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Metastatic Pancreatic Ductal Adenocarcinoma

MedGen UID:
1688030
Concept ID:
C5204113
Neoplastic Process

Definition

An adenocarcinoma that arises from the exocrine pancreatic ducts and has metastasized to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Pancreatic Ductal Adenocarcinoma

Professional guidelines

PubMed

Singh RR, O'Reilly EM
Drugs 2020 May;80(7):647-669. doi: 10.1007/s40265-020-01304-0. PMID: 32306207Free PMC Article
Sakaguchi T, Valente R, Tanaka K, Satoi S, Del Chiaro M
Pancreatology 2019 Jul;19(5):672-680. Epub 2019 Jun 7 doi: 10.1016/j.pan.2019.05.466. PMID: 31285145
Pokorny AMJ, Chin VT, Nagrial AM, Yip D, Chantrill LA
Intern Med J 2018 Jun;48(6):637-644. doi: 10.1111/imj.13810. PMID: 29898269

Recent clinical studies

Etiology

Carrato A, Pazo-Cid R, Macarulla T, Gallego J, Jiménez-Fonseca P, Rivera F, Cano MT, Rodriguez-Garrote M, Pericay C, Alés I, Layos L, Graña B, Iranzo V, Gallego I, Garcia-Carbonero R, de Mena IR, Guillén-Ponce C, Aranda E
NEJM Evid 2024 Feb;3(2):EVIDoa2300144. Epub 2024 Jan 23 doi: 10.1056/EVIDoa2300144. PMID: 38320486
Wainberg ZA, Melisi D, Macarulla T, Pazo Cid R, Chandana SR, De La Fouchardière C, Dean A, Kiss I, Lee WJ, Goetze TO, Van Cutsem E, Paulson AS, Bekaii-Saab T, Pant S, Hubner RA, Xiao Z, Chen H, Benzaghou F, O'Reilly EM
Lancet 2023 Oct 7;402(10409):1272-1281. Epub 2023 Sep 11 doi: 10.1016/S0140-6736(23)01366-1. PMID: 37708904Free PMC Article
Klein-Brill A, Amar-Farkash S, Lawrence G, Collisson EA, Aran D
JAMA Netw Open 2022 Jun 1;5(6):e2216199. doi: 10.1001/jamanetworkopen.2022.16199. PMID: 35675073Free PMC Article
Gourd E
Lancet Oncol 2018 Feb;19(2):e81. Epub 2017 Dec 21 doi: 10.1016/S1470-2045(17)30953-1. PMID: 29276021
Wang-Gillam A, Li CP, Bodoky G, Dean A, Shan YS, Jameson G, Macarulla T, Lee KH, Cunningham D, Blanc JF, Hubner RA, Chiu CF, Schwartsmann G, Siveke JT, Braiteh F, Moyo V, Belanger B, Dhindsa N, Bayever E, Von Hoff DD, Chen LT; NAPOLI-1 Study Group
Lancet 2016 Feb 6;387(10018):545-557. Epub 2015 Nov 29 doi: 10.1016/S0140-6736(15)00986-1. PMID: 26615328

Diagnosis

Bodeker KL, Smith BJ, Berg DJ, Chandrasekharan C, Sharif S, Fei N, Vollstedt S, Brown H, Chandler M, Lorack A, McMichael S, Wulfekuhle J, Wagner BA, Buettner GR, Allen BG, Caster JM, Dion B, Kamgar M, Buatti JM, Cullen JJ
Redox Biol 2024 Nov;77:103375. Epub 2024 Oct 2 doi: 10.1016/j.redox.2024.103375. PMID: 39369582Free PMC Article
Ng CF, Glaspy J, Placencio-Hickok VR, Thomassian S, Gong J, Osipov A, Hendifar AE, Moshayedi N
J Natl Compr Canc Netw 2022 Oct;20(10):1076-1079. doi: 10.6004/jnccn.2022.7039. PMID: 36240849
Wainberg ZA, Bekaii-Saab T, Boland PM, Dayyani F, Macarulla T, Mody K, Belanger B, Maxwell F, Moore Y, Thiagalingam A, Wang T, Zhang B, Dean A
Eur J Cancer 2021 Jul;151:14-24. Epub 2021 May 4 doi: 10.1016/j.ejca.2021.03.028. PMID: 33957442
Singh RR, O'Reilly EM
Drugs 2020 May;80(7):647-669. doi: 10.1007/s40265-020-01304-0. PMID: 32306207Free PMC Article
Pokorny AMJ, Chin VT, Nagrial AM, Yip D, Chantrill LA
Intern Med J 2018 Jun;48(6):637-644. doi: 10.1111/imj.13810. PMID: 29898269

Therapy

Wainberg ZA, Melisi D, Macarulla T, Pazo Cid R, Chandana SR, De La Fouchardière C, Dean A, Kiss I, Lee WJ, Goetze TO, Van Cutsem E, Paulson AS, Bekaii-Saab T, Pant S, Hubner RA, Xiao Z, Chen H, Benzaghou F, O'Reilly EM
Lancet 2023 Oct 7;402(10409):1272-1281. Epub 2023 Sep 11 doi: 10.1016/S0140-6736(23)01366-1. PMID: 37708904Free PMC Article
Ho WJ, Jaffee EM, Zheng L
Nat Rev Clin Oncol 2020 Sep;17(9):527-540. Epub 2020 May 12 doi: 10.1038/s41571-020-0363-5. PMID: 32398706Free PMC Article
Wang-Gillam A, Hubner RA, Siveke JT, Von Hoff DD, Belanger B, de Jong FA, Mirakhur B, Chen LT
Eur J Cancer 2019 Feb;108:78-87. Epub 2019 Jan 14 doi: 10.1016/j.ejca.2018.12.007. PMID: 30654298
Gourd E
Lancet Oncol 2018 Feb;19(2):e81. Epub 2017 Dec 21 doi: 10.1016/S1470-2045(17)30953-1. PMID: 29276021
Wang-Gillam A, Li CP, Bodoky G, Dean A, Shan YS, Jameson G, Macarulla T, Lee KH, Cunningham D, Blanc JF, Hubner RA, Chiu CF, Schwartsmann G, Siveke JT, Braiteh F, Moyo V, Belanger B, Dhindsa N, Bayever E, Von Hoff DD, Chen LT; NAPOLI-1 Study Group
Lancet 2016 Feb 6;387(10018):545-557. Epub 2015 Nov 29 doi: 10.1016/S0140-6736(15)00986-1. PMID: 26615328

Prognosis

Geerinckx B, Teuwen LA, Foo T, Vandamme T, Smith A, Peeters M, Price T
Expert Rev Anticancer Ther 2023 Jul-Dec;23(12):1237-1249. Epub 2023 Dec 8 doi: 10.1080/14737140.2023.2270161. PMID: 37842857
Ng CF, Glaspy J, Placencio-Hickok VR, Thomassian S, Gong J, Osipov A, Hendifar AE, Moshayedi N
J Natl Compr Canc Netw 2022 Oct;20(10):1076-1079. doi: 10.6004/jnccn.2022.7039. PMID: 36240849
Sakaguchi T, Valente R, Tanaka K, Satoi S, Del Chiaro M
Pancreatology 2019 Jul;19(5):672-680. Epub 2019 Jun 7 doi: 10.1016/j.pan.2019.05.466. PMID: 31285145
Wang-Gillam A, Hubner RA, Siveke JT, Von Hoff DD, Belanger B, de Jong FA, Mirakhur B, Chen LT
Eur J Cancer 2019 Feb;108:78-87. Epub 2019 Jan 14 doi: 10.1016/j.ejca.2018.12.007. PMID: 30654298
Gourd E
Lancet Oncol 2018 Feb;19(2):e81. Epub 2017 Dec 21 doi: 10.1016/S1470-2045(17)30953-1. PMID: 29276021

Clinical prediction guides

Nichetti F, Rota S, Ambrosini P, Pircher C, Gusmaroli E, Droz Dit Busset M, Pusceddu S, Sposito C, Coppa J, Morano F, Pietrantonio F, Di Bartolomeo M, Mariani L, Mazzaferro V, de Braud F, Niger M
JAMA Netw Open 2024 Jan 2;7(1):e2350756. doi: 10.1001/jamanetworkopen.2023.50756. PMID: 38190183Free PMC Article
Wainberg ZA, Melisi D, Macarulla T, Pazo Cid R, Chandana SR, De La Fouchardière C, Dean A, Kiss I, Lee WJ, Goetze TO, Van Cutsem E, Paulson AS, Bekaii-Saab T, Pant S, Hubner RA, Xiao Z, Chen H, Benzaghou F, O'Reilly EM
Lancet 2023 Oct 7;402(10409):1272-1281. Epub 2023 Sep 11 doi: 10.1016/S0140-6736(23)01366-1. PMID: 37708904Free PMC Article
Klein-Brill A, Amar-Farkash S, Lawrence G, Collisson EA, Aran D
JAMA Netw Open 2022 Jun 1;5(6):e2216199. doi: 10.1001/jamanetworkopen.2022.16199. PMID: 35675073Free PMC Article
Wainberg ZA, Bekaii-Saab T, Boland PM, Dayyani F, Macarulla T, Mody K, Belanger B, Maxwell F, Moore Y, Thiagalingam A, Wang T, Zhang B, Dean A
Eur J Cancer 2021 Jul;151:14-24. Epub 2021 May 4 doi: 10.1016/j.ejca.2021.03.028. PMID: 33957442
Ho WJ, Jaffee EM, Zheng L
Nat Rev Clin Oncol 2020 Sep;17(9):527-540. Epub 2020 May 12 doi: 10.1038/s41571-020-0363-5. PMID: 32398706Free PMC Article

Recent systematic reviews

Dekker EN, Narayan RR, Ahmami MA, Meddouch A, Verkolf EMM, Gehrels AM, Besselink MGH, van Eijck CHJ, Homs MYV, Mostert B, O'Kane GM, de Wilde RF, Wilmink JW, O'Reilly EM, Qadan M, Groot Koerkamp B
Br J Surg 2024 Oct 1;111(10) doi: 10.1093/bjs/znae244. PMID: 39400008Free PMC Article
Nichetti F, Rota S, Ambrosini P, Pircher C, Gusmaroli E, Droz Dit Busset M, Pusceddu S, Sposito C, Coppa J, Morano F, Pietrantonio F, Di Bartolomeo M, Mariani L, Mazzaferro V, de Braud F, Niger M
JAMA Netw Open 2024 Jan 2;7(1):e2350756. doi: 10.1001/jamanetworkopen.2023.50756. PMID: 38190183Free PMC Article
Petrelli F, Parisi A, Tomasello G, Mini E, Arru M, Russo A, Garrone O, Khakoo S, Ardito R, Ghidini M
BMC Gastroenterol 2023 Jun 19;23(1):212. doi: 10.1186/s12876-023-02853-w. PMID: 37337148Free PMC Article
Dayyani F, Macarulla T, Johnson A, Wainberg ZA
Cancer Treat Rev 2023 Feb;113:102502. Epub 2022 Dec 29 doi: 10.1016/j.ctrv.2022.102502. PMID: 36641880
Lindemann J, du Toit L, Kotze U, Bernon M, Krige J, Jonas E
HPB (Oxford) 2021 Feb;23(2):173-186. Epub 2020 Oct 22 doi: 10.1016/j.hpb.2020.09.022. PMID: 33268268

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