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Skin Myoepithelioma

MedGen UID:
1708368
•Concept ID:
C5238499
•
Neoplastic Process
Synonym: Cutaneous Myoepithelioma

Definition

A benign skin neoplasm composed exclusively of myoepithelial cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin Myoepithelioma

Professional guidelines

PubMed

Mesenchymal tumours with melanocytic expression: a potential pitfall in the differential diagnosis of malignant melanoma.
Saleh JS, Whittington CP, Bresler SC, Patel RM
Pathology 2023 Mar;55(2):258-268. Epub 2022 Dec 28 doi: 10.1016/j.pathol.2022.12.340. PMID: 36639332

Recent clinical studies

Etiology

SOX10-Internal Tandem Duplications and PLAG1 or HMGA2 Fusions Segregate Eccrine-Type and Apocrine-Type Cutaneous Mixed Tumors.
Macagno N, Kervarrec T, Thanguturi S, Sohier P, Pissaloux D, Mescam L, Jullie ML, Frouin E, Osio A, Faisant M, Le Loarer F, Cribier B, Calonje E, Luna EVE, Massi D, Goto K, Nishida H, Paindavoine S, Houlier A, Tantot J, Benzerdjeb N, Tirode F, De la Fouchardière A, Battistella M
Mod Pathol 2024 Mar;37(3):100430. Epub 2024 Jan 23 doi: 10.1016/j.modpat.2024.100430. PMID: 38266920
EWSR1-ATF1 Fusion in a Myoepithelial Carcinoma of Soft Tissue With Small Round Cell Morphology: A Potential Diagnostic Pitfall.
Leckey BD Jr, John I, Reyes-Múgica M, Naous R
Pediatr Dev Pathol 2021 May-Jun;24(3):258-263. Epub 2021 Mar 8 doi: 10.1177/1093526621998869. PMID: 33683984
Primary cutaneous myoepithelial carcinoma: a case report and review of the literature.
Frost MW, Steiniche T, Damsgaard TE, Stolle LB
APMIS 2014 May;122(5):369-79. Epub 2013 Aug 29 doi: 10.1111/apm.12156. PMID: 23992447
Primary myoepithelial carcinoma of palate.
Ren J, Liu Z, Liu X, Li Y, Zhang X, Li Z, Yang Y, Yang Y, Chen Y, Jiang S
World J Surg Oncol 2011 Sep 14;9:104. doi: 10.1186/1477-7819-9-104. PMID: 21917131Free PMC Article
Tumoral, quasitumoral and pseudotumoral lesions of the superficial and somatic soft tissue: new entities and new variants of old entities recorded during the last 25 years. Part IX: excerpta VII.
Bisceglia M, Fisher C, Suster S, Kazakov DV, Cooper K, Michal M
Pathologica 2005 Oct;97(5):343-60. PMID: 16480035

Diagnosis

PRAME immunohistochemistry in soft tissue tumors and mimics: a study of 350 cases highlighting its imperfect specificity but potentially useful diagnostic applications.
Cammareri C, Beltzung F, Michal M, Vanhersecke L, Coindre JM, Velasco V, Le Loarer F, Vergier B, Perret R
Virchows Arch 2023 Aug;483(2):145-156. Epub 2023 Jul 21 doi: 10.1007/s00428-023-03606-6. PMID: 37477762
Association between prognosis and complete resection in primary cutaneous myoepithelial carcinoma: two case presentations and literature review.
Mizuta H, Takahashi A, Namikawa K, Ogata D, Yamazaki N
Dermatol Ther 2020 Jul;33(4):e13485. Epub 2020 Jun 2 doi: 10.1111/dth.13485. PMID: 32369232
Cutaneous myoepithelial carcinoma with disseminated metastases.
Johnson GE, Stevens K, Morrison AO, Stuart L, Gardner JM, Rachal M, Parker DC
Cutis 2017 Jun;99(6):E19-E26. PMID: 28686765
Myoepithelial Tumors: An Update.
Jo VY
Surg Pathol Clin 2015 Sep;8(3):445-66. doi: 10.1016/j.path.2015.05.005. PMID: 26297065
Metastatic parachordoma.
Guedes A, Barreto BG, Barreto LG, de Oliveira Araújo IB, Queiroz AC, Athanazio DA, Athanazio PR
J Cutan Pathol 2009 Feb;36(2):270-3. doi: 10.1111/j.1600-0560.2008.01032.x. PMID: 19208078

Therapy

Association between skin flap thickness and Frey's syndrome in parotid surgery.
Durgut O, Basut O, Demir UL, Ozmen OA, Kasapoglu F, Coskun H
Head Neck 2013 Dec;35(12):1781-6. Epub 2013 Mar 8 doi: 10.1002/hed.23233. PMID: 23471856
Unusual myoid, perivascular, and postradiation lesions, with emphasis on atypical vascular lesion, postradiation cutaneous angiosarcoma, myoepithelial tumors, myopericytoma, and perivascular epithelioid cell tumor.
Fisher C
Semin Diagn Pathol 2013 Feb;30(1):73-84. doi: 10.1053/j.semdp.2012.01.006. PMID: 23327731
A subset of cutaneous and soft tissue mixed tumors are genetically linked to their salivary gland counterpart.
Bahrami A, Dalton JD, Krane JF, Fletcher CD
Genes Chromosomes Cancer 2012 Feb;51(2):140-8. Epub 2011 Oct 28 doi: 10.1002/gcc.20938. PMID: 22038920Free PMC Article
Malignant myoepithelioma of the breast.
Terada T
Pathol Int 2011 Feb;61(2):99-103. Epub 2010 Dec 13 doi: 10.1111/j.1440-1827.2010.02638.x. PMID: 21255187
Clear cell myoepithelial neoplasm of the breast.
Cartagena N Jr, Cabello-Inchausti B, Willis I, Poppiti R Jr
Hum Pathol 1988 Oct;19(10):1239-43. doi: 10.1016/s0046-8177(88)80159-x. PMID: 2844648

Prognosis

Association between prognosis and complete resection in primary cutaneous myoepithelial carcinoma: two case presentations and literature review.
Mizuta H, Takahashi A, Namikawa K, Ogata D, Yamazaki N
Dermatol Ther 2020 Jul;33(4):e13485. Epub 2020 Jun 2 doi: 10.1111/dth.13485. PMID: 32369232
New fusion sarcomas: histopathology and clinical significance of selected entities.
Miettinen M, Felisiak-Golabek A, Luiña Contreras A, Glod J, Kaplan RN, Killian JK, Lasota J
Hum Pathol 2019 Apr;86:57-65. Epub 2019 Jan 8 doi: 10.1016/j.humpath.2018.12.006. PMID: 30633925Free PMC Article
Acral Metastasis of the Fingers: Report of 2 Cases.
Baños-Arévalo AJ, López-Navarro N, Gallego-Domínguez E, Herrera E
Actas Dermosifiliogr (Engl Ed) 2018 Dec;109(10):e1-e4. Epub 2018 May 1 doi: 10.1016/j.ad.2017.03.024. PMID: 29724431
Myoepithelial Tumors: An Update.
Jo VY
Surg Pathol Clin 2015 Sep;8(3):445-66. doi: 10.1016/j.path.2015.05.005. PMID: 26297065
Metastatic myoepithelial carcinoma in a child.
Law RM, Viglione MP, Barrett TL
J Cutan Pathol 2008 Aug;35(8):779-81. Epub 2008 Apr 17 doi: 10.1111/j.1600-0560.2007.00901.x. PMID: 18422689

Clinical prediction guides

SOX10-Internal Tandem Duplications and PLAG1 or HMGA2 Fusions Segregate Eccrine-Type and Apocrine-Type Cutaneous Mixed Tumors.
Macagno N, Kervarrec T, Thanguturi S, Sohier P, Pissaloux D, Mescam L, Jullie ML, Frouin E, Osio A, Faisant M, Le Loarer F, Cribier B, Calonje E, Luna EVE, Massi D, Goto K, Nishida H, Paindavoine S, Houlier A, Tantot J, Benzerdjeb N, Tirode F, De la Fouchardière A, Battistella M
Mod Pathol 2024 Mar;37(3):100430. Epub 2024 Jan 23 doi: 10.1016/j.modpat.2024.100430. PMID: 38266920
Cutaneous Myoepithelial Neoplasms on Acral Sites Show Distinctive and Reproducible Histopathologic and Immunohistochemical Features.
Mehta A, Davey J, Gharpuray-Pandit D, Plaza JA, Billings SD, Balogh P, Tchrakian N, Selvan S, Wiedemeyer K, Hornick JL, Brenn T
Am J Surg Pathol 2022 Sep 1;46(9):1241-1249. Epub 2022 Mar 31 doi: 10.1097/PAS.0000000000001896. PMID: 35354162
Metastatic myoepithelial carcinoma in a child.
Law RM, Viglione MP, Barrett TL
J Cutan Pathol 2008 Aug;35(8):779-81. Epub 2008 Apr 17 doi: 10.1111/j.1600-0560.2007.00901.x. PMID: 18422689
Benign myoepithelioma of the skin.
Fernández-Figueras MT, Puig L, Trias I, Lorenzo JC, Navas-Palacios JJ
Am J Dermatopathol 1998 Apr;20(2):208-12. doi: 10.1097/00000372-199804000-00020. PMID: 9557794
Adenomyoepithelioma of the skin: a case report with immunohistochemical and ultrastructural observations.
Wallis NT, Banerjee SS, Eyden BP, Armstrong GR
Histopathology 1997 Oct;31(4):374-7. doi: 10.1046/j.1365-2559.1997.2700863.x. PMID: 9363454

Recent systematic reviews

Impact of adjuvant therapy on survival in patients with myoepithelial carcinoma: A systematic review and individual patient data analysis of 691 patients.
Giridhar P, Gupta P, Mallick S, Upadhyay AD, Rath GK
Radiother Oncol 2019 Nov;140:125-130. Epub 2019 Jul 2 doi: 10.1016/j.radonc.2019.06.017. PMID: 31276988

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