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Adnexal Adenocarcinoma, Not Otherwise Specified

MedGen UID:
1715455
•Concept ID:
C5238476
•
Neoplastic Process
Synonym: Adnexal Adenocarcinoma, NOS

Definition

An adnexal carcinoma with ductal/glandular differentiation lacking specific histological features that would allow further classification. (WHO 2018) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdnexal Adenocarcinoma, Not Otherwise Specified

Professional guidelines

PubMed

S1-Guideline Sebaceous Carcinoma.
Utikal J, Nagel P, Müller V, Becker JC, Dippel E, Frisman A, Gschnell M, Griewank K, Hadaschik E, Helbig D, Hillen U, Leiter U, Pföhler C, Krönig L, Ziemer M, Ugurel S
J Dtsch Dermatol Ges 2024 May;22(5):730-747. Epub 2024 Apr 28 doi: 10.1111/ddg.15405. PMID: 38679790
Periocular skin cancer: Diagnosis and management.
Moran JM, Phelps PO
Dis Mon 2020 Oct;66(10):101046. Epub 2020 Jun 27 doi: 10.1016/j.disamonth.2020.101046. PMID: 32600650
Treatment of Malignant Cutaneous Adnexal Neoplasms.
Bernárdez C, Requena L
Actas Dermosifiliogr (Engl Ed) 2018 Jan-Feb;109(1):6-23. Epub 2017 Oct 6 doi: 10.1016/j.ad.2017.04.005. PMID: 28988763

Recent clinical studies

Etiology

Sweat Gland Tumors Arising on Acral Sites: A Molecular Survey.
Kervarrec T, Tallet A, Macagno N, de la Fouchardière A, Pissaloux D, Tirode F, Bravo IG, Nicolas A, Baulande S, Sohier P, Balme B, Osio A, Jullie ML, Moulonguet I, Bonsang B, Tournier E, Herfs M, Frouin E, Zidan A, Calonje E, Berthon P, Touzé A, Seris A, Mortier L, Jouary T, Cribier B, Battistella M
Am J Surg Pathol 2023 Oct 1;47(10):1096-1107. Epub 2023 Jul 31 doi: 10.1097/PAS.0000000000002098. PMID: 37505808
Occult and subsequent cancer incidence following risk-reducing surgery in BRCA mutation carriers.
Zakhour M, Danovitch Y, Lester J, Rimel BJ, Walsh CS, Li AJ, Karlan BY, Cass I
Gynecol Oncol 2016 Nov;143(2):231-235. Epub 2016 Sep 9 doi: 10.1016/j.ygyno.2016.08.336. PMID: 27623252
Increased risk of histologically defined cancer subtypes in human immunodeficiency virus-infected individuals: clues for possible immunosuppression-related or infectious etiology.
Shiels MS, Engels EA
Cancer 2012 Oct 1;118(19):4869-76. Epub 2012 Feb 22 doi: 10.1002/cncr.27454. PMID: 22359254Free PMC Article
An immunohistochemical panel to differentiate metastatic breast carcinoma to skin from primary sweat gland carcinomas with a review of the literature.
Rollins-Raval M, Chivukula M, Tseng GC, Jukic D, Dabbs DJ
Arch Pathol Lab Med 2011 Aug;135(8):975-83. doi: 10.5858/2009-0445-OAR2. PMID: 21809988

Diagnosis

Ancillary immunohistochemical and molecular testing in the classification of cutaneous sweat gland/duct neoplasms: A validation study with emphasis on histomorphologic correlation and pathological diagnosis.
Nguyen AJ, Johnson E, Camilleri M, Wieland C, Lehman JS, Agrawal S, Comfere N, Fadra N, Knudson RA, Greipp P, Halling K, Ray Guo R
Hum Pathol 2024 Aug;150:1-8. Epub 2024 Jun 12 doi: 10.1016/j.humpath.2024.06.006. PMID: 38876201
Sweat Gland Tumors Arising on Acral Sites: A Molecular Survey.
Kervarrec T, Tallet A, Macagno N, de la Fouchardière A, Pissaloux D, Tirode F, Bravo IG, Nicolas A, Baulande S, Sohier P, Balme B, Osio A, Jullie ML, Moulonguet I, Bonsang B, Tournier E, Herfs M, Frouin E, Zidan A, Calonje E, Berthon P, Touzé A, Seris A, Mortier L, Jouary T, Cribier B, Battistella M
Am J Surg Pathol 2023 Oct 1;47(10):1096-1107. Epub 2023 Jul 31 doi: 10.1097/PAS.0000000000002098. PMID: 37505808
Extrauterine Mesonephric-like Carcinoma: A Comprehensive Single Institution Study of 33 Cases.
Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792
Occult and subsequent cancer incidence following risk-reducing surgery in BRCA mutation carriers.
Zakhour M, Danovitch Y, Lester J, Rimel BJ, Walsh CS, Li AJ, Karlan BY, Cass I
Gynecol Oncol 2016 Nov;143(2):231-235. Epub 2016 Sep 9 doi: 10.1016/j.ygyno.2016.08.336. PMID: 27623252
An immunohistochemical panel to differentiate metastatic breast carcinoma to skin from primary sweat gland carcinomas with a review of the literature.
Rollins-Raval M, Chivukula M, Tseng GC, Jukic D, Dabbs DJ
Arch Pathol Lab Med 2011 Aug;135(8):975-83. doi: 10.5858/2009-0445-OAR2. PMID: 21809988

Prognosis

Ancillary immunohistochemical and molecular testing in the classification of cutaneous sweat gland/duct neoplasms: A validation study with emphasis on histomorphologic correlation and pathological diagnosis.
Nguyen AJ, Johnson E, Camilleri M, Wieland C, Lehman JS, Agrawal S, Comfere N, Fadra N, Knudson RA, Greipp P, Halling K, Ray Guo R
Hum Pathol 2024 Aug;150:1-8. Epub 2024 Jun 12 doi: 10.1016/j.humpath.2024.06.006. PMID: 38876201
Extrauterine Mesonephric-like Carcinoma: A Comprehensive Single Institution Study of 33 Cases.
Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792
Occult and subsequent cancer incidence following risk-reducing surgery in BRCA mutation carriers.
Zakhour M, Danovitch Y, Lester J, Rimel BJ, Walsh CS, Li AJ, Karlan BY, Cass I
Gynecol Oncol 2016 Nov;143(2):231-235. Epub 2016 Sep 9 doi: 10.1016/j.ygyno.2016.08.336. PMID: 27623252
An immunohistochemical panel to differentiate metastatic breast carcinoma to skin from primary sweat gland carcinomas with a review of the literature.
Rollins-Raval M, Chivukula M, Tseng GC, Jukic D, Dabbs DJ
Arch Pathol Lab Med 2011 Aug;135(8):975-83. doi: 10.5858/2009-0445-OAR2. PMID: 21809988
Podoplanin is a highly sensitive and specific marker to distinguish primary skin adnexal carcinomas from adenocarcinomas metastatic to skin.
Liang H, Wu H, Giorgadze TA, Sariya D, Bellucci KS, Veerappan R, Liegl B, Acs G, Elenitsas R, Shukla S, Youngberg GA, Coogan PS, Pasha T, Zhang PJ, Xu X
Am J Surg Pathol 2007 Feb;31(2):304-10. doi: 10.1097/01.pas.0000213388.47913.f1. PMID: 17255777

Clinical prediction guides

Ancillary immunohistochemical and molecular testing in the classification of cutaneous sweat gland/duct neoplasms: A validation study with emphasis on histomorphologic correlation and pathological diagnosis.
Nguyen AJ, Johnson E, Camilleri M, Wieland C, Lehman JS, Agrawal S, Comfere N, Fadra N, Knudson RA, Greipp P, Halling K, Ray Guo R
Hum Pathol 2024 Aug;150:1-8. Epub 2024 Jun 12 doi: 10.1016/j.humpath.2024.06.006. PMID: 38876201
Sweat Gland Tumors Arising on Acral Sites: A Molecular Survey.
Kervarrec T, Tallet A, Macagno N, de la Fouchardière A, Pissaloux D, Tirode F, Bravo IG, Nicolas A, Baulande S, Sohier P, Balme B, Osio A, Jullie ML, Moulonguet I, Bonsang B, Tournier E, Herfs M, Frouin E, Zidan A, Calonje E, Berthon P, Touzé A, Seris A, Mortier L, Jouary T, Cribier B, Battistella M
Am J Surg Pathol 2023 Oct 1;47(10):1096-1107. Epub 2023 Jul 31 doi: 10.1097/PAS.0000000000002098. PMID: 37505808
Extrauterine Mesonephric-like Carcinoma: A Comprehensive Single Institution Study of 33 Cases.
Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792
An immunohistochemical panel to differentiate metastatic breast carcinoma to skin from primary sweat gland carcinomas with a review of the literature.
Rollins-Raval M, Chivukula M, Tseng GC, Jukic D, Dabbs DJ
Arch Pathol Lab Med 2011 Aug;135(8):975-83. doi: 10.5858/2009-0445-OAR2. PMID: 21809988
Podoplanin is a highly sensitive and specific marker to distinguish primary skin adnexal carcinomas from adenocarcinomas metastatic to skin.
Liang H, Wu H, Giorgadze TA, Sariya D, Bellucci KS, Veerappan R, Liegl B, Acs G, Elenitsas R, Shukla S, Youngberg GA, Coogan PS, Pasha T, Zhang PJ, Xu X
Am J Surg Pathol 2007 Feb;31(2):304-10. doi: 10.1097/01.pas.0000213388.47913.f1. PMID: 17255777

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