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Decreased post-bronchodilator forced vital capacity

MedGen UID:
1685757
•Concept ID:
C5139290
•
Finding
Synonyms: Decreased post bronchodilator forced vital capacity; Decreased postbronchodilator forced vital capacity
 
HPO: HP:0032357

Definition

An abnormal reduction in the amount of air a person can expel following maximal insipiration, with the test being performed after the administration of a bronchodilating medication. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased post-bronchodilator forced vital capacity

Professional guidelines

PubMed

Self-management interventions for people with chronic obstructive pulmonary disease.
Schrijver J, Lenferink A, Brusse-Keizer M, Zwerink M, van der Valk PD, van der Palen J, Effing TW
Cochrane Database Syst Rev 2022 Jan 10;1(1):CD002990. doi: 10.1002/14651858.CD002990.pub4. PMID: 35001366Free PMC Article
Post-bronchodilator spirometry reference values in adults and implications for disease management.
Johannessen A, Lehmann S, Omenaas ER, Eide GE, Bakke PS, Gulsvik A
Am J Respir Crit Care Med 2006 Jun 15;173(12):1316-25. Epub 2006 Mar 23 doi: 10.1164/rccm.200601-023OC. PMID: 16556696
Regular inhaled short acting beta2 agonists for the management of stable chronic obstructive pulmonary disease: Cochrane systematic review and meta-analysis.
Ram FS, Sestini P
Thorax 2003 Jul;58(7):580-4. doi: 10.1136/thorax.58.7.580. PMID: 12832670Free PMC Article

Recent clinical studies

Etiology

Body mass index trajectories from birth to early adulthood and lung function development.
Wang G, Hallberg J, Merid SK, Kumar A, Klevebro S, Habchi B, Chaleckis R, Wheelock CE, Hernandez-Pacheco N, Ekström S, Janson C, Kull I, Bergström A, Melén E
Eur Respir J 2025 Jan;65(1) Epub 2025 Jan 2 doi: 10.1183/13993003.00298-2024. PMID: 39467611Free PMC Article
The effect of nebulized N-acetylcysteine on the phlegm of chronic obstructive pulmonary disease: the NEWEST study.
Rhee CK, Lim SY, Lee WY, Jung JY, Park YB, Lee CY, Hwang YI, Song JW, Choi WI, Yoo KH, Kim KU, Kim YI, Kim TH, Park SJ, Shin KC, Um SJ, Yoon HK, Lee HS, Kim DK, Leem AY; Korean Pulmonary Rehabilitation Study Group
BMC Pulm Med 2024 Sep 2;24(1):434. doi: 10.1186/s12890-024-03243-y. PMID: 39223526Free PMC Article
The role of FEV(1)/FVC in the prediction of acute exacerbation of COPD.
Jang JG, Kim Y, Shin SH, Min KH, Jung KS, Kim YI, Park S, Na JO, Lee H, Yoo KH
Respir Med 2024 Nov-Dec;234:107780. Epub 2024 Aug 30 doi: 10.1016/j.rmed.2024.107780. PMID: 39216610
Clinical Implications of Bronchodilator Testing: Diagnosing and Differentiating COPD and Asthma-COPD Overlap.
Annangi S, Coz-Yataco AO
Respir Care 2022 Apr;67(4):440-447. doi: 10.4187/respcare.09215. PMID: 35338095
Self-management interventions for people with chronic obstructive pulmonary disease.
Schrijver J, Lenferink A, Brusse-Keizer M, Zwerink M, van der Valk PD, van der Palen J, Effing TW
Cochrane Database Syst Rev 2022 Jan 10;1(1):CD002990. doi: 10.1002/14651858.CD002990.pub4. PMID: 35001366Free PMC Article

Diagnosis

The role of FEV(1)/FVC in the prediction of acute exacerbation of COPD.
Jang JG, Kim Y, Shin SH, Min KH, Jung KS, Kim YI, Park S, Na JO, Lee H, Yoo KH
Respir Med 2024 Nov-Dec;234:107780. Epub 2024 Aug 30 doi: 10.1016/j.rmed.2024.107780. PMID: 39216610
Preserved ratio impaired spirometry is associated with small airway dysfunction and reduced total lung capacity.
Zhao N, Wu F, Peng J, Zheng Y, Tian H, Yang H, Deng Z, Wang Z, Li H, Wen X, Xiao S, Huang P, Dai C, Lu L, Zhou K, Chen S, Zhou Y, Ran P
Respir Res 2022 Oct 31;23(1):298. doi: 10.1186/s12931-022-02216-1. PMID: 36316732Free PMC Article
Clinical Implications of Bronchodilator Testing: Diagnosing and Differentiating COPD and Asthma-COPD Overlap.
Annangi S, Coz-Yataco AO
Respir Care 2022 Apr;67(4):440-447. doi: 10.4187/respcare.09215. PMID: 35338095
Self-management interventions for people with chronic obstructive pulmonary disease.
Schrijver J, Lenferink A, Brusse-Keizer M, Zwerink M, van der Valk PD, van der Palen J, Effing TW
Cochrane Database Syst Rev 2022 Jan 10;1(1):CD002990. doi: 10.1002/14651858.CD002990.pub4. PMID: 35001366Free PMC Article
Evaluating How Post-Bronchodilator Vital Capacities Affect the Diagnosis of Obstruction in Pulmonary Function Tests.
Blagev DP, Sorenson D, Linares-Perdomo O, Bamberg S, Hegewald M, Morris AH
Respir Care 2016 Nov;61(11):1523-1529. Epub 2016 Sep 13 doi: 10.4187/respcare.04611. PMID: 27624631

Therapy

The effect of nebulized N-acetylcysteine on the phlegm of chronic obstructive pulmonary disease: the NEWEST study.
Rhee CK, Lim SY, Lee WY, Jung JY, Park YB, Lee CY, Hwang YI, Song JW, Choi WI, Yoo KH, Kim KU, Kim YI, Kim TH, Park SJ, Shin KC, Um SJ, Yoon HK, Lee HS, Kim DK, Leem AY; Korean Pulmonary Rehabilitation Study Group
BMC Pulm Med 2024 Sep 2;24(1):434. doi: 10.1186/s12890-024-03243-y. PMID: 39223526Free PMC Article
Clinical Implications of Bronchodilator Testing: Diagnosing and Differentiating COPD and Asthma-COPD Overlap.
Annangi S, Coz-Yataco AO
Respir Care 2022 Apr;67(4):440-447. doi: 10.4187/respcare.09215. PMID: 35338095
Self-management interventions for people with chronic obstructive pulmonary disease.
Schrijver J, Lenferink A, Brusse-Keizer M, Zwerink M, van der Valk PD, van der Palen J, Effing TW
Cochrane Database Syst Rev 2022 Jan 10;1(1):CD002990. doi: 10.1002/14651858.CD002990.pub4. PMID: 35001366Free PMC Article
Can roflumilast, a phosphodiesterase-4 inhibitor, improve clinical outcomes in patients with moderate-to-severe chronic obstructive pulmonary disease? A meta-analysis.
Luo J, Wang K, Liu D, Liang BM, Liu CT
Respir Res 2016 Feb 17;17:18. doi: 10.1186/s12931-016-0330-y. PMID: 26887407Free PMC Article
Post-bronchodilator spirometry reference values in adults and implications for disease management.
Johannessen A, Lehmann S, Omenaas ER, Eide GE, Bakke PS, Gulsvik A
Am J Respir Crit Care Med 2006 Jun 15;173(12):1316-25. Epub 2006 Mar 23 doi: 10.1164/rccm.200601-023OC. PMID: 16556696

Prognosis

The role of FEV(1)/FVC in the prediction of acute exacerbation of COPD.
Jang JG, Kim Y, Shin SH, Min KH, Jung KS, Kim YI, Park S, Na JO, Lee H, Yoo KH
Respir Med 2024 Nov-Dec;234:107780. Epub 2024 Aug 30 doi: 10.1016/j.rmed.2024.107780. PMID: 39216610
The effect of pulmonary rehabilitation on cardiovascular risk, oxidative stress and systemic inflammation in patients with COPD.
Muñoz Montiel A, Ruiz-Esteban P, Doménech Del Río A, Valdivielso P, Sánchez Chaparro MÁ, Olveira C
Respir Med 2024 Oct;232:107740. Epub 2024 Jul 14 doi: 10.1016/j.rmed.2024.107740. PMID: 39009098
Preserved ratio impaired spirometry is associated with small airway dysfunction and reduced total lung capacity.
Zhao N, Wu F, Peng J, Zheng Y, Tian H, Yang H, Deng Z, Wang Z, Li H, Wen X, Xiao S, Huang P, Dai C, Lu L, Zhou K, Chen S, Zhou Y, Ran P
Respir Res 2022 Oct 31;23(1):298. doi: 10.1186/s12931-022-02216-1. PMID: 36316732Free PMC Article
Forced Oscillation Technique and Small Airway Involvement in Chronic Hypersensitivity Pneumonitis.
Dias OM, Baldi BG, Chate RC, Ribeiro de Carvalho CR, Dellacà RL, Milesi I, Pereira de Albuquerque AL
Arch Bronconeumol (Engl Ed) 2019 Oct;55(10):519-525. Epub 2019 Apr 8 doi: 10.1016/j.arbres.2019.01.022. PMID: 30975515
Post-bronchodilator spirometry reference values in adults and implications for disease management.
Johannessen A, Lehmann S, Omenaas ER, Eide GE, Bakke PS, Gulsvik A
Am J Respir Crit Care Med 2006 Jun 15;173(12):1316-25. Epub 2006 Mar 23 doi: 10.1164/rccm.200601-023OC. PMID: 16556696

Clinical prediction guides

Body mass index trajectories from birth to early adulthood and lung function development.
Wang G, Hallberg J, Merid SK, Kumar A, Klevebro S, Habchi B, Chaleckis R, Wheelock CE, Hernandez-Pacheco N, Ekström S, Janson C, Kull I, Bergström A, Melén E
Eur Respir J 2025 Jan;65(1) Epub 2025 Jan 2 doi: 10.1183/13993003.00298-2024. PMID: 39467611Free PMC Article
The effect of nebulized N-acetylcysteine on the phlegm of chronic obstructive pulmonary disease: the NEWEST study.
Rhee CK, Lim SY, Lee WY, Jung JY, Park YB, Lee CY, Hwang YI, Song JW, Choi WI, Yoo KH, Kim KU, Kim YI, Kim TH, Park SJ, Shin KC, Um SJ, Yoon HK, Lee HS, Kim DK, Leem AY; Korean Pulmonary Rehabilitation Study Group
BMC Pulm Med 2024 Sep 2;24(1):434. doi: 10.1186/s12890-024-03243-y. PMID: 39223526Free PMC Article
The role of FEV(1)/FVC in the prediction of acute exacerbation of COPD.
Jang JG, Kim Y, Shin SH, Min KH, Jung KS, Kim YI, Park S, Na JO, Lee H, Yoo KH
Respir Med 2024 Nov-Dec;234:107780. Epub 2024 Aug 30 doi: 10.1016/j.rmed.2024.107780. PMID: 39216610
Preserved ratio impaired spirometry is associated with small airway dysfunction and reduced total lung capacity.
Zhao N, Wu F, Peng J, Zheng Y, Tian H, Yang H, Deng Z, Wang Z, Li H, Wen X, Xiao S, Huang P, Dai C, Lu L, Zhou K, Chen S, Zhou Y, Ran P
Respir Res 2022 Oct 31;23(1):298. doi: 10.1186/s12931-022-02216-1. PMID: 36316732Free PMC Article
Self-management interventions for people with chronic obstructive pulmonary disease.
Schrijver J, Lenferink A, Brusse-Keizer M, Zwerink M, van der Valk PD, van der Palen J, Effing TW
Cochrane Database Syst Rev 2022 Jan 10;1(1):CD002990. doi: 10.1002/14651858.CD002990.pub4. PMID: 35001366Free PMC Article

Recent systematic reviews

Self-management interventions for people with chronic obstructive pulmonary disease.
Schrijver J, Lenferink A, Brusse-Keizer M, Zwerink M, van der Valk PD, van der Palen J, Effing TW
Cochrane Database Syst Rev 2022 Jan 10;1(1):CD002990. doi: 10.1002/14651858.CD002990.pub4. PMID: 35001366Free PMC Article
Can roflumilast, a phosphodiesterase-4 inhibitor, improve clinical outcomes in patients with moderate-to-severe chronic obstructive pulmonary disease? A meta-analysis.
Luo J, Wang K, Liu D, Liang BM, Liu CT
Respir Res 2016 Feb 17;17:18. doi: 10.1186/s12931-016-0330-y. PMID: 26887407Free PMC Article
Regular inhaled short acting beta2 agonists for the management of stable chronic obstructive pulmonary disease: Cochrane systematic review and meta-analysis.
Ram FS, Sestini P
Thorax 2003 Jul;58(7):580-4. doi: 10.1136/thorax.58.7.580. PMID: 12832670Free PMC Article

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