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Clostridium difficile enteritis

MedGen UID:
1687484
•Concept ID:
C5139166
•
Disease or Syndrome
Synonym: C. difficile enteritis
 
HPO: HP:0032167

Definition

An infection of the small intestine (enteritis) by clostridium difficile. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClostridium difficile enteritis

Professional guidelines

PubMed

Pouchitis: pathophysiology and management.
Shen B
Nat Rev Gastroenterol Hepatol 2024 Jul;21(7):463-476. Epub 2024 Apr 25 doi: 10.1038/s41575-024-00920-5. PMID: 38664536
Recommendations and guidelines for the treatment of Clostridioides difficile infection in Taiwan.
Wu KS, Syue LS, Cheng A, Yen TY, Chen HM, Chiu YH, Hsu YL, Chiu CH, Su TY, Tsai WL, Chen WY, Huang CH, Hung HM, Huang LJ, Kuo HJ, Lin PC, Yang CH, Hong PL, Lee SS, Chen YS, Liu YC, Huang LM; Infectious Diseases Society of Taiwan; Medical Foundation in Memory of Dr. Deh-Lin Cheng; Foundation of Professor Wei-Chuan Hsieh for Infectious Diseases Research and Education; CY Lee's Research Foundation for Pediatric Infectious Diseases and Vaccines; 5th Guidelines Recommendations for Evidence-based Antimicrobial agents use in Taiwan (GREAT) working group
J Microbiol Immunol Infect 2020 Apr;53(2):191-208. Epub 2020 Feb 14 doi: 10.1016/j.jmii.2020.02.002. PMID: 32169531
Clostridium difficile infection: clinical spectrum and approach to management.
Vaishnavi C
Indian J Gastroenterol 2011 Dec;30(6):245-54. Epub 2011 Dec 20 doi: 10.1007/s12664-011-0148-y. PMID: 22183580

Curated

UK NICE Guideline NG199, Clostridioides difficile infection: antimicrobial prescribing, 2021

Recent clinical studies

Etiology

Prophylactic acid suppressants in children in the intensive care unit: a systematic review with meta-analysis and trial sequential analysis.
Jensen MM, Marker S, Do HQ, Barbateskovic M, Perner A, Møller MH
Acta Anaesthesiol Scand 2021 Mar;65(3):292-301. Epub 2020 Nov 22 doi: 10.1111/aas.13731. PMID: 33147375
Inpatients With 'Unexplained' Leukocytosis.
Haburchak DR, Alchreiki M
Am J Med 2020 Apr;133(4):508-514. Epub 2019 Nov 9 doi: 10.1016/j.amjmed.2019.10.019. PMID: 31715161
Clostridium difficile enteritis: a new role for an old foe.
Killeen S, Martin ST, Hyland J, O' Connell PR, Winter DC
Surgeon 2014 Oct;12(5):256-62. Epub 2014 Mar 4 doi: 10.1016/j.surge.2014.01.008. PMID: 24618362
Clostridium difficile of the ileum following total abdominal colectomy, with or without proctectomy: who is at risk?
Tsiouris A, Neale JA, Reickert CA, Times M
Dis Colon Rectum 2012 Apr;55(4):424-8. doi: 10.1097/DCR.0b013e31823f86a2. PMID: 22426266
Clostridium difficile enteritis: a review and pooled analysis of the cases.
Kim JH, Muder RR
Anaerobe 2011 Apr;17(2):52-5. Epub 2011 Feb 18 doi: 10.1016/j.anaerobe.2011.02.002. PMID: 21334446

Diagnosis

Inpatients With 'Unexplained' Leukocytosis.
Haburchak DR, Alchreiki M
Am J Med 2020 Apr;133(4):508-514. Epub 2019 Nov 9 doi: 10.1016/j.amjmed.2019.10.019. PMID: 31715161
Fulminant Clostridium difficile enteritis causing abdominal compartment syndrome.
Thai H, Guerron AD, Bencsath KP, Liu X, Loor M
Surg Infect (Larchmt) 2014 Dec;15(6):821-5. doi: 10.1089/sur.2013.026. PMID: 24824419
Clostridium difficile enteritis: a new role for an old foe.
Killeen S, Martin ST, Hyland J, O' Connell PR, Winter DC
Surgeon 2014 Oct;12(5):256-62. Epub 2014 Mar 4 doi: 10.1016/j.surge.2014.01.008. PMID: 24618362
Treatment of metronidazole-refractory Clostridium difficile enteritis with vancomycin.
Follmar KE, Condron SA, Turner II, Nathan JD, Ludwig KA
Surg Infect (Larchmt) 2008 Apr;9(2):195-200. doi: 10.1089/sur.2006.089. PMID: 18426352
Clostridium difficile enteritis: an early postoperative complication in inflammatory bowel disease patients after colectomy.
Lundeen SJ, Otterson MF, Binion DG, Carman ET, Peppard WJ
J Gastrointest Surg 2007 Feb;11(2):138-42. doi: 10.1007/s11605-006-0022-x. PMID: 17390162

Therapy

Inpatients With 'Unexplained' Leukocytosis.
Haburchak DR, Alchreiki M
Am J Med 2020 Apr;133(4):508-514. Epub 2019 Nov 9 doi: 10.1016/j.amjmed.2019.10.019. PMID: 31715161
Fulminant Clostridium difficile enteritis causing abdominal compartment syndrome.
Thai H, Guerron AD, Bencsath KP, Liu X, Loor M
Surg Infect (Larchmt) 2014 Dec;15(6):821-5. doi: 10.1089/sur.2013.026. PMID: 24824419
Clostridium difficile enteritis: a review and pooled analysis of the cases.
Kim JH, Muder RR
Anaerobe 2011 Apr;17(2):52-5. Epub 2011 Feb 18 doi: 10.1016/j.anaerobe.2011.02.002. PMID: 21334446
Clostridium difficile enteritis after colectomy.
Causey MW, Spencer MP, Steele SR
Am Surg 2009 Dec;75(12):1203-6. PMID: 19999913
Treatment of metronidazole-refractory Clostridium difficile enteritis with vancomycin.
Follmar KE, Condron SA, Turner II, Nathan JD, Ludwig KA
Surg Infect (Larchmt) 2008 Apr;9(2):195-200. doi: 10.1089/sur.2006.089. PMID: 18426352

Prognosis

Inpatients With 'Unexplained' Leukocytosis.
Haburchak DR, Alchreiki M
Am J Med 2020 Apr;133(4):508-514. Epub 2019 Nov 9 doi: 10.1016/j.amjmed.2019.10.019. PMID: 31715161
Thirty-Day Readmissions After Hospitalization for Clostridium difficile Enteritis Measures and Predictors: A Nationwide Analysis.
Goyal A, Chatterjee K, Punjabi C, Rangaswami J
Infect Control Hosp Epidemiol 2017 Jul;38(7):876-878. Epub 2017 May 10 doi: 10.1017/ice.2017.97. PMID: 28486996
Clostridium difficile enteritis: a new role for an old foe.
Killeen S, Martin ST, Hyland J, O' Connell PR, Winter DC
Surgeon 2014 Oct;12(5):256-62. Epub 2014 Mar 4 doi: 10.1016/j.surge.2014.01.008. PMID: 24618362
Clostridium difficile enteritis: a review and pooled analysis of the cases.
Kim JH, Muder RR
Anaerobe 2011 Apr;17(2):52-5. Epub 2011 Feb 18 doi: 10.1016/j.anaerobe.2011.02.002. PMID: 21334446
Fatal Clostridium difficile enteritis caused by the BI/NAP1/027 strain: a case series of ileal C. difficile infections.
Lavallée C, Laufer B, Pépin J, Mitchell A, Dubé S, Labbé AC
Clin Microbiol Infect 2009 Dec;15(12):1093-9. Epub 2009 Jul 22 doi: 10.1111/j.1469-0691.2009.03004.x. PMID: 19681954

Clinical prediction guides

Prophylactic use of acid suppressants in adult acutely ill hospitalised patients: A systematic review with meta-analysis and trial sequential analysis.
Marker S, Barbateskovic M, Perner A, Wetterslev J, Jakobsen JC, Krag M, Granholm A, Anthon CT, Møller MH
Acta Anaesthesiol Scand 2020 Jul;64(6):714-728. Epub 2020 Mar 5 doi: 10.1111/aas.13568. PMID: 32060905
Inpatients With 'Unexplained' Leukocytosis.
Haburchak DR, Alchreiki M
Am J Med 2020 Apr;133(4):508-514. Epub 2019 Nov 9 doi: 10.1016/j.amjmed.2019.10.019. PMID: 31715161
Effects of stress ulcer prophylaxis in adult ICU patients receiving renal replacement therapy (Sup-Icu RENal, SIREN): Study protocol for a pre-planned observational study.
Schefold JC, Perner A, Lange T, Wetterslev J, Wise MP, Borthwick M, Bendel S, Keus F, Guttormsen AB, Marker S, Krag M, Møller MH; SUP-ICU investigators
Trials 2018 Jan 10;19(1):26. doi: 10.1186/s13063-017-2408-3. PMID: 29321041Free PMC Article
Thirty-Day Readmissions After Hospitalization for Clostridium difficile Enteritis Measures and Predictors: A Nationwide Analysis.
Goyal A, Chatterjee K, Punjabi C, Rangaswami J
Infect Control Hosp Epidemiol 2017 Jul;38(7):876-878. Epub 2017 May 10 doi: 10.1017/ice.2017.97. PMID: 28486996
Measurement of fecal lactoferrin as a marker of fecal leukocytes.
Guerrant RL, Araujo V, Soares E, Kotloff K, Lima AA, Cooper WH, Lee AG
J Clin Microbiol 1992 May;30(5):1238-42. doi: 10.1128/jcm.30.5.1238-1242.1992. PMID: 1583125Free PMC Article

Recent systematic reviews

Prophylactic acid suppressants in children in the intensive care unit: a systematic review with meta-analysis and trial sequential analysis.
Jensen MM, Marker S, Do HQ, Barbateskovic M, Perner A, Møller MH
Acta Anaesthesiol Scand 2021 Mar;65(3):292-301. Epub 2020 Nov 22 doi: 10.1111/aas.13731. PMID: 33147375
Prophylactic use of acid suppressants in adult acutely ill hospitalised patients: A systematic review with meta-analysis and trial sequential analysis.
Marker S, Barbateskovic M, Perner A, Wetterslev J, Jakobsen JC, Krag M, Granholm A, Anthon CT, Møller MH
Acta Anaesthesiol Scand 2020 Jul;64(6):714-728. Epub 2020 Mar 5 doi: 10.1111/aas.13568. PMID: 32060905
Clostridium difficile enteritis: a new role for an old foe.
Killeen S, Martin ST, Hyland J, O' Connell PR, Winter DC
Surgeon 2014 Oct;12(5):256-62. Epub 2014 Mar 4 doi: 10.1016/j.surge.2014.01.008. PMID: 24618362

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2021
      UK NICE Guideline NG199, Clostridioides difficile infection: antimicrobial prescribing, 2021

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

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