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Prostate Neuroendocrine Carcinoma

MedGen UID:
1691118
•Concept ID:
C5204069
•
Neoplastic Process

Definition

An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the prostate gland. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm. [from NCI]

Professional guidelines

PubMed

Treatment-related Neuroendocrine Prostate Carcinoma-Diagnostic and Molecular Correlates.
Gopalan A
Adv Anat Pathol 2024 Mar 1;31(2):70-79. Epub 2024 Jan 15 doi: 10.1097/PAP.0000000000000431. PMID: 38223983
Emerging trends in the evaluation and management of small cell prostate cancer: a clinical and molecular perspective.
Monn MF, Cheng L
Expert Rev Anticancer Ther 2016 Oct;16(10):1029-37. Epub 2016 Aug 26 doi: 10.1080/14737140.2016.1226137. PMID: 27534689
The role of neuroendocrine cells in prostate cancer: a comprehensive review of current literature and subsequent rationale to broaden and integrate current treatment modalities.
Lugnani F, Simone G, Biava PM, Ablin RJ
Curr Med Chem 2014;21(9):1082-92. doi: 10.2174/0929867321666131201143752. PMID: 24304274

Recent clinical studies

Diagnosis

Large-cell neuroendocrine tumor of the prostate: a case report and review of the literature.
Sleiman W, Karray O, Abi Abdallah M, Bleichner-Perez S, Kourda J, Cosma-Opris M, Assouad S, Riffaud JC, Bart S, Coloby P
J Med Case Rep 2021 May 7;15(1):254. doi: 10.1186/s13256-021-02830-5. PMID: 33957979Free PMC Article

Clinical prediction guides

Large-cell neuroendocrine tumor of the prostate: a case report and review of the literature.
Sleiman W, Karray O, Abi Abdallah M, Bleichner-Perez S, Kourda J, Cosma-Opris M, Assouad S, Riffaud JC, Bart S, Coloby P
J Med Case Rep 2021 May 7;15(1):254. doi: 10.1186/s13256-021-02830-5. PMID: 33957979Free PMC Article

Supplemental Content

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