U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Advanced Colorectal Adenocarcinoma

MedGen UID:
1719745
•Concept ID:
C5237826
•
Neoplastic Process

Definition

Colorectal adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Colorectal Adenocarcinoma

Professional guidelines

PubMed

Early magnesium modifications as a surrogate marker of efficacy of cetuximab-based anticancer treatment in KRAS wild-type advanced colorectal cancer patients.
Vincenzi B, Galluzzo S, Santini D, Rocci L, Loupakis F, Correale P, Addeo R, Zoccoli A, Napolitano A, Graziano F, Ruzzo A, Falcone A, Francini G, Dicuonzo G, Tonini G
Ann Oncol 2011 May;22(5):1141-1146. Epub 2010 Nov 29 doi: 10.1093/annonc/mdq550. PMID: 21115601
Phase II trial of mitomycin plus cisplatin in the treatment of advanced colorectal adenocarcinoma.
Demicheli R, Jirillo A, Bonciarelli G, Lonardi F, Balli M
Tumori 1987 Oct 31;73(5):505-6. doi: 10.1177/030089168707300513. PMID: 3686683
Long-term ambulatory treatment of metastatic colorectal adenocarcinoma by continuous intravenous infusion of 5-fluorouracil.
Quebbeman E, Ausman R, Hansen R, Becker T, Caballero G, Ritch P, Jenkins D, Blake D, Tangen L, Schulte W
J Surg Oncol 1985 Sep;30(1):60-5. doi: 10.1002/jso.2930300115. PMID: 3935873

Recent clinical studies

Etiology

Chemokine- and chemokine receptor-based signature predicts immunotherapy response in female colorectal adenocarcinoma patients.
Zhu W, Wu C, Hu S, Liu S, Zhao S, Zhang D, Qiu G, Cheng X, Huang J
Sci Rep 2023 Dec 4;13(1):21358. doi: 10.1038/s41598-023-48623-2. PMID: 38049474Free PMC Article
Mucinous histology is associated with poor prognosis in locally advanced colorectal adenocarcinoma treated with postoperative first-line adjuvant chemotherapy: A systematic review and meta-analysis.
Zhang Y, Chen Y, Huang J, Wu X, Tang R, Huang Q, Xu Y, Peng X, Fu K, Xiao S
Eur J Surg Oncol 2022 Oct;48(10):2075-2081. Epub 2022 Jun 23 doi: 10.1016/j.ejso.2022.06.024. PMID: 35768312
MET and RON receptor tyrosine kinases in colorectal adenocarcinoma: molecular features as drug targets and antibody-drug conjugates for therapy.
Yao HP, Tong XM, Hudson R, Wang MH
J Exp Clin Cancer Res 2020 Sep 22;39(1):198. doi: 10.1186/s13046-020-01711-x. PMID: 32962738Free PMC Article
Revisiting the Cancer and Leukemia Group B/Southwest Oncology Group 80405 Trial: a phase III trial of chemotherapy and biologic agents for patients with untreated advanced colorectal adenocarcinoma.
Venook AP, Blanke CD, Niedzwiecki D, Lenz HJ, Taylor JR, Hollis DR, Sutherland S, Goldberg RM
Clin Colorectal Cancer 2007 May;6(7):536-8. doi: 10.3816/CCC.2007.n.021. PMID: 17553204
Cancer and Leukemia Group B/Southwest Oncology Group trial 80405: a phase III trial of chemotherapy and biologics for patients with untreated advanced colorectal adenocarcinoma.
Venook AP, Blanke CD, Niedzwiecki D, Lenz HJ, Taylor JR, Hollis DR, Sutherland S, Goldberg RM
Clin Colorectal Cancer 2005 Nov;5(4):292-4. doi: 10.3816/ccc.2005.n.043. PMID: 16356309

Diagnosis

RAS Mutational Status in Advanced Colorectal Adenocarcinoma Treated With Anti-angiogenics: Preliminary Experience With Liquid Biopsy.
DE Santiago BG, López-Gómez M, Delgado-López PD, Gordo AJ, Neria F, Thuissard-Vasallo IJ, Gómez-Raposo C, Tevar FZ, Moreno-Rubio J, Hernández AM, Iglesias I, Casado E
In Vivo 2021 Sep-Oct;35(5):2841-2844. doi: 10.21873/invivo.12571. PMID: 34410976Free PMC Article
Primary adenocarcinoma of the bladder lacks mismatch repair deficiency and demonstrates PD-L1 expression in tumor-infiltrating immune cells, with implications in both diagnosis and therapeutics.
Jones D, Guan JJ, Calagua C, Hansel DE, Epstein JI, Ye H
Hum Pathol 2019 Dec;94:58-63. Epub 2019 Oct 27 doi: 10.1016/j.humpath.2019.10.005. PMID: 31666198
Computer Aided Diagnosis for Confocal Laser Endomicroscopy in Advanced Colorectal Adenocarcinoma.
Ştefănescu D, Streba C, Cârţână ET, Săftoiu A, Gruionu G, Gruionu LG
PLoS One 2016;11(5):e0154863. Epub 2016 May 4 doi: 10.1371/journal.pone.0154863. PMID: 27144985Free PMC Article
Secreted recombinant P53 protein from Pichia pastoris is a useful antigen for detection of serum p53: autoantibody in patients with advanced colorectal adenocarcinoma.
Abdelmoula-Souissi S, Zouari N, Miladi-Abdenadher I, Yaich-Kolsi O, Ayadi-Masmoudi I, Khabir A, Masmoudi H, Frikha M, Mokdad-Gargouri R
Mol Biol Rep 2013 May;40(5):3865-72. Epub 2013 Mar 26 doi: 10.1007/s11033-012-2467-1. PMID: 23526366
Treatment of advanced colorectal adenocarcinoma with weekly high-dose l-leucovorin and 5-fluorouracil.
Nozue M, Isaka N, Maruyama T, Kawamoto T, Seino KI, Tanagichi H, Fukao K
Oncol Rep 2002 Jan-Feb;9(1):93-6. PMID: 11748463

Therapy

TAS-102, Irinotecan, and bevacizumab in pre-treated metastatic colorectal cancer (TABAsCO), a phase II clinical trial.
Boland PM, Mukherjee S, Imanirad I, Vijayvergia N, Cohen SD, Gupta M, Iyer RV, Bakin A, Wang J, Chatley S, Cahill B, Vadehra D, Attwood K, Hochster HS, Fountzilas C
Br J Cancer 2024 Nov;131(8):1290-1297. Epub 2024 Sep 7 doi: 10.1038/s41416-024-02845-x. PMID: 39244627Free PMC Article
RAS Mutational Status in Advanced Colorectal Adenocarcinoma Treated With Anti-angiogenics: Preliminary Experience With Liquid Biopsy.
DE Santiago BG, López-Gómez M, Delgado-López PD, Gordo AJ, Neria F, Thuissard-Vasallo IJ, Gómez-Raposo C, Tevar FZ, Moreno-Rubio J, Hernández AM, Iglesias I, Casado E
In Vivo 2021 Sep-Oct;35(5):2841-2844. doi: 10.21873/invivo.12571. PMID: 34410976Free PMC Article
Revisiting the Cancer and Leukemia Group B/Southwest Oncology Group 80405 Trial: a phase III trial of chemotherapy and biologic agents for patients with untreated advanced colorectal adenocarcinoma.
Venook AP, Blanke CD, Niedzwiecki D, Lenz HJ, Taylor JR, Hollis DR, Sutherland S, Goldberg RM
Clin Colorectal Cancer 2007 May;6(7):536-8. doi: 10.3816/CCC.2007.n.021. PMID: 17553204
Cancer and Leukemia Group B/Southwest Oncology Group trial 80405: a phase III trial of chemotherapy and biologics for patients with untreated advanced colorectal adenocarcinoma.
Venook AP, Blanke CD, Niedzwiecki D, Lenz HJ, Taylor JR, Hollis DR, Sutherland S, Goldberg RM
Clin Colorectal Cancer 2005 Nov;5(4):292-4. doi: 10.3816/ccc.2005.n.043. PMID: 16356309
Adriamycin, mitomycin C, and 5-fluorouracil in combination for advanced colorectal adenocarcinoma previously treated with 5-fluorouracil.
Kessinger MA, Foley JF, Lemon HM
Cancer Clin Trials 1979 Winter;2(4):317-9. PMID: 394867

Prognosis

Chemokine- and chemokine receptor-based signature predicts immunotherapy response in female colorectal adenocarcinoma patients.
Zhu W, Wu C, Hu S, Liu S, Zhao S, Zhang D, Qiu G, Cheng X, Huang J
Sci Rep 2023 Dec 4;13(1):21358. doi: 10.1038/s41598-023-48623-2. PMID: 38049474Free PMC Article
Mucinous histology is associated with poor prognosis in locally advanced colorectal adenocarcinoma treated with postoperative first-line adjuvant chemotherapy: A systematic review and meta-analysis.
Zhang Y, Chen Y, Huang J, Wu X, Tang R, Huang Q, Xu Y, Peng X, Fu K, Xiao S
Eur J Surg Oncol 2022 Oct;48(10):2075-2081. Epub 2022 Jun 23 doi: 10.1016/j.ejso.2022.06.024. PMID: 35768312
MET and RON receptor tyrosine kinases in colorectal adenocarcinoma: molecular features as drug targets and antibody-drug conjugates for therapy.
Yao HP, Tong XM, Hudson R, Wang MH
J Exp Clin Cancer Res 2020 Sep 22;39(1):198. doi: 10.1186/s13046-020-01711-x. PMID: 32962738Free PMC Article
Phosphorylation status of Akt and caspase-9 in gastric and colorectal carcinomas.
Sangawa A, Shintani M, Yamao N, Kamoshida S
Int J Clin Exp Pathol 2014;7(6):3312-7. Epub 2014 May 15 PMID: 25031754Free PMC Article
Treatment of advanced colorectal adenocarcinoma with weekly high-dose l-leucovorin and 5-fluorouracil.
Nozue M, Isaka N, Maruyama T, Kawamoto T, Seino KI, Tanagichi H, Fukao K
Oncol Rep 2002 Jan-Feb;9(1):93-6. PMID: 11748463

Clinical prediction guides

Chemokine- and chemokine receptor-based signature predicts immunotherapy response in female colorectal adenocarcinoma patients.
Zhu W, Wu C, Hu S, Liu S, Zhao S, Zhang D, Qiu G, Cheng X, Huang J
Sci Rep 2023 Dec 4;13(1):21358. doi: 10.1038/s41598-023-48623-2. PMID: 38049474Free PMC Article
Mucinous histology is associated with poor prognosis in locally advanced colorectal adenocarcinoma treated with postoperative first-line adjuvant chemotherapy: A systematic review and meta-analysis.
Zhang Y, Chen Y, Huang J, Wu X, Tang R, Huang Q, Xu Y, Peng X, Fu K, Xiao S
Eur J Surg Oncol 2022 Oct;48(10):2075-2081. Epub 2022 Jun 23 doi: 10.1016/j.ejso.2022.06.024. PMID: 35768312
Association of overexpression of TIF1γ with colorectal carcinogenesis and advanced colorectal adenocarcinoma.
Jain S, Singhal S, Francis F, Hajdu C, Wang JH, Suriawinata A, Wang YQ, Zhang M, Weinshel EH, Francois F, Pei ZH, Lee P, Xu RL
World J Gastroenterol 2011 Sep 21;17(35):3994-4000. doi: 10.3748/wjg.v17.i35.3994. PMID: 22046087Free PMC Article
Phase II study of 3-deazauridine in advanced colorectal adenocarcinoma.
Bruno S, Creaven PJ, Ledesma E, Poster D, Yoon J, Mittelman A
Am J Clin Oncol 1982 Feb;5(1):69-71. PMID: 7081140
Adriamycin, mitomycin C, and 5-fluorouracil in combination for advanced colorectal adenocarcinoma previously treated with 5-fluorouracil.
Kessinger MA, Foley JF, Lemon HM
Cancer Clin Trials 1979 Winter;2(4):317-9. PMID: 394867

Recent systematic reviews

Mucinous histology is associated with poor prognosis in locally advanced colorectal adenocarcinoma treated with postoperative first-line adjuvant chemotherapy: A systematic review and meta-analysis.
Zhang Y, Chen Y, Huang J, Wu X, Tang R, Huang Q, Xu Y, Peng X, Fu K, Xiao S
Eur J Surg Oncol 2022 Oct;48(10):2075-2081. Epub 2022 Jun 23 doi: 10.1016/j.ejso.2022.06.024. PMID: 35768312

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...