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Lipid-laden macrophages in bronchoalveolar fluid

MedGen UID:
1719296
•Concept ID:
C5397970
•
Finding
HPO: HP:0032978

Definition

Accumulation of lipids in alveolar macrophages with droplet-shaped fat inclusions. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLipid-laden macrophages in bronchoalveolar fluid

Professional guidelines

PubMed

Clinical Utility of Bronchoalveolar Lavage Pepsin in Diagnosis of Gastroesophageal Reflux among Wheezy Infants.
Abdallah AF, El-Desoky T, Fathi K, Elkashef WF, Zaki A
Can Respir J 2016;2016:9480843. Epub 2016 Jul 19 doi: 10.1155/2016/9480843. PMID: 27516725Free PMC Article
Clinical utility of flexible bronchoscopy and bronchoalveolar lavage in young children with recurrent wheezing.
Schellhase DE, Fawcett DD, Schutze GE, Lensing SY, Tryka AF
J Pediatr 1998 Feb;132(2):312-8. doi: 10.1016/s0022-3476(98)70451-2. PMID: 9506647

Recent clinical studies

Etiology

Bronchoalveolar lavage cytology in children with chronic unexplained cough and severely neurologically impaired children.
Pavić I, Karačić DE, Hojsak I
Lab Med 2024 Jan 6;55(1):20-26. doi: 10.1093/labmed/lmad028. PMID: 37078851
Bronchoalveolar lavage profiles in uncontrolled wheezy children compared by asthma predictive index.
Ezmigna D, Brown M, Daines C, Morgan W
Pediatr Pulmonol 2022 Jan;57(1):293-299. Epub 2021 Oct 18 doi: 10.1002/ppul.25716. PMID: 34609079
Systemic Juvenile Idiopathic Arthritis-Associated Lung Disease: Characterization and Risk Factors.
Schulert GS, Yasin S, Carey B, Chalk C, Do T, Schapiro AH, Husami A, Watts A, Brunner HI, Huggins J, Mellins ED, Morgan EM, Ting T, Trapnell BC, Wikenheiser-Brokamp KA, Towe C, Grom AA
Arthritis Rheumatol 2019 Nov;71(11):1943-1954. Epub 2019 Oct 1 doi: 10.1002/art.41073. PMID: 31379071Free PMC Article
Lipid-laden bronchoalveolar macrophages in asthma and chronic cough.
Gibeon D, Zhu J, Sogbesan A, Banya W, Rossios C, Saito J, Rocha JP, Hull JH, Menzies-Gow AN, Bhavsar PK, Chung KF
Respir Med 2014 Jan;108(1):71-7. Epub 2013 Oct 10 doi: 10.1016/j.rmed.2013.10.005. PMID: 24172051
Lipoid pneumonia: an overview.
Hadda V, Khilnani GC
Expert Rev Respir Med 2010 Dec;4(6):799-807. doi: 10.1586/ers.10.74. PMID: 21128754

Diagnosis

Lipid-laden macrophage index as a marker of aspiration in children, is it reliable? A scoping review.
Orishchak O, Moise A, Al-Osamey F, Kaspy K, Daniel SJ
Int J Pediatr Otorhinolaryngol 2024 Nov;186:112151. Epub 2024 Oct 28 doi: 10.1016/j.ijporl.2024.112151. PMID: 39504853
Testing for lipid-laden macrophages in bronchoalveolar lavage fluid to diagnose vaping-associated pulmonary injury. Are we there yet?
Pambuccian SE
J Am Soc Cytopathol 2020 Jan-Feb;9(1):1-8. Epub 2019 Nov 6 doi: 10.1016/j.jasc.2019.10.002. PMID: 31735586
Systemic Juvenile Idiopathic Arthritis-Associated Lung Disease: Characterization and Risk Factors.
Schulert GS, Yasin S, Carey B, Chalk C, Do T, Schapiro AH, Husami A, Watts A, Brunner HI, Huggins J, Mellins ED, Morgan EM, Ting T, Trapnell BC, Wikenheiser-Brokamp KA, Towe C, Grom AA
Arthritis Rheumatol 2019 Nov;71(11):1943-1954. Epub 2019 Oct 1 doi: 10.1002/art.41073. PMID: 31379071Free PMC Article
The utility of the lipid-laden macrophage index for the evaluation of aspiration in children.
Lahiri T
Cancer Cytopathol 2014 Mar;122(3):161-2. Epub 2013 Dec 2 doi: 10.1002/cncy.21365. PMID: 24302605
Lipoid pneumonia: an overview.
Hadda V, Khilnani GC
Expert Rev Respir Med 2010 Dec;4(6):799-807. doi: 10.1586/ers.10.74. PMID: 21128754

Therapy

Bronchoalveolar lavage cytology in children with chronic unexplained cough and severely neurologically impaired children.
Pavić I, Karačić DE, Hojsak I
Lab Med 2024 Jan 6;55(1):20-26. doi: 10.1093/labmed/lmad028. PMID: 37078851
E-cigarette or vaping product use-associated lung injury: A review of clinico-radio-pathological characteristics.
Garg I, Vidholia A, Garg A, Singh S, Agahi A, Laroia A, Saboo SS, Comellas AP, Hoffman EA, Nagpal P
Respir Investig 2022 Nov;60(6):738-749. Epub 2022 Aug 11 doi: 10.1016/j.resinv.2022.06.011. PMID: 35963780
Testing for lipid-laden macrophages in bronchoalveolar lavage fluid to diagnose vaping-associated pulmonary injury. Are we there yet?
Pambuccian SE
J Am Soc Cytopathol 2020 Jan-Feb;9(1):1-8. Epub 2019 Nov 6 doi: 10.1016/j.jasc.2019.10.002. PMID: 31735586
Reflux aspiration in children with neurodisability--a significant problem, but can we measure it?
Trinick R, Johnston N, Dalzell AM, McNamara PS
J Pediatr Surg 2012 Feb;47(2):291-8. doi: 10.1016/j.jpedsurg.2011.11.019. PMID: 22325378
Lipoid pneumonia: an uncommon entity.
Khilnani GC, Hadda V
Indian J Med Sci 2009 Oct;63(10):474-80. PMID: 19901490

Prognosis

Bronchoalveolar lavage profiles in uncontrolled wheezy children compared by asthma predictive index.
Ezmigna D, Brown M, Daines C, Morgan W
Pediatr Pulmonol 2022 Jan;57(1):293-299. Epub 2021 Oct 18 doi: 10.1002/ppul.25716. PMID: 34609079
Clinical predictors of laryngotracheoesophageal clefts and tracheoesophageal fistulae in children with dysphagia.
Mattos C, Phinizy P, Duffy KL, Sobol S, Piccione J
Pediatr Pulmonol 2021 Dec;56(12):3792-3795. Epub 2021 Aug 27 doi: 10.1002/ppul.25628. PMID: 34387933
Lipoid pneumonia: an overview.
Hadda V, Khilnani GC
Expert Rev Respir Med 2010 Dec;4(6):799-807. doi: 10.1586/ers.10.74. PMID: 21128754
The lipid laden macrophage index as a marker of aspiration in patients with type I and II laryngeal clefts.
Kieran SM, Katz E, Rosen R, Khatwa U, Martin T, Rahbar R
Int J Pediatr Otorhinolaryngol 2010 Jul;74(7):743-6. Epub 2010 Apr 14 doi: 10.1016/j.ijporl.2010.03.028. PMID: 20394993
Lipoid pneumonia: an uncommon entity.
Khilnani GC, Hadda V
Indian J Med Sci 2009 Oct;63(10):474-80. PMID: 19901490

Clinical prediction guides

Lipid-laden macrophage index as a marker of aspiration in children, is it reliable? A scoping review.
Orishchak O, Moise A, Al-Osamey F, Kaspy K, Daniel SJ
Int J Pediatr Otorhinolaryngol 2024 Nov;186:112151. Epub 2024 Oct 28 doi: 10.1016/j.ijporl.2024.112151. PMID: 39504853
Bronchoalveolar lavage profiles in uncontrolled wheezy children compared by asthma predictive index.
Ezmigna D, Brown M, Daines C, Morgan W
Pediatr Pulmonol 2022 Jan;57(1):293-299. Epub 2021 Oct 18 doi: 10.1002/ppul.25716. PMID: 34609079
Clinical predictors of laryngotracheoesophageal clefts and tracheoesophageal fistulae in children with dysphagia.
Mattos C, Phinizy P, Duffy KL, Sobol S, Piccione J
Pediatr Pulmonol 2021 Dec;56(12):3792-3795. Epub 2021 Aug 27 doi: 10.1002/ppul.25628. PMID: 34387933
Lipid-laden bronchoalveolar macrophages in asthma and chronic cough.
Gibeon D, Zhu J, Sogbesan A, Banya W, Rossios C, Saito J, Rocha JP, Hull JH, Menzies-Gow AN, Bhavsar PK, Chung KF
Respir Med 2014 Jan;108(1):71-7. Epub 2013 Oct 10 doi: 10.1016/j.rmed.2013.10.005. PMID: 24172051
Lipoid pneumonia: an overview.
Hadda V, Khilnani GC
Expert Rev Respir Med 2010 Dec;4(6):799-807. doi: 10.1586/ers.10.74. PMID: 21128754

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