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Acral Nevus

MedGen UID:
1689815
•Concept ID:
C5230922
•
Neoplastic Process
Synonyms: Acral nevus; Acral Skin Nevus; Nevus of Acral Skin
SNOMED CT: Acral nevus (816201004); Acral nevus (816213009)

Definition

A melanocytic nevus that arises from the palms, soles, and nails. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcral Nevus

Professional guidelines

PubMed

Recent advancements in the diagnosis and treatment of acral melanoma.
Alhaskawi A, Ezzi SHA, Dong Y, Zhou H, Wang Z, Lai J, Yao C, Kota VG, Abdulla MHAH, Lu H
J Zhejiang Univ Sci B 2024 Feb 15;25(2):106-122. doi: 10.1631/jzus.B2300221. PMID: 38303495Free PMC Article

Recent clinical studies

Etiology

Juvenile melanocytic acral nevus: A comparative study between MANIAC and non-MANIAC nevus and its clinicopathological characteristics.
García-Rabasco A, Roselló-Añón A, De-Unamuno-Bustos B, Ferrer-Guillén B, Alegre De Miquel V
J Cutan Pathol 2019 Dec;46(12):898-904. Epub 2019 Aug 14 doi: 10.1111/cup.13553. PMID: 31373032
Depletion of primary cilium in acral melanoma.
Love NR, Lang UE, Cheung C, Kim J
J Cutan Pathol 2019 Sep;46(9):665-671. Epub 2019 May 14 doi: 10.1111/cup.13484. PMID: 31020686
The prevalence of melanocytic nevi on the soles in the Japanese population.
Kogushi-Nishi H, Kawasaki J, Kageshita T, Ishihara T, Ihn H
J Am Acad Dermatol 2009 May;60(5):767-71. doi: 10.1016/j.jaad.2008.12.048. PMID: 19389519
Melanocytic nevi simulant of melanoma with medicolegal relevance.
Massi G
Virchows Arch 2007 Sep;451(3):623-47. Epub 2007 Jul 26 doi: 10.1007/s00428-007-0459-7. PMID: 17653760
Acral lentiginous nevus.
Han KH, Cho KH
J Dermatol 1998 Jan;25(1):23-7. doi: 10.1111/j.1346-8138.1998.tb02340.x. PMID: 9519605

Diagnosis

Recent advancements in the diagnosis and treatment of acral melanoma.
Alhaskawi A, Ezzi SHA, Dong Y, Zhou H, Wang Z, Lai J, Yao C, Kota VG, Abdulla MHAH, Lu H
J Zhejiang Univ Sci B 2024 Feb 15;25(2):106-122. doi: 10.1631/jzus.B2300221. PMID: 38303495Free PMC Article
Depletion of primary cilium in acral melanoma.
Love NR, Lang UE, Cheung C, Kim J
J Cutan Pathol 2019 Sep;46(9):665-671. Epub 2019 May 14 doi: 10.1111/cup.13484. PMID: 31020686
Key points in dermoscopic differentiation between early acral melanoma and acral nevus.
Saida T, Koga H, Uhara H
J Dermatol 2011 Jan;38(1):25-34. doi: 10.1111/j.1346-8138.2010.01174.x. PMID: 21175752
Melanocytic nevi simulant of melanoma with medicolegal relevance.
Massi G
Virchows Arch 2007 Sep;451(3):623-47. Epub 2007 Jul 26 doi: 10.1007/s00428-007-0459-7. PMID: 17653760
Acral lentiginous nevus.
Han KH, Cho KH
J Dermatol 1998 Jan;25(1):23-7. doi: 10.1111/j.1346-8138.1998.tb02340.x. PMID: 9519605

Therapy

Clinical implication of PRAME immunohistochemistry in differentiating melanoma in situ and dysplastic nevus in non-acral nevus-associated melanoma in situ: An institutional experience and meta-analysis.
Bui CM, Vuong HG, Le MK, D'Angelo J, Mannava K, Smoller BR
J Cutan Pathol 2024 Oct;51(10):783-789. Epub 2024 Jun 21 doi: 10.1111/cup.14671. PMID: 39031706
Dermoscopic Image Classification of Pigmented Nevus under Deep Learning and the Correlation with Pathological Features.
Yang S, Shu C, Hu H, Ma G, Yang M
Comput Math Methods Med 2022;2022:9726181. Epub 2022 May 28 doi: 10.1155/2022/9726181. PMID: 35669372Free PMC Article
Depletion of primary cilium in acral melanoma.
Love NR, Lang UE, Cheung C, Kim J
J Cutan Pathol 2019 Sep;46(9):665-671. Epub 2019 May 14 doi: 10.1111/cup.13484. PMID: 31020686
Hyperspectroscopic screening of melanoma on acral volar skin.
Nagaoka T, Nakamura A, Okutani H, Kiyohara Y, Koga H, Saida T, Sota T
Skin Res Technol 2013 Feb;19(1):e290-6. Epub 2012 Jun 14 doi: 10.1111/j.1600-0846.2012.00642.x. PMID: 22698068

Prognosis

Recent advancements in the diagnosis and treatment of acral melanoma.
Alhaskawi A, Ezzi SHA, Dong Y, Zhou H, Wang Z, Lai J, Yao C, Kota VG, Abdulla MHAH, Lu H
J Zhejiang Univ Sci B 2024 Feb 15;25(2):106-122. doi: 10.1631/jzus.B2300221. PMID: 38303495Free PMC Article
TERT amplification but not activation of canonical Wnt/β-catenin pathway is involved in acral lentiginous melanoma progression to metastasis.
Ramani NS, Aung PP, Gu J, Sfamenos S, Sdringola-Maranga C, Nagarajan P, Tetzlaff MT, Curry JL, Ivan D, Diab A, Prieto VG, Hwu WJ, Torres-Cabala CA
Mod Pathol 2020 Oct;33(10):2067-2074. Epub 2020 May 13 doi: 10.1038/s41379-020-0565-5. PMID: 32404956
Dermoscopic Findings of an Unusual Acral Nevus on the Hand of a Child.
Liebman TN, Diakow MN, Glick SA
Pediatr Dermatol 2017 May;34(3):e137-e139. Epub 2017 Mar 20 doi: 10.1111/pde.13105. PMID: 28317165
Key points in dermoscopic differentiation between early acral melanoma and acral nevus.
Saida T, Koga H, Uhara H
J Dermatol 2011 Jan;38(1):25-34. doi: 10.1111/j.1346-8138.2010.01174.x. PMID: 21175752
Acral lentiginous nevus.
Han KH, Cho KH
J Dermatol 1998 Jan;25(1):23-7. doi: 10.1111/j.1346-8138.1998.tb02340.x. PMID: 9519605

Clinical prediction guides

Dermoscopic Image Classification of Pigmented Nevus under Deep Learning and the Correlation with Pathological Features.
Yang S, Shu C, Hu H, Ma G, Yang M
Comput Math Methods Med 2022;2022:9726181. Epub 2022 May 28 doi: 10.1155/2022/9726181. PMID: 35669372Free PMC Article
Dermoscopic characteristics of acral melanocytic nevi in children and adolescents.
Savas Erdogan S, Falay Gur T, Turgut Erdemir AV, Dogan B
Pediatr Dermatol 2020 Jul;37(4):597-603. Epub 2020 Apr 14 doi: 10.1111/pde.14136. PMID: 32291825
Juvenile melanocytic acral nevus: A comparative study between MANIAC and non-MANIAC nevus and its clinicopathological characteristics.
García-Rabasco A, Roselló-Añón A, De-Unamuno-Bustos B, Ferrer-Guillén B, Alegre De Miquel V
J Cutan Pathol 2019 Dec;46(12):898-904. Epub 2019 Aug 14 doi: 10.1111/cup.13553. PMID: 31373032
Outcomes of biopsies and excisions of dysplastic acral nevi: a study of 187 lesions.
Bronsnick T, Kazi N, Kirkorian AY, Rao BK
Dermatol Surg 2014 Apr;40(4):455-9. Epub 2014 Jan 23 doi: 10.1111/dsu.12448. PMID: 24456372
The prevalence of melanocytic nevi on the soles in the Japanese population.
Kogushi-Nishi H, Kawasaki J, Kageshita T, Ishihara T, Ihn H
J Am Acad Dermatol 2009 May;60(5):767-71. doi: 10.1016/j.jaad.2008.12.048. PMID: 19389519

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