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Advanced Cutaneous Melanoma

MedGen UID:
1728947
•Concept ID:
C5419184
•
Neoplastic Process

Definition

Cutaneous melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Cutaneous Melanoma

Professional guidelines

PubMed

Clinical treatment options for early-stage and advanced conjunctival melanoma.
Zeng Y, Hu C, Shu L, Pan Y, Zhao L, Pu X, Wu F
Surv Ophthalmol 2021 May-Jun;66(3):461-470. Epub 2020 Sep 25 doi: 10.1016/j.survophthal.2020.09.004. PMID: 32980421
Nivolumab and ipilimumab: immunotherapy for treatment of malignant melanoma.
Carreau NA, Pavlick AC
Future Oncol 2019 Feb;15(4):349-358. Epub 2018 Oct 18 doi: 10.2217/fon-2018-0607. PMID: 30334646
Mucosal Melanoma: Epidemiology, Biology and Treatment.
Spencer KR, Mehnert JM
Cancer Treat Res 2016;167:295-320. doi: 10.1007/978-3-319-22539-5_13. PMID: 26601869

Recent clinical studies

Etiology

Recent and Emerging Therapies for Cutaneous Squamous Cell Carcinomas of the Head and Neck.
Varra V, Smile TD, Geiger JL, Koyfman SA
Curr Treat Options Oncol 2020 Apr 23;21(5):37. doi: 10.1007/s11864-020-00739-7. PMID: 32328817
Efficacy of adoptive therapy with tumor-infiltrating lymphocytes and recombinant interleukin-2 in advanced cutaneous melanoma: a systematic review and meta-analysis.
Dafni U, Michielin O, Lluesma SM, Tsourti Z, Polydoropoulou V, Karlis D, Besser MJ, Haanen J, Svane IM, Ohashi PS, Kammula US, Orcurto A, Zimmermann S, Trueb L, Klebanoff CA, Lotze MT, Kandalaft LE, Coukos G
Ann Oncol 2019 Dec 1;30(12):1902-1913. doi: 10.1093/annonc/mdz398. PMID: 31566658
Melanoma.
Schadendorf D, van Akkooi ACJ, Berking C, Griewank KG, Gutzmer R, Hauschild A, Stang A, Roesch A, Ugurel S
Lancet 2018 Sep 15;392(10151):971-984. doi: 10.1016/S0140-6736(18)31559-9. PMID: 30238891
Checkpoint inhibition for advanced mucosal melanoma.
Thierauf J, Veit JA, Hess J, Treiber N, Lisson C, Weissinger SE, Bommer M, Hoffmann TK
Eur J Dermatol 2017 Apr 1;27(2):160-165. doi: 10.1684/ejd.2016.2949. PMID: 28174141
Mucosal Melanoma: Epidemiology, Biology and Treatment.
Spencer KR, Mehnert JM
Cancer Treat Res 2016;167:295-320. doi: 10.1007/978-3-319-22539-5_13. PMID: 26601869

Diagnosis

Multiomic profiling of checkpoint inhibitor-treated melanoma: Identifying predictors of response and resistance, and markers of biological discordance.
Newell F, Pires da Silva I, Johansson PA, Menzies AM, Wilmott JS, Addala V, Carlino MS, Rizos H, Nones K, Edwards JJ, Lakis V, Kazakoff SH, Mukhopadhyay P, Ferguson PM, Leonard C, Koufariotis LT, Wood S, Blank CU, Thompson JF, Spillane AJ, Saw RPM, Shannon KF, Pearson JV, Mann GJ, Hayward NK, Scolyer RA, Waddell N, Long GV
Cancer Cell 2022 Jan 10;40(1):88-102.e7. Epub 2021 Dec 23 doi: 10.1016/j.ccell.2021.11.012. PMID: 34951955
Recent and Emerging Therapies for Cutaneous Squamous Cell Carcinomas of the Head and Neck.
Varra V, Smile TD, Geiger JL, Koyfman SA
Curr Treat Options Oncol 2020 Apr 23;21(5):37. doi: 10.1007/s11864-020-00739-7. PMID: 32328817
Efficacy of adoptive therapy with tumor-infiltrating lymphocytes and recombinant interleukin-2 in advanced cutaneous melanoma: a systematic review and meta-analysis.
Dafni U, Michielin O, Lluesma SM, Tsourti Z, Polydoropoulou V, Karlis D, Besser MJ, Haanen J, Svane IM, Ohashi PS, Kammula US, Orcurto A, Zimmermann S, Trueb L, Klebanoff CA, Lotze MT, Kandalaft LE, Coukos G
Ann Oncol 2019 Dec 1;30(12):1902-1913. doi: 10.1093/annonc/mdz398. PMID: 31566658
Nivolumab and ipilimumab: immunotherapy for treatment of malignant melanoma.
Carreau NA, Pavlick AC
Future Oncol 2019 Feb;15(4):349-358. Epub 2018 Oct 18 doi: 10.2217/fon-2018-0607. PMID: 30334646
Mucosal Melanoma: Epidemiology, Biology and Treatment.
Spencer KR, Mehnert JM
Cancer Treat Res 2016;167:295-320. doi: 10.1007/978-3-319-22539-5_13. PMID: 26601869

Therapy

Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma.
Lee KA, Thomas AM, Bolte LA, Björk JR, de Ruijter LK, Armanini F, Asnicar F, Blanco-Miguez A, Board R, Calbet-Llopart N, Derosa L, Dhomen N, Brooks K, Harland M, Harries M, Leeming ER, Lorigan P, Manghi P, Marais R, Newton-Bishop J, Nezi L, Pinto F, Potrony M, Puig S, Serra-Bellver P, Shaw HM, Tamburini S, Valpione S, Vijay A, Waldron L, Zitvogel L, Zolfo M, de Vries EGE, Nathan P, Fehrmann RSN, Bataille V, Hospers GAP, Spector TD, Weersma RK, Segata N
Nat Med 2022 Mar;28(3):535-544. Epub 2022 Feb 28 doi: 10.1038/s41591-022-01695-5. PMID: 35228751Free PMC Article
Multiomic profiling of checkpoint inhibitor-treated melanoma: Identifying predictors of response and resistance, and markers of biological discordance.
Newell F, Pires da Silva I, Johansson PA, Menzies AM, Wilmott JS, Addala V, Carlino MS, Rizos H, Nones K, Edwards JJ, Lakis V, Kazakoff SH, Mukhopadhyay P, Ferguson PM, Leonard C, Koufariotis LT, Wood S, Blank CU, Thompson JF, Spillane AJ, Saw RPM, Shannon KF, Pearson JV, Mann GJ, Hayward NK, Scolyer RA, Waddell N, Long GV
Cancer Cell 2022 Jan 10;40(1):88-102.e7. Epub 2021 Dec 23 doi: 10.1016/j.ccell.2021.11.012. PMID: 34951955
Principles of Targeted Therapy for Melanoma.
Sun J, Carr MJ, Khushalani NI
Surg Clin North Am 2020 Feb;100(1):175-188. Epub 2019 Nov 1 doi: 10.1016/j.suc.2019.09.013. PMID: 31753111
Efficacy of adoptive therapy with tumor-infiltrating lymphocytes and recombinant interleukin-2 in advanced cutaneous melanoma: a systematic review and meta-analysis.
Dafni U, Michielin O, Lluesma SM, Tsourti Z, Polydoropoulou V, Karlis D, Besser MJ, Haanen J, Svane IM, Ohashi PS, Kammula US, Orcurto A, Zimmermann S, Trueb L, Klebanoff CA, Lotze MT, Kandalaft LE, Coukos G
Ann Oncol 2019 Dec 1;30(12):1902-1913. doi: 10.1093/annonc/mdz398. PMID: 31566658
Melanoma.
Schadendorf D, van Akkooi ACJ, Berking C, Griewank KG, Gutzmer R, Hauschild A, Stang A, Roesch A, Ugurel S
Lancet 2018 Sep 15;392(10151):971-984. doi: 10.1016/S0140-6736(18)31559-9. PMID: 30238891

Prognosis

Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma.
Lee KA, Thomas AM, Bolte LA, Björk JR, de Ruijter LK, Armanini F, Asnicar F, Blanco-Miguez A, Board R, Calbet-Llopart N, Derosa L, Dhomen N, Brooks K, Harland M, Harries M, Leeming ER, Lorigan P, Manghi P, Marais R, Newton-Bishop J, Nezi L, Pinto F, Potrony M, Puig S, Serra-Bellver P, Shaw HM, Tamburini S, Valpione S, Vijay A, Waldron L, Zitvogel L, Zolfo M, de Vries EGE, Nathan P, Fehrmann RSN, Bataille V, Hospers GAP, Spector TD, Weersma RK, Segata N
Nat Med 2022 Mar;28(3):535-544. Epub 2022 Feb 28 doi: 10.1038/s41591-022-01695-5. PMID: 35228751Free PMC Article
Multiomic profiling of checkpoint inhibitor-treated melanoma: Identifying predictors of response and resistance, and markers of biological discordance.
Newell F, Pires da Silva I, Johansson PA, Menzies AM, Wilmott JS, Addala V, Carlino MS, Rizos H, Nones K, Edwards JJ, Lakis V, Kazakoff SH, Mukhopadhyay P, Ferguson PM, Leonard C, Koufariotis LT, Wood S, Blank CU, Thompson JF, Spillane AJ, Saw RPM, Shannon KF, Pearson JV, Mann GJ, Hayward NK, Scolyer RA, Waddell N, Long GV
Cancer Cell 2022 Jan 10;40(1):88-102.e7. Epub 2021 Dec 23 doi: 10.1016/j.ccell.2021.11.012. PMID: 34951955
Recent and Emerging Therapies for Cutaneous Squamous Cell Carcinomas of the Head and Neck.
Varra V, Smile TD, Geiger JL, Koyfman SA
Curr Treat Options Oncol 2020 Apr 23;21(5):37. doi: 10.1007/s11864-020-00739-7. PMID: 32328817
Melanoma.
Schadendorf D, van Akkooi ACJ, Berking C, Griewank KG, Gutzmer R, Hauschild A, Stang A, Roesch A, Ugurel S
Lancet 2018 Sep 15;392(10151):971-984. doi: 10.1016/S0140-6736(18)31559-9. PMID: 30238891
Update on systemic therapy for advanced cutaneous melanoma and recent development of novel drugs.
Swe T, Kim KB
Clin Exp Metastasis 2018 Aug;35(5-6):503-520. Epub 2018 Jul 17 doi: 10.1007/s10585-018-9913-y. PMID: 30019239

Clinical prediction guides

Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma.
Lee KA, Thomas AM, Bolte LA, Björk JR, de Ruijter LK, Armanini F, Asnicar F, Blanco-Miguez A, Board R, Calbet-Llopart N, Derosa L, Dhomen N, Brooks K, Harland M, Harries M, Leeming ER, Lorigan P, Manghi P, Marais R, Newton-Bishop J, Nezi L, Pinto F, Potrony M, Puig S, Serra-Bellver P, Shaw HM, Tamburini S, Valpione S, Vijay A, Waldron L, Zitvogel L, Zolfo M, de Vries EGE, Nathan P, Fehrmann RSN, Bataille V, Hospers GAP, Spector TD, Weersma RK, Segata N
Nat Med 2022 Mar;28(3):535-544. Epub 2022 Feb 28 doi: 10.1038/s41591-022-01695-5. PMID: 35228751Free PMC Article
Multiomic profiling of checkpoint inhibitor-treated melanoma: Identifying predictors of response and resistance, and markers of biological discordance.
Newell F, Pires da Silva I, Johansson PA, Menzies AM, Wilmott JS, Addala V, Carlino MS, Rizos H, Nones K, Edwards JJ, Lakis V, Kazakoff SH, Mukhopadhyay P, Ferguson PM, Leonard C, Koufariotis LT, Wood S, Blank CU, Thompson JF, Spillane AJ, Saw RPM, Shannon KF, Pearson JV, Mann GJ, Hayward NK, Scolyer RA, Waddell N, Long GV
Cancer Cell 2022 Jan 10;40(1):88-102.e7. Epub 2021 Dec 23 doi: 10.1016/j.ccell.2021.11.012. PMID: 34951955
Rational use of (18)F-FDG PET/CT in patients with advanced cutaneous melanoma: A systematic review.
Bisschop C, de Heer EC, Brouwers AH, Hospers GAP, Jalving M
Crit Rev Oncol Hematol 2020 Sep;153:103044. Epub 2020 Jul 1 doi: 10.1016/j.critrevonc.2020.103044. PMID: 32673997
Update on systemic therapy for advanced cutaneous melanoma and recent development of novel drugs.
Swe T, Kim KB
Clin Exp Metastasis 2018 Aug;35(5-6):503-520. Epub 2018 Jul 17 doi: 10.1007/s10585-018-9913-y. PMID: 30019239
Checkpoint inhibition for advanced mucosal melanoma.
Thierauf J, Veit JA, Hess J, Treiber N, Lisson C, Weissinger SE, Bommer M, Hoffmann TK
Eur J Dermatol 2017 Apr 1;27(2):160-165. doi: 10.1684/ejd.2016.2949. PMID: 28174141

Recent systematic reviews

Immune checkpoint inhibitors in advanced cutaneous melanoma: a systematic review and meta-analysis of efficacy and review of characteristics.
Mahdiabadi S, Momtazmanesh S, Karimi A, Rezaei N
Expert Rev Anticancer Ther 2023 Jul-Dec;23(12):1281-1293. Epub 2023 Dec 8 doi: 10.1080/14737140.2023.2278509. PMID: 37908134
Rational use of (18)F-FDG PET/CT in patients with advanced cutaneous melanoma: A systematic review.
Bisschop C, de Heer EC, Brouwers AH, Hospers GAP, Jalving M
Crit Rev Oncol Hematol 2020 Sep;153:103044. Epub 2020 Jul 1 doi: 10.1016/j.critrevonc.2020.103044. PMID: 32673997
Novel cancer therapies for advanced cutaneous melanoma: The added value of radiomics in the decision making process-A systematic review.
Guerrisi A, Loi E, Ungania S, Russillo M, Bruzzaniti V, Elia F, Desiderio F, Marconi R, Solivetti FM, Strigari L
Cancer Med 2020 Mar;9(5):1603-1612. Epub 2020 Jan 17 doi: 10.1002/cam4.2709. PMID: 31951322Free PMC Article
Efficacy of adoptive therapy with tumor-infiltrating lymphocytes and recombinant interleukin-2 in advanced cutaneous melanoma: a systematic review and meta-analysis.
Dafni U, Michielin O, Lluesma SM, Tsourti Z, Polydoropoulou V, Karlis D, Besser MJ, Haanen J, Svane IM, Ohashi PS, Kammula US, Orcurto A, Zimmermann S, Trueb L, Klebanoff CA, Lotze MT, Kandalaft LE, Coukos G
Ann Oncol 2019 Dec 1;30(12):1902-1913. doi: 10.1093/annonc/mdz398. PMID: 31566658
Electrochemotherapy for the Treatment of Unresectable Locoregionally Advanced Cutaneous Melanoma: A Systematic Review.
Aguado-Romeo MJ, Benot-López S, Romero-Tabares A
Actas Dermosifiliogr 2017 Mar;108(2):91-97. Epub 2016 Oct 18 doi: 10.1016/j.ad.2016.08.008. PMID: 27769538

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