondary Enuresis: Pathophysiology, Diagnosis, and Treatment.
Haid B, Tekgül S
Eur Urol Focus 2017 Apr;3(2-3):198-206. Epub 2017 Sep 6 doi: 10.1016/j.euf.2017.08.010. PMID: 28888814

Recent clinical studies

Etiology

Associations between overactive bladder and sleep patterns: a cross-sectional study based on 2007-2014 NHANES.
Lu Z, Zhang J, Lin S, Fan Z, He Z, Tang F
BMC Urol 2023 Nov 13;23(1):184. doi: 10.1186/s12894-023-01329-z. PMID: 37957629Free PMC Article
A positive association between the prevalence of circadian syndrome and overactive bladder in United States adults.
Xiao Y, Yin S, Wang J, Cui J, Yang Z, Wang J, Bai Y
Front Public Health 2023;11:1137191. Epub 2023 Aug 10 doi: 10.3389/fpubh.2023.1137191. PMID: 37637821Free PMC Article
Relationship Between Marijuana Use and Overactive Bladder (OAB): A Cross-Sectional Research of NHANES 2005 to 2018.
Zhu S, Wang Z, Tao Z, Wang S, Wang Z
Am J Med 2023 Jan;136(1):72-78. Epub 2022 Sep 21 doi: 10.1016/j.amjmed.2022.08.031. PMID: 36150516
SUFU white paper on overactive bladder anticholinergic medications and dementia risk.
Zillioux J, Welk B, Suskind AM, Gormley EA, Goldman HB
Neurourol Urodyn 2022 Nov;41(8):1928-1933. Epub 2022 Sep 6 doi: 10.1002/nau.25037. PMID: 36066046
Efficacy of percutaneous and transcutaneous tibial nerve stimulation in women with idiopathic overactive bladder: A prospective randomised controlled trial.
Sonmez R, Yildiz N, Alkan H
Ann Phys Rehabil Med 2022 Jan;65(1):101486. Epub 2021 Nov 11 doi: 10.1016/j.rehab.2021.101486. PMID: 33429090

Diagnosis

Overactive bladder syndrome: Management and treatment options.
Hutchinson A, Nesbitt A, Joshi A, Clubb A, Perera M
Aust J Gen Pract 2020 Sep;49(9):593-598. doi: 10.31128/AJGP-11-19-5142. PMID: 32864677
Diagnosis and Treatment of Overactive Bladder (Non-Neurogenic) in Adults: AUA/SUFU Guideline Amendment 2019.
Lightner DJ, Gomelsky A, Souter L, Vasavada SP
J Urol 2019 Sep;202(3):558-563. Epub 2019 Aug 8 doi: 10.1097/JU.0000000000000309. PMID: 31039103
A Comprehensive Review of Overactive Bladder Pathophysiology: On the Way to Tailored Treatment.
Peyronnet B, Mironska E, Chapple C, Cardozo L, Oelke M, Dmochowski R, Amarenco G, Gamé X, Kirby R, Van Der Aa F, Cornu JN
Eur Urol 2019 Jun;75(6):988-1000. Epub 2019 Mar 26 doi: 10.1016/j.eururo.2019.02.038. PMID: 30922690
An overview of urinary incontinence.
Bardsley A
Br J Nurs 2016 Oct 13;25(18):S14-S21. doi: 10.12968/bjon.2016.25.18.S14. PMID: 27734727
Overactive Bladder.
White N, Iglesia CB
Obstet Gynecol Clin North Am 2016 Mar;43(1):59-68. doi: 10.1016/j.ogc.2015.10.002. PMID: 26880508

Therapy

Comparative assessment of efficacy and safety of approved oral therapies for overactive bladder: a systematic review and network meta-analysis.
He W, Huang G, Cui W, Tian Y, Sun Q, Zhao X, Zhao Y, Li D, Liu X
Int Braz J Urol 2023 Sep-Oct;49(5):535-563. doi: 10.1590/S1677-5538.IBJU.2023.0158. PMID: 37506033Free PMC Article
Efficacy and safety of vibegron compared with mirabegron for overactive bladder: A systematic review and network meta-analysis.
He W, Zhang Y, Huang G, Tian Y, Sun Q, Liu X
Low Urin Tract Symptoms 2023 May;15(3):80-88. Epub 2023 Mar 2 doi: 10.1111/luts.12475. PMID: 36863312
Efficacy of overactive neurogenic bladder treatment: A systematic review of randomized controlled trials.
Bapir R, Bhatti KH, Eliwa A, García-Perdomo HA, Gherabi N, Hennessey D, Magri V, Mourmouris P, Ouattara A, Perletti G, Philipraj J, Stamatiou K, Trinchieri A, Buchholz N
Arch Ital Urol Androl 2022 Dec 28;94(4):492-506. doi: 10.4081/aiua.2022.4.492. PMID: 36576454
Diagnosis and Treatment of Overactive Bladder (Non-Neurogenic) in Adults: AUA/SUFU Guideline Amendment 2019.
Lightner DJ, Gomelsky A, Souter L, Vasavada SP
J Urol 2019 Sep;202(3):558-563. Epub 2019 Aug 8 doi: 10.1097/JU.0000000000000309. PMID: 31039103
Tolterodine.
Hills CJ, Winter SA, Balfour JA
Drugs 1998 Jun;55(6):813-20; discussion 821-2. doi: 10.2165/00003495-199855060-00008. PMID: 9617596

Prognosis

Urinary Incontinence and Pelvic Organ Prolapse in Women.
Tunn R, Baessler K, Knüpfer S, Hampel C
Dtsch Arztebl Int 2023 Feb 3;120(5):71-80. doi: 10.3238/arztebl.m2022.0406. PMID: 36647585Free PMC Article
Pelvic floor muscle strength and the incidence of pelvic floor disorders after vaginal and cesarean delivery.
Blomquist JL, Carroll M, Muñoz A, Handa VL
Am J Obstet Gynecol 2020 Jan;222(1):62.e1-62.e8. Epub 2019 Aug 8 doi: 10.1016/j.ajog.2019.08.003. PMID: 31422064
Association of Delivery Mode With Pelvic Floor Disorders After Childbirth.
Blomquist JL, Muñoz A, Carroll M, Handa VL
JAMA 2018 Dec 18;320(23):2438-2447. doi: 10.1001/jama.2018.18315. PMID: 30561480Free PMC Article
Frailty and Lower Urinary Tract Symptoms.
Suskind AM
Curr Urol Rep 2017 Sep;18(9):67. doi: 10.1007/s11934-017-0720-9. PMID: 28718161Free PMC Article
Biomarkers in overactive bladder.
Bhide AA, Cartwright R, Khullar V, Digesu GA
Int Urogynecol J 2013 Jul;24(7):1065-72. Epub 2013 Jan 12 doi: 10.1007/s00192-012-2027-1. PMID: 23314226

Clinical prediction guides

Associations between overactive bladder and sleep patterns: a cross-sectional study based on 2007-2014 NHANES.
Lu Z, Zhang J, Lin S, Fan Z, He Z, Tang F
BMC Urol 2023 Nov 13;23(1):184. doi: 10.1186/s12894-023-01329-z. PMID: 37957629Free PMC Article
Sacral neuromodulation for overactive bladder using the InterStim and BetterStim systems.
Meng L, Tian Z, Zhang Y, Wang J, Liao L, Chen G, Tian X, Ma L, Li Y, Shi B, Zhang Y, Ling Q, Zhang P, Wei Z, Zhong T, Xu Z, Li J, Luo D
Sci Rep 2022 Dec 24;12(1):22299. doi: 10.1038/s41598-022-26267-y. PMID: 36566332Free PMC Article
Prevalence and clinical characteristics of overactive bladder in systemic sclerosis.
Motegi SI, Sekiguchi A, Sekine Y, Nakayama H, Suzuki K, Ishikawa O
Mod Rheumatol 2020 Mar;30(2):327-331. Epub 2019 Apr 1 doi: 10.1080/14397595.2019.1589913. PMID: 30836050
Basic and clinical aspects of antimuscarinic agents used to treat overactive bladder.
Yamada S, Ito Y, Nishijima S, Kadekawa K, Sugaya K
Pharmacol Ther 2018 Sep;189:130-148. Epub 2018 Apr 27 doi: 10.1016/j.pharmthera.2018.04.010. PMID: 29709423
Overactive bladder and its effects on sexual dysfunction among women.
Ergenoglu AM, Yeniel AÖ, Itil IM, Askar N, Meseri R, Petri E
Acta Obstet Gynecol Scand 2013 Oct;92(10):1202-7. doi: 10.1111/aogs.12203. PMID: 23782424

Recent systematic reviews

Bladder training for treating overactive bladder in adults.
Funada S, Yoshioka T, Luo Y, Sato A, Akamatsu S, Watanabe N
Cochrane Database Syst Rev 2023 Oct 9;10(10):CD013571. doi: 10.1002/14651858.CD013571.pub2. PMID: 37811598Free PMC Article
Comparative assessment of efficacy and safety of approved oral therapies for overactive bladder: a systematic review and network meta-analysis.
He W, Huang G, Cui W, Tian Y, Sun Q, Zhao X, Zhao Y, Li D, Liu X
Int Braz J Urol 2023 Sep-Oct;49(5):535-563. doi: 10.1590/S1677-5538.IBJU.2023.0158. PMID: 37506033Free PMC Article
Efficacy and safety of vibegron compared with mirabegron for overactive bladder: A systematic review and network meta-analysis.
He W, Zhang Y, Huang G, Tian Y, Sun Q, Liu X
Low Urin Tract Symptoms 2023 May;15(3):80-88. Epub 2023 Mar 2 doi: 10.1111/luts.12475. PMID: 36863312
Efficacy of overactive neurogenic bladder treatment: A systematic review of randomized controlled trials.
Bapir R, Bhatti KH, Eliwa A, García-Perdomo HA, Gherabi N, Hennessey D, Magri V, Mourmouris P, Ouattara A, Perletti G, Philipraj J, Stamatiou K, Trinchieri A, Buchholz N
Arch Ital Urol Androl 2022 Dec 28;94(4):492-506. doi: 10.4081/aiua.2022.4.492. PMID: 36576454
European Association of Urology Guidelines on the Diagnosis and Management of Female Non-neurogenic Lower Urinary Tract Symptoms. Part 1: Diagnostics, Overactive Bladder, Stress Urinary Incontinence, and Mixed Urinary Incontinence.
Nambiar AK, Arlandis S, Bø K, Cobussen-Boekhorst H, Costantini E, de Heide M, Farag F, Groen J, Karavitakis M, Lapitan MC, Manso M, Arteaga SM, Riogh ANA, O'Connor E, Omar MI, Peyronnet B, Phé V, Sakalis VI, Sihra N, Tzelves L, van Poelgeest-Pomfret ML, van den Bos TWL, van der Vaart H, Harding CK
Eur Urol 2022 Jul;82(1):49-59. Epub 2022 Feb 23 doi: 10.1016/j.eururo.2022.01.045. PMID: 35216856

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