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Sinonasal Adenocarcinoma, Salivary-Type

MedGen UID:
1685449
•Concept ID:
C5205717
•
Neoplastic Process
Synonym: Nasal Cavity and Paranasal Sinus Adenocarcinoma, Salivary-Type

Definition

Adenocarcinomas that arise from the seromucinous glands and surface epithelium of the nasal cavity and paranasal sinuses. These adenocarcinomas morphologically resemble the adenocarcinomas that arise from the major and minor salivary glands. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSinonasal Adenocarcinoma, Salivary-Type

Recent clinical studies

Etiology

Human Papillomavirus-Associated Multiphenotypic Carcinoma: First Description of a Vulval Case.
Currie CC, Leaning D, McCluggage WG, Spoor E
Int J Gynecol Pathol 2025 Jan 1;44(1):37-41. Epub 2024 Apr 9 doi: 10.1097/PGP.0000000000001034. PMID: 38661560
Expanding the spectrum of low-grade sinonasal adenocarcinoma with biphasic seromucinous differentiation and activating HRAS/AKT1 mutations.
Hadnagy VS, Körner M, Rössle M, Dubach P, Pabst G, Kotulova A, Weder S, Seifert R, Rushing EJ, Holzmann D, Hüllner M, Freiberger SN, Rupp NJ
Histopathology 2024 Dec;85(6):899-908. Epub 2024 Jun 24 doi: 10.1111/his.15251. PMID: 38923026
ETV6 Gene Rearrangements Characterize a Morphologically Distinct Subset of Sinonasal Low-grade Non-intestinal-type Adenocarcinoma: A Novel Translocation-associated Carcinoma Restricted to the Sinonasal Tract.
Andreasen S, Skálová A, Agaimy A, Bishop JA, Laco J, Leivo I, Franchi A, Larsen SR, Erentaite D, Ulhøi BP, von Buchwald C, Melchior LC, Michal M, Kiss K
Am J Surg Pathol 2017 Nov;41(11):1552-1560. doi: 10.1097/PAS.0000000000000912. PMID: 28719468
Among sinonasal tumors, CDX-2 immunoexpression is not restricted to intestinal-type adenocarcinomas.
Tilson MP, Gallia GL, Bishop JA
Head Neck Pathol 2014 Mar;8(1):59-65. Epub 2013 Jul 12 doi: 10.1007/s12105-013-0475-7. PMID: 23846317Free PMC Article

Diagnosis

Human Papillomavirus-Associated Multiphenotypic Carcinoma: First Description of a Vulval Case.
Currie CC, Leaning D, McCluggage WG, Spoor E
Int J Gynecol Pathol 2025 Jan 1;44(1):37-41. Epub 2024 Apr 9 doi: 10.1097/PGP.0000000000001034. PMID: 38661560
Sinonasal Adenocarcinomas: An Update.
Arcovito G, Franchi A
Surg Pathol Clin 2024 Dec;17(4):653-666. Epub 2024 Aug 17 doi: 10.1016/j.path.2024.07.005. PMID: 39489555
Sinonasal Adenocarcinoma: Update on Classification, Immunophenotype and Molecular Features.
Leivo I
Head Neck Pathol 2016 Mar;10(1):68-74. Epub 2016 Feb 1 doi: 10.1007/s12105-016-0694-9. PMID: 26830399Free PMC Article
Among sinonasal tumors, CDX-2 immunoexpression is not restricted to intestinal-type adenocarcinomas.
Tilson MP, Gallia GL, Bishop JA
Head Neck Pathol 2014 Mar;8(1):59-65. Epub 2013 Jul 12 doi: 10.1007/s12105-013-0475-7. PMID: 23846317Free PMC Article

Prognosis

Signet-ring cell adenocarcinoma of sinonasal tract: an immunohistochemical study of the mucins profile.
Castillo C, Buob D, Mortuaire G, Chevalier D, Aubert S, Copin MC, Leroy X
Arch Pathol Lab Med 2007 Jun;131(6):961-4. doi: 10.5858/2007-131-961-SCAOST. PMID: 17550327

Clinical prediction guides

Primary and Secondary/ Metastatic Salivary Duct Carcinoma Presenting within the Sinonasal Tract.
Agaimy A, Mueller SK, Bishop JA, Chiosea SI
Head Neck Pathol 2021 Sep;15(3):769-779. Epub 2021 Jan 11 doi: 10.1007/s12105-020-01271-8. PMID: 33428064Free PMC Article
Among sinonasal tumors, CDX-2 immunoexpression is not restricted to intestinal-type adenocarcinomas.
Tilson MP, Gallia GL, Bishop JA
Head Neck Pathol 2014 Mar;8(1):59-65. Epub 2013 Jul 12 doi: 10.1007/s12105-013-0475-7. PMID: 23846317Free PMC Article

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