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Increased HDL2b concentration

MedGen UID:
1694588
•Concept ID:
C5139336
•
Finding
HPO: HP:0032424

Definition

An elevation above the normal concentration of the HDL2b subfraction in the blood circulation. An HDL2b particle is defined as an HDL particle with a size of 9.7-12 nm. [from HPO]

Professional guidelines

PubMed

"Essential" phospholipids versus nicotinic acid in the treatment of patients with type IIb hyperlipoproteinemia and ischemic heart disease.
Klimov AN, Konstantinov VO, Lipovetsky BM, Kuznetsov AS, Lozovsky VT, Trufanov VF, Plavinsky SL, Gundermann KJ, Schumacher R
Cardiovasc Drugs Ther 1995 Dec;9(6):779-84. doi: 10.1007/BF00879871. PMID: 8850382
Plasma high density lipoprotein particle size alteration by simvastatin treatment in patients with hypercholesterolaemia.
Johansson J, Mölgaard J, Olsson AG
Atherosclerosis 1991 Dec;91(3):175-84. doi: 10.1016/0021-9150(91)90165-y. PMID: 1789802
The effects of nicotinic acid treatment on high density lipoprotein particle size subclass levels in hyperlipidaemic subjects.
Johansson J, Carlson LA
Atherosclerosis 1990 Aug;83(2-3):207-16. doi: 10.1016/0021-9150(90)90166-g. PMID: 2242098

Recent clinical studies

Etiology

Changes in plasma HDL and its subcomponents HDL2b and HDL3 regulate inflammatory response by modulating SOCS1 signaling to affect severity degree and prognosis of sepsis.
Li H, Liu W, Su W, Yang Z, Chen Y, Fu Y, Zhang T, Fu W, Chen W, Sun Y
Infect Genet Evol 2021 Jul;91:104804. Epub 2021 Mar 5 doi: 10.1016/j.meegid.2021.104804. PMID: 33684569
Influence of CETP on High-Density Lipoprotein Subclasses in Patients with Coronary Heart Disease.
Ding L, Jiang W, Chen Z, Zhang C, Tian Y, Long S
Clin Lab 2020 Nov 1;66(11) doi: 10.7754/Clin.Lab.2020.200241. PMID: 33180445
Shift of high-density lipoprotein size distribution toward large particles in patients with proteinuria.
Soto-Miranda E, Carreón-Torres E, Lorenzo K, Bazán-Salinas B, García-Sánchez C, Franco M, Posadas-Romero C, Fragoso JM, López-Olmos V, Madero M, Rodriguez-Pérez JM, Vargas-Alarcón G, Pérez-Méndez O
Clin Chim Acta 2012 Dec 24;414:241-5. Epub 2012 Oct 2 doi: 10.1016/j.cca.2012.09.028. PMID: 23041214
The relationship between high density lipoprotein subclass profile and plasma lipids concentrations.
Tian L, Fu M
Lipids Health Dis 2010 Oct 17;9:118. doi: 10.1186/1476-511X-9-118. PMID: 20950490Free PMC Article
Effect of total parenteral nutrition with intravenous fat on lipids and high density lipoprotein heterogeneity in neonates.
Forte TM, Genzel-Boroviczeny O, Austin MA, Kao LC, Scott C, Albers JJ, D'Harlingue AE
JPEN J Parenter Enteral Nutr 1989 Sep-Oct;13(5):490-500. doi: 10.1177/0148607189013005490. PMID: 2514290

Diagnosis

Influence of CETP on High-Density Lipoprotein Subclasses in Patients with Coronary Heart Disease.
Ding L, Jiang W, Chen Z, Zhang C, Tian Y, Long S
Clin Lab 2020 Nov 1;66(11) doi: 10.7754/Clin.Lab.2020.200241. PMID: 33180445
Acute exercise and training alter blood lipid and lipoprotein profiles differently in overweight and obese men and women.
Greene NP, Martin SE, Crouse SF
Obesity (Silver Spring) 2012 Aug;20(8):1618-27. Epub 2012 Mar 16 doi: 10.1038/oby.2012.65. PMID: 22421926
The relationship between high density lipoprotein subclass profile and apolipoprotein concentrations.
Tian L, Fu M
J Endocrinol Invest 2011 Jun;34(6):461-72. doi: 10.1007/BF03346714. PMID: 21747218
The relationship between high density lipoprotein subclass profile and plasma lipids concentrations.
Tian L, Fu M
Lipids Health Dis 2010 Oct 17;9:118. doi: 10.1186/1476-511X-9-118. PMID: 20950490Free PMC Article
A case-control study on the relationship between HDL2b and non-alcoholic fatty liver disease in Chinese type 2 diabetic patients.
Ma YH, Zhao L, Xian XD, Yang D, Huang W, Wang YH, Mueller O, Chang E, Konigshofer Y, Van-Cleve M, Liu G, Yang JK
Clin Chem Lab Med 2009;47(9):1067-72. doi: 10.1515/CCLM.2009.257. PMID: 19728847

Therapy

Consuming High-Fat and Low-Fat Ground Beef Depresses High-Density and Low-Density Lipoprotein Cholesterol Concentrations, and Reduces Small, Dense Low-Density Lipoprotein Particle Abundance.
Lytle JR, Price T, Crouse SF, Smith DR, Walzem RL, Smith SB
Nutrients 2023 Jan 10;15(2) doi: 10.3390/nu15020337. PMID: 36678207Free PMC Article
Acute exercise and training alter blood lipid and lipoprotein profiles differently in overweight and obese men and women.
Greene NP, Martin SE, Crouse SF
Obesity (Silver Spring) 2012 Aug;20(8):1618-27. Epub 2012 Mar 16 doi: 10.1038/oby.2012.65. PMID: 22421926
HDL subspecies in young adult twins: heritability and impact of overweight.
Pietiläinen KH, Söderlund S, Rissanen A, Nakanishi S, Jauhiainen M, Taskinen MR, Kaprio J
Obesity (Silver Spring) 2009 Jun;17(6):1208-14. Epub 2009 Feb 19 doi: 10.1038/oby.2008.675. PMID: 19584879
Alterations in plasma lipids, lipoproteins and high density lipoprotein subfractions in peripheral arterial disease.
Mowat BF, Skinner ER, Wilson HM, Leng GC, Fowkes FG, Horrobin D
Atherosclerosis 1997 Jun;131(2):161-6. doi: 10.1016/s0021-9150(97)06097-8. PMID: 9199268
Effects of weight-loss by exercise and by diet on apolipoproteins A-I and A-II and the particle-size distribution of high-density lipoproteins in men.
Williams PT, Krauss RM, Vranizan KM, Albers JJ, Wood PD
Metabolism 1992 Apr;41(4):441-9. doi: 10.1016/0026-0495(92)90082-l. PMID: 1556953Free PMC Article

Prognosis

Changes in plasma HDL and its subcomponents HDL2b and HDL3 regulate inflammatory response by modulating SOCS1 signaling to affect severity degree and prognosis of sepsis.
Li H, Liu W, Su W, Yang Z, Chen Y, Fu Y, Zhang T, Fu W, Chen W, Sun Y
Infect Genet Evol 2021 Jul;91:104804. Epub 2021 Mar 5 doi: 10.1016/j.meegid.2021.104804. PMID: 33684569
High serum cholesteryl ester transfer rates and small high-density lipoproteins are associated with young age in patients with acute myocardial infarction.
Zeller M, Masson D, Farnier M, Lorgis L, Deckert V, Pais de Barros JP, Desrumaux C, Sicard P, Grober J, Blache D, Gambert P, Rochette L, Cottin Y, Lagrost L
J Am Coll Cardiol 2007 Nov 13;50(20):1948-55. Epub 2007 Oct 29 doi: 10.1016/j.jacc.2007.06.052. PMID: 17996559
Relationship between apolipoprotein concentrations and HDL subclasses distribution.
Tian L, Fu M, Jia L, Xu Y, Long S, Tian H, Tian Y
Lipids 2007 May;42(5):419-26. Epub 2007 Mar 8 doi: 10.1007/s11745-007-3031-y. PMID: 17476546
Relations between particle size of HDL and LDL lipoproteins and cholesterol esterification rate.
Dobiásová M, Urbanová Z, Samánek M
Physiol Res 2005;54(2):159-65. PMID: 15544423

Clinical prediction guides

Changes in plasma HDL and its subcomponents HDL2b and HDL3 regulate inflammatory response by modulating SOCS1 signaling to affect severity degree and prognosis of sepsis.
Li H, Liu W, Su W, Yang Z, Chen Y, Fu Y, Zhang T, Fu W, Chen W, Sun Y
Infect Genet Evol 2021 Jul;91:104804. Epub 2021 Mar 5 doi: 10.1016/j.meegid.2021.104804. PMID: 33684569
Shift of high-density lipoprotein size distribution toward large particles in patients with proteinuria.
Soto-Miranda E, Carreón-Torres E, Lorenzo K, Bazán-Salinas B, García-Sánchez C, Franco M, Posadas-Romero C, Fragoso JM, López-Olmos V, Madero M, Rodriguez-Pérez JM, Vargas-Alarcón G, Pérez-Méndez O
Clin Chim Acta 2012 Dec 24;414:241-5. Epub 2012 Oct 2 doi: 10.1016/j.cca.2012.09.028. PMID: 23041214
The relationship between high density lipoprotein subclass profile and apolipoprotein concentrations.
Tian L, Fu M
J Endocrinol Invest 2011 Jun;34(6):461-72. doi: 10.1007/BF03346714. PMID: 21747218
Alterations of high density lipoprotein subclasses in obese subjects.
Tian L, Jia L, Mingde F, Tian Y, Xu Y, Tian H, Yang Y
Lipids 2006 Aug;41(8):789-96. doi: 10.1007/s11745-006-5032-7. PMID: 17120933
Lipoprotein profile and high-density lipoproteins: subfractions distribution in centenarians.
Barbagallo CM, Averna MR, Fradà G, Noto D, Cavera G, Notarbartolo A
Gerontology 1998;44(2):106-10. doi: 10.1159/000021992. PMID: 9523222

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