U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Prostate Adenocarcinoma with Paneth Cell-Like Neuroendocrine Differentiation

MedGen UID:
1705089
•Concept ID:
C5203866
•
Neoplastic Process

Definition

A prostate adenocarcinoma characterized by the presence of cells with eosinophilic cytoplasmic granules that are positive for neuroendocrine markers by immunohistochemistry. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProstate Adenocarcinoma with Paneth Cell-Like Neuroendocrine Differentiation

Professional guidelines

PubMed

Reporting Trends, Practices, and Resource Utilization in Neuroendocrine Tumors of the Prostate Gland: A Survey among Thirty-Nine Genitourinary Pathologists.
Mohanty SK, Lobo A, Williamson SR, Shah RB, Trpkov K, Varma M, Sirohi D, Aron M, Kandukari SR, Balzer BL, Luthringer DL, Ro J, Osunkoya AO, Desai S, Menon S, Nigam LK, Sardana R, Roy P, Kaushal S, Midha D, Swain M, Ambekar A, Mitra S, Rao V, Soni S, Jain K, Diwaker P, Pattnaik N, Sharma S, Chakrabarti I, Sable M, Jain E, Jain D, Samra S, Vankalakunti M, Mohanty S, Parwani AV, Sancheti S, Kumari N, Jha S, Dixit M, Malik V, Arora S, Munjal G, Gopalan A, Magi-Galluzzi C, Dhillon J
Int J Surg Pathol 2023 Sep;31(6):993-1005. Epub 2022 Aug 9 doi: 10.1177/10668969221116629. PMID: 35946087

Recent clinical studies

Etiology

Neuroendocrine differentiation in usual-type prostatic adenocarcinoma: Molecular characterization and clinical significance.
Kaur H, Samarska I, Lu J, Faisal F, Maughan BL, Murali S, Asrani K, Alshalalfa M, Antonarakis ES, Epstein JI, Joshu CE, Schaeffer EM, Mosquera JM, Lotan TL
Prostate 2020 Sep;80(12):1012-1023. Epub 2020 Jul 10 doi: 10.1002/pros.24035. PMID: 32649013Free PMC Article
Significance of Paneth cell-like differentiation in prostatic adenocarcinoma: a retrospective cohort study of 80 cases.
Salles DC, Mata DA, Epstein JI
Hum Pathol 2020 Aug;102:7-12. Epub 2020 May 20 doi: 10.1016/j.humpath.2020.05.003. PMID: 32445653
Prostate cancer with Paneth cell-like neuroendocrine differentiation has recognizable histomorphology and harbors AURKA gene amplification.
Park K, Chen Z, MacDonald TY, Siddiqui J, Ye H, Erbersdobler A, Shevchuk MM, Robinson BD, Sanda MG, Chinnaiyan AM, Beltran H, Rubin MA, Mosquera JM
Hum Pathol 2014 Oct;45(10):2136-43. Epub 2014 Jun 26 doi: 10.1016/j.humpath.2014.06.008. PMID: 25128228Free PMC Article
Prognostic significance of paneth cell-like neuroendocrine differentiation in adenocarcinoma of the prostate.
Tamas EF, Epstein JI
Am J Surg Pathol 2006 Aug;30(8):980-5. doi: 10.1097/00000478-200608000-00008. PMID: 16861969
Paneth cell-like change in prostatic adenocarcinoma represents neuroendocrine differentiation: report of 30 cases.
Adlakha H, Bostwick DG
Hum Pathol 1994 Feb;25(2):135-9. doi: 10.1016/0046-8177(94)90268-2. PMID: 7509774

Diagnosis

Reporting Trends, Practices, and Resource Utilization in Neuroendocrine Tumors of the Prostate Gland: A Survey among Thirty-Nine Genitourinary Pathologists.
Mohanty SK, Lobo A, Williamson SR, Shah RB, Trpkov K, Varma M, Sirohi D, Aron M, Kandukari SR, Balzer BL, Luthringer DL, Ro J, Osunkoya AO, Desai S, Menon S, Nigam LK, Sardana R, Roy P, Kaushal S, Midha D, Swain M, Ambekar A, Mitra S, Rao V, Soni S, Jain K, Diwaker P, Pattnaik N, Sharma S, Chakrabarti I, Sable M, Jain E, Jain D, Samra S, Vankalakunti M, Mohanty S, Parwani AV, Sancheti S, Kumari N, Jha S, Dixit M, Malik V, Arora S, Munjal G, Gopalan A, Magi-Galluzzi C, Dhillon J
Int J Surg Pathol 2023 Sep;31(6):993-1005. Epub 2022 Aug 9 doi: 10.1177/10668969221116629. PMID: 35946087
Primary Prostatic Carcinoma With De Novo Diffuse Neuroendocrine Differentiation.
Galea LA, Mow C, Fine SW, Manohar P
Int J Surg Pathol 2022 Apr;30(2):232-236. Epub 2021 Aug 2 doi: 10.1177/10668969211035844. PMID: 34338584Free PMC Article
Variant of prostatic adenocarcinoma with Paneth cell-like neuroendocrine differentiation readily misdiagnosed as Gleason pattern 5.
So JS, Gordetsky J, Epstein JI
Hum Pathol 2014 Dec;45(12):2388-93. Epub 2014 Aug 23 doi: 10.1016/j.humpath.2014.08.004. PMID: 25277321
Primary carcinoid tumors of the urinary bladder and prostatic urethra: a clinicopathologic study of 6 cases.
Chen YB, Epstein JI
Am J Surg Pathol 2011 Mar;35(3):442-6. doi: 10.1097/PAS.0b013e318208f96a. PMID: 21317716
Rare histological patterns of prostatic ductal adenocarcinoma.
Lee TK, Miller JS, Epstein JI
Pathology 2010 Jun;42(4):319-24. doi: 10.3109/00313021003767314. PMID: 20438402

Therapy

Primary Prostatic Carcinoma With De Novo Diffuse Neuroendocrine Differentiation.
Galea LA, Mow C, Fine SW, Manohar P
Int J Surg Pathol 2022 Apr;30(2):232-236. Epub 2021 Aug 2 doi: 10.1177/10668969211035844. PMID: 34338584Free PMC Article
Prognostic significance of paneth cell-like neuroendocrine differentiation in adenocarcinoma of the prostate.
Tamas EF, Epstein JI
Am J Surg Pathol 2006 Aug;30(8):980-5. doi: 10.1097/00000478-200608000-00008. PMID: 16861969

Prognosis

Neuroendocrine differentiation in usual-type prostatic adenocarcinoma: Molecular characterization and clinical significance.
Kaur H, Samarska I, Lu J, Faisal F, Maughan BL, Murali S, Asrani K, Alshalalfa M, Antonarakis ES, Epstein JI, Joshu CE, Schaeffer EM, Mosquera JM, Lotan TL
Prostate 2020 Sep;80(12):1012-1023. Epub 2020 Jul 10 doi: 10.1002/pros.24035. PMID: 32649013Free PMC Article
Significance of Paneth cell-like differentiation in prostatic adenocarcinoma: a retrospective cohort study of 80 cases.
Salles DC, Mata DA, Epstein JI
Hum Pathol 2020 Aug;102:7-12. Epub 2020 May 20 doi: 10.1016/j.humpath.2020.05.003. PMID: 32445653
Variant of prostatic adenocarcinoma with Paneth cell-like neuroendocrine differentiation readily misdiagnosed as Gleason pattern 5.
So JS, Gordetsky J, Epstein JI
Hum Pathol 2014 Dec;45(12):2388-93. Epub 2014 Aug 23 doi: 10.1016/j.humpath.2014.08.004. PMID: 25277321
Prostate cancer with Paneth cell-like neuroendocrine differentiation has recognizable histomorphology and harbors AURKA gene amplification.
Park K, Chen Z, MacDonald TY, Siddiqui J, Ye H, Erbersdobler A, Shevchuk MM, Robinson BD, Sanda MG, Chinnaiyan AM, Beltran H, Rubin MA, Mosquera JM
Hum Pathol 2014 Oct;45(10):2136-43. Epub 2014 Jun 26 doi: 10.1016/j.humpath.2014.06.008. PMID: 25128228Free PMC Article
Prognostic significance of paneth cell-like neuroendocrine differentiation in adenocarcinoma of the prostate.
Tamas EF, Epstein JI
Am J Surg Pathol 2006 Aug;30(8):980-5. doi: 10.1097/00000478-200608000-00008. PMID: 16861969

Clinical prediction guides

Reporting Trends, Practices, and Resource Utilization in Neuroendocrine Tumors of the Prostate Gland: A Survey among Thirty-Nine Genitourinary Pathologists.
Mohanty SK, Lobo A, Williamson SR, Shah RB, Trpkov K, Varma M, Sirohi D, Aron M, Kandukari SR, Balzer BL, Luthringer DL, Ro J, Osunkoya AO, Desai S, Menon S, Nigam LK, Sardana R, Roy P, Kaushal S, Midha D, Swain M, Ambekar A, Mitra S, Rao V, Soni S, Jain K, Diwaker P, Pattnaik N, Sharma S, Chakrabarti I, Sable M, Jain E, Jain D, Samra S, Vankalakunti M, Mohanty S, Parwani AV, Sancheti S, Kumari N, Jha S, Dixit M, Malik V, Arora S, Munjal G, Gopalan A, Magi-Galluzzi C, Dhillon J
Int J Surg Pathol 2023 Sep;31(6):993-1005. Epub 2022 Aug 9 doi: 10.1177/10668969221116629. PMID: 35946087
Neuroendocrine differentiation in usual-type prostatic adenocarcinoma: Molecular characterization and clinical significance.
Kaur H, Samarska I, Lu J, Faisal F, Maughan BL, Murali S, Asrani K, Alshalalfa M, Antonarakis ES, Epstein JI, Joshu CE, Schaeffer EM, Mosquera JM, Lotan TL
Prostate 2020 Sep;80(12):1012-1023. Epub 2020 Jul 10 doi: 10.1002/pros.24035. PMID: 32649013Free PMC Article
Variant of prostatic adenocarcinoma with Paneth cell-like neuroendocrine differentiation readily misdiagnosed as Gleason pattern 5.
So JS, Gordetsky J, Epstein JI
Hum Pathol 2014 Dec;45(12):2388-93. Epub 2014 Aug 23 doi: 10.1016/j.humpath.2014.08.004. PMID: 25277321
Prognostic significance of paneth cell-like neuroendocrine differentiation in adenocarcinoma of the prostate.
Tamas EF, Epstein JI
Am J Surg Pathol 2006 Aug;30(8):980-5. doi: 10.1097/00000478-200608000-00008. PMID: 16861969
Paneth cell-like change of the prostate gland. A histological, immunohistochemical, and electron microscopic study.
Weaver MG, Abdul-Karim FW, Srigley J, Bostwick DG, Ro JY, Ayala AG
Am J Surg Pathol 1992 Jan;16(1):62-8. doi: 10.1097/00000478-199201000-00009. PMID: 1370193

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...