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Near Diploidy

MedGen UID:
1712986
•Concept ID:
C5237005
•
Cell or Molecular Dysfunction
Synonym: Near Diploid

Definition

A chromosomal abnormality in which the total chromosome number is slightly more (hyperdiploid) or slightly less (hypodiploid) than the normal diploid number. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNear Diploidy

Professional guidelines

PubMed

Evolving significance of prognostic markers associated with new treatment strategies in neuroblastoma.
Mora J, Gerald WL, Cheung NK
Cancer Lett 2003 Jul 18;197(1-2):119-24. doi: 10.1016/s0304-3835(03)00094-6. PMID: 12880970
Relationship of tumor-cell ploidy to histologic subtype and treatment outcome in children and adolescents with unresectable rhabdomyosarcoma.
Shapiro DN, Parham DM, Douglass EC, Ashmun R, Webber BL, Newton WA Jr, Hancock ML, Maurer HM, Look AT
J Clin Oncol 1991 Jan;9(1):159-66. doi: 10.1200/JCO.1991.9.1.159. PMID: 1985166

Recent clinical studies

Etiology

Cytogenetic aberrations detected by flow cytometry and fluorescence in situ hybridization in colorectal cancers: two cytogenetic pathways in colorectal carcinogenesis.
Sato T, Oga A, Ikeda E, Todoroki T, Furuya T, Sasaki K
Oncology 1999 Jul;57(1):63-9. doi: 10.1159/000012002. PMID: 10394127
Relationship of tumor DNA-ploidy to serum prostate-specific antigen doubling time after radiotherapy for prostate cancer.
Pollack A, Zagars GK, el-Naggar AK, Terry NH
Urology 1994 Nov;44(5):711-8. doi: 10.1016/s0090-4295(94)80213-0. PMID: 7526527
Near-diploidy: a new prognostic factor for clinically localized prostate cancer treated with external beam radiation therapy.
Pollack A, Zagars GK, el-Naggar AK, Gauwitz MD, Terry NH
Cancer 1994 Apr 1;73(7):1895-903. doi: 10.1002/1097-0142(19940401)73:7<1895::aid-cncr2820730721>3.0.co;2-0. PMID: 7511039
Tumor progression by DNA flow cytometry in human colorectal cancer.
Giaretti W, Santi L
Int J Cancer 1990 Apr 15;45(4):597-603. doi: 10.1002/ijc.2910450404. PMID: 2323838
Cytogenetic findings and prognosis in neuroblastoma with emphasis on marker chromosome 1.
Hayashi Y, Kanda N, Inaba T, Hanada R, Nagahara N, Muchi H, Yamamoto K
Cancer 1989 Jan 1;63(1):126-32. doi: 10.1002/1097-0142(19890101)63:1<126::aid-cncr2820630120>3.0.co;2-z. PMID: 2910410

Diagnosis

MYCN gain and MYCN amplification in a stage 4S neuroblastoma.
Noguera R, Cañete A, Pellín A, Ruiz A, Tasso M, Navarro S, Castel V, Llombart-Bosch A
Cancer Genet Cytogenet 2003 Jan 15;140(2):157-61. doi: 10.1016/s0165-4608(02)00677-5. PMID: 12645655
Numerical aberrations of chromosomes 1 and 7 in renal cell carcinomas as detected by interphase cytogenetics.
Beck JL, Hopman AH, Feitz WF, Schalken J, Schaafsma HE, Van de Kaa CA, Ramaekers FC, Hanselaar AG, De Wilde PC
J Pathol 1995 Jun;176(2):123-35. doi: 10.1002/path.1711760205. PMID: 7636622
Clear cell sarcoma of the kidney--immunohistochemical study and flow cytometric DNA analysis of 7 cases.
Choi YJ, Jung WH, Jung SH, Park C
Yonsei Med J 1994 Sep;35(3):336-43. doi: 10.3349/ymj.1994.35.3.336. PMID: 7975743
Association of near-diploid DNA content and N-myc amplification in neuroblastomas.
Dominici C, Negroni A, Romeo A, Castello MA, Clerico A, Scopinaro M, Mauro F, Raschellà G
Clin Exp Metastasis 1989 Mar-Apr;7(2):201-11. doi: 10.1007/BF01787024. PMID: 2920475
Clinical importance of near-diploid tumor stem lines in patients with osteosarcoma of an extremity.
Look AT, Douglass EC, Meyer WH
N Engl J Med 1988 Jun 16;318(24):1567-72. doi: 10.1056/NEJM198806163182403. PMID: 3163773

Therapy

Meta-Analysis of Cancer Triploidy: Rearrangements of Genome Complements in Male Human Tumors Are Characterized by XXY Karyotypes.
Vainshelbaum NM, Zayakin P, Kleina R, Giuliani A, Erenpreisa J
Genes (Basel) 2019 Aug 13;10(8) doi: 10.3390/genes10080613. PMID: 31412657Free PMC Article
Numerical aberrations of chromosomes 1 and 7 in renal cell carcinomas as detected by interphase cytogenetics.
Beck JL, Hopman AH, Feitz WF, Schalken J, Schaafsma HE, Van de Kaa CA, Ramaekers FC, Hanselaar AG, De Wilde PC
J Pathol 1995 Jun;176(2):123-35. doi: 10.1002/path.1711760205. PMID: 7636622
Clear cell sarcoma of the kidney--immunohistochemical study and flow cytometric DNA analysis of 7 cases.
Choi YJ, Jung WH, Jung SH, Park C
Yonsei Med J 1994 Sep;35(3):336-43. doi: 10.3349/ymj.1994.35.3.336. PMID: 7975743
Cytogenetic and corresponding flow cytometric DNA analysis of renal cell neoplasms.
el-Naggar AK, Pathak S
Anticancer Res 1992 Sep-Oct;12(5):1491-500. PMID: 1444211

Prognosis

Meta-Analysis of Cancer Triploidy: Rearrangements of Genome Complements in Male Human Tumors Are Characterized by XXY Karyotypes.
Vainshelbaum NM, Zayakin P, Kleina R, Giuliani A, Erenpreisa J
Genes (Basel) 2019 Aug 13;10(8) doi: 10.3390/genes10080613. PMID: 31412657Free PMC Article
MYCN gain and MYCN amplification in a stage 4S neuroblastoma.
Noguera R, Cañete A, Pellín A, Ruiz A, Tasso M, Navarro S, Castel V, Llombart-Bosch A
Cancer Genet Cytogenet 2003 Jan 15;140(2):157-61. doi: 10.1016/s0165-4608(02)00677-5. PMID: 12645655
Relationship of tumor DNA-ploidy to serum prostate-specific antigen doubling time after radiotherapy for prostate cancer.
Pollack A, Zagars GK, el-Naggar AK, Terry NH
Urology 1994 Nov;44(5):711-8. doi: 10.1016/s0090-4295(94)80213-0. PMID: 7526527
Near-diploidy: a new prognostic factor for clinically localized prostate cancer treated with external beam radiation therapy.
Pollack A, Zagars GK, el-Naggar AK, Gauwitz MD, Terry NH
Cancer 1994 Apr 1;73(7):1895-903. doi: 10.1002/1097-0142(19940401)73:7<1895::aid-cncr2820730721>3.0.co;2-0. PMID: 7511039
Cytogenetic findings and prognosis in neuroblastoma with emphasis on marker chromosome 1.
Hayashi Y, Kanda N, Inaba T, Hanada R, Nagahara N, Muchi H, Yamamoto K
Cancer 1989 Jan 1;63(1):126-32. doi: 10.1002/1097-0142(19890101)63:1<126::aid-cncr2820630120>3.0.co;2-z. PMID: 2910410

Clinical prediction guides

Relationship between chromosomal instability and intratumoral regional DNA ploidy heterogeneity in primary gastric cancers.
Furuya T, Uchiyama T, Murakami T, Adachi A, Kawauchi S, Oga A, Hirano T, Sasaki K
Clin Cancer Res 2000 Jul;6(7):2815-20. PMID: 10914729
Cytogenetic aberrations detected by flow cytometry and fluorescence in situ hybridization in colorectal cancers: two cytogenetic pathways in colorectal carcinogenesis.
Sato T, Oga A, Ikeda E, Todoroki T, Furuya T, Sasaki K
Oncology 1999 Jul;57(1):63-9. doi: 10.1159/000012002. PMID: 10394127
Relationship of tumor DNA-ploidy to serum prostate-specific antigen doubling time after radiotherapy for prostate cancer.
Pollack A, Zagars GK, el-Naggar AK, Terry NH
Urology 1994 Nov;44(5):711-8. doi: 10.1016/s0090-4295(94)80213-0. PMID: 7526527
Near-diploidy: a new prognostic factor for clinically localized prostate cancer treated with external beam radiation therapy.
Pollack A, Zagars GK, el-Naggar AK, Gauwitz MD, Terry NH
Cancer 1994 Apr 1;73(7):1895-903. doi: 10.1002/1097-0142(19940401)73:7<1895::aid-cncr2820730721>3.0.co;2-0. PMID: 7511039
Association of near-diploid DNA content and N-myc amplification in neuroblastomas.
Dominici C, Negroni A, Romeo A, Castello MA, Clerico A, Scopinaro M, Mauro F, Raschellà G
Clin Exp Metastasis 1989 Mar-Apr;7(2):201-11. doi: 10.1007/BF01787024. PMID: 2920475

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