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Refractory Adenovirus Infection

MedGen UID:
1684480
•Concept ID:
C4763551
•
Disease or Syndrome

Definition

An adenovirus infection that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Adenovirus Infection

Professional guidelines

PubMed

Haploidentical Stem Cell Transplantation with Post-Transplant Cyclophosphamide for Primary Immune Deficiency Disorders in Children: Challenges and Outcome from a Tertiary Care Center in South India.
Uppuluri R, Sivasankaran M, Patel S, Swaminathan VV, Ramanan KM, Ravichandran N, Ramakrishnan B, Jayakumar I, Vaidhyanathan L, Raj R
J Clin Immunol 2019 Feb;39(2):182-187. Epub 2019 Feb 18 doi: 10.1007/s10875-019-00600-z. PMID: 30778805Free PMC Article
Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy.
Lamfers ML, Grill J, Dirven CM, Van Beusechem VW, Geoerger B, Van Den Berg J, Alemany R, Fueyo J, Curiel DT, Vassal G, Pinedo HM, Vandertop WP, Gerritsen WR
Cancer Res 2002 Oct 15;62(20):5736-42. PMID: 12384532
Advances in the management of hemophagocytic lymphohistiocytosis.
Imashuku S
Int J Hematol 2000 Jul;72(1):1-11. PMID: 10979202

Recent clinical studies

Etiology

Adenoviral Penton and Hexon Proteins Are Equivalent Immunogenic Targets of Virus-Specific T Cells after Hematopoietic Stem Cell Transplantation in Children.
Wintering A, Tischer-Zimmermann S, Schultze-Florey R, Beier R, Sauer M, Blasczyk R, Heim A, Eiz-Vesper B, Maecker-Kolhoff B
Transplant Cell Ther 2023 Jun;29(6):391.e1-391.e7. Epub 2023 Mar 18 doi: 10.1016/j.jtct.2023.03.013. PMID: 36934995
Adenovirus infection diagnosed by metagenomic next-generation sequencing after haploidentical hematopoietic stem cell transplantation: A multicenter study in China.
Wu Q, Wu Y, Zhao Y, Zhang Y, Cao J, Wu D, Zhou J, Chen F
Transpl Infect Dis 2023 Apr;25(2):e14054. Epub 2023 Mar 12 doi: 10.1111/tid.14054. PMID: 36908212
Impact of viral coinfection and macrolide-resistant mycoplasma infection in children with refractory Mycoplasma pneumoniae pneumonia.
Zhou Y, Wang J, Chen W, Shen N, Tao Y, Zhao R, Luo L, Li B, Cao Q
BMC Infect Dis 2020 Aug 26;20(1):633. doi: 10.1186/s12879-020-05356-1. PMID: 32847534Free PMC Article
The successful use of alemtuzumab for treatment of steroid-refractory acute graft-versus-host disease in pediatric patients.
Khandelwal P, Lawrence J, Filipovich AH, Davies SM, Bleesing JJ, Jordan MB, Mehta P, Jodele S, Grimley MS, Kumar A, Myers K, Marsh RA
Pediatr Transplant 2014 Feb;18(1):94-102. Epub 2013 Oct 30 doi: 10.1111/petr.12183. PMID: 24384050Free PMC Article
Adoptive T-cell transfer for refractory viral infections with cytomegalovirus, Epstein-Barr virus or adenovirus after allogeneic stem cell transplantation.
Feucht J, Joachim L, Lang P, Feuchtinger T
Klin Padiatr 2013 May;225(3):164-9. Epub 2013 May 22 doi: 10.1055/s-0033-1333749. PMID: 23700092

Diagnosis

Evaluating anterior corneal surface using Placido ring mires for irregular astigmatism in refractory corneal subepithelial infiltrates after adenoviral conjunctivitis.
Toyokawa N, Araki-Sasaki K, Kimura H, Kuroda S
BMC Ophthalmol 2024 Nov 28;24(1):515. doi: 10.1186/s12886-024-03774-2. PMID: 39609742Free PMC Article
Viral Coinfections in Kawasaki Disease: A Meta-analysis.
Neubauer HC, Lopez MA, Haq HA, Ouellette L, Ramirez AA, Wallace SS
Hosp Pediatr 2023 Jun 1;13(6):e153-e169. doi: 10.1542/hpeds.2023-007150. PMID: 37170763
Adenovirus infection diagnosed by metagenomic next-generation sequencing after haploidentical hematopoietic stem cell transplantation: A multicenter study in China.
Wu Q, Wu Y, Zhao Y, Zhang Y, Cao J, Wu D, Zhou J, Chen F
Transpl Infect Dis 2023 Apr;25(2):e14054. Epub 2023 Mar 12 doi: 10.1111/tid.14054. PMID: 36908212
Mystery eye: Human adenovirus and the enigma of epidemic keratoconjunctivitis.
Jonas RA, Ung L, Rajaiya J, Chodosh J
Prog Retin Eye Res 2020 May;76:100826. Epub 2019 Dec 28 doi: 10.1016/j.preteyeres.2019.100826. PMID: 31891773Free PMC Article
IgA vasculitis (Henoch-Schönlein purpura).
Farhadian JA, Castilla C, Shvartsbeyn M, Meehan SA, Neimann A, Pomeranz MK
Dermatol Online J 2015 Dec 16;21(12) PMID: 26990342

Therapy

Viral Coinfections in Kawasaki Disease: A Meta-analysis.
Neubauer HC, Lopez MA, Haq HA, Ouellette L, Ramirez AA, Wallace SS
Hosp Pediatr 2023 Jun 1;13(6):e153-e169. doi: 10.1542/hpeds.2023-007150. PMID: 37170763
Adenovirus infection in pediatric transplant recipients: are effective antiviral agents coming our way?
Lopez SMC, Michaels MG, Green M
Curr Opin Organ Transplant 2018 Aug;23(4):395-399. doi: 10.1097/MOT.0000000000000542. PMID: 29846196
Off-the-Shelf Virus-Specific T Cells to Treat BK Virus, Human Herpesvirus 6, Cytomegalovirus, Epstein-Barr Virus, and Adenovirus Infections After Allogeneic Hematopoietic Stem-Cell Transplantation.
Tzannou I, Papadopoulou A, Naik S, Leung K, Martinez CA, Ramos CA, Carrum G, Sasa G, Lulla P, Watanabe A, Kuvalekar M, Gee AP, Wu MF, Liu H, Grilley BJ, Krance RA, Gottschalk S, Brenner MK, Rooney CM, Heslop HE, Leen AM, Omer B
J Clin Oncol 2017 Nov 1;35(31):3547-3557. Epub 2017 Aug 7 doi: 10.1200/JCO.2017.73.0655. PMID: 28783452Free PMC Article
Refractory adenovirus infection after simultaneous kidney-pancreas transplantation: successful treatment with intravenous ribavirin and pooled human intravenous immunoglobulin.
Emovon OE, Lin A, Howell DN, Afzal F, Baillie M, Rogers J, Baliga PK, Chavin K, Nickeleit V, Rajagapalan PR, Self S
Nephrol Dial Transplant 2003 Nov;18(11):2436-8. doi: 10.1093/ndt/gfg365. PMID: 14551382
Adenovirus enhancement of transferrin-polylysine-mediated gene delivery.
Curiel DT, Agarwal S, Wagner E, Cotten M
Proc Natl Acad Sci U S A 1991 Oct 1;88(19):8850-4. doi: 10.1073/pnas.88.19.8850. PMID: 1681545Free PMC Article

Prognosis

Impact of viral coinfection and macrolide-resistant mycoplasma infection in children with refractory Mycoplasma pneumoniae pneumonia.
Zhou Y, Wang J, Chen W, Shen N, Tao Y, Zhao R, Luo L, Li B, Cao Q
BMC Infect Dis 2020 Aug 26;20(1):633. doi: 10.1186/s12879-020-05356-1. PMID: 32847534Free PMC Article
Clearance of Treatment Refractory Adenoviremia via Adenovirus-specific Donor T-Cell Transfer During Aplasia After αβTCR-CD19-Depleted Stem Cell Transplantation.
Gössling KL, Fouz H, Kyrillopoulou O, Aubin M, Maecker-Kolhoff B, Adams O, Borkhardt A, Babor F, Schuster FR, Siepermann M, Schumm M, Lang P, Eiz-Vesper B, Meisel R
Clin Infect Dis 2019 Apr 8;68(8):1406-1409. doi: 10.1093/cid/ciy820. PMID: 30357314
The successful use of alemtuzumab for treatment of steroid-refractory acute graft-versus-host disease in pediatric patients.
Khandelwal P, Lawrence J, Filipovich AH, Davies SM, Bleesing JJ, Jordan MB, Mehta P, Jodele S, Grimley MS, Kumar A, Myers K, Marsh RA
Pediatr Transplant 2014 Feb;18(1):94-102. Epub 2013 Oct 30 doi: 10.1111/petr.12183. PMID: 24384050Free PMC Article
Fatal adenoviral and enteroviral infections and an Epstein-Barr virus positive large B-cell lymphoma after alemtuzumab treatment in a patient with refractory Sézary syndrome.
Roch N, Salameire D, Gressin R, Morand P, Epaulard O, Pavese P, Brion JP, Stahl JP
Scand J Infect Dis 2008;40(4):343-6. doi: 10.1080/00365540701684817. PMID: 17934981
Fatal adenovirus infection during alemtuzumab (anti-CD52 monoclonal antibody) treatment of a patient with fludarabine-refractory B-cell chronic lymphocytic leukemia.
Cavalli-Björkman N, Osby E, Lundin J, Kalin M, Osterborg A, Gruber A
Med Oncol 2002;19(4):277-80. doi: 10.1385/MO:19:4:277. PMID: 12512923

Clinical prediction guides

Viral Coinfections in Kawasaki Disease: A Meta-analysis.
Neubauer HC, Lopez MA, Haq HA, Ouellette L, Ramirez AA, Wallace SS
Hosp Pediatr 2023 Jun 1;13(6):e153-e169. doi: 10.1542/hpeds.2023-007150. PMID: 37170763
Off-the-Shelf Virus-Specific T Cells to Treat BK Virus, Human Herpesvirus 6, Cytomegalovirus, Epstein-Barr Virus, and Adenovirus Infections After Allogeneic Hematopoietic Stem-Cell Transplantation.
Tzannou I, Papadopoulou A, Naik S, Leung K, Martinez CA, Ramos CA, Carrum G, Sasa G, Lulla P, Watanabe A, Kuvalekar M, Gee AP, Wu MF, Liu H, Grilley BJ, Krance RA, Gottschalk S, Brenner MK, Rooney CM, Heslop HE, Leen AM, Omer B
J Clin Oncol 2017 Nov 1;35(31):3547-3557. Epub 2017 Aug 7 doi: 10.1200/JCO.2017.73.0655. PMID: 28783452Free PMC Article
The successful use of alemtuzumab for treatment of steroid-refractory acute graft-versus-host disease in pediatric patients.
Khandelwal P, Lawrence J, Filipovich AH, Davies SM, Bleesing JJ, Jordan MB, Mehta P, Jodele S, Grimley MS, Kumar A, Myers K, Marsh RA
Pediatr Transplant 2014 Feb;18(1):94-102. Epub 2013 Oct 30 doi: 10.1111/petr.12183. PMID: 24384050Free PMC Article
Induction of immunological tolerance to adenoviral vectors by using a novel dendritic cell-based strategy.
Kushwah R, Oliver JR, Duan R, Zhang L, Keshavjee S, Hu J
J Virol 2012 Apr;86(7):3422-35. Epub 2012 Jan 18 doi: 10.1128/JVI.06172-11. PMID: 22258241Free PMC Article
Specific gene inhibition by adenovirus-mediated expression of small interfering RNA.
Zhao LJ, Jian H, Zhu H
Gene 2003 Oct 16;316:137-41. doi: 10.1016/s0378-1119(03)00750-9. PMID: 14563560

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