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Dedifferentiated Lesion

MedGen UID:
1696699
•Concept ID:
C5203962
•
Finding

Definition

A lesion composed of cells that have undergone transformation to less mature forms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDedifferentiated Lesion

Professional guidelines

PubMed

Treatment of De-Differentiated Liposarcoma in the Era of Immunotherapy.
Zhou MY, Bui NQ, Charville GW, Ganjoo KN, Pan M
Int J Mol Sci 2023 May 31;24(11) doi: 10.3390/ijms24119571. PMID: 37298520Free PMC Article
Differential diagnosis of T2 hypointense masses in musculoskeletal MRI.
Finkelstein D, Foremny G, Singer A, Clifford P, Pretell-Mazzini J, Kerr DA, Subhawong TK
Skeletal Radiol 2021 Oct;50(10):1981-1994. Epub 2021 Mar 2 doi: 10.1007/s00256-021-03711-0. PMID: 33651128
Liposarcoma: Multimodality Management and Future Targeted Therapies.
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article

Recent clinical studies

Etiology

Chondrosarcoma.
Weinschenk RC, Wang WL, Lewis VO
J Am Acad Orthop Surg 2021 Jul 1;29(13):553-562. doi: 10.5435/JAAOS-D-20-01188. PMID: 33595238
Benign Breast Disease in Women.
Stachs A, Stubert J, Reimer T, Hartmann S
Dtsch Arztebl Int 2019 Aug 9;116(33-34):565-574. doi: 10.3238/arztebl.2019.0565. PMID: 31554551Free PMC Article
Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis.
Wirka RC, Wagh D, Paik DT, Pjanic M, Nguyen T, Miller CL, Kundu R, Nagao M, Coller J, Koyano TK, Fong R, Woo YJ, Liu B, Montgomery SB, Wu JC, Zhu K, Chang R, Alamprese M, Tallquist MD, Kim JB, Quertermous T
Nat Med 2019 Aug;25(8):1280-1289. Epub 2019 Jul 29 doi: 10.1038/s41591-019-0512-5. PMID: 31359001Free PMC Article
Collapsing glomerulopathy: update.
Morales E, Alonso M, Gutiérrez E
Med Clin (Barc) 2019 May 3;152(9):361-367. Epub 2018 Dec 13 doi: 10.1016/j.medcli.2018.10.021. PMID: 30554809
Liposarcoma: Multimodality Management and Future Targeted Therapies.
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article

Diagnosis

Chordoma.
Ulici V, Hart J
Arch Pathol Lab Med 2022 Mar 1;146(3):386-395. doi: 10.5858/arpa.2020-0258-RA. PMID: 34319396
Dedifferentiated and undifferentiated neoplasms: A conceptual approach.
Baraban E, Cooper K
Semin Diagn Pathol 2021 Nov;38(6):119-126. Epub 2020 Sep 5 doi: 10.1053/j.semdp.2020.09.002. PMID: 32948384
Benign Breast Disease in Women.
Stachs A, Stubert J, Reimer T, Hartmann S
Dtsch Arztebl Int 2019 Aug 9;116(33-34):565-574. doi: 10.3238/arztebl.2019.0565. PMID: 31554551Free PMC Article
Collapsing glomerulopathy: update.
Morales E, Alonso M, Gutiérrez E
Med Clin (Barc) 2019 May 3;152(9):361-367. Epub 2018 Dec 13 doi: 10.1016/j.medcli.2018.10.021. PMID: 30554809
Fourth-ventricular immature teratoma.
Furtado SV, Ghosal N, Rokade VB, Hegde AS
J Clin Neurosci 2011 Feb;18(2):296-8. Epub 2010 Oct 27 doi: 10.1016/j.jocn.2010.03.061. PMID: 21030259

Therapy

Colchicine Blocks Abdominal Aortic Aneurysm Development by Maintaining Vascular Smooth Muscle Cell Homeostasis.
Chen M, Yang D, Zhou Y, Yang C, Lin W, Li J, Liu J, Ye J, Huang W, Ma W, Li W, Chen J, Zhang Y, Shi GP, Luo J, Li J, Luo S
Int J Biol Sci 2024;20(6):2092-2110. Epub 2024 Mar 17 doi: 10.7150/ijbs.93544. PMID: 38617538Free PMC Article
Molecular patterns of resistance to immune checkpoint blockade in melanoma.
Lauss M, Phung B, Borch TH, Harbst K, Kaminska K, Ebbesson A, Hedenfalk I, Yuan J, Nielsen K, Ingvar C, Carneiro A, Isaksson K, Pietras K, Svane IM, Donia M, Jönsson G
Nat Commun 2024 Apr 9;15(1):3075. doi: 10.1038/s41467-024-47425-y. PMID: 38594286Free PMC Article
Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial.
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Liposarcoma: Multimodality Management and Future Targeted Therapies.
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article
Is primary radiotherapy an appropriate option for the treatment of verrucous carcinoma of the head and neck?
Ferlito A, Rinaldo A, Mannarà GM
J Laryngol Otol 1998 Feb;112(2):132-9. doi: 10.1017/s0022215100140137. PMID: 9578870

Prognosis

Chordoma.
Ulici V, Hart J
Arch Pathol Lab Med 2022 Mar 1;146(3):386-395. doi: 10.5858/arpa.2020-0258-RA. PMID: 34319396
Chondrosarcoma.
Weinschenk RC, Wang WL, Lewis VO
J Am Acad Orthop Surg 2021 Jul 1;29(13):553-562. doi: 10.5435/JAAOS-D-20-01188. PMID: 33595238
Endometrial carcinoma: molecular subtypes, precursors and the role of pathology in early diagnosis.
Huvila J, Pors J, Thompson EF, Gilks CB
J Pathol 2021 Apr;253(4):355-365. Epub 2021 Feb 6 doi: 10.1002/path.5608. PMID: 33368243
Collapsing glomerulopathy: update.
Morales E, Alonso M, Gutiérrez E
Med Clin (Barc) 2019 May 3;152(9):361-367. Epub 2018 Dec 13 doi: 10.1016/j.medcli.2018.10.021. PMID: 30554809
Fourth-ventricular immature teratoma.
Furtado SV, Ghosal N, Rokade VB, Hegde AS
J Clin Neurosci 2011 Feb;18(2):296-8. Epub 2010 Oct 27 doi: 10.1016/j.jocn.2010.03.061. PMID: 21030259

Clinical prediction guides

Molecular patterns of resistance to immune checkpoint blockade in melanoma.
Lauss M, Phung B, Borch TH, Harbst K, Kaminska K, Ebbesson A, Hedenfalk I, Yuan J, Nielsen K, Ingvar C, Carneiro A, Isaksson K, Pietras K, Svane IM, Donia M, Jönsson G
Nat Commun 2024 Apr 9;15(1):3075. doi: 10.1038/s41467-024-47425-y. PMID: 38594286Free PMC Article
Nrf2 induces malignant transformation of hepatic progenitor cells by inducing β-catenin expression.
Fragoulis A, Schenkel J, Schröder N, Brandt EF, Weiand M, Neu T, Ramadori P, Caspers T, Kant S, Pufe T, Mohs A, Trautwein C, Longerich T, Streetz KL, Wruck CJ
Redox Biol 2022 Nov;57:102453. Epub 2022 Sep 13 doi: 10.1016/j.redox.2022.102453. PMID: 36209041Free PMC Article
Gastric adenocarcinoma of fundic gland type with signet-ring cell carcinoma component: A case report and review of the literature.
Kai K, Satake M, Tokunaga O
World J Gastroenterol 2018 Jul 14;24(26):2915-2920. doi: 10.3748/wjg.v24.i26.2915. PMID: 30018486Free PMC Article
In vivo reprogramming drives Kras-induced cancer development.
Shibata H, Komura S, Yamada Y, Sankoda N, Tanaka A, Ukai T, Kabata M, Sakurai S, Kuze B, Woltjen K, Haga H, Ito Y, Kawaguchi Y, Yamamoto T, Yamada Y
Nat Commun 2018 May 25;9(1):2081. doi: 10.1038/s41467-018-04449-5. PMID: 29802314Free PMC Article
The management of deep-seated, lowgrade lipomatous lesions.
Al-Ani Z, Fernando M, Wilkinson V, Kotnis N
Br J Radiol 2018 Jun;91(1086):20170725. Epub 2018 Jan 17 doi: 10.1259/bjr.20170725. PMID: 29303371

Recent systematic reviews

How miRNAs Regulate Schwann Cells during Peripheral Nerve Regeneration-A Systemic Review.
Borger A, Stadlmayr S, Haertinger M, Semmler L, Supper P, Millesi F, Radtke C
Int J Mol Sci 2022 Mar 22;23(7) doi: 10.3390/ijms23073440. PMID: 35408800Free PMC Article
Primary hepatic gastrointestinal stromal tumor with right adrenal gland invasion: A case report and systematic literature review.
Xu L, Zhang M, Xu M
Medicine (Baltimore) 2019 May;98(20):e15482. doi: 10.1097/MD.0000000000015482. PMID: 31096446Free PMC Article
Intralesional vs. extralesional procedures for low-grade central chondrosarcoma: a systematic review of the literature.
Zoccali C, Baldi J, Attala D, Rossi B, Anelli V, Annovazzi A, Ferraresi V
Arch Orthop Trauma Surg 2018 Jul;138(7):929-937. Epub 2018 Apr 10 doi: 10.1007/s00402-018-2930-0. PMID: 29633075

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