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Accelerated tumor formation

MedGen UID:
1706725
•Concept ID:
C5232788
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAccelerated tumor formation

Professional guidelines

PubMed

Precision treatment in advanced hepatocellular carcinoma.
Yang X, Yang C, Zhang S, Geng H, Zhu AX, Bernards R, Qin W, Fan J, Wang C, Gao Q
Cancer Cell 2024 Feb 12;42(2):180-197. doi: 10.1016/j.ccell.2024.01.007. PMID: 38350421
Clinical consensus guideline on the management of phaeochromocytoma and paraganglioma in patients harbouring germline SDHD pathogenic variants.
Taïeb D, Wanna GB, Ahmad M, Lussey-Lepoutre C, Perrier ND, Nölting S, Amar L, Timmers HJLM, Schwam ZG, Estrera AL, Lim M, Pollom EL, Vitzthum L, Bourdeau I, Casey RT, Castinetti F, Clifton-Bligh R, Corssmit EPM, de Krijger RR, Del Rivero J, Eisenhofer G, Ghayee HK, Gimenez-Roqueplo AP, Grossman A, Imperiale A, Jansen JC, Jha A, Kerstens MN, Kunst HPM, Liu JK, Maher ER, Marchioni D, Mercado-Asis LB, Mete O, Naruse M, Nilubol N, Pandit-Taskar N, Sebag F, Tanabe A, Widimsky J, Meuter L, Lenders JWM, Pacak K
Lancet Diabetes Endocrinol 2023 May;11(5):345-361. Epub 2023 Mar 31 doi: 10.1016/S2213-8587(23)00038-4. PMID: 37011647Free PMC Article
Review of precision cancer medicine: Evolution of the treatment paradigm.
Tsimberidou AM, Fountzilas E, Nikanjam M, Kurzrock R
Cancer Treat Rev 2020 Jun;86:102019. Epub 2020 Mar 31 doi: 10.1016/j.ctrv.2020.102019. PMID: 32251926Free PMC Article

Recent clinical studies

Etiology

Association between MDM2 SNP309 and endometrial cancer risk: A PRISMA-compliant meta-analysis.
Zou X, Zhang Y, Zhang L, Li J, Zhu C, Cheng Q, Zhou J, Chen Y
Medicine (Baltimore) 2018 Dec;97(49):e13273. doi: 10.1097/MD.0000000000013273. PMID: 30544386Free PMC Article
Omega-3 Fatty Acids Prevent Early Pancreatic Carcinogenesis via Repression of the AKT Pathway.
Ding Y, Mullapudi B, Torres C, Mascariñas E, Mancinelli G, Diaz AM, McKinney R, Barron M, Schultz M, Heiferman M, Wojtanek M, Adrian K, DeCant B, Rao S, Ouellette M, Tsao MS, Bentrem DJ, Grippo PJ
Nutrients 2018 Sep 12;10(9) doi: 10.3390/nu10091289. PMID: 30213082Free PMC Article
Obesity-associated Breast Cancer: Analysis of risk factors.
Engin A
Adv Exp Med Biol 2017;960:571-606. doi: 10.1007/978-3-319-48382-5_25. PMID: 28585217
Neutrophils drive accelerated tumor progression in the collagen-dense mammary tumor microenvironment.
García-Mendoza MG, Inman DR, Ponik SM, Jeffery JJ, Sheerar DS, Van Doorn RR, Keely PJ
Breast Cancer Res 2016 May 11;18(1):49. doi: 10.1186/s13058-016-0703-7. PMID: 27169366Free PMC Article
The obesity-cancer link: lessons learned from a fatless mouse.
Hursting SD, Nunez NP, Varticovski L, Vinson C
Cancer Res 2007 Mar 15;67(6):2391-3. doi: 10.1158/0008-5472.CAN-06-4237. PMID: 17363554

Diagnosis

Reduced sister chromatid cohesion acts as a tumor penetrance modifier.
Wang J, Thomas HR, Chen Y, Percival SM, Waldrep SC, Ramaker RC, Thompson RG, Cooper SJ, Chong Z, Parant JM
PLoS Genet 2022 Aug;18(8):e1010341. Epub 2022 Aug 22 doi: 10.1371/journal.pgen.1010341. PMID: 35994499Free PMC Article
Modeling SHH-driven medulloblastoma with patient iPS cell-derived neural stem cells.
Susanto E, Marin Navarro A, Zhou L, Sundström A, van Bree N, Stantic M, Moslem M, Tailor J, Rietdijk J, Zubillaga V, Hübner JM, Weishaupt H, Wolfsberger J, Alafuzoff I, Nordgren A, Magnaldo T, Siesjö P, Johnsen JI, Kool M, Tammimies K, Darabi A, Swartling FJ, Falk A, Wilhelm M
Proc Natl Acad Sci U S A 2020 Aug 18;117(33):20127-20138. Epub 2020 Aug 3 doi: 10.1073/pnas.1920521117. PMID: 32747535Free PMC Article
Association between MDM2 SNP309 and endometrial cancer risk: A PRISMA-compliant meta-analysis.
Zou X, Zhang Y, Zhang L, Li J, Zhu C, Cheng Q, Zhou J, Chen Y
Medicine (Baltimore) 2018 Dec;97(49):e13273. doi: 10.1097/MD.0000000000013273. PMID: 30544386Free PMC Article
Gankyrin promotes tumor growth and metastasis through activation of IL-6/STAT3 signaling in human cholangiocarcinoma.
Zheng T, Hong X, Wang J, Pei T, Liang Y, Yin D, Song R, Song X, Lu Z, Qi S, Liu J, Sun B, Xie C, Pan S, Li Y, Luo X, Li S, Fang X, Bhatta N, Jiang H, Liu L
Hepatology 2014 Mar;59(3):935-46. Epub 2014 Jan 29 doi: 10.1002/hep.26705. PMID: 24037855
DNA damage, somatic aneuploidy, and malignant sarcoma susceptibility in muscular dystrophies.
Schmidt WM, Uddin MH, Dysek S, Moser-Thier K, Pirker C, Höger H, Ambros IM, Ambros PF, Berger W, Bittner RE
PLoS Genet 2011 Apr;7(4):e1002042. Epub 2011 Apr 14 doi: 10.1371/journal.pgen.1002042. PMID: 21533183Free PMC Article

Therapy

Non-canonical Small GTPase RBJ Promotes NSCLC Progression Through the Canonical MEK/ERK Signaling Pathway.
Wang Y, Shen X, Wang Q, Guo Z, Hu L, Dong Z, Hu W
Curr Pharm Des 2022;28(42):3446-3455. doi: 10.2174/1381612829666221117124048. PMID: 36397632
Association between MDM2 SNP309 and endometrial cancer risk: A PRISMA-compliant meta-analysis.
Zou X, Zhang Y, Zhang L, Li J, Zhu C, Cheng Q, Zhou J, Chen Y
Medicine (Baltimore) 2018 Dec;97(49):e13273. doi: 10.1097/MD.0000000000013273. PMID: 30544386Free PMC Article
Omega-3 Fatty Acids Prevent Early Pancreatic Carcinogenesis via Repression of the AKT Pathway.
Ding Y, Mullapudi B, Torres C, Mascariñas E, Mancinelli G, Diaz AM, McKinney R, Barron M, Schultz M, Heiferman M, Wojtanek M, Adrian K, DeCant B, Rao S, Ouellette M, Tsao MS, Bentrem DJ, Grippo PJ
Nutrients 2018 Sep 12;10(9) doi: 10.3390/nu10091289. PMID: 30213082Free PMC Article
DNA damage, somatic aneuploidy, and malignant sarcoma susceptibility in muscular dystrophies.
Schmidt WM, Uddin MH, Dysek S, Moser-Thier K, Pirker C, Höger H, Ambros IM, Ambros PF, Berger W, Bittner RE
PLoS Genet 2011 Apr;7(4):e1002042. Epub 2011 Apr 14 doi: 10.1371/journal.pgen.1002042. PMID: 21533183Free PMC Article
Effect of an hdm-2 antagonist peptide inhibitor on cell cycle progression in p53-deficient H1299 human lung carcinoma cells.
VanderBorght A, Valckx A, Van Dun J, Grand-Perret T, De Schepper S, Vialard J, Janicot M, Arts J
Oncogene 2006 Oct 26;25(50):6672-7. Epub 2006 May 29 doi: 10.1038/sj.onc.1209667. PMID: 16732328

Prognosis

The DDX6/KIFC1 signaling axis, as regulated by YY1, contributes to the malignant behavior of pancreatic cancer.
Deng X, Liu Z, Wang B, Ma J, Meng X
FASEB J 2024 Apr 15;38(7):e23581. doi: 10.1096/fj.202400166R. PMID: 38551642
SMAD4 is critical in suppression of BRAF-V600E serrated tumorigenesis.
Tong K, Kothari OA, Haro KS, Panda A, Bandari MM, Carrick JN, Hur JJ, Zhang L, Chan CS, Xing J, Gatza ML, Ganesan S, Verzi MP
Oncogene 2021 Oct;40(41):6034-6048. Epub 2021 Aug 27 doi: 10.1038/s41388-021-01997-x. PMID: 34453124Free PMC Article
LINC01224 accelerates malignant transformation via MiR-193a-5p/CDK8 axis in gastric cancer.
Sun H, Yan J, Tian G, Chen X, Song W
Cancer Med 2021 Feb;10(4):1377-1393. doi: 10.1002/cam4.3726. PMID: 33655711Free PMC Article
Obesity-associated Breast Cancer: Analysis of risk factors.
Engin A
Adv Exp Med Biol 2017;960:571-606. doi: 10.1007/978-3-319-48382-5_25. PMID: 28585217
Gankyrin promotes tumor growth and metastasis through activation of IL-6/STAT3 signaling in human cholangiocarcinoma.
Zheng T, Hong X, Wang J, Pei T, Liang Y, Yin D, Song R, Song X, Lu Z, Qi S, Liu J, Sun B, Xie C, Pan S, Li Y, Luo X, Li S, Fang X, Bhatta N, Jiang H, Liu L
Hepatology 2014 Mar;59(3):935-46. Epub 2014 Jan 29 doi: 10.1002/hep.26705. PMID: 24037855

Clinical prediction guides

Non-canonical Small GTPase RBJ Promotes NSCLC Progression Through the Canonical MEK/ERK Signaling Pathway.
Wang Y, Shen X, Wang Q, Guo Z, Hu L, Dong Z, Hu W
Curr Pharm Des 2022;28(42):3446-3455. doi: 10.2174/1381612829666221117124048. PMID: 36397632
Reduced sister chromatid cohesion acts as a tumor penetrance modifier.
Wang J, Thomas HR, Chen Y, Percival SM, Waldrep SC, Ramaker RC, Thompson RG, Cooper SJ, Chong Z, Parant JM
PLoS Genet 2022 Aug;18(8):e1010341. Epub 2022 Aug 22 doi: 10.1371/journal.pgen.1010341. PMID: 35994499Free PMC Article
Obesity-associated Breast Cancer: Analysis of risk factors.
Engin A
Adv Exp Med Biol 2017;960:571-606. doi: 10.1007/978-3-319-48382-5_25. PMID: 28585217
Loss of TGFβ signaling promotes colon cancer progression and tumor-associated inflammation.
Principe DR, DeCant B, Staudacher J, Vitello D, Mangan RJ, Wayne EA, Mascariñas E, Diaz AM, Bauer J, McKinney RD, Khazaie K, Pasche B, Dawson DW, Munshi HG, Grippo PJ, Jung B
Oncotarget 2017 Jan 17;8(3):3826-3839. doi: 10.18632/oncotarget.9830. PMID: 27270652Free PMC Article
FBXW7 mutations in melanoma and a new therapeutic paradigm.
Aydin IT, Melamed RD, Adams SJ, Castillo-Martin M, Demir A, Bryk D, Brunner G, Cordon-Cardo C, Osman I, Rabadan R, Celebi JT
J Natl Cancer Inst 2014 Jun;106(6):dju107. Epub 2014 May 16 doi: 10.1093/jnci/dju107. PMID: 24838835Free PMC Article

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