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Cutaneous Epithelioid Angiomatous Nodule

MedGen UID:
1701525
•Concept ID:
C5230993
•
Neoplastic Process
Synonyms: Cutaneous epithelioid angiomatoid nodule; Cutaneous epithelioid angiomatous nodule
SNOMED CT: Cutaneous epithelioid angiomatous nodule (817950008); Cutaneous epithelioid angiomatoid nodule (817950008)

Definition

A distinctive benign cutaneous vascular proliferation with prominent epithelioid morphology. It appears to be reactive. (WHO 2018) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous Epithelioid Angiomatous Nodule

Recent clinical studies

Etiology

Categorization of cutaneous epithelioid angiomatous nodule as epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia: Clinicopathologic, immunohistochemical, and molecular analyses of seven lesions.
Goto K, Ogawa K, Fukai T, Miura K, Yanagihara S, Honma K, Motoi T
J Cutan Pathol 2022 Sep;49(9):765-771. Epub 2022 May 10 doi: 10.1111/cup.14246. PMID: 35490255
Cutaneous epithelioid angiomatous nodule: a report of a series including a case with moderate cytologic atypia and immunosuppression.
Chetty R, Kamil ZS, Wang A, Al Habeeb A, Ghazarian D
Diagn Pathol 2018 Aug 13;13(1):50. doi: 10.1186/s13000-018-0729-5. PMID: 30103782Free PMC Article
Cutaneous epithelioid angiomatous nodule: different views or interpretations in the analysis of ten new cases.
Al-Daraji WI, Prescott RJ, Abdellaoui A, Khan MM, Kulkarni K, Youssef MM, Zelger BG, Zelger B
Dermatol Online J 2009 Mar 15;15(3):2. PMID: 19379646
Cutaneous epithelioid angiomatous nodule: a case series and proposed classification.
Sangüeza OP, Walsh SN, Sheehan DJ, Orland AF, Llombart B, Requena L
Am J Dermatopathol 2008 Feb;30(1):16-20. doi: 10.1097/DAD.0b013e31815f2b07. PMID: 18212538
Cutaneous epithelioid angiomatous nodule: a distinct lesion in the morphologic spectrum of epithelioid vascular tumors.
Brenn T, Fletcher CD
Am J Dermatopathol 2004 Feb;26(1):14-21. doi: 10.1097/00000372-200402000-00003. PMID: 14726818

Diagnosis

Categorization of cutaneous epithelioid angiomatous nodule as epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia: Clinicopathologic, immunohistochemical, and molecular analyses of seven lesions.
Goto K, Ogawa K, Fukai T, Miura K, Yanagihara S, Honma K, Motoi T
J Cutan Pathol 2022 Sep;49(9):765-771. Epub 2022 May 10 doi: 10.1111/cup.14246. PMID: 35490255
Diagnostically Challenging Epithelioid Vascular Tumors.
Ko JS, Billings SD
Surg Pathol Clin 2015 Sep;8(3):331-51. doi: 10.1016/j.path.2015.05.001. PMID: 26297060
Cutaneous epithelioid angiomatous nodule: a case with metachronous lesions.
Pavlidakey PG, Burroughs C, Karrs T, Somach SC
Am J Dermatopathol 2011 Dec;33(8):831-4. doi: 10.1097/DAD.0b013e3181fef12c. PMID: 21931284
Cutaneous vascular tumours: an update.
Goh SG, Calonje E
Histopathology 2008 May;52(6):661-73. Epub 2008 Feb 6 doi: 10.1111/j.1365-2559.2007.02924.x. PMID: 18266723
Cutaneous epithelioid angiomatous nodule: a case series and proposed classification.
Sangüeza OP, Walsh SN, Sheehan DJ, Orland AF, Llombart B, Requena L
Am J Dermatopathol 2008 Feb;30(1):16-20. doi: 10.1097/DAD.0b013e31815f2b07. PMID: 18212538

Therapy

Diagnostically Challenging Multifocal Penile Epithelioid Hemangioma Successfully Treated With Doxorubicin Hydrochloride.
Fawzi MM, El Anany G, Abdelraouf MM, Elbendary A
Am J Dermatopathol 2024 Apr 1;46(4):228-231. Epub 2024 Mar 8 doi: 10.1097/DAD.0000000000002642. PMID: 38457672
Cutaneous epithelioid angiomatous nodule: a report of a series including a case with moderate cytologic atypia and immunosuppression.
Chetty R, Kamil ZS, Wang A, Al Habeeb A, Ghazarian D
Diagn Pathol 2018 Aug 13;13(1):50. doi: 10.1186/s13000-018-0729-5. PMID: 30103782Free PMC Article

Prognosis

Cutaneous epithelioid angiomatous nodule: a report of a series including a case with moderate cytologic atypia and immunosuppression.
Chetty R, Kamil ZS, Wang A, Al Habeeb A, Ghazarian D
Diagn Pathol 2018 Aug 13;13(1):50. doi: 10.1186/s13000-018-0729-5. PMID: 30103782Free PMC Article
Cutaneous epithelioid angiomatous nodule: a case with metachronous lesions.
Pavlidakey PG, Burroughs C, Karrs T, Somach SC
Am J Dermatopathol 2011 Dec;33(8):831-4. doi: 10.1097/DAD.0b013e3181fef12c. PMID: 21931284
Cutaneous epithelioid angiomatous nodule: different views or interpretations in the analysis of ten new cases.
Al-Daraji WI, Prescott RJ, Abdellaoui A, Khan MM, Kulkarni K, Youssef MM, Zelger BG, Zelger B
Dermatol Online J 2009 Mar 15;15(3):2. PMID: 19379646
Cutaneous epithelioid angiomatous nodule: a case series and proposed classification.
Sangüeza OP, Walsh SN, Sheehan DJ, Orland AF, Llombart B, Requena L
Am J Dermatopathol 2008 Feb;30(1):16-20. doi: 10.1097/DAD.0b013e31815f2b07. PMID: 18212538

Clinical prediction guides

Categorization of cutaneous epithelioid angiomatous nodule as epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia: Clinicopathologic, immunohistochemical, and molecular analyses of seven lesions.
Goto K, Ogawa K, Fukai T, Miura K, Yanagihara S, Honma K, Motoi T
J Cutan Pathol 2022 Sep;49(9):765-771. Epub 2022 May 10 doi: 10.1111/cup.14246. PMID: 35490255
Cutaneous epithelioid angiomatous nodule: a report of a series including a case with moderate cytologic atypia and immunosuppression.
Chetty R, Kamil ZS, Wang A, Al Habeeb A, Ghazarian D
Diagn Pathol 2018 Aug 13;13(1):50. doi: 10.1186/s13000-018-0729-5. PMID: 30103782Free PMC Article
Cutaneous epithelioid angiomatous nodule: a case with metachronous lesions.
Pavlidakey PG, Burroughs C, Karrs T, Somach SC
Am J Dermatopathol 2011 Dec;33(8):831-4. doi: 10.1097/DAD.0b013e3181fef12c. PMID: 21931284
Cutaneous epithelioid angiomatous nodule: a distinct lesion in the morphologic spectrum of epithelioid vascular tumors.
Brenn T, Fletcher CD
Am J Dermatopathol 2004 Feb;26(1):14-21. doi: 10.1097/00000372-200402000-00003. PMID: 14726818

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