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Human Papillomavirus-Related Penile Intraepithelial Neoplasia

MedGen UID:
1688317
•Concept ID:
C5206635
•
Neoplastic Process
Synonyms: HPV-Related PeIN; Human Papillomavirus-Associated Penile Intraepithelial Neoplasia; Human Papillomavirus-Related PeIN; Penile Intraepithelial Neoplasia, HPV-Associated; Penile Intraepithelial Neoplasia, HPV-Related; Penile Intraepithelial Neoplasia, Human Papillomavirus- Related; Penile Intraepithelial Neoplasia, Human Papillomavirus-Associated

Definition

Intraepithelial neoplasia of the penis caused by human papillomavirus infection. [from NCI]

Professional guidelines

PubMed

Penile intraepithelial neoplasia incidence, clinical classification, microenvironment and implications for imiquimod treatment.
Avitan O, Rafael T, Vreeburg M, Elst L, Bekers EM, Albersen M, Jordanova ES, Brouwer O
BJU Int 2024 Dec;134(6):881-889. Epub 2024 Jul 19 doi: 10.1111/bju.16473. PMID: 39030899
Treatment of Carcinoma In Situ of the Glans Penis With Topical Imiquimod Followed by Carbon Dioxide Laser Excision.
Torelli T, Catanzaro MA, Nicolai N, Giannatempo P, Necchi A, Raggi D, Paolini B, Colecchia M, Piva L, Biasoni D, Stagni S, Tesone A, Salvioni R
Clin Genitourin Cancer 2017 Jun;15(3):e483-e487. Epub 2017 Jan 18 doi: 10.1016/j.clgc.2017.01.009. PMID: 28209454

Recent clinical studies

Etiology

Human papillomavirus-related anogenital premalignancies and cancer in renal transplant recipients: A Danish nationwide, registry-based cohort study.
Reinholdt K, Thomsen LT, Dehlendorff C, Larsen HK, Sørensen SS, Haedersdal M, Kjaer SK
Int J Cancer 2020 May 1;146(9):2413-2422. Epub 2019 Aug 2 doi: 10.1002/ijc.32565. PMID: 31291470
Human papillomavirus-related genital disease in the immunocompromised host: Part I.
Gormley RH, Kovarik CL
J Am Acad Dermatol 2012 Jun;66(6):867.e1-14; quiz 881-2. doi: 10.1016/j.jaad.2010.12.050. PMID: 22583720
Human papillomavirus-related disease in men: not just a women's issue.
Palefsky JM
J Adolesc Health 2010 Apr;46(4 Suppl):S12-9. doi: 10.1016/j.jadohealth.2010.01.010. PMID: 20307839Free PMC Article
Human papillomavirus-related disease in people with HIV.
Palefsky J
Curr Opin HIV AIDS 2009 Jan;4(1):52-6. doi: 10.1097/COH.0b013e32831a7246. PMID: 19339939Free PMC Article
Human papillomavirus related diseases in Malaysians.
Cheah PL
Malays J Pathol 1994 Jun;16(1):15-7. PMID: 16329570

Diagnosis

Human papillomavirus-related anogenital premalignancies and cancer in renal transplant recipients: A Danish nationwide, registry-based cohort study.
Reinholdt K, Thomsen LT, Dehlendorff C, Larsen HK, Sørensen SS, Haedersdal M, Kjaer SK
Int J Cancer 2020 May 1;146(9):2413-2422. Epub 2019 Aug 2 doi: 10.1002/ijc.32565. PMID: 31291470
Prevalence of human papillomavirus-related diseases in the Republic of Korea: a cross-sectional study.
Oh JK, Choi HY, Han M, Lee JK, Min KJ, Ki M
Sex Transm Infect 2019 Jun;95(4):292-299. Epub 2019 Jan 24 doi: 10.1136/sextrans-2018-053742. PMID: 30679392
Advances in the pathology of penile carcinomas.
Chaux A, Cubilla AL
Hum Pathol 2012 Jun;43(6):771-89. doi: 10.1016/j.humpath.2012.01.014. PMID: 22595011
Human papillomavirus-related genital disease in the immunocompromised host: Part I.
Gormley RH, Kovarik CL
J Am Acad Dermatol 2012 Jun;66(6):867.e1-14; quiz 881-2. doi: 10.1016/j.jaad.2010.12.050. PMID: 22583720
Distinctive association of p16INK4a overexpression with penile intraepithelial neoplasia depicting warty and/or basaloid features: a study of 141 cases evaluating a new nomenclature.
Chaux A, Pfannl R, Lloveras B, Alejo M, Clavero O, Lezcano C, Muñoz N, de Sanjosé S, Bosch X, Hernández-Pérez M, Velazquez EF, Cubilla AL
Am J Surg Pathol 2010 Mar;34(3):385-92. doi: 10.1097/PAS.0b013e3181cdad23. PMID: 20139761

Therapy

Penile intraepithelial neoplasia incidence, clinical classification, microenvironment and implications for imiquimod treatment.
Avitan O, Rafael T, Vreeburg M, Elst L, Bekers EM, Albersen M, Jordanova ES, Brouwer O
BJU Int 2024 Dec;134(6):881-889. Epub 2024 Jul 19 doi: 10.1111/bju.16473. PMID: 39030899
Human papillomavirus-related anogenital premalignancies and cancer in renal transplant recipients: A Danish nationwide, registry-based cohort study.
Reinholdt K, Thomsen LT, Dehlendorff C, Larsen HK, Sørensen SS, Haedersdal M, Kjaer SK
Int J Cancer 2020 May 1;146(9):2413-2422. Epub 2019 Aug 2 doi: 10.1002/ijc.32565. PMID: 31291470
Treatment of Carcinoma In Situ of the Glans Penis With Topical Imiquimod Followed by Carbon Dioxide Laser Excision.
Torelli T, Catanzaro MA, Nicolai N, Giannatempo P, Necchi A, Raggi D, Paolini B, Colecchia M, Piva L, Biasoni D, Stagni S, Tesone A, Salvioni R
Clin Genitourin Cancer 2017 Jun;15(3):e483-e487. Epub 2017 Jan 18 doi: 10.1016/j.clgc.2017.01.009. PMID: 28209454
Human papillomavirus-related disease in men: not just a women's issue.
Palefsky JM
J Adolesc Health 2010 Apr;46(4 Suppl):S12-9. doi: 10.1016/j.jadohealth.2010.01.010. PMID: 20307839Free PMC Article
Human papillomavirus-related disease in people with HIV.
Palefsky J
Curr Opin HIV AIDS 2009 Jan;4(1):52-6. doi: 10.1097/COH.0b013e32831a7246. PMID: 19339939Free PMC Article

Prognosis

Penile intraepithelial neoplasia incidence, clinical classification, microenvironment and implications for imiquimod treatment.
Avitan O, Rafael T, Vreeburg M, Elst L, Bekers EM, Albersen M, Jordanova ES, Brouwer O
BJU Int 2024 Dec;134(6):881-889. Epub 2024 Jul 19 doi: 10.1111/bju.16473. PMID: 39030899
Human papillomavirus-related anogenital premalignancies and cancer in renal transplant recipients: A Danish nationwide, registry-based cohort study.
Reinholdt K, Thomsen LT, Dehlendorff C, Larsen HK, Sørensen SS, Haedersdal M, Kjaer SK
Int J Cancer 2020 May 1;146(9):2413-2422. Epub 2019 Aug 2 doi: 10.1002/ijc.32565. PMID: 31291470
Advances in the pathology of penile carcinomas.
Chaux A, Cubilla AL
Hum Pathol 2012 Jun;43(6):771-89. doi: 10.1016/j.humpath.2012.01.014. PMID: 22595011
Differentiated precursor lesions and low-grade variants of squamous cell carcinomas are frequent findings in foreskins of patients from a region of high penile cancer incidence.
Oertell J, Caballero C, Iglesias M, Chaux A, Amat L, Ayala E, Rodríguez I, Velázquez EF, Barreto JE, Ayala G, Cubilla AL
Histopathology 2011 May;58(6):925-33. doi: 10.1111/j.1365-2559.2011.03816.x. PMID: 21585428
Distinctive association of p16INK4a overexpression with penile intraepithelial neoplasia depicting warty and/or basaloid features: a study of 141 cases evaluating a new nomenclature.
Chaux A, Pfannl R, Lloveras B, Alejo M, Clavero O, Lezcano C, Muñoz N, de Sanjosé S, Bosch X, Hernández-Pérez M, Velazquez EF, Cubilla AL
Am J Surg Pathol 2010 Mar;34(3):385-92. doi: 10.1097/PAS.0b013e3181cdad23. PMID: 20139761

Clinical prediction guides

Penile intraepithelial neoplasia incidence, clinical classification, microenvironment and implications for imiquimod treatment.
Avitan O, Rafael T, Vreeburg M, Elst L, Bekers EM, Albersen M, Jordanova ES, Brouwer O
BJU Int 2024 Dec;134(6):881-889. Epub 2024 Jul 19 doi: 10.1111/bju.16473. PMID: 39030899
Advances in the pathology of penile carcinomas.
Chaux A, Cubilla AL
Hum Pathol 2012 Jun;43(6):771-89. doi: 10.1016/j.humpath.2012.01.014. PMID: 22595011
Warty-basaloid carcinoma: clinicopathological features of a distinctive penile neoplasm. Report of 45 cases.
Chaux A, Tamboli P, Ayala A, Soares F, Rodríguez I, Barreto J, Cubilla AL
Mod Pathol 2010 Jun;23(6):896-904. Epub 2010 Mar 19 doi: 10.1038/modpathol.2010.69. PMID: 20305615
Distinctive association of p16INK4a overexpression with penile intraepithelial neoplasia depicting warty and/or basaloid features: a study of 141 cases evaluating a new nomenclature.
Chaux A, Pfannl R, Lloveras B, Alejo M, Clavero O, Lezcano C, Muñoz N, de Sanjosé S, Bosch X, Hernández-Pérez M, Velazquez EF, Cubilla AL
Am J Surg Pathol 2010 Mar;34(3):385-92. doi: 10.1097/PAS.0b013e3181cdad23. PMID: 20139761

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