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Advanced Fibrosarcoma

MedGen UID:
1715457
•Concept ID:
C5239070
•
Neoplastic Process

Definition

Fibrosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Fibrosarcoma

Professional guidelines

PubMed

Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142Free PMC Article
Advances in the Diagnosis and Management of Neonatal Sarcomas.
Rashid T, Noyd DH, Iranzad N, Davis JT, Deel MD
Clin Perinatol 2021 Mar;48(1):117-145. doi: 10.1016/j.clp.2020.11.007. PMID: 33583500
Differential Diagnosis of Benign Spindle Cell Lesions.
Magro G
Surg Pathol Clin 2018 Mar;11(1):91-121. Epub 2017 Dec 9 doi: 10.1016/j.path.2017.09.005. PMID: 29413661

Recent clinical studies

Etiology

An update on selected cutaneous (myo) fibroblastic mesenchymal tumors.
Georgantzoglou N, Linos K
Semin Diagn Pathol 2023 Jul;40(4):295-305. Epub 2023 Apr 25 doi: 10.1053/j.semdp.2023.04.018. PMID: 37150655Free PMC Article
Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142Free PMC Article
Advances in the Diagnosis and Management of Neonatal Sarcomas.
Rashid T, Noyd DH, Iranzad N, Davis JT, Deel MD
Clin Perinatol 2021 Mar;48(1):117-145. doi: 10.1016/j.clp.2020.11.007. PMID: 33583500
Dermatofibrosarcoma Protuberans.
Reha J, Katz SC
Surg Clin North Am 2016 Oct;96(5):1031-46. doi: 10.1016/j.suc.2016.05.006. PMID: 27542641
The evolution of systemic therapy in sarcoma.
Constantinidou A, Pollack S, Loggers E, Rodler E, Jones RL
Expert Rev Anticancer Ther 2013 Feb;13(2):211-23. doi: 10.1586/era.12.161. PMID: 23406562

Diagnosis

Dermatofibrosarcoma Protuberans: What Is This?
Vitiello GA, Lee AY, Berman RS
Surg Clin North Am 2022 Aug;102(4):657-665. doi: 10.1016/j.suc.2022.05.004. PMID: 35952694
Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142Free PMC Article
Advances in the Diagnosis and Management of Neonatal Sarcomas.
Rashid T, Noyd DH, Iranzad N, Davis JT, Deel MD
Clin Perinatol 2021 Mar;48(1):117-145. doi: 10.1016/j.clp.2020.11.007. PMID: 33583500
Leptomeningeal metastases of solid cancer.
Le Rhun E, Galanis E
Curr Opin Neurol 2016 Dec;29(6):797-805. doi: 10.1097/WCO.0000000000000393. PMID: 27661208
Dermatofibrosarcoma Protuberans.
Reha J, Katz SC
Surg Clin North Am 2016 Oct;96(5):1031-46. doi: 10.1016/j.suc.2016.05.006. PMID: 27542641

Therapy

β-Sitosterol as a Promising Anticancer Agent for Chemoprevention and Chemotherapy: Mechanisms of Action and Future Prospects.
Wang H, Wang Z, Zhang Z, Liu J, Hong L
Adv Nutr 2023 Sep;14(5):1085-1110. Epub 2023 May 27 doi: 10.1016/j.advnut.2023.05.013. PMID: 37247842Free PMC Article
Cancer-associated fibroblast-derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib.
Eun JW, Yoon JH, Ahn HR, Kim S, Kim YB, Lim SB, Park W, Kang TW, Baek GO, Yoon MG, Son JA, Weon JH, Kim SS, Cho HJ, Cheong JY
Cancer Commun (Lond) 2023 Apr;43(4):455-479. Epub 2023 Mar 14 doi: 10.1002/cac2.12414. PMID: 36919193Free PMC Article
Dermatofibrosarcoma Protuberans.
Acosta AE, Vélez CS
Curr Treat Options Oncol 2017 Aug 10;18(9):56. doi: 10.1007/s11864-017-0498-5. PMID: 28795284
Leptomeningeal metastases of solid cancer.
Le Rhun E, Galanis E
Curr Opin Neurol 2016 Dec;29(6):797-805. doi: 10.1097/WCO.0000000000000393. PMID: 27661208
The evolution of systemic therapy in sarcoma.
Constantinidou A, Pollack S, Loggers E, Rodler E, Jones RL
Expert Rev Anticancer Ther 2013 Feb;13(2):211-23. doi: 10.1586/era.12.161. PMID: 23406562

Prognosis

Cancer-associated fibroblast-derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib.
Eun JW, Yoon JH, Ahn HR, Kim S, Kim YB, Lim SB, Park W, Kang TW, Baek GO, Yoon MG, Son JA, Weon JH, Kim SS, Cho HJ, Cheong JY
Cancer Commun (Lond) 2023 Apr;43(4):455-479. Epub 2023 Mar 14 doi: 10.1002/cac2.12414. PMID: 36919193Free PMC Article
The Biology of Myxofibrosarcoma: State of the Art and Future Perspectives.
Sambri A, De Paolis M, Spinnato P, Donati DM, Bianchi G
Oncol Res Treat 2020;43(6):314-322. Epub 2020 May 25 doi: 10.1159/000507334. PMID: 32450554
Dermatofibrosarcoma Protuberans.
Acosta AE, Vélez CS
Curr Treat Options Oncol 2017 Aug 10;18(9):56. doi: 10.1007/s11864-017-0498-5. PMID: 28795284
Fibrous and fibrohistiocytic neoplasms: an update.
Clarke LE
Dermatol Clin 2012 Oct;30(4):643-56, vi. Epub 2012 Aug 11 doi: 10.1016/j.det.2012.06.005. PMID: 23021051
Advances in management of dermatofibrosarcoma protuberans.
Johnson-Jahangir H, Ratner D
Dermatol Clin 2011 Apr;29(2):191-200, viii. doi: 10.1016/j.det.2011.02.003. PMID: 21421145

Clinical prediction guides

Cancer-associated fibroblast-derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib.
Eun JW, Yoon JH, Ahn HR, Kim S, Kim YB, Lim SB, Park W, Kang TW, Baek GO, Yoon MG, Son JA, Weon JH, Kim SS, Cho HJ, Cheong JY
Cancer Commun (Lond) 2023 Apr;43(4):455-479. Epub 2023 Mar 14 doi: 10.1002/cac2.12414. PMID: 36919193Free PMC Article
Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142Free PMC Article
A tonsillar location of a malignant schwannoma: a case report.
Boujguenna I, Ousehal H, Zaroual A, Bouderkaoui MEL, Raji A, Bouyaali C, Ganouni NCIE, Fakhri A, Rais H
Diagn Pathol 2022 May 30;17(1):48. doi: 10.1186/s13000-022-01226-3. PMID: 35637541Free PMC Article
"Hey! Whatever happened to hemangiopericytoma and fibrosarcoma?" An update on selected conceptual advances in soft tissue pathology which have occurred over the past 50 years.
Folpe AL
Hum Pathol 2020 Jan;95:113-136. Epub 2019 Oct 24 doi: 10.1016/j.humpath.2019.10.001. PMID: 31669060
A systems biology approach to overcome TRAIL resistance in cancer treatment.
Selvarajoo K
Prog Biophys Mol Biol 2017 Sep;128:142-154. Epub 2017 Mar 9 doi: 10.1016/j.pbiomolbio.2017.02.009. PMID: 28286052

Recent systematic reviews

Disease-Specific Mortality of Dermatofibrosarcoma Protuberans After Mohs Surgery Versus Wide Local Excision: A Systematic Review and Meta-Analysis.
Crum OM, O'Hern K, Demer AM, Brewer JD
Dermatol Surg 2024 Apr 1;50(4):317-321. Epub 2024 Feb 8 doi: 10.1097/DSS.0000000000004088. PMID: 38335454
Dermatofibrosarcoma protuberans of the scalp: Surgical management in a multicentric series of 11 cases and systematic review of the literature.
Kuhlmann C, Ehrl D, Taha S, Wachtel N, Schmid A, Bronsert P, Zeller J, Giunta RE, Eisenhardt SU, Braig D
Surgery 2023 Jun;173(6):1463-1475. Epub 2023 Apr 1 doi: 10.1016/j.surg.2023.02.026. PMID: 37012145
Imatinib Treatment for Locally Advanced or Metastatic Dermatofibrosarcoma Protuberans: A Systematic Review.
Navarrete-Dechent C, Mori S, Barker CA, Dickson MA, Nehal KS
JAMA Dermatol 2019 Mar 1;155(3):361-369. doi: 10.1001/jamadermatol.2018.4940. PMID: 30601909Free PMC Article
A systematic review of targeted agents for non-small cell lung cancer.
Vestergaard HH, Christensen MR, Lassen UN
Acta Oncol 2018 Feb;57(2):176-186. Epub 2017 Nov 25 doi: 10.1080/0284186X.2017.1404634. PMID: 29172833
A systematic review and meta-analysis of randomized trials on the role of targeted therapy in the management of advanced gastric cancer: Evidence does not translate?
Ciliberto D, Staropoli N, Caglioti F, Gualtieri S, Fiorillo L, Chiellino S, De Angelis AM, Mendicino F, Botta C, Caraglia M, Tassone P, Tagliaferri P
Cancer Biol Ther 2015;16(8):1148-59. Epub 2015 Jun 10 doi: 10.1080/15384047.2015.1056415. PMID: 26061272Free PMC Article

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