U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Steatohepatitic Hepatocellular Carcinoma

MedGen UID:
1728788
•Concept ID:
C5417718
•
Neoplastic Process

Definition

Hepatocellular carcinoma characterized by the presence of steatohepatitis features, including macrovesicular steatosis, fibrosis, ballooning of malignant hepatocytes, Mallory bodies, and inflammation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSteatohepatitic Hepatocellular Carcinoma

Recent clinical studies

Etiology

Imaging and prognostic characterization of fat-containing hepatocellular carcinoma subtypes.
Faure A, Dioguardi Burgio M, Cannella R, Sartoris R, Bouattour M, Hobeika C, Cauchy F, Trapani L, Beaufrère A, Vilgrain V, Ronot M
Radiol Med 2024 May;129(5):687-701. Epub 2024 Mar 21 doi: 10.1007/s11547-024-01807-w. PMID: 38512627
Pathological overview of steatohepatitic hepatocellular carcinoma in a surgical series.
Trapani L, Beaufrère A, Hobeika C, Codjia T, Albuquerque M, Bouattour M, Lesurtel M, Cauchy F, Paradis V
Histopathology 2023 Oct;83(4):526-537. Epub 2023 May 24 doi: 10.1111/his.14941. PMID: 37222200
Clinicopathological assessment of steatohepatitic hepatocellular carcinoma.
Yamaoka K, Saitoh S, Kinowaki K, Fujiyama S, Kawamura Y, Sezaki H, Hosaka T, Akuta N, Kobayashi M, Suzuki F, Suzuki Y, Arase Y, Ikeda K, Fukusato T, Kumada H
Clin Res Hepatol Gastroenterol 2022 Oct;46(8):101799. Epub 2021 Sep 7 doi: 10.1016/j.clinre.2021.101799. PMID: 34500120
Steatotic and Steatohepatitic Hepatocellular Carcinomas: Features in a Series With Predominantly Viral Etiology.
Aykutlu U, Argon A, Orman M, Ulukaya S, Zeytunlu M, Karasu Z, Günşar F, Nart D, Akarca U, Yilmaz F
Am J Surg Pathol 2021 Sep 1;45(9):1252-1263. doi: 10.1097/PAS.0000000000001714. PMID: 33826548
The steatohepatitic variant of hepatocellular carcinoma and its association with underlying steatohepatitis.
Salomao M, Remotti H, Vaughan R, Siegel AB, Lefkowitch JH, Moreira RK
Hum Pathol 2012 May;43(5):737-46. Epub 2011 Oct 20 doi: 10.1016/j.humpath.2011.07.005. PMID: 22018903

Diagnosis

Imaging and prognostic characterization of fat-containing hepatocellular carcinoma subtypes.
Faure A, Dioguardi Burgio M, Cannella R, Sartoris R, Bouattour M, Hobeika C, Cauchy F, Trapani L, Beaufrère A, Vilgrain V, Ronot M
Radiol Med 2024 May;129(5):687-701. Epub 2024 Mar 21 doi: 10.1007/s11547-024-01807-w. PMID: 38512627
Clinicopathological assessment of steatohepatitic hepatocellular carcinoma.
Yamaoka K, Saitoh S, Kinowaki K, Fujiyama S, Kawamura Y, Sezaki H, Hosaka T, Akuta N, Kobayashi M, Suzuki F, Suzuki Y, Arase Y, Ikeda K, Fukusato T, Kumada H
Clin Res Hepatol Gastroenterol 2022 Oct;46(8):101799. Epub 2021 Sep 7 doi: 10.1016/j.clinre.2021.101799. PMID: 34500120
Steatohepatitic hepatocellular carcinoma: imaging findings with clinicopathological correlation.
Inui S, Kondo H, Tanahashi Y, Fukukura Y, Sano K, Morisaka H, Saito K, Kondo F, Fukusato T, Furui S, Oba H
Clin Radiol 2021 Feb;76(2):160.e15-160.e25. Epub 2020 Oct 10 doi: 10.1016/j.crad.2020.09.011. PMID: 33046228
Distinctive features of hepatocellular carcinoma in non-alcoholic fatty liver disease.
Degasperi E, Colombo M
Lancet Gastroenterol Hepatol 2016 Oct;1(2):156-164. Epub 2016 Sep 8 doi: 10.1016/S2468-1253(16)30018-8. PMID: 28404072
The steatohepatitic variant of hepatocellular carcinoma and its association with underlying steatohepatitis.
Salomao M, Remotti H, Vaughan R, Siegel AB, Lefkowitch JH, Moreira RK
Hum Pathol 2012 May;43(5):737-46. Epub 2011 Oct 20 doi: 10.1016/j.humpath.2011.07.005. PMID: 22018903

Therapy

Steatohepatitic hepatocellular Carcinoma:A new approach to classifying morphological subtypes of hepatocellular carcinoma.
Soon GST, Callea F, Burt AD, Cook S, Terracciano L, Ercan C, Dienes HP, Goodman ZD, Roberts EA, Clouston AD, Gouw ASH, Kleiner DE, Park YN, Chung T, Schirmacher P, Tiniakos D, Dimopoulou K, Weber A, Endhardt K, Torbenson M
Hum Pathol 2024 Jul;149:55-65. Epub 2024 Jun 12 doi: 10.1016/j.humpath.2024.06.007. PMID: 38876199

Prognosis

Imaging and prognostic characterization of fat-containing hepatocellular carcinoma subtypes.
Faure A, Dioguardi Burgio M, Cannella R, Sartoris R, Bouattour M, Hobeika C, Cauchy F, Trapani L, Beaufrère A, Vilgrain V, Ronot M
Radiol Med 2024 May;129(5):687-701. Epub 2024 Mar 21 doi: 10.1007/s11547-024-01807-w. PMID: 38512627
Pathological overview of steatohepatitic hepatocellular carcinoma in a surgical series.
Trapani L, Beaufrère A, Hobeika C, Codjia T, Albuquerque M, Bouattour M, Lesurtel M, Cauchy F, Paradis V
Histopathology 2023 Oct;83(4):526-537. Epub 2023 May 24 doi: 10.1111/his.14941. PMID: 37222200
Steatotic and Steatohepatitic Hepatocellular Carcinomas: Features in a Series With Predominantly Viral Etiology.
Aykutlu U, Argon A, Orman M, Ulukaya S, Zeytunlu M, Karasu Z, Günşar F, Nart D, Akarca U, Yilmaz F
Am J Surg Pathol 2021 Sep 1;45(9):1252-1263. doi: 10.1097/PAS.0000000000001714. PMID: 33826548
Distinctive features of hepatocellular carcinoma in non-alcoholic fatty liver disease.
Degasperi E, Colombo M
Lancet Gastroenterol Hepatol 2016 Oct;1(2):156-164. Epub 2016 Sep 8 doi: 10.1016/S2468-1253(16)30018-8. PMID: 28404072
Steatohepatitic hepatocellular carcinoma, a morphologic indicator of associated metabolic risk factors: a study from India.
Jain D, Nayak NC, Kumaran V, Saigal S
Arch Pathol Lab Med 2013 Jul;137(7):961-6. doi: 10.5858/arpa.2012-0048-OA. PMID: 23808468

Clinical prediction guides

Imaging and prognostic characterization of fat-containing hepatocellular carcinoma subtypes.
Faure A, Dioguardi Burgio M, Cannella R, Sartoris R, Bouattour M, Hobeika C, Cauchy F, Trapani L, Beaufrère A, Vilgrain V, Ronot M
Radiol Med 2024 May;129(5):687-701. Epub 2024 Mar 21 doi: 10.1007/s11547-024-01807-w. PMID: 38512627
Steatohepatitic hepatocellular carcinoma: imaging findings with clinicopathological correlation.
Inui S, Kondo H, Tanahashi Y, Fukukura Y, Sano K, Morisaka H, Saito K, Kondo F, Fukusato T, Furui S, Oba H
Clin Radiol 2021 Feb;76(2):160.e15-160.e25. Epub 2020 Oct 10 doi: 10.1016/j.crad.2020.09.011. PMID: 33046228
Steatohepatitic variant of hepatocellular carcinoma in the absence of metabolic syndrome or background steatosis: a clinical, pathological, and genetic study.
Yeh MM, Liu Y, Torbenson M
Hum Pathol 2015 Nov;46(11):1769-75. Epub 2015 Aug 4 doi: 10.1016/j.humpath.2015.07.018. PMID: 26410018
Steatohepatitic hepatocellular carcinoma, a morphologic indicator of associated metabolic risk factors: a study from India.
Jain D, Nayak NC, Kumaran V, Saigal S
Arch Pathol Lab Med 2013 Jul;137(7):961-6. doi: 10.5858/arpa.2012-0048-OA. PMID: 23808468

Supplemental Content

Table of contents

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...