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Metastatic Sinonasal Squamous Cell Carcinoma

MedGen UID:
1701061
•Concept ID:
C5206859
•
Neoplastic Process
Synonym: Metastatic Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma

Definition

Nasal cavity and/or paranasal sinus squamous cell carcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Professional guidelines

PubMed

Management of orbital invasion in sinonasal squamous cell carcinoma: 15 years' experience.
Li R, Tian S, Zhu Y, Zhu W, Wang S
Int Forum Allergy Rhinol 2020 Feb;10(2):243-255. Epub 2019 Nov 22 doi: 10.1002/alr.22465. PMID: 31756058
Multidisciplinary Clinic Management of Head and Neck Cancer.
Townsend M, Kallogjeri D, Scott-Wittenborn N, Gerull K, Jansen S, Nussenbaum B
JAMA Otolaryngol Head Neck Surg 2017 Dec 1;143(12):1213-1219. doi: 10.1001/jamaoto.2017.1855. PMID: 29075744Free PMC Article
The Role of Targeted Therapy in the Management of Sinonasal Malignancies.
Kashat L, Le CH, Chiu AG
Otolaryngol Clin North Am 2017 Apr;50(2):443-455. doi: 10.1016/j.otc.2016.12.016. PMID: 28314406

Recent clinical studies

Etiology

Sinonasal Squamous Cell Carcinoma Survival Outcomes Following Induction Chemotherapy vs Standard of Care Therapy.
Murr AT, Lenze NR, Weiss JM, Grilley-Olson JE, Patel SA, Shen C, Chera BS, Zanation AM, Thorp BD, Sheth SH
Otolaryngol Head Neck Surg 2022 Nov;167(5):846-851. Epub 2022 Mar 8 doi: 10.1177/01945998221083097. PMID: 35259033Free PMC Article
Prognostic Factors of Sinonasal Squamous Cell Carcinomas Arising De Novo and From Inverted Papilloma.
Li Y, Wang C, Wang R, Zhang J, Liu H, Shi Q, Chen X, Hou L, Ma H, Zhong Q, Li P, Feng L, He S, Zhang L, Fang J
Am J Rhinol Allergy 2021 Jan;35(1):114-121. Epub 2020 Jul 12 doi: 10.1177/1945892420939422. PMID: 32659112
Management of orbital invasion in sinonasal squamous cell carcinoma: 15 years' experience.
Li R, Tian S, Zhu Y, Zhu W, Wang S
Int Forum Allergy Rhinol 2020 Feb;10(2):243-255. Epub 2019 Nov 22 doi: 10.1002/alr.22465. PMID: 31756058
Squamous cell carcinoma of the maxillary sinus: A population-based analysis.
Dubal PM, Bhojwani A, Patel TD, Zuckerman O, Baredes S, Liu JK, Eloy JA
Laryngoscope 2016 Feb;126(2):399-404. Epub 2015 Sep 22 doi: 10.1002/lary.25601. PMID: 26393540
Squamous cell carcinoma of the nasal cavity: A population-based analysis.
Unsal AA, Dubal PM, Patel TD, Vazquez A, Baredes S, Liu JK, Eloy JA
Laryngoscope 2016 Mar;126(3):560-5. Epub 2015 Aug 22 doi: 10.1002/lary.25531. PMID: 26297930

Diagnosis

Top 10 Clear Cell Head and Neck Lesions to Contemplate.
Cipriani NA, Kakkar A
Head Neck Pathol 2023 Mar;17(1):33-52. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01518-6. PMID: 36928734Free PMC Article
Stimulated Raman Histology for Rapid Intra-Operative Diagnosis of Sinonasal and Skull Base Tumors.
Fitzgerald CWR, Dogan S, Bou-Nassif R, Mclean T, Woods R, Cracchiolo JR, Ganly I, Tabar V, Cohen MA
Laryngoscope 2022 Nov;132(11):2142-2147. Epub 2022 May 30 doi: 10.1002/lary.30233. PMID: 35634892Free PMC Article
Squamous cell carcinoma of the maxillary sinus: A population-based analysis.
Dubal PM, Bhojwani A, Patel TD, Zuckerman O, Baredes S, Liu JK, Eloy JA
Laryngoscope 2016 Feb;126(2):399-404. Epub 2015 Sep 22 doi: 10.1002/lary.25601. PMID: 26393540
Squamous cell carcinoma of the nasal cavity: A population-based analysis.
Unsal AA, Dubal PM, Patel TD, Vazquez A, Baredes S, Liu JK, Eloy JA
Laryngoscope 2016 Mar;126(3):560-5. Epub 2015 Aug 22 doi: 10.1002/lary.25531. PMID: 26297930
Metastatic squamous cell carcinoma resembling cellulitis and osteomyelitis of the fifth toe.
Kaplansky DB, Kademian ME, VanCourt RB
J Foot Ankle Surg 2006 May-Jun;45(3):182-4. doi: 10.1053/j.jfas.2006.02.005. PMID: 16651199

Therapy

Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma.
Contrera KJ, Ferrarotto R, Gunn B, Su SY, Kies MS, Glisson BS, Garden AS, Roberts D, Habna C, Hoff CO, El-Naggar A, Williams MD, Raza SM, DeMonte F, Chen MM, Chambers MS, Hanna EY
Clin Cancer Res 2025 Jan 17;31(2):258-265. doi: 10.1158/1078-0432.CCR-24-1416. PMID: 39531535
The SINTART 1 study. A phase II non-randomised controlled trial of induction chemotherapy, surgery, photon-, proton- and carbon ion-based radiotherapy integration in patients with locally advanced resectable sinonasal tumours.
Resteghini C, Castelnuovo P, Nicolai P, Orlandi E, Bossi P, Vischioni B, Schreiber A, Gambazza S, Iacovelli NA, Battaglia P, Guzzo M, Turri-Zanoni M, Mattavelli D, Facchinetti N, Calareso G, Ravanelli M, Facco C, Tartaro T, Licitra L
Eur J Cancer 2023 Jul;187:185-194. Epub 2023 Apr 5 doi: 10.1016/j.ejca.2023.03.033. PMID: 37164774
Sinonasal Squamous Cell Carcinoma Survival Outcomes Following Induction Chemotherapy vs Standard of Care Therapy.
Murr AT, Lenze NR, Weiss JM, Grilley-Olson JE, Patel SA, Shen C, Chera BS, Zanation AM, Thorp BD, Sheth SH
Otolaryngol Head Neck Surg 2022 Nov;167(5):846-851. Epub 2022 Mar 8 doi: 10.1177/01945998221083097. PMID: 35259033Free PMC Article
Management of orbital invasion in sinonasal squamous cell carcinoma: 15 years' experience.
Li R, Tian S, Zhu Y, Zhu W, Wang S
Int Forum Allergy Rhinol 2020 Feb;10(2):243-255. Epub 2019 Nov 22 doi: 10.1002/alr.22465. PMID: 31756058
Lymph node metastasis in sinonasal squamous cell carcinoma treated with IMRT/3D-CRT.
Guan X, Wang X, Liu Y, Hu C, Zhu G
Oral Oncol 2013 Jan;49(1):60-5. Epub 2012 Aug 9 doi: 10.1016/j.oraloncology.2012.07.009. PMID: 22884302

Prognosis

Prognostic Factors of Sinonasal Squamous Cell Carcinomas Arising De Novo and From Inverted Papilloma.
Li Y, Wang C, Wang R, Zhang J, Liu H, Shi Q, Chen X, Hou L, Ma H, Zhong Q, Li P, Feng L, He S, Zhang L, Fang J
Am J Rhinol Allergy 2021 Jan;35(1):114-121. Epub 2020 Jul 12 doi: 10.1177/1945892420939422. PMID: 32659112
Management of orbital invasion in sinonasal squamous cell carcinoma: 15 years' experience.
Li R, Tian S, Zhu Y, Zhu W, Wang S
Int Forum Allergy Rhinol 2020 Feb;10(2):243-255. Epub 2019 Nov 22 doi: 10.1002/alr.22465. PMID: 31756058
Endoscopic Resection of Sinonasal Malignancy: A Systematic Review and Meta-analysis.
Rawal RB, Farzal Z, Federspiel JJ, Sreenath SB, Thorp BD, Zanation AM
Otolaryngol Head Neck Surg 2016 Sep;155(3):376-86. Epub 2016 May 10 doi: 10.1177/0194599816646968. PMID: 27165676
Squamous cell carcinoma of the maxillary sinus: A population-based analysis.
Dubal PM, Bhojwani A, Patel TD, Zuckerman O, Baredes S, Liu JK, Eloy JA
Laryngoscope 2016 Feb;126(2):399-404. Epub 2015 Sep 22 doi: 10.1002/lary.25601. PMID: 26393540
Metastatic squamous cell carcinoma resembling cellulitis and osteomyelitis of the fifth toe.
Kaplansky DB, Kademian ME, VanCourt RB
J Foot Ankle Surg 2006 May-Jun;45(3):182-4. doi: 10.1053/j.jfas.2006.02.005. PMID: 16651199

Clinical prediction guides

Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma.
Contrera KJ, Ferrarotto R, Gunn B, Su SY, Kies MS, Glisson BS, Garden AS, Roberts D, Habna C, Hoff CO, El-Naggar A, Williams MD, Raza SM, DeMonte F, Chen MM, Chambers MS, Hanna EY
Clin Cancer Res 2025 Jan 17;31(2):258-265. doi: 10.1158/1078-0432.CCR-24-1416. PMID: 39531535
Double trouble: Synchronous and metachronous primaries confound ctHPVDNA monitoring.
Naegele S, Efthymiou V, Hirayama S, Zhao BY, Das D, Chan AW, Richmon JD, Iafrate AJ, Faden DL
Head Neck 2023 Jun;45(6):E25-E30. Epub 2023 Apr 20 doi: 10.1002/hed.27378. PMID: 37080924Free PMC Article
Sinonasal Squamous Cell Carcinoma Survival Outcomes Following Induction Chemotherapy vs Standard of Care Therapy.
Murr AT, Lenze NR, Weiss JM, Grilley-Olson JE, Patel SA, Shen C, Chera BS, Zanation AM, Thorp BD, Sheth SH
Otolaryngol Head Neck Surg 2022 Nov;167(5):846-851. Epub 2022 Mar 8 doi: 10.1177/01945998221083097. PMID: 35259033Free PMC Article
Prognostic Factors of Sinonasal Squamous Cell Carcinomas Arising De Novo and From Inverted Papilloma.
Li Y, Wang C, Wang R, Zhang J, Liu H, Shi Q, Chen X, Hou L, Ma H, Zhong Q, Li P, Feng L, He S, Zhang L, Fang J
Am J Rhinol Allergy 2021 Jan;35(1):114-121. Epub 2020 Jul 12 doi: 10.1177/1945892420939422. PMID: 32659112
Orbital Exenteration to Manage Infiltrative Sinonasal, Orbital Adnexal, and Cutaneous Malignancies Provides Acceptable Survival Outcomes: An Institutional Review, Literature Review, and Meta-Analysis.
Hoffman GR, Jefferson ND, Reid CB, Eisenberg RL
J Oral Maxillofac Surg 2016 Mar;74(3):631-43. Epub 2015 Sep 28 doi: 10.1016/j.joms.2015.09.019. PMID: 26475973

Recent systematic reviews

What is the rate of occult nodal metastasis in squamous cell carcinomas of the sinonasal tract? A systematic review.
Poutoglidis A, Georgalas C, Fyrmpas G, Karamitsou P
Eur Arch Otorhinolaryngol 2024 Jul;281(7):3325-3331. Epub 2024 Feb 17 doi: 10.1007/s00405-024-08481-8. PMID: 38367074
Survival Outcomes of De Novo vs Inverted Papilloma-Associated Sinonasal Squamous Cell Carcinoma: A Systematic Review and Meta-analysis.
Lee JJ, Peterson AM, Embry TW, Wamkpah NS, Kallogjeri D, Doering MM, Schneider JS, Klatt-Cromwell CN, Pipkorn P
JAMA Otolaryngol Head Neck Surg 2021 Apr 1;147(4):350-359. doi: 10.1001/jamaoto.2020.5261. PMID: 33507208Free PMC Article
Endoscopic Resection of Sinonasal Malignancy: A Systematic Review and Meta-analysis.
Rawal RB, Farzal Z, Federspiel JJ, Sreenath SB, Thorp BD, Zanation AM
Otolaryngol Head Neck Surg 2016 Sep;155(3):376-86. Epub 2016 May 10 doi: 10.1177/0194599816646968. PMID: 27165676

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