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Decreased HDL2b concentration

MedGen UID:
1702457
•Concept ID:
C5139335
•
Finding
HPO: HP:0032423

Definition

A reduction below the normal concentration of the HDL2b subfraction in the blood circulation. An HDL2b particle is defined as an HDL particle with a size of 9.7-12 nm. [from HPO]

Professional guidelines

PubMed

Plasma high density lipoprotein particle size alteration by simvastatin treatment in patients with hypercholesterolaemia.
Johansson J, Mölgaard J, Olsson AG
Atherosclerosis 1991 Dec;91(3):175-84. doi: 10.1016/0021-9150(91)90165-y. PMID: 1789802
The effects of nicotinic acid treatment on high density lipoprotein particle size subclass levels in hyperlipidaemic subjects.
Johansson J, Carlson LA
Atherosclerosis 1990 Aug;83(2-3):207-16. doi: 10.1016/0021-9150(90)90166-g. PMID: 2242098

Recent clinical studies

Etiology

Influence of CETP on High-Density Lipoprotein Subclasses in Patients with Coronary Heart Disease.
Ding L, Jiang W, Chen Z, Zhang C, Tian Y, Long S
Clin Lab 2020 Nov 1;66(11) doi: 10.7754/Clin.Lab.2020.200241. PMID: 33180445
The impact of plasma triglyceride and apolipoproteins concentrations on high-density lipoprotein subclasses distribution.
Tian L, Xu Y, Fu M, Peng T, Liu Y, Long S
Lipids Health Dis 2011 Jan 21;10:17. doi: 10.1186/1476-511X-10-17. PMID: 21251287Free PMC Article
A case-control study on the relationship between HDL2b and non-alcoholic fatty liver disease in Chinese type 2 diabetic patients.
Ma YH, Zhao L, Xian XD, Yang D, Huang W, Wang YH, Mueller O, Chang E, Konigshofer Y, Van-Cleve M, Liu G, Yang JK
Clin Chem Lab Med 2009;47(9):1067-72. doi: 10.1515/CCLM.2009.257. PMID: 19728847
Decreased high-density lipoprotein (HDL) particle size, prebeta-, and large HDL subspecies concentration in Finnish low-HDL families: relationship with intima-media thickness.
Watanabe H, Söderlund S, Soro-Paavonen A, Hiukka A, Leinonen E, Alagona C, Salonen R, Tuomainen TP, Ehnholm C, Jauhiainen M, Taskinen MR
Arterioscler Thromb Vasc Biol 2006 Apr;26(4):897-902. Epub 2006 Feb 9 doi: 10.1161/01.ATV.0000209577.04246.c0. PMID: 16469947
Effects of weight-loss by exercise and by diet on apolipoproteins A-I and A-II and the particle-size distribution of high-density lipoproteins in men.
Williams PT, Krauss RM, Vranizan KM, Albers JJ, Wood PD
Metabolism 1992 Apr;41(4):441-9. doi: 10.1016/0026-0495(92)90082-l. PMID: 1556953Free PMC Article

Diagnosis

Influence of CETP on High-Density Lipoprotein Subclasses in Patients with Coronary Heart Disease.
Ding L, Jiang W, Chen Z, Zhang C, Tian Y, Long S
Clin Lab 2020 Nov 1;66(11) doi: 10.7754/Clin.Lab.2020.200241. PMID: 33180445
The Correlation between Blood HbA1c and HDL Subclasses in Patients with Metabolic Syndrome.
Xiao L, Tian Y, Wu J, Li N, Zhang C, Chen W, Long S
Clin Lab 2020 Sep 1;66(9) doi: 10.7754/Clin.Lab.2020.191247. PMID: 32902228
Low concentrations of phospholipids and plasma HDL cholesterol subclasses in asymptomatic subjects with high coronary calcium scores.
García-Sánchez C, Posadas-Romero C, Posadas-Sánchez R, Carreón-Torres E, Rodríguez-Pérez JM, Juárez-Rojas JG, Martínez-Sánchez C, Fragoso JM, González-Pacheco H, Vargas-Alarcón G, Pérez-Méndez Ó
Atherosclerosis 2015 Feb;238(2):250-5. Epub 2014 Dec 9 doi: 10.1016/j.atherosclerosis.2014.12.004. PMID: 25528434
The relationship between high density lipoprotein subclass profile and apolipoprotein concentrations.
Tian L, Fu M
J Endocrinol Invest 2011 Jun;34(6):461-72. doi: 10.1007/BF03346714. PMID: 21747218
A case-control study on the relationship between HDL2b and non-alcoholic fatty liver disease in Chinese type 2 diabetic patients.
Ma YH, Zhao L, Xian XD, Yang D, Huang W, Wang YH, Mueller O, Chang E, Konigshofer Y, Van-Cleve M, Liu G, Yang JK
Clin Chem Lab Med 2009;47(9):1067-72. doi: 10.1515/CCLM.2009.257. PMID: 19728847

Therapy

Consuming High-Fat and Low-Fat Ground Beef Depresses High-Density and Low-Density Lipoprotein Cholesterol Concentrations, and Reduces Small, Dense Low-Density Lipoprotein Particle Abundance.
Lytle JR, Price T, Crouse SF, Smith DR, Walzem RL, Smith SB
Nutrients 2023 Jan 10;15(2) doi: 10.3390/nu15020337. PMID: 36678207Free PMC Article
HDL subspecies in young adult twins: heritability and impact of overweight.
Pietiläinen KH, Söderlund S, Rissanen A, Nakanishi S, Jauhiainen M, Taskinen MR, Kaprio J
Obesity (Silver Spring) 2009 Jun;17(6):1208-14. Epub 2009 Feb 19 doi: 10.1038/oby.2008.675. PMID: 19584879
Low cholesteryl ester transfer protein (CETP) concentration but normal CETP activity in serum from patients with short-term hypothyroidism Lack of relationship to lipoprotein abnormalities.
Dedecjus M, Masson D, Gautier T, de Barros JP, Gambert P, Lewinski A, Adamczewski Z, Moulin P, Lagrost L
Clin Endocrinol (Oxf) 2003 May;58(5):581-8. doi: 10.1046/j.1365-2265.2003.01755.x. PMID: 12699439
Responses of HDL subclasses, Lp(A-I) and Lp(A-I:A-II) levels and lipolytic enzyme activities to continuous oral estrogen-progestin and transdermal estrogen with cyclic progestin regimens in postmenopausal women.
Tilly-Kiesi M, Kahri J, Pyörälä T, Puolakka J, Luotola H, Lappi M, Lahdenperä S, Taskinen MR
Atherosclerosis 1997 Mar 21;129(2):249-59. doi: 10.1016/s0021-9150(96)06036-4. PMID: 9105568
Effects of weight-loss by exercise and by diet on apolipoproteins A-I and A-II and the particle-size distribution of high-density lipoproteins in men.
Williams PT, Krauss RM, Vranizan KM, Albers JJ, Wood PD
Metabolism 1992 Apr;41(4):441-9. doi: 10.1016/0026-0495(92)90082-l. PMID: 1556953Free PMC Article

Prognosis

Low concentrations of phospholipids and plasma HDL cholesterol subclasses in asymptomatic subjects with high coronary calcium scores.
García-Sánchez C, Posadas-Romero C, Posadas-Sánchez R, Carreón-Torres E, Rodríguez-Pérez JM, Juárez-Rojas JG, Martínez-Sánchez C, Fragoso JM, González-Pacheco H, Vargas-Alarcón G, Pérez-Méndez Ó
Atherosclerosis 2015 Feb;238(2):250-5. Epub 2014 Dec 9 doi: 10.1016/j.atherosclerosis.2014.12.004. PMID: 25528434
High serum cholesteryl ester transfer rates and small high-density lipoproteins are associated with young age in patients with acute myocardial infarction.
Zeller M, Masson D, Farnier M, Lorgis L, Deckert V, Pais de Barros JP, Desrumaux C, Sicard P, Grober J, Blache D, Gambert P, Rochette L, Cottin Y, Lagrost L
J Am Coll Cardiol 2007 Nov 13;50(20):1948-55. Epub 2007 Oct 29 doi: 10.1016/j.jacc.2007.06.052. PMID: 17996559
Relations between particle size of HDL and LDL lipoproteins and cholesterol esterification rate.
Dobiásová M, Urbanová Z, Samánek M
Physiol Res 2005;54(2):159-65. PMID: 15544423
Alterations in the concentration of an apolipoprotein E-containing subfraction of plasma high density lipoprotein in coronary heart disease.
Wilson HM, Patel JC, Russell D, Skinner ER
Clin Chim Acta 1993 Nov 15;220(2):175-87. doi: 10.1016/0009-8981(93)90046-7. PMID: 8111962

Clinical prediction guides

Low concentrations of phospholipids and plasma HDL cholesterol subclasses in asymptomatic subjects with high coronary calcium scores.
García-Sánchez C, Posadas-Romero C, Posadas-Sánchez R, Carreón-Torres E, Rodríguez-Pérez JM, Juárez-Rojas JG, Martínez-Sánchez C, Fragoso JM, González-Pacheco H, Vargas-Alarcón G, Pérez-Méndez Ó
Atherosclerosis 2015 Feb;238(2):250-5. Epub 2014 Dec 9 doi: 10.1016/j.atherosclerosis.2014.12.004. PMID: 25528434
The relationship between high density lipoprotein subclass profile and apolipoprotein concentrations.
Tian L, Fu M
J Endocrinol Invest 2011 Jun;34(6):461-72. doi: 10.1007/BF03346714. PMID: 21747218
High serum cholesteryl ester transfer rates and small high-density lipoproteins are associated with young age in patients with acute myocardial infarction.
Zeller M, Masson D, Farnier M, Lorgis L, Deckert V, Pais de Barros JP, Desrumaux C, Sicard P, Grober J, Blache D, Gambert P, Rochette L, Cottin Y, Lagrost L
J Am Coll Cardiol 2007 Nov 13;50(20):1948-55. Epub 2007 Oct 29 doi: 10.1016/j.jacc.2007.06.052. PMID: 17996559
Alterations of high density lipoprotein subclasses in obese subjects.
Tian L, Jia L, Mingde F, Tian Y, Xu Y, Tian H, Yang Y
Lipids 2006 Aug;41(8):789-96. doi: 10.1007/s11745-006-5032-7. PMID: 17120933
Low cholesteryl ester transfer protein (CETP) concentration but normal CETP activity in serum from patients with short-term hypothyroidism Lack of relationship to lipoprotein abnormalities.
Dedecjus M, Masson D, Gautier T, de Barros JP, Gambert P, Lewinski A, Adamczewski Z, Moulin P, Lagrost L
Clin Endocrinol (Oxf) 2003 May;58(5):581-8. doi: 10.1046/j.1365-2265.2003.01755.x. PMID: 12699439

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