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Retinal nerve fiber edema

MedGen UID:
1689646
Concept ID:
C5209223
Pathologic Function
Synonym: Retinal nerve fibre oedema
 
HPO: HP:0020120

Definition

Swelling (edema) of the retinal nerve fibers. [from HPO]

Term Hierarchy

Conditions with this feature

Leber hereditary optic neuropathy, autosomal recessive
MedGen UID:
1786310
Concept ID:
C5543589
Disease or Syndrome

Professional guidelines

PubMed

Sefi-Yurdakul N
Int Ophthalmol 2024 Sep 21;44(1):384. doi: 10.1007/s10792-024-03316-1. PMID: 39305361
Muhtaseb RE, Huther A, Alwreikat AM, Ramsey DJ
Eye (Lond) 2024 Oct;38(15):2985-2991. Epub 2024 Jul 9 doi: 10.1038/s41433-024-03205-y. PMID: 38982301Free PMC Article
Sibony PA, Kupersmith MJ, Kardon RH
J Neuroophthalmol 2021 Mar 1;41(1):77-92. doi: 10.1097/WNO.0000000000001078. PMID: 32909979Free PMC Article

Recent clinical studies

Etiology

Oertel FC, Sotirchos ES, Zimmermann HG, Motamedi S, Specovius S, Asseyer ES, Chien C, Cook L, Vasileiou E, Filippatou A, Calabresi PA, Saidha S, Pandit L, D'Cunha A, Outteryck O, Zéphir H, Pittock S, Flanagan EP, Bhatti MT, Rommer PS, Bsteh G, Zrzavy T, Kuempfel T, Aktas O, Ringelstein M, Albrecht P, Ayzenberg I, Pakeerathan T, Knier B, Aly L, Asgari N, Soelberg K, Marignier R, Tilikete CF, Cobo Calvo A, Villoslada P, Sanchez-Dalmau B, Martinez-Lapiscina EH, Llufriu S, Green AJ, Yeaman MR, Smith TJ, Brandt AU, Chen J, Paul F, Havla J; with the GJCF International Clinical Consortium for NMOSD and the CROCTINO study group
Ann Neurol 2022 Sep;92(3):476-485. Epub 2022 Jul 16 doi: 10.1002/ana.26440. PMID: 35703428
Chen JJ, Sotirchos ES, Henderson AD, Vasileiou ES, Flanagan EP, Bhatti MT, Jamali S, Eggenberger ER, Dinome M, Frohman LP, Arnold AC, Bonelli L, Seleme N, Mejia-Vergara AJ, Moss HE, Padungkiatsagul T, Stiebel-Kalish H, Lotan I, Hellmann MA, Hodge D, Oertel FC, Paul F, Saidha S, Calabresi PA, Pittock SJ
Mult Scler Relat Disord 2022 Feb;58:103525. Epub 2022 Jan 11 doi: 10.1016/j.msard.2022.103525. PMID: 35038647Free PMC Article
Au A, Hilely A, Scharf J, Gunnemann F, Wang D, Chehaibou I, Iovino C, Grondin C, Farecki ML, Falavarjani KG, Phasukkijwatana N, Battista M, Borrelli E, Sacconi R, Powell B, Hom G, Greenlee TE, Conti TF, Ledesma-Gil G, Teke MY, Choudhry N, Fung AT, Krivosic V, Baek J, Lee MY, Sugiura Y, Querques G, Peiretti E, Rosen R, Lee WK, Yannuzzi LA, Zur D, Loewenstein A, Pauleikhoff D, Singh R, Modi Y, Hubschman JP, Ip M, Sadda S, Freund KB, Sarraf D
Invest Ophthalmol Vis Sci 2020 May 11;61(5):54. doi: 10.1167/iovs.61.5.54. PMID: 32460316Free PMC Article
Lim HB, Sung JY, Ahn SI, Jo YJ, Kim JY
Optom Vis Sci 2018 Mar;95(3):247-255. doi: 10.1097/OPX.0000000000001181. PMID: 29420438
Fong DS, Frederick AR Jr, Blumenkranz MS, Walton DS
Ophthalmic Surg Lasers 1998 Apr;29(4):332-5. PMID: 9571668

Diagnosis

Sibony PA, Kupersmith MJ, Kardon RH
J Neuroophthalmol 2021 Mar 1;41(1):77-92. doi: 10.1097/WNO.0000000000001078. PMID: 32909979Free PMC Article
Suciu CI, Suciu VI, Nicoara SD
J Diabetes Res 2020;2020:6655021. Epub 2020 Dec 31 doi: 10.1155/2020/6655021. PMID: 33490283Free PMC Article
Costello F, Malmqvist L, Hamann S
Asia Pac J Ophthalmol (Phila) 2018 Jul-Aug;7(4):271-279. Epub 2018 Jul 12 doi: 10.22608/APO.2018124. PMID: 29998632
Asensio-Sánchez VM, Trujillo-Guzmán L
Arch Soc Esp Oftalmol 2015 Oct;90(10):481-3. Epub 2015 Jul 3 doi: 10.1016/j.oftal.2015.05.001. PMID: 26148443
Ripandelli G, Coppé AM, Capaldo A, Stirpe M
Semin Ophthalmol 1998 Dec;13(4):199-202. doi: 10.3109/08820539809056053. PMID: 9878670

Therapy

Nislic E, Trnacevic S, Pidro A, Djozic A, Begic E
Transplant Proc 2022 Oct;54(8):2192-2196. Epub 2022 Sep 13 doi: 10.1016/j.transproceed.2022.08.001. PMID: 36109201
Lee AG, Mader TH, Gibson CR, Brunstetter TJ, Tarver WJ
Eye (Lond) 2018 Jul;32(7):1164-1167. Epub 2018 Mar 12 doi: 10.1038/s41433-018-0070-y. PMID: 29527011Free PMC Article
Liu KC, Dagli M
JAMA Ophthalmol 2017 Dec 14;135(12):e174877. doi: 10.1001/jamaophthalmol.2017.4877. PMID: 29242933
Barber AJ, Baccouche B
Vision Res 2017 Oct;139:82-92. Epub 2017 Oct 16 doi: 10.1016/j.visres.2017.06.014. PMID: 28988945
Lee AG, Mader TH, Gibson CR, Tarver W
JAMA Ophthalmol 2017 Sep 1;135(9):992-994. doi: 10.1001/jamaophthalmol.2017.2396. PMID: 28727859

Prognosis

Govindaraju VK, Trese MGJ, Faia LJ
Ophthalmic Surg Lasers Imaging Retina 2022 Jul;53(7):393-396. Epub 2022 Jul 1 doi: 10.3928/23258160-20220617-02. PMID: 35858233
Sibony PA, Kupersmith MJ, Kardon RH
J Neuroophthalmol 2021 Mar 1;41(1):77-92. doi: 10.1097/WNO.0000000000001078. PMID: 32909979Free PMC Article
Suciu CI, Suciu VI, Nicoara SD
J Diabetes Res 2020;2020:6655021. Epub 2020 Dec 31 doi: 10.1155/2020/6655021. PMID: 33490283Free PMC Article
Stefánsson E, Olafsdottir OB, Eliasdottir TS, Vehmeijer W, Einarsdottir AB, Bek T, Torp TL, Grauslund J, Eysteinsson T, Karlsson RA, Van Keer K, Stalmans I, Vandewalle E, Todorova MG, Hammer M, Garhöfer G, Schmetterer L, Šín M, Hardarson SH
Prog Retin Eye Res 2019 May;70:1-22. Epub 2019 Apr 15 doi: 10.1016/j.preteyeres.2019.04.001. PMID: 30999027
Green JP, Newman NJ, Stowe ZN, Nemeroff CB
J Neuroophthalmol 1996 Dec;16(4):241-6. doi: 10.3109/01658109609044632. PMID: 8956158

Clinical prediction guides

Ding X, Chang RT, Zhang X, Liu L, Yang Y, Lu L, Lin X
Br J Ophthalmol 2024 Dec 17;109(1):107-112. doi: 10.1136/bjo-2023-325113. PMID: 39237291
Stefánsson E, Olafsdottir OB, Eliasdottir TS, Vehmeijer W, Einarsdottir AB, Bek T, Torp TL, Grauslund J, Eysteinsson T, Karlsson RA, Van Keer K, Stalmans I, Vandewalle E, Todorova MG, Hammer M, Garhöfer G, Schmetterer L, Šín M, Hardarson SH
Prog Retin Eye Res 2019 May;70:1-22. Epub 2019 Apr 15 doi: 10.1016/j.preteyeres.2019.04.001. PMID: 30999027
Lim HB, Sung JY, Ahn SI, Jo YJ, Kim JY
Optom Vis Sci 2018 Mar;95(3):247-255. doi: 10.1097/OPX.0000000000001181. PMID: 29420438
Barber AJ, Baccouche B
Vision Res 2017 Oct;139:82-92. Epub 2017 Oct 16 doi: 10.1016/j.visres.2017.06.014. PMID: 28988945
Onal S, Tugal-Tutkun I, Neri P, P Herbort C
Int Ophthalmol 2014 Apr;34(2):401-35. Epub 2013 Jul 9 doi: 10.1007/s10792-013-9822-7. PMID: 23835664

Recent systematic reviews

Nita M, Grzybowski A
Curr Pharm Des 2017;23(4):639-654. doi: 10.2174/1381612823666170111095723. PMID: 28078992

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