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Solitary Cutaneous Reticulohistiocytosis

MedGen UID:
1708820
•Concept ID:
C5239292
•
Disease or Syndrome

Definition

A reactive cutaneous proliferation of macrophages associated with local trauma. It is characterized by the presence of giant cells with ground-glass cytoplasm. It presents as a single, asymptomatic, cutaneous or mucosal, firm xanthomatous to dark-red papule or nodule. (WHO 2018) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSolitary Cutaneous Reticulohistiocytosis

Recent clinical studies

Etiology

Multiple juvenile xanthogranuloma.
Garcia-Sirvent L, Espineira-Sicre J, Ruiz-Sanchez J, Cuesta-Montero L
Dermatol Online J 2024 Mar 15;30(1) doi: 10.5070/D330163291. PMID: 38762861
Juvenile xanthogranulomas in Asian children.
Wee LWY, Ling HY, Ho VPY, Foong AYW, Koh MJA
Dermatol Ther 2022 Feb;35(2):e15224. Epub 2021 Dec 4 doi: 10.1111/dth.15224. PMID: 34820973
JUVENILE XANTHOGRANULOMA: A CASE REPORT.
Silva SPD, Viveiros C, Almeida R, Pereira MA, Vaz R, Portela A
Rev Paul Pediatr 2019 Apr-Jun;37(2):257-260. Epub 2019 Feb 25 doi: 10.1590/1984-0462/;2019;37;2;00013. PMID: 30810696Free PMC Article
The non-Langerhans' cell histiocytoses in childhood.
Burgdorf WH, Zelger B
Cutis 1996 Sep;58(3):201-7. PMID: 8886534
Primary histiocytic dermatoses.
Ringel E, Moschella S
Arch Dermatol 1985 Dec;121(12):1531-41. PMID: 2998286

Diagnosis

Multiple juvenile xanthogranuloma.
Garcia-Sirvent L, Espineira-Sicre J, Ruiz-Sanchez J, Cuesta-Montero L
Dermatol Online J 2024 Mar 15;30(1) doi: 10.5070/D330163291. PMID: 38762861
Juvenile xanthogranulomas: Examining single, multiple, and extracutaneous presentations.
So N, Liu R, Hogeling M
Pediatr Dermatol 2020 Jul;37(4):637-644. Epub 2020 May 28 doi: 10.1111/pde.14174. PMID: 32468628
Solitary juvenile xanthogranuloma with tibial involvement: a case report.
Zhi Y, Duan Y, Zhang H, Yin X, Qu T, Guan G, Su L, Dong Q
Int J Clin Exp Pathol 2015;8(1):164-70. Epub 2015 Jan 1 PMID: 25755703Free PMC Article
Nonepithelial skin tumors with multinucleated giant cells.
Gómez-Mateo Mdel C, Monteagudo C
Semin Diagn Pathol 2013 Feb;30(1):58-72. doi: 10.1053/j.semdp.2012.01.004. PMID: 23327730
Primary histiocytic dermatoses.
Ringel E, Moschella S
Arch Dermatol 1985 Dec;121(12):1531-41. PMID: 2998286

Therapy

Dermoscopic follow-up of cutaneous rosai-dorfman: Spontaneous regression.
Hu C, Cao Y, Yang X, Cao Z, Xu M, Shi L, Wang X
Photodiagnosis Photodyn Ther 2021 Jun;34:102263. Epub 2021 Mar 23 doi: 10.1016/j.pdpdt.2021.102263. PMID: 33771755
Metformin-Induced Generalized Fixed Drug Eruption With Cutaneous Hemophagocytosis.
Ramírez-Bellver JL, Lopez J, Macias E, Fuertes L, Andres I, Alegria V, Gimeno I, Perez A, Perez Y, Requena L
Am J Dermatopathol 2017 Jun;39(6):471-475. doi: 10.1097/DAD.0000000000000800. PMID: 27906695
Primary cutaneous langerhans cell sarcoma: a report of four cases and review of the literature.
Sagransky MJ, Deng AC, Magro CM
Am J Dermatopathol 2013 Apr;35(2):196-204. doi: 10.1097/DAD.0b013e3182661c0b. PMID: 23051626
Clinical and histopathologic spectrum of cutaneous Rosai-Dorfman disease in Taiwan.
Lu CI, Kuo TT, Wong WR, Hong HS
J Am Acad Dermatol 2004 Dec;51(6):931-9. doi: 10.1016/j.jaad.2004.04.030. PMID: 15583585
Histiocytosis X: a seven-year experience at a children's hospital.
Esterly NB, Maurer HS, Gonzalez-Crussi F
J Am Acad Dermatol 1985 Sep;13(3):481-96. doi: 10.1016/s0190-9622(85)70192-2. PMID: 3877082

Prognosis

Dermoscopic follow-up of cutaneous rosai-dorfman: Spontaneous regression.
Hu C, Cao Y, Yang X, Cao Z, Xu M, Shi L, Wang X
Photodiagnosis Photodyn Ther 2021 Jun;34:102263. Epub 2021 Mar 23 doi: 10.1016/j.pdpdt.2021.102263. PMID: 33771755
Intracranial juvenile xanthogranuloma in an infant.
Myeong HS, Koh EJ, Cheon JE, Park SH, Kim SK
Childs Nerv Syst 2021 Oct;37(10):3265-3269. Epub 2021 Mar 4 doi: 10.1007/s00381-021-05088-w. PMID: 33660104
Primary cutaneous histiocytic sarcoma: A report of five cases with primary cutaneous involvement and review of the literature.
Magro CM, Kazi N, Sisinger AE
Ann Diagn Pathol 2018 Feb;32:56-62. Epub 2017 Dec 2 doi: 10.1016/j.anndiagpath.2017.10.004. PMID: 29414400
Cutaneous disseminated xanthogranuloma in an adult: case report and review of the literature.
Asarch A, Thiele JJ, Ashby-Richardson H, Norden PS
Cutis 2009 May;83(5):243-9. PMID: 19537282
Primary histiocytic dermatoses.
Ringel E, Moschella S
Arch Dermatol 1985 Dec;121(12):1531-41. PMID: 2998286

Clinical prediction guides

On the knowledge of solitary juvenile xanthogranuloma of the eyelid: a case series and literature review.
Chen R, Liu S, Tang L, Yu X, Meng Z, Hu Y, Li J, Liang X
Graefes Arch Clin Exp Ophthalmol 2022 Jul;260(7):2339-2345. Epub 2022 Jan 27 doi: 10.1007/s00417-022-05560-6. PMID: 35084531Free PMC Article
Dermoscopic follow-up of cutaneous rosai-dorfman: Spontaneous regression.
Hu C, Cao Y, Yang X, Cao Z, Xu M, Shi L, Wang X
Photodiagnosis Photodyn Ther 2021 Jun;34:102263. Epub 2021 Mar 23 doi: 10.1016/j.pdpdt.2021.102263. PMID: 33771755
Intracranial juvenile xanthogranuloma in an infant.
Myeong HS, Koh EJ, Cheon JE, Park SH, Kim SK
Childs Nerv Syst 2021 Oct;37(10):3265-3269. Epub 2021 Mar 4 doi: 10.1007/s00381-021-05088-w. PMID: 33660104
Congenital Unilesional Cutaneous Langerhans Cell Histiocytosis: A Case Report.
Ungari M, Caresana G, Tanzi G, Drera B, Frittoli MC, Gusolfino MD, Ferrero G, Varotti E, Manotti L, Trombatore M, Bertoni R
Am J Dermatopathol 2021 Mar 1;43(3):e38-e42. doi: 10.1097/DAD.0000000000001770. PMID: 32769549
Solitary intracerebral juvenile xanthogranuloma. Case report and review of the literature.
Schultz KD Jr, Petronio J, Narad C, Hunter SB
Pediatr Neurosurg 1997 Jun;26(6):315-21. doi: 10.1159/000121212. PMID: 9485160

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