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Prolonged need of intravenous antibiotic therapy

MedGen UID:
1695503
•Concept ID:
C5139075
•
Finding
HPO: HP:0020095

Definition

Clinical assessment of a requirement to treat with intravenous antibiotics over an unusually prolonged period of time. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProlonged need of intravenous antibiotic therapy

Professional guidelines

PubMed

Evaluation of a Paradigm Shift From Intravenous Antibiotics to Oral Step-Down Therapy for the Treatment of Infective Endocarditis: A Narrative Review.
Spellberg B, Chambers HF, Musher DM, Walsh TL, Bayer AS
JAMA Intern Med 2020 May 1;180(5):769-777. doi: 10.1001/jamainternmed.2020.0555. PMID: 32227127Free PMC Article
Proposed Guidelines for the Management of ESBL in Prosthetic Joint Infections.
Antony S, Khan I, Chowdhury O, Heydemann J, Antony N, Heydemann J, Isaac D
Infect Disord Drug Targets 2020;20(5):563-569. doi: 10.2174/1871526519666190613121936. PMID: 31203809
Update on the Management of Pediatric Acute Osteomyelitis and Septic Arthritis.
Castellazzi L, Mantero M, Esposito S
Int J Mol Sci 2016 Jun 1;17(6) doi: 10.3390/ijms17060855. PMID: 27258258Free PMC Article

Recent clinical studies

Etiology

Intraosseous regional prophylaxis in total knee arthroplasty.
Young SW, Chen W, Clarke HD, Spangehl MJ
Bone Joint J 2023 Nov 1;105-B(11):1135-1139. doi: 10.1302/0301-620X.105B11.BJJ-2023-0708. PMID: 37907081
Etiology and Factors Affecting Severe Complications and Mortality of Febrile Neutropenia in Children with Acute Leukemia.
Erbaş İC, Çakıl Güzin A, Özdem Alataş Ş, Karaoğlu Asrak H, Akans İ, Akyol Ş, Özlü C, Tüfekçi Ö, Yılmaz Ş, Ören H, Belet N
Turk J Haematol 2023 Aug 31;40(3):143-153. Epub 2023 Aug 1 doi: 10.4274/tjh.galenos.2023.2023.0185. PMID: 37525503Free PMC Article
Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective colorectal surgery.
Willis MA, Toews I, Soltau SL, Kalff JC, Meerpohl JJ, Vilz TO
Cochrane Database Syst Rev 2023 Feb 7;2(2):CD014909. doi: 10.1002/14651858.CD014909.pub2. PMID: 36748942Free PMC Article
Dalbavancin as an option for treatment of S. aureus bacteremia (DOTS): study protocol for a phase 2b, multicenter, randomized, open-label clinical trial.
Turner NA, Zaharoff S, King H, Evans S, Hamasaki T, Lodise T, Ghazaryan V, Beresnev T, Riccobene T, Patel R, Doernberg SB, Rappo U, Fowler VG Jr, Holland TL; Antibacterial Resistance Leadership Group (ARLG)
Trials 2022 May 16;23(1):407. doi: 10.1186/s13063-022-06370-1. PMID: 35578360Free PMC Article
Safety of prolonged outpatient courses of intravenous antibiotics: a prospective cohort study.
Browning S, Loewenthal MR, Freelander I, Dobson PM, Schneider K, Davis JS
Clin Microbiol Infect 2022 Jun;28(6):832-837. Epub 2022 Jan 8 doi: 10.1016/j.cmi.2021.12.020. PMID: 35017063

Diagnosis

Etiology and Factors Affecting Severe Complications and Mortality of Febrile Neutropenia in Children with Acute Leukemia.
Erbaş İC, Çakıl Güzin A, Özdem Alataş Ş, Karaoğlu Asrak H, Akans İ, Akyol Ş, Özlü C, Tüfekçi Ö, Yılmaz Ş, Ören H, Belet N
Turk J Haematol 2023 Aug 31;40(3):143-153. Epub 2023 Aug 1 doi: 10.4274/tjh.galenos.2023.2023.0185. PMID: 37525503Free PMC Article
Dalbavancin as an option for treatment of S. aureus bacteremia (DOTS): study protocol for a phase 2b, multicenter, randomized, open-label clinical trial.
Turner NA, Zaharoff S, King H, Evans S, Hamasaki T, Lodise T, Ghazaryan V, Beresnev T, Riccobene T, Patel R, Doernberg SB, Rappo U, Fowler VG Jr, Holland TL; Antibacterial Resistance Leadership Group (ARLG)
Trials 2022 May 16;23(1):407. doi: 10.1186/s13063-022-06370-1. PMID: 35578360Free PMC Article
Update on the Management of Pediatric Acute Osteomyelitis and Septic Arthritis.
Castellazzi L, Mantero M, Esposito S
Int J Mol Sci 2016 Jun 1;17(6) doi: 10.3390/ijms17060855. PMID: 27258258Free PMC Article
Principles and practice of antibiotic therapy of diabetic foot infections.
Lipsky BA, Berendt AR
Diabetes Metab Res Rev 2000 Sep-Oct;16 Suppl 1:S42-6. doi: 10.1002/1520-7560(200009/10)16:1+<::aid-dmrr109>3.0.co;2-b. PMID: 11054887
Preterm labor and preterm premature rupture of the membranes. Diagnosis and management.
Mercer BM, Lewis R
Infect Dis Clin North Am 1997 Mar;11(1):177-201. doi: 10.1016/s0891-5520(05)70348-2. PMID: 9067791

Therapy

Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective colorectal surgery.
Willis MA, Toews I, Soltau SL, Kalff JC, Meerpohl JJ, Vilz TO
Cochrane Database Syst Rev 2023 Feb 7;2(2):CD014909. doi: 10.1002/14651858.CD014909.pub2. PMID: 36748942Free PMC Article
Dalbavancin as an option for treatment of S. aureus bacteremia (DOTS): study protocol for a phase 2b, multicenter, randomized, open-label clinical trial.
Turner NA, Zaharoff S, King H, Evans S, Hamasaki T, Lodise T, Ghazaryan V, Beresnev T, Riccobene T, Patel R, Doernberg SB, Rappo U, Fowler VG Jr, Holland TL; Antibacterial Resistance Leadership Group (ARLG)
Trials 2022 May 16;23(1):407. doi: 10.1186/s13063-022-06370-1. PMID: 35578360Free PMC Article
Evaluation of a Paradigm Shift From Intravenous Antibiotics to Oral Step-Down Therapy for the Treatment of Infective Endocarditis: A Narrative Review.
Spellberg B, Chambers HF, Musher DM, Walsh TL, Bayer AS
JAMA Intern Med 2020 May 1;180(5):769-777. doi: 10.1001/jamainternmed.2020.0555. PMID: 32227127Free PMC Article
Update on the Management of Pediatric Acute Osteomyelitis and Septic Arthritis.
Castellazzi L, Mantero M, Esposito S
Int J Mol Sci 2016 Jun 1;17(6) doi: 10.3390/ijms17060855. PMID: 27258258Free PMC Article
Dalbavancin: a review.
Scheinfeld N
Drugs Today (Barc) 2007 May;43(5):305-16. doi: 10.1358/dot.2007.43.5.1088618. PMID: 17724497

Prognosis

Prevalence and predictors of prolonged length of stay among patients admitted under general internal medicine in a tertiary government hospital in Manila, Philippines: a retrospective cross-sectional study.
Besa JJV, Masamayor EMI, Tamondong-Lachica DR, Palileo-Villanueva LM
BMC Health Serv Res 2023 Jan 18;23(1):50. doi: 10.1186/s12913-022-08885-4. PMID: 36653777Free PMC Article
Dalbavancin as an option for treatment of S. aureus bacteremia (DOTS): study protocol for a phase 2b, multicenter, randomized, open-label clinical trial.
Turner NA, Zaharoff S, King H, Evans S, Hamasaki T, Lodise T, Ghazaryan V, Beresnev T, Riccobene T, Patel R, Doernberg SB, Rappo U, Fowler VG Jr, Holland TL; Antibacterial Resistance Leadership Group (ARLG)
Trials 2022 May 16;23(1):407. doi: 10.1186/s13063-022-06370-1. PMID: 35578360Free PMC Article
Safety of prolonged outpatient courses of intravenous antibiotics: a prospective cohort study.
Browning S, Loewenthal MR, Freelander I, Dobson PM, Schneider K, Davis JS
Clin Microbiol Infect 2022 Jun;28(6):832-837. Epub 2022 Jan 8 doi: 10.1016/j.cmi.2021.12.020. PMID: 35017063
Evaluation of a Paradigm Shift From Intravenous Antibiotics to Oral Step-Down Therapy for the Treatment of Infective Endocarditis: A Narrative Review.
Spellberg B, Chambers HF, Musher DM, Walsh TL, Bayer AS
JAMA Intern Med 2020 May 1;180(5):769-777. doi: 10.1001/jamainternmed.2020.0555. PMID: 32227127Free PMC Article
Update on the Management of Pediatric Acute Osteomyelitis and Septic Arthritis.
Castellazzi L, Mantero M, Esposito S
Int J Mol Sci 2016 Jun 1;17(6) doi: 10.3390/ijms17060855. PMID: 27258258Free PMC Article

Clinical prediction guides

Prevalence and predictors of prolonged length of stay among patients admitted under general internal medicine in a tertiary government hospital in Manila, Philippines: a retrospective cross-sectional study.
Besa JJV, Masamayor EMI, Tamondong-Lachica DR, Palileo-Villanueva LM
BMC Health Serv Res 2023 Jan 18;23(1):50. doi: 10.1186/s12913-022-08885-4. PMID: 36653777Free PMC Article
Safety of prolonged outpatient courses of intravenous antibiotics: a prospective cohort study.
Browning S, Loewenthal MR, Freelander I, Dobson PM, Schneider K, Davis JS
Clin Microbiol Infect 2022 Jun;28(6):832-837. Epub 2022 Jan 8 doi: 10.1016/j.cmi.2021.12.020. PMID: 35017063
Evaluation of a Paradigm Shift From Intravenous Antibiotics to Oral Step-Down Therapy for the Treatment of Infective Endocarditis: A Narrative Review.
Spellberg B, Chambers HF, Musher DM, Walsh TL, Bayer AS
JAMA Intern Med 2020 May 1;180(5):769-777. doi: 10.1001/jamainternmed.2020.0555. PMID: 32227127Free PMC Article
Prolonged administration of β-lactam antibiotics - a comprehensive review and critical appraisal.
Osthoff M, Siegemund M, Balestra G, Abdul-Aziz MH, Roberts JA
Swiss Med Wkly 2016;146:w14368. Epub 2016 Oct 10 doi: 10.4414/smw.2016.14368. PMID: 27731492
Prolonged infusion versus intermittent boluses of β-lactam antibiotics for treatment of acute infections: a meta-analysis.
Teo J, Liew Y, Lee W, Kwa AL
Int J Antimicrob Agents 2014 May;43(5):403-11. Epub 2014 Mar 1 doi: 10.1016/j.ijantimicag.2014.01.027. PMID: 24657044

Recent systematic reviews

Local tissue concentrations of cefazolin during total joint arthroplasty: a systematic review.
Mannarino M, Montreuil J, Tanzer M, Hart A
Can J Surg 2023 Jul-Aug;66(4):E415-E421. Epub 2023 Aug 8 doi: 10.1503/cjs.019621. PMID: 37553255Free PMC Article
Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective colorectal surgery.
Willis MA, Toews I, Soltau SL, Kalff JC, Meerpohl JJ, Vilz TO
Cochrane Database Syst Rev 2023 Feb 7;2(2):CD014909. doi: 10.1002/14651858.CD014909.pub2. PMID: 36748942Free PMC Article
Duration of intravenous antibiotic therapy in people with cystic fibrosis.
Abbott L, Plummer A, Hoo ZH, Wildman M
Cochrane Database Syst Rev 2019 Sep 5;9(9):CD006682. doi: 10.1002/14651858.CD006682.pub6. PMID: 31487382Free PMC Article
Duration of intravenous antibiotic therapy in people with cystic fibrosis.
Plummer A, Wildman M
Cochrane Database Syst Rev 2013 May 31;(5):CD006682. doi: 10.1002/14651858.CD006682.pub4. PMID: 23728662
Duration of intravenous antibiotic therapy in people with cystic fibrosis.
Plummer A, Wildman M
Cochrane Database Syst Rev 2011 Jan 19;(1):CD006682. doi: 10.1002/14651858.CD006682.pub3. PMID: 21249681

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