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Increased CSF serine concentration

MedGen UID:
1705485
•Concept ID:
C5139612
•
Finding
Synonym: High serine levels in cerebrospinal fluid
 
HPO: HP:0500227

Definition

Abnormally increased levels of serine in cerebrospinal fluid. [from HPO]

Professional guidelines

PubMed

Blood D-serine levels correlate with aging and dopaminergic treatment in Parkinson's disease.
Imarisio A, Yahyavi I, Avenali M, Di Maio A, Buongarzone G, Galandra C, Picascia M, Filosa A, Gasparri C, Monti MC, Rondanelli M, Pacchetti C, Errico F, Valente EM, Usiello A
Neurobiol Dis 2024 Mar;192:106413. Epub 2024 Jan 20 doi: 10.1016/j.nbd.2024.106413. PMID: 38253208
Treatment of parkinsonism with L-threo-3,4-dihydroxyphenylserine: a pharmacokinetic study.
Suzuki T, Sakoda S, Ueji M, Kishimoto S, Hayashi A, Kondo T, Narabayashi H
Neurology 1984 Nov;34(11):1446-50. doi: 10.1212/wnl.34.11.1446. PMID: 6436731

Recent clinical studies

Etiology

GSK-3 Inhibitor Elraglusib Enhances Tumor-Infiltrating Immune Cell Activation in Tumor Biopsies and Synergizes with Anti-PD-L1 in a Murine Model of Colorectal Cancer.
Huntington KE, Louie AD, Srinivasan PR, Schorl C, Lu S, Silverberg D, Newhouse D, Wu Z, Zhou L, Borden BA, Giles FJ, Dooner M, Carneiro BA, El-Deiry WS
Int J Mol Sci 2023 Jun 29;24(13) doi: 10.3390/ijms241310870. PMID: 37446056Free PMC Article
Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers.
Wang S, Liu Z, Ye T, Mabrouk OS, Maltbie T, Aasly J, West AB
Acta Neuropathol Commun 2017 Nov 22;5(1):86. doi: 10.1186/s40478-017-0492-y. PMID: 29166931Free PMC Article
Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline.
Gourmaud S, Paquet C, Dumurgier J, Pace C, Bouras C, Gray F, Laplanche JL, Meurs EF, Mouton-Liger F, Hugon J
J Psychiatry Neurosci 2015 May;40(3):151-61. doi: 10.1503/jpn.140062. PMID: 25455349Free PMC Article
Immune system and glucose metabolism interaction in schizophrenia: a chicken-egg dilemma.
Steiner J, Bernstein HG, Schiltz K, Müller UJ, Westphal S, Drexhage HA, Bogerts B
Prog Neuropsychopharmacol Biol Psychiatry 2014 Jan 3;48:287-94. Epub 2012 Oct 17 doi: 10.1016/j.pnpbp.2012.09.016. PMID: 23085507
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker RA, Muller DN, Hafler DA
Nature 2013 Apr 25;496(7446):518-22. Epub 2013 Mar 6 doi: 10.1038/nature11868. PMID: 23467095Free PMC Article

Diagnosis

Differential effects on blood and cerebrospinal fluid immune protein markers and kynurenine pathway metabolites from aerobic physical exercise in healthy subjects.
Isung J, Granqvist M, Trepci A, Huang J, Schwieler L, Kierkegaard M, Erhardt S, Jokinen J, Piehl F
Sci Rep 2021 Jan 18;11(1):1669. doi: 10.1038/s41598-021-81306-4. PMID: 33462306Free PMC Article
Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers.
Wang S, Liu Z, Ye T, Mabrouk OS, Maltbie T, Aasly J, West AB
Acta Neuropathol Commun 2017 Nov 22;5(1):86. doi: 10.1186/s40478-017-0492-y. PMID: 29166931Free PMC Article
CSF d-serine concentrations are similar in Alzheimer's disease, other dementias, and elderly controls.
Biemans EA, Verhoeven-Duif NM, Gerrits J, Claassen JA, Kuiperij HB, Verbeek MM
Neurobiol Aging 2016 Jun;42:213-6. Epub 2016 Mar 23 doi: 10.1016/j.neurobiolaging.2016.03.017. PMID: 27143438
Immune system and glucose metabolism interaction in schizophrenia: a chicken-egg dilemma.
Steiner J, Bernstein HG, Schiltz K, Müller UJ, Westphal S, Drexhage HA, Bogerts B
Prog Neuropsychopharmacol Biol Psychiatry 2014 Jan 3;48:287-94. Epub 2012 Oct 17 doi: 10.1016/j.pnpbp.2012.09.016. PMID: 23085507
Cell-derived microparticles: a new challenge in neuroscience.
Doeuvre L, Plawinski L, Toti F, Anglés-Cano E
J Neurochem 2009 Jul;110(2):457-68. Epub 2009 May 13 doi: 10.1111/j.1471-4159.2009.06163.x. PMID: 19457085

Therapy

Blood D-serine levels correlate with aging and dopaminergic treatment in Parkinson's disease.
Imarisio A, Yahyavi I, Avenali M, Di Maio A, Buongarzone G, Galandra C, Picascia M, Filosa A, Gasparri C, Monti MC, Rondanelli M, Pacchetti C, Errico F, Valente EM, Usiello A
Neurobiol Dis 2024 Mar;192:106413. Epub 2024 Jan 20 doi: 10.1016/j.nbd.2024.106413. PMID: 38253208
GSK-3 Inhibitor Elraglusib Enhances Tumor-Infiltrating Immune Cell Activation in Tumor Biopsies and Synergizes with Anti-PD-L1 in a Murine Model of Colorectal Cancer.
Huntington KE, Louie AD, Srinivasan PR, Schorl C, Lu S, Silverberg D, Newhouse D, Wu Z, Zhou L, Borden BA, Giles FJ, Dooner M, Carneiro BA, El-Deiry WS
Int J Mol Sci 2023 Jun 29;24(13) doi: 10.3390/ijms241310870. PMID: 37446056Free PMC Article
Anesthesia and tau pathology.
Whittington RA, Bretteville A, Dickler MF, Planel E
Prog Neuropsychopharmacol Biol Psychiatry 2013 Dec 2;47:147-55. Epub 2013 Mar 25 doi: 10.1016/j.pnpbp.2013.03.004. PMID: 23535147Free PMC Article
Treatment of parkinsonism with L-threo-3,4-dihydroxyphenylserine: a pharmacokinetic study.
Suzuki T, Sakoda S, Ueji M, Kishimoto S, Hayashi A, Kondo T, Narabayashi H
Neurology 1984 Nov;34(11):1446-50. doi: 10.1212/wnl.34.11.1446. PMID: 6436731
Nonketotic hyperglycinemia: clinical, biochemical, and therapeutic considerations.
Langan TJ, Pueschel SM
Curr Probl Pediatr 1983 Jan;13(3):1-30. doi: 10.1016/0045-9380(83)90016-6. PMID: 6301756

Prognosis

Immune system and glucose metabolism interaction in schizophrenia: a chicken-egg dilemma.
Steiner J, Bernstein HG, Schiltz K, Müller UJ, Westphal S, Drexhage HA, Bogerts B
Prog Neuropsychopharmacol Biol Psychiatry 2014 Jan 3;48:287-94. Epub 2012 Oct 17 doi: 10.1016/j.pnpbp.2012.09.016. PMID: 23085507
Neuropeptide changes and neuroactive amino acids in CSF from humans and sheep with neuronal ceroid lipofuscinoses (NCLs, Batten disease).
Kay GW, Verbeek MM, Furlong JM, Willemsen MA, Palmer DN
Neurochem Int 2009 Dec;55(8):783-8. Epub 2009 Aug 5 doi: 10.1016/j.neuint.2009.07.012. PMID: 19664668Free PMC Article
Cell-derived microparticles: a new challenge in neuroscience.
Doeuvre L, Plawinski L, Toti F, Anglés-Cano E
J Neurochem 2009 Jul;110(2):457-68. Epub 2009 May 13 doi: 10.1111/j.1471-4159.2009.06163.x. PMID: 19457085
Increased concentrations of 14-3-3 epsilon, gamma and zeta isoforms in cerebrospinal fluid of AIDS patients with neuronal destruction.
Wakabayashi H, Yano M, Tachikawa N, Oka S, Maeda M, Kido H
Clin Chim Acta 2001 Oct;312(1-2):97-105. doi: 10.1016/s0009-8981(01)00595-2. PMID: 11580914
Thrombin and trypsin induce granulocyte-macrophage colony-stimulating factor and interleukin-6 gene expression in cultured normal human keratinocytes.
Wakita H, Furukawa F, Takigawa M
Proc Assoc Am Physicians 1997 Mar;109(2):190-207. PMID: 9069588

Clinical prediction guides

GSK-3 Inhibitor Elraglusib Enhances Tumor-Infiltrating Immune Cell Activation in Tumor Biopsies and Synergizes with Anti-PD-L1 in a Murine Model of Colorectal Cancer.
Huntington KE, Louie AD, Srinivasan PR, Schorl C, Lu S, Silverberg D, Newhouse D, Wu Z, Zhou L, Borden BA, Giles FJ, Dooner M, Carneiro BA, El-Deiry WS
Int J Mol Sci 2023 Jun 29;24(13) doi: 10.3390/ijms241310870. PMID: 37446056Free PMC Article
CSF d-serine concentrations are similar in Alzheimer's disease, other dementias, and elderly controls.
Biemans EA, Verhoeven-Duif NM, Gerrits J, Claassen JA, Kuiperij HB, Verbeek MM
Neurobiol Aging 2016 Jun;42:213-6. Epub 2016 Mar 23 doi: 10.1016/j.neurobiolaging.2016.03.017. PMID: 27143438
5-HT(1A) receptor antagonist improves behavior performance of delirium rats through inhibiting PI3K/Akt/mTOR activation-induced NLRP3 activity.
Qiu Y, Huang X, Huang L, Tang L, Jiang J, Chen L, Li S
IUBMB Life 2016 Apr;68(4):311-9. Epub 2016 Mar 7 doi: 10.1002/iub.1491. PMID: 26946964
Cell-derived microparticles: a new challenge in neuroscience.
Doeuvre L, Plawinski L, Toti F, Anglés-Cano E
J Neurochem 2009 Jul;110(2):457-68. Epub 2009 May 13 doi: 10.1111/j.1471-4159.2009.06163.x. PMID: 19457085
Rapamycin inhibits GM-CSF-induced neutrophil migration.
Gomez-Cambronero J
FEBS Lett 2003 Aug 28;550(1-3):94-100. doi: 10.1016/s0014-5793(03)00828-7. PMID: 12935893Free PMC Article

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