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Transformed Mycosis Fungoides

MedGen UID:
1710523
•Concept ID:
C5237457
•
Neoplastic Process

Definition

Histologic transformation of mycosis fungoides to an aggressive non-Hodgkin lymphoma. [from NCI]

Professional guidelines

PubMed

Is immunohistochemical expression of GATA3 helpful in the differential diagnosis of transformed mycosis fungoides and primary cutaneous CD30-positive T cell lymphoproliferative disorders?
Collins K, Gu J, Aung PP, Nagarajan P, Curry JL, Huen A, Ivan D, Prieto VG, Tetzlaff MT, Duvic M, Miranda RN, Vega F, Torres-Cabala CA
Virchows Arch 2021 Aug;479(2):377-383. Epub 2021 Feb 18 doi: 10.1007/s00428-021-03056-y. PMID: 33604757
Effectiveness of brentuximab vedotin before and after allogeneic stem-cell transplantation in the management of transformed mycosis fungoides.
André R, Ram-Wolff C, Battistella M, Peffault de Latour R, Petit A, Bouaziz JD, Brice P, Bagot M, de Masson A
Br J Dermatol 2020 Jun;182(6):1503-1504. Epub 2020 Feb 12 doi: 10.1111/bjd.18806. PMID: 31854457
Assessment of diagnostic criteria between primary cutaneous anaplastic large-cell lymphoma and CD30-rich transformed mycosis fungoides; a study of 66 cases.
Fauconneau A, Pham-Ledard A, Cappellen D, Frison E, Prochazkova-Carlotti M, Parrens M, Dalle S, Joly P, Viraben R, Franck F, Ingen-Housz-Oro S, Giacchero D, Jullié ML, Vergier B, Merlio JP, Beylot-Barry M
Br J Dermatol 2015 Jun;172(6):1547-1554. Epub 2015 May 16 doi: 10.1111/bjd.13690. PMID: 25645336

Recent clinical studies

Etiology

Disease characteristics, prognosis, and response to therapy in patients with large-cell transformed mycosis fungoides: A single-center retrospective study.
O'Donnell M, Zaya R, Correia E, Krishnasamy S, Sahu J, Shi W, Cha J, Alpdogan SO, Porcu P, Nikbakht N
J Am Acad Dermatol 2022 Jun;86(6):1285-1292. Epub 2021 Jul 14 doi: 10.1016/j.jaad.2021.07.013. PMID: 34273458
Transformation of Mycosis Fungoides/Sezary Syndrome: Clinical Characteristics and Prognosis.
Vural S, Akay BN, Botsalı A, Atilla E, Parlak N, Okçu Heper A, Şanlı H
Turk J Haematol 2018 Mar 1;35(1):35-41. Epub 2017 May 23 doi: 10.4274/tjh.2016.0502. PMID: 28533196Free PMC Article
Altered microRNA expression in folliculotropic and transformed mycosis fungoides.
Marosvári D, Téglási V, Csala I, Marschalkó M, Bödör C, Timár B, Csomor J, Hársing J, Reiniger L
Pathol Oncol Res 2015 Jul;21(3):821-5. Epub 2015 Feb 20 doi: 10.1007/s12253-015-9897-8. PMID: 25698383
The significance of MUM1/IRF4 protein expression and IRF4 translocation of CD30(+) cutaneous T-cell lymphoproliferative disorders: a study of 53 cases.
Kiran T, Demirkesen C, Eker C, Kumusoglu H, Tuzuner N
Leuk Res 2013 Apr;37(4):396-400. Epub 2013 Jan 18 doi: 10.1016/j.leukres.2012.12.001. PMID: 23332472
Prognostic factors in transformed mycosis fungoides: a retrospective analysis of 100 cases.
Benner MF, Jansen PM, Vermeer MH, Willemze R
Blood 2012 Feb 16;119(7):1643-9. Epub 2011 Dec 12 doi: 10.1182/blood-2011-08-376319. PMID: 22160616

Diagnosis

Differential molecular programs of cutaneous anaplastic large cell lymphoma and CD30-positive transformed mycosis fungoides.
Lai P, Liu F, Liu X, Sun J, Wang Y
Front Immunol 2023;14:1270365. Epub 2023 Sep 18 doi: 10.3389/fimmu.2023.1270365. PMID: 37790936Free PMC Article
Transformed Mycosis Fungoides with a Cytotoxic T-Cell Phenotype.
Hiraiwa S, Hashimoto N, Ueda T, Sugiyama T, Yokoyama K, Matsuyama T, Tajiri T, Nakamura N
Int J Surg Pathol 2022 Oct;30(7):816-822. Epub 2022 Mar 7 doi: 10.1177/10668969221084267. PMID: 35253522
Prognostic Significance of CD30 in Transformed Mycosis Fungoides.
Travaglino A, Russo D, Varricchio S, Pignatiello S, Baldo A, Picardi M, Pane F, Mascolo M
Am J Clin Pathol 2021 Aug 4;156(3):350-355. doi: 10.1093/ajcp/aqaa261. PMID: 33769436
Transformation of Mycosis Fungoides/Sezary Syndrome: Clinical Characteristics and Prognosis.
Vural S, Akay BN, Botsalı A, Atilla E, Parlak N, Okçu Heper A, Şanlı H
Turk J Haematol 2018 Mar 1;35(1):35-41. Epub 2017 May 23 doi: 10.4274/tjh.2016.0502. PMID: 28533196Free PMC Article
Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): part I. Diagnosis: clinical and histopathologic features and new molecular and biologic markers.
Jawed SI, Myskowski PL, Horwitz S, Moskowitz A, Querfeld C
J Am Acad Dermatol 2014 Feb;70(2):205.e1-16; quiz 221-2. doi: 10.1016/j.jaad.2013.07.049. PMID: 24438969

Therapy

Pooled analysis of pralatrexate single-agent studies in patients with relapsed/refractory peripheral T-cell lymphoma.
O'Connor OA, Ko BS, Wang MC, Maruyama D, Song Y, Yeoh EM, Manamley N, Tobinai K
Blood Adv 2024 Jun 11;8(11):2601-2611. doi: 10.1182/bloodadvances.2023010441. PMID: 38429077Free PMC Article
Disease characteristics, prognosis, and response to therapy in patients with large-cell transformed mycosis fungoides: A single-center retrospective study.
O'Donnell M, Zaya R, Correia E, Krishnasamy S, Sahu J, Shi W, Cha J, Alpdogan SO, Porcu P, Nikbakht N
J Am Acad Dermatol 2022 Jun;86(6):1285-1292. Epub 2021 Jul 14 doi: 10.1016/j.jaad.2021.07.013. PMID: 34273458
All-oral metronomic DEVEC schedule in elderly patients with peripheral T cell lymphoma.
Cox MC, Banchi M, Pelliccia S, Di Napoli A, Marcheselli L, Patti C, Anticoli Borza P, Battistini R, Di Gregorio F, Orlandi P, Bocci G
Cancer Chemother Pharmacol 2020 Dec;86(6):841-846. Epub 2020 Oct 18 doi: 10.1007/s00280-020-04172-3. PMID: 33070248Free PMC Article
Brentuximab vedotin in CD30(+) primary cutaneous T-cell lymphomas: a review and analysis of existing data.
Enos TH, Feigenbaum LS, Wickless HW
Int J Dermatol 2017 Dec;56(12):1400-1405. Epub 2017 Aug 1 doi: 10.1111/ijd.13696. PMID: 28762479
Uncommon hematologic malignancies. Case 3. Parotid swelling during treatment for transformed mycosis fungoides.
Bird BR, Daly PA
J Clin Oncol 2003 Nov 15;21(22):4251-2. doi: 10.1200/JCO.2003.03.027. PMID: 14615457

Prognosis

Prognostic Significance of CD30 in Transformed Mycosis Fungoides.
Travaglino A, Russo D, Varricchio S, Pignatiello S, Baldo A, Picardi M, Pane F, Mascolo M
Am J Clin Pathol 2021 Aug 4;156(3):350-355. doi: 10.1093/ajcp/aqaa261. PMID: 33769436
Transformation of Mycosis Fungoides/Sezary Syndrome: Clinical Characteristics and Prognosis.
Vural S, Akay BN, Botsalı A, Atilla E, Parlak N, Okçu Heper A, Şanlı H
Turk J Haematol 2018 Mar 1;35(1):35-41. Epub 2017 May 23 doi: 10.4274/tjh.2016.0502. PMID: 28533196Free PMC Article
Altered microRNA expression in folliculotropic and transformed mycosis fungoides.
Marosvári D, Téglási V, Csala I, Marschalkó M, Bödör C, Timár B, Csomor J, Hársing J, Reiniger L
Pathol Oncol Res 2015 Jul;21(3):821-5. Epub 2015 Feb 20 doi: 10.1007/s12253-015-9897-8. PMID: 25698383
Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): part I. Diagnosis: clinical and histopathologic features and new molecular and biologic markers.
Jawed SI, Myskowski PL, Horwitz S, Moskowitz A, Querfeld C
J Am Acad Dermatol 2014 Feb;70(2):205.e1-16; quiz 221-2. doi: 10.1016/j.jaad.2013.07.049. PMID: 24438969
The significance of MUM1/IRF4 protein expression and IRF4 translocation of CD30(+) cutaneous T-cell lymphoproliferative disorders: a study of 53 cases.
Kiran T, Demirkesen C, Eker C, Kumusoglu H, Tuzuner N
Leuk Res 2013 Apr;37(4):396-400. Epub 2013 Jan 18 doi: 10.1016/j.leukres.2012.12.001. PMID: 23332472

Clinical prediction guides

Role of B-cells in Mycosis Fungoides.
Nielsen PR, Eriksen JO, Sørensen MD, Wehkamp U, Lindahl LM, Bzorek M, Iversen L, Woetman A, Ødum N, Litman T, Gjerdrum LMR
Acta Derm Venereol 2021 Mar 11;101(3):adv00413. doi: 10.2340/00015555-3775. PMID: 33686443Free PMC Article
Is immunohistochemical expression of GATA3 helpful in the differential diagnosis of transformed mycosis fungoides and primary cutaneous CD30-positive T cell lymphoproliferative disorders?
Collins K, Gu J, Aung PP, Nagarajan P, Curry JL, Huen A, Ivan D, Prieto VG, Tetzlaff MT, Duvic M, Miranda RN, Vega F, Torres-Cabala CA
Virchows Arch 2021 Aug;479(2):377-383. Epub 2021 Feb 18 doi: 10.1007/s00428-021-03056-y. PMID: 33604757
Telomerase functions beyond telomere maintenance in primary cutaneous T-cell lymphoma.
Chevret E, Andrique L, Prochazkova-Carlotti M, Ferrer J, Cappellen D, Laharanne E, Idrissi Y, Boettiger A, Sahraoui W, Ruiz F, Pham-Ledard A, Vergier B, Belloc F, Dubus P, Beylot-Barry M, Merlio JP
Blood 2014 Mar 20;123(12):1850-9. Epub 2014 Jan 27 doi: 10.1182/blood-2013-05-500686. PMID: 24470590
The significance of MUM1/IRF4 protein expression and IRF4 translocation of CD30(+) cutaneous T-cell lymphoproliferative disorders: a study of 53 cases.
Kiran T, Demirkesen C, Eker C, Kumusoglu H, Tuzuner N
Leuk Res 2013 Apr;37(4):396-400. Epub 2013 Jan 18 doi: 10.1016/j.leukres.2012.12.001. PMID: 23332472
Prognostic factors in transformed mycosis fungoides: a retrospective analysis of 100 cases.
Benner MF, Jansen PM, Vermeer MH, Willemze R
Blood 2012 Feb 16;119(7):1643-9. Epub 2011 Dec 12 doi: 10.1182/blood-2011-08-376319. PMID: 22160616

Recent systematic reviews

Prognostic Significance of CD30 in Transformed Mycosis Fungoides.
Travaglino A, Russo D, Varricchio S, Pignatiello S, Baldo A, Picardi M, Pane F, Mascolo M
Am J Clin Pathol 2021 Aug 4;156(3):350-355. doi: 10.1093/ajcp/aqaa261. PMID: 33769436

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