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Smoker-inclusions in alveolar macrophages

MedGen UID:
1714914
Concept ID:
C5397978
Finding
HPO: HP:0032986

Definition

In otherwise healthy smokers, characteristic so called smoker-inclusion can be found within the macrophages in the bronchoalveolar fluid. These blue/ black/ round/ oval cytoplasmic inclusions consist of pigmented lipid deposits. [from HPO]

Term Hierarchy

Professional guidelines

PubMed

Park JA
Int J Mol Sci 2021 Jan 14;22(2) doi: 10.3390/ijms22020793. PMID: 33466873Free PMC Article
Gopalaswamy R, Shanmugam S, Mondal R, Subbian S
J Biomed Sci 2020 Jun 17;27(1):74. doi: 10.1186/s12929-020-00667-6. PMID: 32552732Free PMC Article
Heukels P, Moor CC, von der Thüsen JH, Wijsenbeek MS, Kool M
Respir Med 2019 Feb;147:79-91. Epub 2019 Jan 9 doi: 10.1016/j.rmed.2018.12.015. PMID: 30704705

Recent clinical studies

Etiology

Wan R, Srikaram P, Xie S, Chen Q, Hu C, Wan M, Li Y, Gao P
Respir Res 2024 Apr 20;25(1):174. doi: 10.1186/s12931-024-02790-6. PMID: 38643159Free PMC Article
Malainou C, Abdin SM, Lachmann N, Matt U, Herold S
J Clin Invest 2023 Oct 2;133(19) doi: 10.1172/JCI170501. PMID: 37781922Free PMC Article
Lugg ST, Scott A, Parekh D, Naidu B, Thickett DR
Thorax 2022 Jan;77(1):94-101. Epub 2021 May 13 doi: 10.1136/thoraxjnl-2020-216296. PMID: 33986144Free PMC Article
Grant RA, Morales-Nebreda L, Markov NS, Swaminathan S, Querrey M, Guzman ER, Abbott DA, Donnelly HK, Donayre A, Goldberg IA, Klug ZM, Borkowski N, Lu Z, Kihshen H, Politanska Y, Sichizya L, Kang M, Shilatifard A, Qi C, Lomasney JW, Argento AC, Kruser JM, Malsin ES, Pickens CO, Smith SB, Walter JM, Pawlowski AE, Schneider D, Nannapaneni P, Abdala-Valencia H, Bharat A, Gottardi CJ, Budinger GRS, Misharin AV, Singer BD, Wunderink RG; NU SCRIPT Study Investigators
Nature 2021 Feb;590(7847):635-641. Epub 2021 Jan 11 doi: 10.1038/s41586-020-03148-w. PMID: 33429418Free PMC Article
Ziegenhagen MW, Müller-Quernheim J
J Intern Med 2003 Jan;253(1):18-30. doi: 10.1046/j.1365-2796.2003.01074.x. PMID: 12588535

Diagnosis

Prieto LI, Sturmlechner I, Graves SI, Zhang C, Goplen NP, Yi ES, Sun J, Li H, Baker DJ
Cancer Cell 2023 Jul 10;41(7):1261-1275.e6. Epub 2023 Jun 1 doi: 10.1016/j.ccell.2023.05.006. PMID: 37267954Free PMC Article
Bo H, Moure UAE, Yang Y, Pan J, Li L, Wang M, Ke X, Cui H
Front Cell Infect Microbiol 2023;13:1062963. Epub 2023 Mar 3 doi: 10.3389/fcimb.2023.1062963. PMID: 36936766Free PMC Article
Kho SS, Ganapaty S, Omar N, Tan SZ, Nasarudin MZ, Abdul Rahaman JA
Thorax 2022 Aug;77(8):842-843. Epub 2022 Mar 18 doi: 10.1136/thoraxjnl-2021-217940. PMID: 35304426
Ogger PP, Albers GJ, Hewitt RJ, O'Sullivan BJ, Powell JE, Calamita E, Ghai P, Walker SA, McErlean P, Saunders P, Kingston S, Molyneaux PL, Halket JM, Gray R, Chambers DC, Maher TM, Lloyd CM, Byrne AJ
Sci Immunol 2020 Oct 23;5(52) doi: 10.1126/sciimmunol.abc1884. PMID: 33097591Free PMC Article
Papiris SA, Triantafillidou C, Kolilekas L, Markoulaki D, Manali ED
Drug Saf 2010 Jul 1;33(7):539-58. doi: 10.2165/11532320-000000000-00000. PMID: 20553056

Therapy

Hu Y, Shao X, Xing L, Li X, Nonis GM, Koelwyn GJ, Zhang X, Sin DD
Cells 2023 Dec 5;12(24) doi: 10.3390/cells12242771. PMID: 38132091Free PMC Article
Lugg ST, Scott A, Parekh D, Naidu B, Thickett DR
Thorax 2022 Jan;77(1):94-101. Epub 2021 May 13 doi: 10.1136/thoraxjnl-2020-216296. PMID: 33986144Free PMC Article
Liu X, Gao C, Wang Y, Niu L, Jiang S, Pan S
Oxid Med Cell Longev 2021;2021:9973457. Epub 2021 Jun 13 doi: 10.1155/2021/9973457. PMID: 34234888Free PMC Article
Ogger PP, Albers GJ, Hewitt RJ, O'Sullivan BJ, Powell JE, Calamita E, Ghai P, Walker SA, McErlean P, Saunders P, Kingston S, Molyneaux PL, Halket JM, Gray R, Chambers DC, Maher TM, Lloyd CM, Byrne AJ
Sci Immunol 2020 Oct 23;5(52) doi: 10.1126/sciimmunol.abc1884. PMID: 33097591Free PMC Article
Craig VJ, Zhang L, Hagood JS, Owen CA
Am J Respir Cell Mol Biol 2015 Nov;53(5):585-600. doi: 10.1165/rcmb.2015-0020TR. PMID: 26121236Free PMC Article

Prognosis

Malainou C, Abdin SM, Lachmann N, Matt U, Herold S
J Clin Invest 2023 Oct 2;133(19) doi: 10.1172/JCI170501. PMID: 37781922Free PMC Article
Perrot CY, Karampitsakos T, Herazo-Maya JD
Am J Physiol Cell Physiol 2023 Oct 1;325(4):C1046-C1057. Epub 2023 Sep 11 doi: 10.1152/ajpcell.00302.2023. PMID: 37694283Free PMC Article
Bikle DD
Curr Osteoporos Rep 2022 Jun;20(3):186-193. Epub 2022 May 4 doi: 10.1007/s11914-022-00732-z. PMID: 35507293Free PMC Article
McCarthy C, Carey BC, Trapnell BC
Am J Respir Crit Care Med 2022 May 1;205(9):1016-1035. doi: 10.1164/rccm.202112-2742SO. PMID: 35227171Free PMC Article
Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, McQuattie-Pimentel AC, Chen CI, Anekalla KR, Joshi N, Williams KJN, Abdala-Valencia H, Yacoub TJ, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Gates K, Lam AP, Nicholson TT, Homan PJ, Soberanes S, Dominguez S, Morgan VK, Saber R, Shaffer A, Hinchcliff M, Marshall SA, Bharat A, Berdnikovs S, Bhorade SM, Bartom ET, Morimoto RI, Balch WE, Sznajder JI, Chandel NS, Mutlu GM, Jain M, Gottardi CJ, Singer BD, Ridge KM, Bagheri N, Shilatifard A, Budinger GRS, Perlman H
J Exp Med 2017 Aug 7;214(8):2387-2404. Epub 2017 Jul 10 doi: 10.1084/jem.20162152. PMID: 28694385Free PMC Article

Clinical prediction guides

Zhang M, Zhang J, Hu H, Zhou Y, Lin Z, Jing H, Sun B
J Transl Med 2024 Jun 27;22(1):598. doi: 10.1186/s12967-024-05398-y. PMID: 38937806Free PMC Article
Wan R, Srikaram P, Xie S, Chen Q, Hu C, Wan M, Li Y, Gao P
Respir Res 2024 Apr 20;25(1):174. doi: 10.1186/s12931-024-02790-6. PMID: 38643159Free PMC Article
Li X, Kolling FW, Aridgides D, Mellinger D, Ashare A, Jakubzick CV
Life Sci Alliance 2022 Nov;5(11) Epub 2022 Jul 12 doi: 10.26508/lsa.202201458. PMID: 35820705Free PMC Article
Dong T, Chen X, Xu H, Song Y, Wang H, Gao Y, Wang J, Du R, Lou H, Dong T
Pharmacol Ther 2022 Nov;239:108208. Epub 2022 May 13 doi: 10.1016/j.pharmthera.2022.108208. PMID: 35569553
Liu X, Gao C, Wang Y, Niu L, Jiang S, Pan S
Oxid Med Cell Longev 2021;2021:9973457. Epub 2021 Jun 13 doi: 10.1155/2021/9973457. PMID: 34234888Free PMC Article

Recent systematic reviews

Li M, Li Z
J Asthma 2025 Jan;62(1):56-63. Epub 2024 Aug 6 doi: 10.1080/02770903.2024.2386634. PMID: 39072611
Fukasawa T, Yoshizaki-Ogawa A, Enomoto A, Yamashita T, Miyagawa K, Sato S, Yoshizaki A
Immunol Med 2024 Sep;47(3):118-129. Epub 2024 May 31 doi: 10.1080/25785826.2024.2360690. PMID: 38818750
Torres AJL, Marchioro SB, Ribeiro MB, de Morais IRB, Freire SM, Nascimento RJM
Crit Rev Immunol 2021;41(3):15-25. doi: 10.1615/CritRevImmunol.2021039675. PMID: 35378008
Chen HJ, Li Yim AYF, Griffith GR, de Jonge WJ, Mannens MMAM, Ferrero E, Henneman P, de Winther MPJ
Front Immunol 2019;10:2887. Epub 2019 Dec 11 doi: 10.3389/fimmu.2019.02887. PMID: 31921150Free PMC Article
Lee A, Kinney P, Chillrud S, Jack D
Ann Glob Health 2015 May-Jun;81(3):368-74. doi: 10.1016/j.aogh.2015.08.006. PMID: 26615071Free PMC Article

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