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Refractory Colon Adenocarcinoma

MedGen UID:
1707710
Concept ID:
C5206375
Neoplastic Process

Definition

Colon adenocarcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Colon Adenocarcinoma

Professional guidelines

PubMed

Strickler JH, Yoshino T, Graham RP, Siena S, Bekaii-Saab T
JAMA Oncol 2022 May 1;8(5):760-769. doi: 10.1001/jamaoncol.2021.8196. PMID: 35238866
Riesco-Martinez MC, Sanchez-Torre A, Garcia-Carbonero R
Expert Opin Investig Drugs 2017 Nov;26(11):1295-1305. Epub 2017 Oct 6 doi: 10.1080/13543784.2017.1385762. PMID: 28965421
Liu ZX, Kiran RP, Bennett AE, Ni RZ, Shen B
Cancer 2011 Jul 15;117(14):3081-92. Epub 2011 Jan 24 doi: 10.1002/cncr.25886. PMID: 21264836

Recent clinical studies

Etiology

Dasari A, Lonardi S, Garcia-Carbonero R, Elez E, Yoshino T, Sobrero A, Yao J, García-Alfonso P, Kocsis J, Cubillo Gracian A, Sartore-Bianchi A, Satoh T, Randrian V, Tomasek J, Chong G, Paulson AS, Masuishi T, Jones J, Csőszi T, Cremolini C, Ghiringhelli F, Shergill A, Hochster HS, Krauss J, Bassam A, Ducreux M, Elme A, Faugeras L, Kasper S, Van Cutsem E, Arnold D, Nanda S, Yang Z, Schelman WR, Kania M, Tabernero J, Eng C; FRESCO-2 Study Investigators
Lancet 2023 Jul 1;402(10395):41-53. Epub 2023 Jun 15 doi: 10.1016/S0140-6736(23)00772-9. PMID: 37331369
Strickler JH, Cercek A, Siena S, André T, Ng K, Van Cutsem E, Wu C, Paulson AS, Hubbard JM, Coveler AL, Fountzilas C, Kardosh A, Kasi PM, Lenz HJ, Ciombor KK, Elez E, Bajor DL, Cremolini C, Sanchez F, Stecher M, Feng W, Bekaii-Saab TS; MOUNTAINEER investigators
Lancet Oncol 2023 May;24(5):496-508. doi: 10.1016/S1470-2045(23)00150-X. PMID: 37142372
Prager GW, Taieb J, Fakih M, Ciardiello F, Van Cutsem E, Elez E, Cruz FM, Wyrwicz L, Stroyakovskiy D, Pápai Z, Poureau PG, Liposits G, Cremolini C, Bondarenko I, Modest DP, Benhadji KA, Amellal N, Leger C, Vidot L, Tabernero J; SUNLIGHT Investigators
N Engl J Med 2023 May 4;388(18):1657-1667. doi: 10.1056/NEJMoa2214963. PMID: 37133585
Filipec Kanizaj T, Mijic M
World J Gastroenterol 2017 May 14;23(18):3214-3227. doi: 10.3748/wjg.v23.i18.3214. PMID: 28566881Free PMC Article
Scoglio D, Ahmed Ali U, Fichera A
World J Gastroenterol 2014 Oct 7;20(37):13211-8. doi: 10.3748/wjg.v20.i37.13211. PMID: 25309058Free PMC Article

Diagnosis

Taraborrelli L, Şenbabaoğlu Y, Wang L, Lim J, Blake K, Kljavin N, Gierke S, Scherl A, Ziai J, McNamara E, Owyong M, Rao S, Calviello AK, Oreper D, Jhunjhunwala S, Argiles G, Bendell J, Kim TW, Ciardiello F, Wongchenko MJ, de Sauvage FJ, de Sousa E Melo F, Yan Y, West NR, Murthy A
Nat Commun 2023 Sep 23;14(1):5945. doi: 10.1038/s41467-023-41618-7. PMID: 37741832Free PMC Article
Ohta Y, Fujii M, Takahashi S, Takano A, Nanki K, Matano M, Hanyu H, Saito M, Shimokawa M, Nishikori S, Hatano Y, Ishii R, Sawada K, Machinaga A, Ikeda W, Imamura T, Sato T
Nature 2022 Aug;608(7924):784-794. Epub 2022 Jul 7 doi: 10.1038/s41586-022-05043-y. PMID: 35798028
Strickler JH, Yoshino T, Graham RP, Siena S, Bekaii-Saab T
JAMA Oncol 2022 May 1;8(5):760-769. doi: 10.1001/jamaoncol.2021.8196. PMID: 35238866
Hallin J, Engstrom LD, Hargis L, Calinisan A, Aranda R, Briere DM, Sudhakar N, Bowcut V, Baer BR, Ballard JA, Burkard MR, Fell JB, Fischer JP, Vigers GP, Xue Y, Gatto S, Fernandez-Banet J, Pavlicek A, Velastagui K, Chao RC, Barton J, Pierobon M, Baldelli E, Patricoin EF 3rd, Cassidy DP, Marx MA, Rybkin II, Johnson ML, Ou SI, Lito P, Papadopoulos KP, Jänne PA, Olson P, Christensen JG
Cancer Discov 2020 Jan;10(1):54-71. Epub 2019 Oct 28 doi: 10.1158/2159-8290.CD-19-1167. PMID: 31658955Free PMC Article
Scoglio D, Ahmed Ali U, Fichera A
World J Gastroenterol 2014 Oct 7;20(37):13211-8. doi: 10.3748/wjg.v20.i37.13211. PMID: 25309058Free PMC Article

Therapy

André T, Pietrantonio F, Avallone A, Gumus M, Wyrwicz L, Kim JG, Yalcin S, Kwiatkowski M, Lonardi S, Zolnierek J, Odeleye-Ajakaye A, Leconte P, Fogelman D, Kim TW
Future Oncol 2023 Dec;19(37):2445-2452. Epub 2023 Sep 13 doi: 10.2217/fon-2022-1105. PMID: 37701986
Dasari A, Lonardi S, Garcia-Carbonero R, Elez E, Yoshino T, Sobrero A, Yao J, García-Alfonso P, Kocsis J, Cubillo Gracian A, Sartore-Bianchi A, Satoh T, Randrian V, Tomasek J, Chong G, Paulson AS, Masuishi T, Jones J, Csőszi T, Cremolini C, Ghiringhelli F, Shergill A, Hochster HS, Krauss J, Bassam A, Ducreux M, Elme A, Faugeras L, Kasper S, Van Cutsem E, Arnold D, Nanda S, Yang Z, Schelman WR, Kania M, Tabernero J, Eng C; FRESCO-2 Study Investigators
Lancet 2023 Jul 1;402(10395):41-53. Epub 2023 Jun 15 doi: 10.1016/S0140-6736(23)00772-9. PMID: 37331369
Prager GW, Taieb J, Fakih M, Ciardiello F, Van Cutsem E, Elez E, Cruz FM, Wyrwicz L, Stroyakovskiy D, Pápai Z, Poureau PG, Liposits G, Cremolini C, Bondarenko I, Modest DP, Benhadji KA, Amellal N, Leger C, Vidot L, Tabernero J; SUNLIGHT Investigators
N Engl J Med 2023 May 4;388(18):1657-1667. doi: 10.1056/NEJMoa2214963. PMID: 37133585
Hallin J, Engstrom LD, Hargis L, Calinisan A, Aranda R, Briere DM, Sudhakar N, Bowcut V, Baer BR, Ballard JA, Burkard MR, Fell JB, Fischer JP, Vigers GP, Xue Y, Gatto S, Fernandez-Banet J, Pavlicek A, Velastagui K, Chao RC, Barton J, Pierobon M, Baldelli E, Patricoin EF 3rd, Cassidy DP, Marx MA, Rybkin II, Johnson ML, Ou SI, Lito P, Papadopoulos KP, Jänne PA, Olson P, Christensen JG
Cancer Discov 2020 Jan;10(1):54-71. Epub 2019 Oct 28 doi: 10.1158/2159-8290.CD-19-1167. PMID: 31658955Free PMC Article
Stein A, Folprecht G
Oncol Res Treat 2018;41(5):282-285. Epub 2018 Apr 26 doi: 10.1159/000488918. PMID: 29705788

Prognosis

Tabernero J, Taieb J, Fakih M, Prager GW, Van Cutsem E, Ciardiello F, Mayer RJ, Amellal N, Skanji D, Calleja E, Yoshino T
ESMO Open 2024 Mar;9(3):102945. Epub 2024 Mar 11 doi: 10.1016/j.esmoop.2024.102945. PMID: 38471240Free PMC Article
Ciardiello D, Mauri G, Sartore-Bianchi A, Siena S, Zampino MG, Fazio N, Cervantes A
Cancer Treat Rev 2024 Mar;124:102683. Epub 2024 Jan 12 doi: 10.1016/j.ctrv.2024.102683. PMID: 38237253
Hallin J, Engstrom LD, Hargis L, Calinisan A, Aranda R, Briere DM, Sudhakar N, Bowcut V, Baer BR, Ballard JA, Burkard MR, Fell JB, Fischer JP, Vigers GP, Xue Y, Gatto S, Fernandez-Banet J, Pavlicek A, Velastagui K, Chao RC, Barton J, Pierobon M, Baldelli E, Patricoin EF 3rd, Cassidy DP, Marx MA, Rybkin II, Johnson ML, Ou SI, Lito P, Papadopoulos KP, Jänne PA, Olson P, Christensen JG
Cancer Discov 2020 Jan;10(1):54-71. Epub 2019 Oct 28 doi: 10.1158/2159-8290.CD-19-1167. PMID: 31658955Free PMC Article
Jun J, Lee SR, Lee JY, Choi MJ, Noh JY, Cheong HJ, Kim WJ, Song JY
Medicine (Baltimore) 2019 Jun;98(25):e16158. doi: 10.1097/MD.0000000000016158. PMID: 31232972Free PMC Article
Filipec Kanizaj T, Mijic M
World J Gastroenterol 2017 May 14;23(18):3214-3227. doi: 10.3748/wjg.v23.i18.3214. PMID: 28566881Free PMC Article

Clinical prediction guides

Tabernero J, Taieb J, Fakih M, Prager GW, Van Cutsem E, Ciardiello F, Mayer RJ, Amellal N, Skanji D, Calleja E, Yoshino T
ESMO Open 2024 Mar;9(3):102945. Epub 2024 Mar 11 doi: 10.1016/j.esmoop.2024.102945. PMID: 38471240Free PMC Article
André T, Pietrantonio F, Avallone A, Gumus M, Wyrwicz L, Kim JG, Yalcin S, Kwiatkowski M, Lonardi S, Zolnierek J, Odeleye-Ajakaye A, Leconte P, Fogelman D, Kim TW
Future Oncol 2023 Dec;19(37):2445-2452. Epub 2023 Sep 13 doi: 10.2217/fon-2022-1105. PMID: 37701986
Prager GW, Taieb J, Fakih M, Ciardiello F, Van Cutsem E, Elez E, Cruz FM, Wyrwicz L, Stroyakovskiy D, Pápai Z, Poureau PG, Liposits G, Cremolini C, Bondarenko I, Modest DP, Benhadji KA, Amellal N, Leger C, Vidot L, Tabernero J; SUNLIGHT Investigators
N Engl J Med 2023 May 4;388(18):1657-1667. doi: 10.1056/NEJMoa2214963. PMID: 37133585
Strickler JH, Yoshino T, Graham RP, Siena S, Bekaii-Saab T
JAMA Oncol 2022 May 1;8(5):760-769. doi: 10.1001/jamaoncol.2021.8196. PMID: 35238866
Hallin J, Engstrom LD, Hargis L, Calinisan A, Aranda R, Briere DM, Sudhakar N, Bowcut V, Baer BR, Ballard JA, Burkard MR, Fell JB, Fischer JP, Vigers GP, Xue Y, Gatto S, Fernandez-Banet J, Pavlicek A, Velastagui K, Chao RC, Barton J, Pierobon M, Baldelli E, Patricoin EF 3rd, Cassidy DP, Marx MA, Rybkin II, Johnson ML, Ou SI, Lito P, Papadopoulos KP, Jänne PA, Olson P, Christensen JG
Cancer Discov 2020 Jan;10(1):54-71. Epub 2019 Oct 28 doi: 10.1158/2159-8290.CD-19-1167. PMID: 31658955Free PMC Article

Recent systematic reviews

Ciardiello D, Mauri G, Sartore-Bianchi A, Siena S, Zampino MG, Fazio N, Cervantes A
Cancer Treat Rev 2024 Mar;124:102683. Epub 2024 Jan 12 doi: 10.1016/j.ctrv.2024.102683. PMID: 38237253
Stein A, Folprecht G
Oncol Res Treat 2018;41(5):282-285. Epub 2018 Apr 26 doi: 10.1159/000488918. PMID: 29705788
Selvaggi F, Pellino G, Canonico S, Sciaudone G
Inflamm Bowel Dis 2014 Jul;20(7):1296-308. doi: 10.1097/MIB.0000000000000026. PMID: 24681656

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