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CSF autoimmune antibody positivity

MedGen UID:
1696901
Concept ID:
C5139230
Finding
Synonym: Cerebrospinal fluid autoimmune antibody positivity
 
HPO: HP:0032265

Definition

The presence of an antibody in the cerebrospinal fluid (CSF) that is directed against the organism's own cells or tissues. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCSF autoimmune antibody positivity

Professional guidelines

PubMed

Jarius S, Aktas O, Ayzenberg I, Bellmann-Strobl J, Berthele A, Giglhuber K, Häußler V, Havla J, Hellwig K, Hümmert MW, Kleiter I, Klotz L, Krumbholz M, Kümpfel T, Paul F, Ringelstein M, Ruprecht K, Senel M, Stellmann JP, Bergh FT, Tumani H, Wildemann B, Trebst C; Neuromyelitis Optica Study Group (NEMOS)
J Neurol 2023 Jul;270(7):3341-3368. Epub 2023 Apr 6 doi: 10.1007/s00415-023-11634-0. PMID: 37022481Free PMC Article
Gresa-Arribas N, Titulaer MJ, Torrents A, Aguilar E, McCracken L, Leypoldt F, Gleichman AJ, Balice-Gordon R, Rosenfeld MR, Lynch D, Graus F, Dalmau J
Lancet Neurol 2014 Feb;13(2):167-77. Epub 2013 Dec 18 doi: 10.1016/S1474-4422(13)70282-5. PMID: 24360484Free PMC Article
Titulaer MJ, McCracken L, Gabilondo I, Armangué T, Glaser C, Iizuka T, Honig LS, Benseler SM, Kawachi I, Martinez-Hernandez E, Aguilar E, Gresa-Arribas N, Ryan-Florance N, Torrents A, Saiz A, Rosenfeld MR, Balice-Gordon R, Graus F, Dalmau J
Lancet Neurol 2013 Feb;12(2):157-65. Epub 2013 Jan 3 doi: 10.1016/S1474-4422(12)70310-1. PMID: 23290630Free PMC Article

Recent clinical studies

Etiology

Jarius S, Aktas O, Ayzenberg I, Bellmann-Strobl J, Berthele A, Giglhuber K, Häußler V, Havla J, Hellwig K, Hümmert MW, Kleiter I, Klotz L, Krumbholz M, Kümpfel T, Paul F, Ringelstein M, Ruprecht K, Senel M, Stellmann JP, Bergh FT, Tumani H, Wildemann B, Trebst C; Neuromyelitis Optica Study Group (NEMOS)
J Neurol 2023 Jul;270(7):3341-3368. Epub 2023 Apr 6 doi: 10.1007/s00415-023-11634-0. PMID: 37022481Free PMC Article
Carta S, Cobo Calvo Á, Armangué T, Saiz A, Lechner C, Rostásy K, Breu M, Baumann M, Höftberger R, Ayzenberg I, Schwake C, Sepulveda M, Martínez-Hernández E, Olivé-Cirera G, Arrambide G, Tintoré M, Bernard-Valnet R, Du Pasquier R, Brilot F, Ramanathan S, Schanda K, Gajofatto A, Ferrari S, Sechi E, Flanagan EP, Pittock SJ, Redenbaugh V, Reindl M, Marignier R, Mariotto S
Neurology 2023 Mar 14;100(11):e1095-e1108. Epub 2022 Dec 16 doi: 10.1212/WNL.0000000000201662. PMID: 36526426Free PMC Article
Flanagan EP, Geschwind MD, Lopez-Chiriboga AS, Blackburn KM, Turaga S, Binks S, Zitser J, Gelfand JM, Day GS, Dunham SR, Rodenbeck SJ, Clardy SL, Solomon AJ, Pittock SJ, McKeon A, Dubey D, Zekeridou A, Toledano M, Turner LE, Vernino S, Irani SR
JAMA Neurol 2023 Jan 1;80(1):30-39. doi: 10.1001/jamaneurol.2022.4251. PMID: 36441519Free PMC Article
Gaig C, Graus F, Compta Y, Högl B, Bataller L, Brüggemann N, Giordana C, Heidbreder A, Kotschet K, Lewerenz J, Macher S, Martí MJ, Montojo T, Pérez-Pérez J, Puertas I, Seitz C, Simabukuro M, Téllez N, Wandinger KP, Iranzo A, Ercilla G, Sabater L, Santamaría J, Dalmau J
Neurology 2017 May 2;88(18):1736-1743. Epub 2017 Apr 5 doi: 10.1212/WNL.0000000000003887. PMID: 28381508Free PMC Article
Titulaer MJ, McCracken L, Gabilondo I, Armangué T, Glaser C, Iizuka T, Honig LS, Benseler SM, Kawachi I, Martinez-Hernandez E, Aguilar E, Gresa-Arribas N, Ryan-Florance N, Torrents A, Saiz A, Rosenfeld MR, Balice-Gordon R, Graus F, Dalmau J
Lancet Neurol 2013 Feb;12(2):157-65. Epub 2013 Jan 3 doi: 10.1016/S1474-4422(12)70310-1. PMID: 23290630Free PMC Article

Diagnosis

Jarius S, Aktas O, Ayzenberg I, Bellmann-Strobl J, Berthele A, Giglhuber K, Häußler V, Havla J, Hellwig K, Hümmert MW, Kleiter I, Klotz L, Krumbholz M, Kümpfel T, Paul F, Ringelstein M, Ruprecht K, Senel M, Stellmann JP, Bergh FT, Tumani H, Wildemann B, Trebst C; Neuromyelitis Optica Study Group (NEMOS)
J Neurol 2023 Jul;270(7):3341-3368. Epub 2023 Apr 6 doi: 10.1007/s00415-023-11634-0. PMID: 37022481Free PMC Article
Flanagan EP, Geschwind MD, Lopez-Chiriboga AS, Blackburn KM, Turaga S, Binks S, Zitser J, Gelfand JM, Day GS, Dunham SR, Rodenbeck SJ, Clardy SL, Solomon AJ, Pittock SJ, McKeon A, Dubey D, Zekeridou A, Toledano M, Turner LE, Vernino S, Irani SR
JAMA Neurol 2023 Jan 1;80(1):30-39. doi: 10.1001/jamaneurol.2022.4251. PMID: 36441519Free PMC Article
Shan F, Long Y, Qiu W
Front Immunol 2018;9:2802. Epub 2018 Dec 5 doi: 10.3389/fimmu.2018.02802. PMID: 30568655Free PMC Article
Titulaer MJ, McCracken L, Gabilondo I, Armangué T, Glaser C, Iizuka T, Honig LS, Benseler SM, Kawachi I, Martinez-Hernandez E, Aguilar E, Gresa-Arribas N, Ryan-Florance N, Torrents A, Saiz A, Rosenfeld MR, Balice-Gordon R, Graus F, Dalmau J
Lancet Neurol 2013 Feb;12(2):157-65. Epub 2013 Jan 3 doi: 10.1016/S1474-4422(12)70310-1. PMID: 23290630Free PMC Article
Jubelt B, Mihai C, Li TM, Veerapaneni P
Curr Neurol Neurosci Rep 2011 Dec;11(6):543-52. doi: 10.1007/s11910-011-0228-5. PMID: 21956758

Therapy

Schlatter MI, Yandamuri SS, O'Connor KC, Nowak RJ, Pham MC, Obaid AH, Redman C, Provost M, McSweeney PA, Pearlman ML, Tees MT, Bowen JD, Nash RA, Georges GE
Ann Clin Transl Neurol 2023 Nov;10(11):2105-2113. Epub 2023 Sep 19 doi: 10.1002/acn3.51898. PMID: 37726935Free PMC Article
Warren N, Swayne A, Siskind D, O'Gorman C, Prain K, Gillis D, Blum S
J Neuropsychiatry Clin Neurosci 2020 Spring;32(2):154-160. Epub 2019 Sep 18 doi: 10.1176/appi.neuropsych.19030079. PMID: 31530118
Jarius S, Ruprecht K, Kleiter I, Borisow N, Asgari N, Pitarokoili K, Pache F, Stich O, Beume LA, Hümmert MW, Ringelstein M, Trebst C, Winkelmann A, Schwarz A, Buttmann M, Zimmermann H, Kuchling J, Franciotta D, Capobianco M, Siebert E, Lukas C, Korporal-Kuhnke M, Haas J, Fechner K, Brandt AU, Schanda K, Aktas O, Paul F, Reindl M, Wildemann B; in cooperation with the Neuromyelitis Optica Study Group (NEMOS)
J Neuroinflammation 2016 Sep 27;13(1):280. doi: 10.1186/s12974-016-0718-0. PMID: 27793206Free PMC Article
Wang T, Lazar CA, Fishbein MC, Lynch JP 3rd
Semin Respir Crit Care Med 2012 Oct;33(5):498-508. Epub 2012 Sep 21 doi: 10.1055/s-0032-1325160. PMID: 23001804
Khan A, Agarwal R
Respir Care 2011 Jul;56(7):1016-28. Epub 2011 Apr 15 doi: 10.4187/respcare.01125. PMID: 21496372

Prognosis

Jarius S, Aktas O, Ayzenberg I, Bellmann-Strobl J, Berthele A, Giglhuber K, Häußler V, Havla J, Hellwig K, Hümmert MW, Kleiter I, Klotz L, Krumbholz M, Kümpfel T, Paul F, Ringelstein M, Ruprecht K, Senel M, Stellmann JP, Bergh FT, Tumani H, Wildemann B, Trebst C; Neuromyelitis Optica Study Group (NEMOS)
J Neurol 2023 Jul;270(7):3341-3368. Epub 2023 Apr 6 doi: 10.1007/s00415-023-11634-0. PMID: 37022481Free PMC Article
Gravier-Dumonceau A, Ameli R, Rogemond V, Ruiz A, Joubert B, Muñiz-Castrillo S, Vogrig A, Picard G, Ambati A, Benaiteau M, Rulquin F, Ciron J, Deiva K, de Broucker T, Kremer L, Kerschen P, Sellal F, Bouldoires B, Genet R, Biberon J, Bigot A, Duval F, Issa N, Rusu EC, Goudot M, Dutray A, Devoize JL, Hopes L, Kaminsky AL, Philbert M, Chanson E, Leblanc A, Morvan E, Andriuta D, Diraison P, Mirebeau G, Derollez C, Bourg V, Bodard Q, Fort C, Grigorashvili-Coin I, Rieul G, Molinier-Tiganas D, Bonnan M, Tchoumi T, Honnorat J, Marignier R
Neurology 2022 Feb 8;98(6):e653-e668. Epub 2021 Nov 19 doi: 10.1212/WNL.0000000000013087. PMID: 34799461Free PMC Article
Shan F, Long Y, Qiu W
Front Immunol 2018;9:2802. Epub 2018 Dec 5 doi: 10.3389/fimmu.2018.02802. PMID: 30568655Free PMC Article
Titulaer MJ, McCracken L, Gabilondo I, Armangué T, Glaser C, Iizuka T, Honig LS, Benseler SM, Kawachi I, Martinez-Hernandez E, Aguilar E, Gresa-Arribas N, Ryan-Florance N, Torrents A, Saiz A, Rosenfeld MR, Balice-Gordon R, Graus F, Dalmau J
Lancet Neurol 2013 Feb;12(2):157-65. Epub 2013 Jan 3 doi: 10.1016/S1474-4422(12)70310-1. PMID: 23290630Free PMC Article
Jubelt B, Mihai C, Li TM, Veerapaneni P
Curr Neurol Neurosci Rep 2011 Dec;11(6):543-52. doi: 10.1007/s11910-011-0228-5. PMID: 21956758

Clinical prediction guides

Cacciaguerra L, Morris P, Tobin WO, Chen JJ, Banks SA, Elsbernd P, Redenbaugh V, Tillema JM, Montini F, Sechi E, Lopez-Chiriboga AS, Zalewski N, Guo Y, Rocca MA, Filippi M, Pittock SJ, Lucchinetti CF, Flanagan EP
Neurology 2023 Mar 28;100(13):e1418-e1432. Epub 2023 Jan 23 doi: 10.1212/WNL.0000000000206820. PMID: 36690455Free PMC Article
Gravier-Dumonceau A, Ameli R, Rogemond V, Ruiz A, Joubert B, Muñiz-Castrillo S, Vogrig A, Picard G, Ambati A, Benaiteau M, Rulquin F, Ciron J, Deiva K, de Broucker T, Kremer L, Kerschen P, Sellal F, Bouldoires B, Genet R, Biberon J, Bigot A, Duval F, Issa N, Rusu EC, Goudot M, Dutray A, Devoize JL, Hopes L, Kaminsky AL, Philbert M, Chanson E, Leblanc A, Morvan E, Andriuta D, Diraison P, Mirebeau G, Derollez C, Bourg V, Bodard Q, Fort C, Grigorashvili-Coin I, Rieul G, Molinier-Tiganas D, Bonnan M, Tchoumi T, Honnorat J, Marignier R
Neurology 2022 Feb 8;98(6):e653-e668. Epub 2021 Nov 19 doi: 10.1212/WNL.0000000000013087. PMID: 34799461Free PMC Article
Shan F, Long Y, Qiu W
Front Immunol 2018;9:2802. Epub 2018 Dec 5 doi: 10.3389/fimmu.2018.02802. PMID: 30568655Free PMC Article
Gresa-Arribas N, Titulaer MJ, Torrents A, Aguilar E, McCracken L, Leypoldt F, Gleichman AJ, Balice-Gordon R, Rosenfeld MR, Lynch D, Graus F, Dalmau J
Lancet Neurol 2014 Feb;13(2):167-77. Epub 2013 Dec 18 doi: 10.1016/S1474-4422(13)70282-5. PMID: 24360484Free PMC Article
Titulaer MJ, McCracken L, Gabilondo I, Armangué T, Glaser C, Iizuka T, Honig LS, Benseler SM, Kawachi I, Martinez-Hernandez E, Aguilar E, Gresa-Arribas N, Ryan-Florance N, Torrents A, Saiz A, Rosenfeld MR, Balice-Gordon R, Graus F, Dalmau J
Lancet Neurol 2013 Feb;12(2):157-65. Epub 2013 Jan 3 doi: 10.1016/S1474-4422(12)70310-1. PMID: 23290630Free PMC Article

Recent systematic reviews

Zara P, Dinoto A, Carta S, Floris V, Turilli D, Budhram A, Ferrari S, Milia S, Solla P, Mariotto S, Flanagan EP, Lopez Chiriboga AS, Sechi E
Eur J Neurol 2023 Oct;30(10):3367-3376. Epub 2023 Jul 19 doi: 10.1111/ene.15983. PMID: 37433584Free PMC Article
Vega E, Arrambide G, Olivé G, Castillo M, Felipe-Rucián A, Tintoré M, Montalban X, Espejo C, Sepúlveda M, Armangué T, Cobo-Calvo A
Eur J Neurol 2023 May;30(5):1515-1527. Epub 2023 Feb 20 doi: 10.1111/ene.15684. PMID: 36704861
Blackman G, Lim MF, Pollak T, Al-Diwani A, Symmonds M, Mazumder A, Carter B, Irani S, David A
J Neurol 2022 Oct;269(10):5302-5311. Epub 2022 Jul 5 doi: 10.1007/s00415-022-11224-6. PMID: 35790561Free PMC Article
Lewis A, Frontera J, Placantonakis DG, Lighter J, Galetta S, Balcer L, Melmed KR
J Neurol Sci 2021 Feb 15;421:117316. Epub 2021 Jan 10 doi: 10.1016/j.jns.2021.117316. PMID: 33561753Free PMC Article
Pearlman DM, Vora HS, Marquis BG, Najjar S, Dudley LA
Br J Psychiatry 2014 Jul;205(1):8-16. doi: 10.1192/bjp.bp.113.137018. PMID: 24986387

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