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BRCA-Associated Malignant Neoplasm

MedGen UID:
1710602
Concept ID:
C5238337
Neoplastic Process
Synonym: BRCA-Mutated Malignant Neoplasm

Definition

A malignant neoplasm caused by deleterious germline mutation in a gene of the BRCA family. [from NCI]

Professional guidelines

PubMed

Washington CR, Richardson DL, Moore KN
Future Oncol 2019 Oct;15(30):3435-3449. Epub 2019 Sep 3 doi: 10.2217/fon-2019-0271. PMID: 31478762
Lee MV, Katabathina VS, Bowerson ML, Mityul MI, Shetty AS, Elsayes KM, Balachandran A, Bhosale PR, McCullough AE, Menias CO
Radiographics 2017 Jul-Aug;37(4):1005-1023. Epub 2017 May 26 doi: 10.1148/rg.2017160144. PMID: 28548905
Peters ML, Tseng JF, Miksad RA
Clin Ther 2016 Jul;38(7):1622-35. Epub 2016 Apr 1 doi: 10.1016/j.clinthera.2016.03.006. PMID: 27041411

Recent clinical studies

Etiology

Bellcross CA
Obstet Gynecol Clin North Am 2022 Mar;49(1):117-147. doi: 10.1016/j.ogc.2021.11.005. PMID: 35168766
Jonsson P, Bandlamudi C, Cheng ML, Srinivasan P, Chavan SS, Friedman ND, Rosen EY, Richards AL, Bouvier N, Selcuklu SD, Bielski CM, Abida W, Mandelker D, Birsoy O, Zhang L, Zehir A, Donoghue MTA, Baselga J, Offit K, Scher HI, O'Reilly EM, Stadler ZK, Schultz N, Socci ND, Viale A, Ladanyi M, Robson ME, Hyman DM, Berger MF, Solit DB, Taylor BS
Nature 2019 Jul;571(7766):576-579. Epub 2019 Jul 10 doi: 10.1038/s41586-019-1382-1. PMID: 31292550Free PMC Article
Kowalewski A, Szylberg Ł, Saganek M, Napiontek W, Antosik P, Grzanka D
J Cancer Res Clin Oncol 2018 Aug;144(8):1503-1507. Epub 2018 May 18 doi: 10.1007/s00432-018-2666-9. PMID: 29777302Free PMC Article
Lee MV, Katabathina VS, Bowerson ML, Mityul MI, Shetty AS, Elsayes KM, Balachandran A, Bhosale PR, McCullough AE, Menias CO
Radiographics 2017 Jul-Aug;37(4):1005-1023. Epub 2017 May 26 doi: 10.1148/rg.2017160144. PMID: 28548905
Narod SA, Salmena L
Discov Med 2011 Nov;12(66):445-53. PMID: 22127115

Diagnosis

Bellcross CA
Obstet Gynecol Clin North Am 2022 Mar;49(1):117-147. doi: 10.1016/j.ogc.2021.11.005. PMID: 35168766
Jonsson P, Bandlamudi C, Cheng ML, Srinivasan P, Chavan SS, Friedman ND, Rosen EY, Richards AL, Bouvier N, Selcuklu SD, Bielski CM, Abida W, Mandelker D, Birsoy O, Zhang L, Zehir A, Donoghue MTA, Baselga J, Offit K, Scher HI, O'Reilly EM, Stadler ZK, Schultz N, Socci ND, Viale A, Ladanyi M, Robson ME, Hyman DM, Berger MF, Solit DB, Taylor BS
Nature 2019 Jul;571(7766):576-579. Epub 2019 Jul 10 doi: 10.1038/s41586-019-1382-1. PMID: 31292550Free PMC Article
Lee MV, Katabathina VS, Bowerson ML, Mityul MI, Shetty AS, Elsayes KM, Balachandran A, Bhosale PR, McCullough AE, Menias CO
Radiographics 2017 Jul-Aug;37(4):1005-1023. Epub 2017 May 26 doi: 10.1148/rg.2017160144. PMID: 28548905
Daniels MS, Lu KH
Semin Oncol 2016 Oct;43(5):543-547. Epub 2016 Sep 20 doi: 10.1053/j.seminoncol.2016.08.005. PMID: 27899185
Goulooze SC, Cohen AF, Rissmann R
Br J Clin Pharmacol 2016 Jan;81(1):171-3. Epub 2015 Oct 24 doi: 10.1111/bcp.12761. PMID: 26344419Free PMC Article

Therapy

Jonsson P, Bandlamudi C, Cheng ML, Srinivasan P, Chavan SS, Friedman ND, Rosen EY, Richards AL, Bouvier N, Selcuklu SD, Bielski CM, Abida W, Mandelker D, Birsoy O, Zhang L, Zehir A, Donoghue MTA, Baselga J, Offit K, Scher HI, O'Reilly EM, Stadler ZK, Schultz N, Socci ND, Viale A, Ladanyi M, Robson ME, Hyman DM, Berger MF, Solit DB, Taylor BS
Nature 2019 Jul;571(7766):576-579. Epub 2019 Jul 10 doi: 10.1038/s41586-019-1382-1. PMID: 31292550Free PMC Article
Pantelidou C, Sonzogni O, De Oliveria Taveira M, Mehta AK, Kothari A, Wang D, Visal T, Li MK, Pinto J, Castrillon JA, Cheney EM, Bouwman P, Jonkers J, Rottenberg S, Guerriero JL, Wulf GM, Shapiro GI
Cancer Discov 2019 Jun;9(6):722-737. Epub 2019 Apr 23 doi: 10.1158/2159-8290.CD-18-1218. PMID: 31015319Free PMC Article
Tray N, Adams S, Esteva FJ
Future Oncol 2018 Oct;14(25):2651-2661. Epub 2018 Sep 3 doi: 10.2217/fon-2018-0131. PMID: 30175620
Goulooze SC, Cohen AF, Rissmann R
Br J Clin Pharmacol 2016 Jan;81(1):171-3. Epub 2015 Oct 24 doi: 10.1111/bcp.12761. PMID: 26344419Free PMC Article
Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M, Mortimer P, Swaisland H, Lau A, O'Connor MJ, Ashworth A, Carmichael J, Kaye SB, Schellens JH, de Bono JS
N Engl J Med 2009 Jul 9;361(2):123-34. Epub 2009 Jun 24 doi: 10.1056/NEJMoa0900212. PMID: 19553641

Prognosis

Bellcross CA
Obstet Gynecol Clin North Am 2022 Mar;49(1):117-147. doi: 10.1016/j.ogc.2021.11.005. PMID: 35168766
Javle M, Shacham-Shmueli E, Xiao L, Varadhachary G, Halpern N, Fogelman D, Boursi B, Uruba S, Margalit O, Wolff RA, Golan T
JAMA Oncol 2021 May 1;7(5):693-699. doi: 10.1001/jamaoncol.2021.0006. PMID: 33662100Free PMC Article
Kowalewski A, Szylberg Ł, Saganek M, Napiontek W, Antosik P, Grzanka D
J Cancer Res Clin Oncol 2018 Aug;144(8):1503-1507. Epub 2018 May 18 doi: 10.1007/s00432-018-2666-9. PMID: 29777302Free PMC Article
Lee MV, Katabathina VS, Bowerson ML, Mityul MI, Shetty AS, Elsayes KM, Balachandran A, Bhosale PR, McCullough AE, Menias CO
Radiographics 2017 Jul-Aug;37(4):1005-1023. Epub 2017 May 26 doi: 10.1148/rg.2017160144. PMID: 28548905
Bordeleau L, Panchal S, Goodwin P
Breast Cancer Res Treat 2010 Jan;119(1):13-24. doi: 10.1007/s10549-009-0566-z. PMID: 19789974

Clinical prediction guides

Shapiro GI, Barry SM
Cancer Treat Res 2023;186:207-221. doi: 10.1007/978-3-031-30065-3_12. PMID: 37978138
Stossel C, Raitses-Gurevich M, Atias D, Beller T, Glick Gorman Y, Halperin S, Peer E, Denroche RE, Zhang A, Notta F, Wilson JM, O'Kane GM, Haimov Talmoud E, Amison N, Schvimer M, Salpeter SJ, Bar V, Zundelevich A, Tirosh I, Tal R, Dinstag G, Kinar Y, Eliezer Y, Ben-David U, Gavert NS, Straussman R, Gallinger SJ, Berger R, Golan T
Cancer Discov 2023 Aug 4;13(8):1826-1843. doi: 10.1158/2159-8290.CD-22-0412. PMID: 37449843Free PMC Article
Bellcross CA
Obstet Gynecol Clin North Am 2022 Mar;49(1):117-147. doi: 10.1016/j.ogc.2021.11.005. PMID: 35168766
Jonsson P, Bandlamudi C, Cheng ML, Srinivasan P, Chavan SS, Friedman ND, Rosen EY, Richards AL, Bouvier N, Selcuklu SD, Bielski CM, Abida W, Mandelker D, Birsoy O, Zhang L, Zehir A, Donoghue MTA, Baselga J, Offit K, Scher HI, O'Reilly EM, Stadler ZK, Schultz N, Socci ND, Viale A, Ladanyi M, Robson ME, Hyman DM, Berger MF, Solit DB, Taylor BS
Nature 2019 Jul;571(7766):576-579. Epub 2019 Jul 10 doi: 10.1038/s41586-019-1382-1. PMID: 31292550Free PMC Article
Girolimetti G, Perrone AM, Santini D, Barbieri E, Guerra F, Ferrari S, Zamagni C, De Iaco P, Gasparre G, Turchetti D
Biomed Res Int 2014;2014:787143. Epub 2014 Jul 22 doi: 10.1155/2014/787143. PMID: 25136623Free PMC Article

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