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Metastatic Primary Malignant Central Nervous System Neoplasm

MedGen UID:
1712056
•Concept ID:
C5237759
•
Neoplastic Process

Definition

A malignant neoplasm that arises from the central nervous system and has spread from its original site of growth to other sites. [from NCI]

Professional guidelines

PubMed

Ependymoma: Evaluation and Management Updates.
Rudà R, Bruno F, Pellerino A, Soffietti R
Curr Oncol Rep 2022 Aug;24(8):985-993. Epub 2022 Apr 6 doi: 10.1007/s11912-022-01260-w. PMID: 35384591Free PMC Article
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
Primary Brain Tumors in Adults: Diagnosis and Treatment.
Perkins A, Liu G
Am Fam Physician 2016 Feb 1;93(3):211-7. PMID: 26926614

Recent clinical studies

Etiology

Central Nervous System Lymphoma.
Shah T, Venur VA
Semin Neurol 2023 Dec;43(6):825-832. Epub 2023 Nov 23 doi: 10.1055/s-0043-1776783. PMID: 37995744
CAR T-cell therapy in large B cell lymphoma.
Boardman AP, Salles G
Hematol Oncol 2023 Jun;41 Suppl 1(Suppl 1):112-118. doi: 10.1002/hon.3153. PMID: 37294963Free PMC Article
Neuro-oncologic Emergencies.
Suarez-Meade P, Marenco-Hillembrand L, Sherman WJ
Curr Oncol Rep 2022 Aug;24(8):975-984. Epub 2022 Mar 30 doi: 10.1007/s11912-022-01259-3. PMID: 35353348
Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence.
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article
Alectinib versus Crizotinib in Untreated ALK-Positive Non-Small-Cell Lung Cancer.
Peters S, Camidge DR, Shaw AT, Gadgeel S, Ahn JS, Kim DW, Ou SI, Pérol M, Dziadziuszko R, Rosell R, Zeaiter A, Mitry E, Golding S, Balas B, Noe J, Morcos PN, Mok T; ALEX Trial Investigators
N Engl J Med 2017 Aug 31;377(9):829-838. Epub 2017 Jun 6 doi: 10.1056/NEJMoa1704795. PMID: 28586279

Diagnosis

Central Nervous System Lymphoma.
Shah T, Venur VA
Semin Neurol 2023 Dec;43(6):825-832. Epub 2023 Nov 23 doi: 10.1055/s-0043-1776783. PMID: 37995744
Leptomeningeal Metastasis: A Review of the Pathophysiology, Diagnostic Methodology, and Therapeutic Landscape.
Nguyen A, Nguyen A, Dada OT, Desai PD, Ricci JC, Godbole NB, Pierre K, Lucke-Wold B
Curr Oncol 2023 Jun 19;30(6):5906-5931. doi: 10.3390/curroncol30060442. PMID: 37366925Free PMC Article
NCCN Guidelines® Insights: Central Nervous System Cancers, Version 2.2022.
Horbinski C, Nabors LB, Portnow J, Baehring J, Bhatia A, Bloch O, Brem S, Butowski N, Cannon DM, Chao S, Chheda MG, Fabiano AJ, Forsyth P, Gigilio P, Hattangadi-Gluth J, Holdhoff M, Junck L, Kaley T, Merrell R, Mrugala MM, Nagpal S, Nedzi LA, Nevel K, Nghiemphu PL, Parney I, Patel TR, Peters K, Puduvalli VK, Rockhill J, Rusthoven C, Shonka N, Swinnen LJ, Weiss S, Wen PY, Willmarth NE, Bergman MA, Darlow S
J Natl Compr Canc Netw 2023 Jan;21(1):12-20. doi: 10.6004/jnccn.2023.0002. PMID: 36634606
Brain malignancies: Glioblastoma and brain metastases.
Lah TT, Novak M, Breznik B
Semin Cancer Biol 2020 Feb;60:262-273. Epub 2019 Oct 22 doi: 10.1016/j.semcancer.2019.10.010. PMID: 31654711
Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence.
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article

Therapy

Diffuse large B-cell lymphoma involving the central nervous system: biologic rationale for targeted therapy.
Roschewski M, Hodson DJ
Haematologica 2024 Feb 1;109(2):388-400. doi: 10.3324/haematol.2021.278613. PMID: 37706315Free PMC Article
Central Nervous System Lymphoma.
Schaff L
Continuum (Minneap Minn) 2023 Dec 1;29(6):1710-1726. doi: 10.1212/CON.0000000000001356. PMID: 38085895
CAR T-cell therapy in large B cell lymphoma.
Boardman AP, Salles G
Hematol Oncol 2023 Jun;41 Suppl 1(Suppl 1):112-118. doi: 10.1002/hon.3153. PMID: 37294963Free PMC Article
Toxicity and efficacy of CAR T-cell therapy in primary and secondary CNS lymphoma: a meta-analysis of 128 patients.
Cook MR, Dorris CS, Makambi KH, Luo Y, Munshi PN, Donato M, Rowley S, Saad A, Goy A, Dunleavy K, Ali A
Blood Adv 2023 Jan 10;7(1):32-39. doi: 10.1182/bloodadvances.2022008525. PMID: 36260735Free PMC Article
Alectinib versus Crizotinib in Untreated ALK-Positive Non-Small-Cell Lung Cancer.
Peters S, Camidge DR, Shaw AT, Gadgeel S, Ahn JS, Kim DW, Ou SI, Pérol M, Dziadziuszko R, Rosell R, Zeaiter A, Mitry E, Golding S, Balas B, Noe J, Morcos PN, Mok T; ALEX Trial Investigators
N Engl J Med 2017 Aug 31;377(9):829-838. Epub 2017 Jun 6 doi: 10.1056/NEJMoa1704795. PMID: 28586279

Prognosis

Central Nervous System Lymphoma.
Shah T, Venur VA
Semin Neurol 2023 Dec;43(6):825-832. Epub 2023 Nov 23 doi: 10.1055/s-0043-1776783. PMID: 37995744
Leptomeningeal Metastasis: A Review of the Pathophysiology, Diagnostic Methodology, and Therapeutic Landscape.
Nguyen A, Nguyen A, Dada OT, Desai PD, Ricci JC, Godbole NB, Pierre K, Lucke-Wold B
Curr Oncol 2023 Jun 19;30(6):5906-5931. doi: 10.3390/curroncol30060442. PMID: 37366925Free PMC Article
Neoplastic Myelopathies.
Pruitt AA
Continuum (Minneap Minn) 2021 Feb 1;27(1):121-142. doi: 10.1212/CON.0000000000000964. PMID: 33522739
Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence.
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article
Epidemiologic and molecular prognostic review of glioblastoma.
Thakkar JP, Dolecek TA, Horbinski C, Ostrom QT, Lightner DD, Barnholtz-Sloan JS, Villano JL
Cancer Epidemiol Biomarkers Prev 2014 Oct;23(10):1985-96. Epub 2014 Jul 22 doi: 10.1158/1055-9965.EPI-14-0275. PMID: 25053711Free PMC Article

Clinical prediction guides

Toxicity and efficacy of CAR T-cell therapy in primary and secondary CNS lymphoma: a meta-analysis of 128 patients.
Cook MR, Dorris CS, Makambi KH, Luo Y, Munshi PN, Donato M, Rowley S, Saad A, Goy A, Dunleavy K, Ali A
Blood Adv 2023 Jan 10;7(1):32-39. doi: 10.1182/bloodadvances.2022008525. PMID: 36260735Free PMC Article
Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence.
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article
Brain metastases: neuroimaging.
Pope WB
Handb Clin Neurol 2018;149:89-112. doi: 10.1016/B978-0-12-811161-1.00007-4. PMID: 29307364Free PMC Article
Epidemiologic and molecular prognostic review of glioblastoma.
Thakkar JP, Dolecek TA, Horbinski C, Ostrom QT, Lightner DD, Barnholtz-Sloan JS, Villano JL
Cancer Epidemiol Biomarkers Prev 2014 Oct;23(10):1985-96. Epub 2014 Jul 22 doi: 10.1158/1055-9965.EPI-14-0275. PMID: 25053711Free PMC Article
Benign metastasizing meningioma.
Pramesh CS, Saklani AP, Pantvaidya GH, Heroor AA, Naresh KN, Sharma S, Deshpande RK
Jpn J Clin Oncol 2003 Feb;33(2):86-8. doi: 10.1093/jjco/hyg022. PMID: 12629059

Recent systematic reviews

Cannabis-based medicines and medical cannabis for adults with cancer pain.
Häuser W, Welsch P, Radbruch L, Fisher E, Bell RF, Moore RA
Cochrane Database Syst Rev 2023 Jun 5;6(6):CD014915. doi: 10.1002/14651858.CD014915.pub2. PMID: 37283486Free PMC Article
Toxicity and efficacy of CAR T-cell therapy in primary and secondary CNS lymphoma: a meta-analysis of 128 patients.
Cook MR, Dorris CS, Makambi KH, Luo Y, Munshi PN, Donato M, Rowley S, Saad A, Goy A, Dunleavy K, Ali A
Blood Adv 2023 Jan 10;7(1):32-39. doi: 10.1182/bloodadvances.2022008525. PMID: 36260735Free PMC Article
Stereotactic radiosurgery versus whole brain radiotherapy in patients with intracranial metastatic disease and small-cell lung cancer: a systematic review and meta-analysis.
Gaebe K, Li AY, Park A, Parmar A, Lok BH, Sahgal A, Chan KKW, Erickson AW, Das S
Lancet Oncol 2022 Jul;23(7):931-939. Epub 2022 May 26 doi: 10.1016/S1470-2045(22)00271-6. PMID: 35644163
Targeted therapy for advanced anaplastic lymphoma kinase (<I>ALK</I>)-rearranged non-small cell lung cancer.
Cameron LB, Hitchen N, Chandran E, Morris T, Manser R, Solomon BJ, Jordan V
Cochrane Database Syst Rev 2022 Jan 7;1(1):CD013453. doi: 10.1002/14651858.CD013453.pub2. PMID: 34994987Free PMC Article
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393

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