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Metastatic Rectal Adenocarcinoma

MedGen UID:
1695687
•Concept ID:
C5205581
•
Neoplastic Process

Definition

An adenocarcinoma that arises from the rectum and has metastasized to another anatomic site. [from NCI]

Professional guidelines

PubMed

Survival Outcomes After Surgical Management of the Primary Tumor With and Without Radiotherapy for Metastatic Rectal Adenocarcinoma: A National Cancer Database (NCDB) Analysis.
Renz P, Wegner RE, Hasan S, Brookover R, Finley G, Monga D, Raj M, McCormick J, Kirichenko A
Clin Colorectal Cancer 2019 Jun;18(2):e237-e243. Epub 2019 Feb 5 doi: 10.1016/j.clcc.2018.12.005. PMID: 30905549Free PMC Article
Bevacizumab in the pre-operative treatment of locally advanced rectal cancer: a systematic review.
Fornaro L, Caparello C, Vivaldi C, Rotella V, Musettini G, Falcone A, Baldini E, Masi G
World J Gastroenterol 2014 May 28;20(20):6081-91. doi: 10.3748/wjg.v20.i20.6081. PMID: 24876730Free PMC Article

Recent clinical studies

Etiology

Concordance between clinical and pathologic assessment of T and N stages of rectal adenocarcinoma patients who underwent surgery without neoadjuvant therapy: A National Cancer Database analysis.
Emile SH, Silva-Alvarenga E, Horesh N, Freund MR, Garoufalia Z, Wexner SD
Eur J Surg Oncol 2023 Feb;49(2):426-432. Epub 2022 Oct 1 doi: 10.1016/j.ejso.2022.09.014. PMID: 36257901
Construction of a predictive model for clinical survival in male patients with non-metastatic rectal adenocarcinoma.
Qu Y, Liu H
Asian J Surg 2023 Jan;46(1):132-142. Epub 2022 Feb 26 doi: 10.1016/j.asjsur.2022.02.004. PMID: 35227564
Minimally invasive, 'en-bloc' seminal vesicle excision for locally advanced rectal adenocarcinoma: surgical technique and short-term outcomes.
Desouza A, Kazi M, Bankar S, Pandey D, Janesh M, Saklani A
ANZ J Surg 2022 Oct;92(10):2595-2599. Epub 2022 Jun 28 doi: 10.1111/ans.17888. PMID: 35762325
Association of obesity with postoperative outcomes after proctectomy.
Sweigert PJ, Chen C, Fahmy JN, Eguia E, Ban KA, deLahunta D, Peters S, Baker MS, Singer MA
Am J Surg 2020 Oct;220(4):1004-1009. Epub 2020 Mar 25 doi: 10.1016/j.amjsurg.2020.03.028. PMID: 32248948
Bevacizumab in the pre-operative treatment of locally advanced rectal cancer: a systematic review.
Fornaro L, Caparello C, Vivaldi C, Rotella V, Musettini G, Falcone A, Baldini E, Masi G
World J Gastroenterol 2014 May 28;20(20):6081-91. doi: 10.3748/wjg.v20.i20.6081. PMID: 24876730Free PMC Article

Diagnosis

Immune checkpoint inhibitor-induced myopericarditis.
Alrayyashi M, Uddin M, Bdiwi M, Afonso L
BMJ Case Rep 2024 Mar 21;17(3) doi: 10.1136/bcr-2023-259497. PMID: 38514163Free PMC Article
Construction of a predictive model for clinical survival in male patients with non-metastatic rectal adenocarcinoma.
Qu Y, Liu H
Asian J Surg 2023 Jan;46(1):132-142. Epub 2022 Feb 26 doi: 10.1016/j.asjsur.2022.02.004. PMID: 35227564
Tectal region papillary neuroglial tumour: a case report.
Page P, Meylor J, Li Y, Patel V, Ahmed A
Br J Neurosurg 2023 Aug;37(4):601-603. Epub 2019 Feb 11 doi: 10.1080/02688697.2018.1562035. PMID: 30741021
Metastatic rectal adenocarcinoma and anal squamous cell carcinoma masquerading as vulvar lymphangioma circumscriptum.
Soh JM, Scott GA, Pavlovitz BT, Mercurio MG
J Obstet Gynaecol 2016 Oct;36(7):876-878. Epub 2016 Sep 10 doi: 10.1080/01443615.2016.1188271. PMID: 27616148
Correlation of CEA but not CA 19-9 as serum biomarkers of disease activity in a case of metastatic rectal adenocarcinoma.
Marks EI, Brennan M, El-Deiry WS
Cancer Biol Ther 2015;16(8):1136-9. doi: 10.1080/15384047.2015.1057360. PMID: 26047368Free PMC Article

Therapy

High dose chemoradiotherapy increases chance of organ preservation with satisfactory functional outcome for rectal cancer.
Wang QX, Zhang S, Xiao WW, Zhou CJ, Chang H, Zeng ZF, Cai PQ, Lu ZH, Chen G, Ding PR, Pan ZZ, Wu XJ, Gao YH
Radiat Oncol 2022 May 18;17(1):98. doi: 10.1186/s13014-022-02066-7. PMID: 35585551Free PMC Article
Survival Outcomes After Surgical Management of the Primary Tumor With and Without Radiotherapy for Metastatic Rectal Adenocarcinoma: A National Cancer Database (NCDB) Analysis.
Renz P, Wegner RE, Hasan S, Brookover R, Finley G, Monga D, Raj M, McCormick J, Kirichenko A
Clin Colorectal Cancer 2019 Jun;18(2):e237-e243. Epub 2019 Feb 5 doi: 10.1016/j.clcc.2018.12.005. PMID: 30905549Free PMC Article
Correlation of CEA but not CA 19-9 as serum biomarkers of disease activity in a case of metastatic rectal adenocarcinoma.
Marks EI, Brennan M, El-Deiry WS
Cancer Biol Ther 2015;16(8):1136-9. doi: 10.1080/15384047.2015.1057360. PMID: 26047368Free PMC Article
Bevacizumab in the pre-operative treatment of locally advanced rectal cancer: a systematic review.
Fornaro L, Caparello C, Vivaldi C, Rotella V, Musettini G, Falcone A, Baldini E, Masi G
World J Gastroenterol 2014 May 28;20(20):6081-91. doi: 10.3748/wjg.v20.i20.6081. PMID: 24876730Free PMC Article
Necrotizing fasciitis secondary to bevacizumab treatment for metastatic rectal adenocarcinoma.
Sendur MA, Aksoy S, Özdemir NY, Zengin N
Indian J Pharmacol 2014 Jan-Feb;46(1):125-6. doi: 10.4103/0253-7613.125195. PMID: 24550600Free PMC Article

Prognosis

Concordance between clinical and pathologic assessment of T and N stages of rectal adenocarcinoma patients who underwent surgery without neoadjuvant therapy: A National Cancer Database analysis.
Emile SH, Silva-Alvarenga E, Horesh N, Freund MR, Garoufalia Z, Wexner SD
Eur J Surg Oncol 2023 Feb;49(2):426-432. Epub 2022 Oct 1 doi: 10.1016/j.ejso.2022.09.014. PMID: 36257901
Construction of a predictive model for clinical survival in male patients with non-metastatic rectal adenocarcinoma.
Qu Y, Liu H
Asian J Surg 2023 Jan;46(1):132-142. Epub 2022 Feb 26 doi: 10.1016/j.asjsur.2022.02.004. PMID: 35227564
Association of obesity with postoperative outcomes after proctectomy.
Sweigert PJ, Chen C, Fahmy JN, Eguia E, Ban KA, deLahunta D, Peters S, Baker MS, Singer MA
Am J Surg 2020 Oct;220(4):1004-1009. Epub 2020 Mar 25 doi: 10.1016/j.amjsurg.2020.03.028. PMID: 32248948
Bevacizumab in the pre-operative treatment of locally advanced rectal cancer: a systematic review.
Fornaro L, Caparello C, Vivaldi C, Rotella V, Musettini G, Falcone A, Baldini E, Masi G
World J Gastroenterol 2014 May 28;20(20):6081-91. doi: 10.3748/wjg.v20.i20.6081. PMID: 24876730Free PMC Article
Necrotizing fasciitis secondary to bevacizumab treatment for metastatic rectal adenocarcinoma.
Sendur MA, Aksoy S, Özdemir NY, Zengin N
Indian J Pharmacol 2014 Jan-Feb;46(1):125-6. doi: 10.4103/0253-7613.125195. PMID: 24550600Free PMC Article

Clinical prediction guides

Concordance between clinical and pathologic assessment of T and N stages of rectal adenocarcinoma patients who underwent surgery without neoadjuvant therapy: A National Cancer Database analysis.
Emile SH, Silva-Alvarenga E, Horesh N, Freund MR, Garoufalia Z, Wexner SD
Eur J Surg Oncol 2023 Feb;49(2):426-432. Epub 2022 Oct 1 doi: 10.1016/j.ejso.2022.09.014. PMID: 36257901
Construction of a predictive model for clinical survival in male patients with non-metastatic rectal adenocarcinoma.
Qu Y, Liu H
Asian J Surg 2023 Jan;46(1):132-142. Epub 2022 Feb 26 doi: 10.1016/j.asjsur.2022.02.004. PMID: 35227564
High dose chemoradiotherapy increases chance of organ preservation with satisfactory functional outcome for rectal cancer.
Wang QX, Zhang S, Xiao WW, Zhou CJ, Chang H, Zeng ZF, Cai PQ, Lu ZH, Chen G, Ding PR, Pan ZZ, Wu XJ, Gao YH
Radiat Oncol 2022 May 18;17(1):98. doi: 10.1186/s13014-022-02066-7. PMID: 35585551Free PMC Article
Metastatic rectal cancer to papillary thyroid carcinoma: a case report and review of literature.
Luo M, Huang Y, Li Y, Zhang Y
BMC Gastroenterol 2020 May 6;20(1):136. doi: 10.1186/s12876-020-01286-z. PMID: 32375670Free PMC Article
Association of obesity with postoperative outcomes after proctectomy.
Sweigert PJ, Chen C, Fahmy JN, Eguia E, Ban KA, deLahunta D, Peters S, Baker MS, Singer MA
Am J Surg 2020 Oct;220(4):1004-1009. Epub 2020 Mar 25 doi: 10.1016/j.amjsurg.2020.03.028. PMID: 32248948

Recent systematic reviews

The Coexistence of RAS and BRAF Mutations in Metastatic Colorectal Cancer: A Case Report and Systematic Literature Review.
Afrăsânie VA, Gafton B, Marinca MV, Alexa-Stratulat T, Miron L, Rusu C, Ivanov AV, Balan GG, Croitoru AE
J Gastrointestin Liver Dis 2020 Jun 3;29(2):251-256. doi: 10.15403/jgld-1003. PMID: 32530992
Bevacizumab in the pre-operative treatment of locally advanced rectal cancer: a systematic review.
Fornaro L, Caparello C, Vivaldi C, Rotella V, Musettini G, Falcone A, Baldini E, Masi G
World J Gastroenterol 2014 May 28;20(20):6081-91. doi: 10.3748/wjg.v20.i20.6081. PMID: 24876730Free PMC Article

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