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Refractory Rectal Adenocarcinoma

MedGen UID:
1691064
•Concept ID:
C5206377
•
Neoplastic Process

Definition

Rectal adenocarcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Rectal Adenocarcinoma

Professional guidelines

PubMed

Bowel rest, intravenous hydration, and continuous high-dose infusion of octreotide acetate for the treatment of chemotherapy-induced diarrhea in patients with colorectal carcinoma.
Petrelli NJ, Rodriguez-Bigas M, Rustum Y, Herrera L, Creaven P
Cancer 1993 Sep 1;72(5):1543-6. doi: 10.1002/1097-0142(19930901)72:5<1543::aid-cncr2820720509>3.0.co;2-z. PMID: 8348489
Treatment of advanced-stage colorectal adenocarcinoma with fluorouracil and high-dose leucovorin calcium: a pilot study.
Hines JD, Zakem MH, Adelstein DJ, Rustum YM
J Clin Oncol 1988 Jan;6(1):142-6. doi: 10.1200/JCO.1988.6.1.142. PMID: 3257256
Hyperthermic pelvic isolation-perfusion in the treatment of refractory pelvic cancer.
Wile A, Smolin M
Arch Surg 1987 Nov;122(11):1321-5. doi: 10.1001/archsurg.1987.01400230107019. PMID: 3675195

Recent clinical studies

Etiology

Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international, multicentre, randomised, double-blind, phase 3 study.
Dasari A, Lonardi S, Garcia-Carbonero R, Elez E, Yoshino T, Sobrero A, Yao J, García-Alfonso P, Kocsis J, Cubillo Gracian A, Sartore-Bianchi A, Satoh T, Randrian V, Tomasek J, Chong G, Paulson AS, Masuishi T, Jones J, Csőszi T, Cremolini C, Ghiringhelli F, Shergill A, Hochster HS, Krauss J, Bassam A, Ducreux M, Elme A, Faugeras L, Kasper S, Van Cutsem E, Arnold D, Nanda S, Yang Z, Schelman WR, Kania M, Tabernero J, Eng C; FRESCO-2 Study Investigators
Lancet 2023 Jul 1;402(10395):41-53. Epub 2023 Jun 15 doi: 10.1016/S0140-6736(23)00772-9. PMID: 37331369
Metastatic rectal neuroendocrine carcinoma presenting with treatment-refractory immune thrombocytopenia: A case report and literature review.
Bancheno WM, Adidam SR, Melaku MA
Medicine (Baltimore) 2022 Jul 22;101(29):e29616. doi: 10.1097/MD.0000000000029616. PMID: 35866784Free PMC Article
Treatment-resistant severe capecitabine-induced diarrhoea resolved with oral budesonide.
Shumar J, Junga Z, Johnson JT, Goldkind L
BMJ Case Rep 2019 Dec 1;12(11) doi: 10.1136/bcr-2019-231544. PMID: 31791985Free PMC Article
Treatment of medically refractory cancer pain with a combination of intrathecal neuromodulation and neurosurgical ablation: case series and literature review.
Bentley JN, Viswanathan A, Rosenberg WS, Patil PG
Pain Med 2014 Sep;15(9):1488-95. Epub 2014 Jun 14 doi: 10.1111/pme.12481. PMID: 24931480
Carcinoma of pelvic pouch following restorative proctocolectomy: report of a case and review of the literature.
Negi SS, Chaudhary A, Gondal R
Dig Surg 2003;20(1):63-5. doi: 10.1159/000068855. PMID: 12637810

Diagnosis

Metastatic rectal neuroendocrine carcinoma presenting with treatment-refractory immune thrombocytopenia: A case report and literature review.
Bancheno WM, Adidam SR, Melaku MA
Medicine (Baltimore) 2022 Jul 22;101(29):e29616. doi: 10.1097/MD.0000000000029616. PMID: 35866784Free PMC Article
A Rare Case of Isolated Chronic Cough Caused by Pulmonary Lymphangitic Carcinomatosis as a Primary Manifestation of Rectum Carcinoma.
Okayama M, Kanemitsu Y, Oguri T, Asano T, Fukuda S, Ohkubo H, Takemura M, Maeno K, Ito Y, Niimi A
Intern Med 2018 Sep 15;57(18):2709-2712. Epub 2018 May 18 doi: 10.2169/internalmedicine.0572-17. PMID: 29780119Free PMC Article
High-doses of proton pump inhibitors in refractory gastro-intestinal cancer: A case series and the state of art.
Falcone R, Roberto M, D'Antonio C, Romiti A, Milano A, Onesti CE, Marchetti P, Fais S
Dig Liver Dis 2016 Dec;48(12):1503-1505. Epub 2016 Sep 1 doi: 10.1016/j.dld.2016.08.126. PMID: 27651344
Modified simultaneous integrated boost radiotherapy for an unresectable huge refractory pelvic tumor diagnosed as a rectal adenocarcinoma.
Nomiya T, Akamatsu H, Harada M, Ota I, Hagiwara Y, Ichikawa M, Miwa M, Kawashiro S, Hagiwara M, Chin M, Hashizume E, Nemoto K
World J Gastroenterol 2014 Dec 28;20(48):18480-6. doi: 10.3748/wjg.v20.i48.18480. PMID: 25561820Free PMC Article
Differential diagnosis between endogenous and exogenous insulin-induced refractory hypoglycemia in a nondiabetic patient.
Bauman WA, Yalow RS
N Engl J Med 1980 Jul 24;303(4):198-9. doi: 10.1056/NEJM198007243030406. PMID: 6991943

Therapy

Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international, multicentre, randomised, double-blind, phase 3 study.
Dasari A, Lonardi S, Garcia-Carbonero R, Elez E, Yoshino T, Sobrero A, Yao J, García-Alfonso P, Kocsis J, Cubillo Gracian A, Sartore-Bianchi A, Satoh T, Randrian V, Tomasek J, Chong G, Paulson AS, Masuishi T, Jones J, Csőszi T, Cremolini C, Ghiringhelli F, Shergill A, Hochster HS, Krauss J, Bassam A, Ducreux M, Elme A, Faugeras L, Kasper S, Van Cutsem E, Arnold D, Nanda S, Yang Z, Schelman WR, Kania M, Tabernero J, Eng C; FRESCO-2 Study Investigators
Lancet 2023 Jul 1;402(10395):41-53. Epub 2023 Jun 15 doi: 10.1016/S0140-6736(23)00772-9. PMID: 37331369
Treatment-resistant severe capecitabine-induced diarrhoea resolved with oral budesonide.
Shumar J, Junga Z, Johnson JT, Goldkind L
BMJ Case Rep 2019 Dec 1;12(11) doi: 10.1136/bcr-2019-231544. PMID: 31791985Free PMC Article
Modified simultaneous integrated boost radiotherapy for an unresectable huge refractory pelvic tumor diagnosed as a rectal adenocarcinoma.
Nomiya T, Akamatsu H, Harada M, Ota I, Hagiwara Y, Ichikawa M, Miwa M, Kawashiro S, Hagiwara M, Chin M, Hashizume E, Nemoto K
World J Gastroenterol 2014 Dec 28;20(48):18480-6. doi: 10.3748/wjg.v20.i48.18480. PMID: 25561820Free PMC Article
Convulsions and refractory ventricular fibrillation after intrathecal injection of a massive dose of tranexamic acid.
Yeh HM, Lau HP, Lin PL, Sun WZ, Mok MS
Anesthesiology 2003 Jan;98(1):270-2. doi: 10.1097/00000542-200301000-00042. PMID: 12503009
Meningorectal fistula as a cause of polymicrobial anaerobic meningitis.
Walsh TJ, Weinstein RA, Malinoff H, Breyer MD, Berelowitz BA
Am J Clin Pathol 1982 Jul;78(1):127-30. doi: 10.1093/ajcp/78.1.127. PMID: 7102600

Prognosis

Metastatic rectal neuroendocrine carcinoma presenting with treatment-refractory immune thrombocytopenia: A case report and literature review.
Bancheno WM, Adidam SR, Melaku MA
Medicine (Baltimore) 2022 Jul 22;101(29):e29616. doi: 10.1097/MD.0000000000029616. PMID: 35866784Free PMC Article
A Phase II Study of Ganetespib as Second-line or Third-line Therapy for Metastatic Pancreatic Cancer.
Cardin DB, Thota R, Goff LW, Berlin JD, Jones CM, Ayers GD, Whisenant JG, Chan E
Am J Clin Oncol 2018 Aug;41(8):772-776. doi: 10.1097/COC.0000000000000377. PMID: 28301350Free PMC Article
Modified simultaneous integrated boost radiotherapy for an unresectable huge refractory pelvic tumor diagnosed as a rectal adenocarcinoma.
Nomiya T, Akamatsu H, Harada M, Ota I, Hagiwara Y, Ichikawa M, Miwa M, Kawashiro S, Hagiwara M, Chin M, Hashizume E, Nemoto K
World J Gastroenterol 2014 Dec 28;20(48):18480-6. doi: 10.3748/wjg.v20.i48.18480. PMID: 25561820Free PMC Article
Convulsions and refractory ventricular fibrillation after intrathecal injection of a massive dose of tranexamic acid.
Yeh HM, Lau HP, Lin PL, Sun WZ, Mok MS
Anesthesiology 2003 Jan;98(1):270-2. doi: 10.1097/00000542-200301000-00042. PMID: 12503009
Metastatic adenocarcinoma of the prostate to the uvea as the initial presenting symptom in a 49-year-old man.
Obek C, Kural AR, Yaycioglu O, Kendiroğlu G, Solok V
Urology 2001 Jul;58(1):106. doi: 10.1016/s0090-4295(01)00981-5. PMID: 11445497

Clinical prediction guides

Surgery for ulcerative colitis complicated with colorectal cancer: when ileal pouch-anal anastomosis is the right choice.
Tonelli F, Di Martino C, Amorosi A, Mini E, Nesi G
Updates Surg 2022 Apr;74(2):637-647. Epub 2022 Feb 25 doi: 10.1007/s13304-022-01250-4. PMID: 35217982Free PMC Article
First-in-human phase I/Ib open-label dose-escalation study of GWN323 (anti-GITR) as a single agent and in combination with spartalizumab (anti-PD-1) in patients with advanced solid tumors and lymphomas.
Piha-Paul SA, Geva R, Tan TJ, Lim DW, Hierro C, Doi T, Rahma O, Lesokhin A, Luke JJ, Otero J, Nardi L, Singh A, Xyrafas A, Chen X, Mataraza J, Bedard PL
J Immunother Cancer 2021 Aug;9(8) doi: 10.1136/jitc-2021-002863. PMID: 34389618Free PMC Article
Preclinical Development and First-in-Human Study of KA2507, a Selective and Potent Inhibitor of Histone Deacetylase 6, for Patients with Refractory Solid Tumors.
Tsimberidou AM, Beer PA, Cartwright CA, Haymaker C, Vo HH, Kiany S, Cecil ARL, Dow J, Haque K, Silva FA, Coe L, Berryman H, Bone EA, Nogueras-Gonzalez GM, Vining D, McElwaine-Johnn H, Wistuba II
Clin Cancer Res 2021 Jul 1;27(13):3584-3594. Epub 2021 May 4 doi: 10.1158/1078-0432.CCR-21-0238. PMID: 33947698
Metastatic adenocarcinoma of the prostate to the uvea as the initial presenting symptom in a 49-year-old man.
Obek C, Kural AR, Yaycioglu O, Kendiroğlu G, Solok V
Urology 2001 Jul;58(1):106. doi: 10.1016/s0090-4295(01)00981-5. PMID: 11445497
Treatment of refractory colorectal carcinomas with fluorouracil, folinic acid, and interferon alfa-2a.
Bernhard H, Klein O, Meyer zum Büschenfelde KH, Knuth A
Semin Oncol 1992 Apr;19(2 Suppl 3):204-7. PMID: 1557648

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