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Colon Large Cell Neuroendocrine Carcinoma

MedGen UID:
1730673
Concept ID:
C5418920
Neoplastic Process

Definition

An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the colon. It is characterized by the presence of malignant large cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColon Large Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Dasari A, Shen C, Devabhaktuni A, Nighot R, Sorbye H
Oncologist 2022 Apr 5;27(4):299-306. doi: 10.1093/oncolo/oyab039. PMID: 35380711Free PMC Article
Koumarianou A, Chatzellis E, Boutzios G, Tsavaris N, Kaltsas G
Endokrynol Pol 2013;64(1):60-72. PMID: 23450449

Recent clinical studies

Etiology

Sorbye H, Hjortland GO, Vestermark LW, Sundlov A, Assmus J, Couvelard A, Perren A, Langer SW
J Neuroendocrinol 2024 Nov;36(11):e13428. Epub 2024 Jun 27 doi: 10.1111/jne.13428. PMID: 38937137
Grundmann N, Voigtländer S, Hakimhashemi A, Pape UF, Meyer M, Müller-Nordhorn J
Cancer Med 2023 Oct;12(19):19949-19958. Epub 2023 Sep 22 doi: 10.1002/cam4.6510. PMID: 37737059Free PMC Article
Dijkstra KK, van den Berg JG, Weeber F, van de Haar J, Velds A, Kaing S, Peters DDGC, Eskens FALM, de Groot DA, Tesselaar MET, Voest EE
Front Endocrinol (Lausanne) 2021;12:627819. Epub 2021 Mar 11 doi: 10.3389/fendo.2021.627819. PMID: 33776923Free PMC Article
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Lin J, Goldblum JR, Bennett AE, Bronner MP, Liu X
Am J Surg Pathol 2012 Feb;36(2):292-5. doi: 10.1097/PAS.0b013e318236e4d2. PMID: 22082602

Diagnosis

Zimmer V, Eltze E
Am J Med 2021 Sep;134(9):e494-e495. Epub 2021 May 11 doi: 10.1016/j.amjmed.2021.04.014. PMID: 33989607
Chen X, Wang X, Abadi M, Kumar A
Clin Colorectal Cancer 2020 Mar;19(1):61-64. Epub 2019 Oct 31 doi: 10.1016/j.clcc.2019.10.005. PMID: 31761668
Acosta AM, Wiley EL
Arch Pathol Lab Med 2016 Oct;140(10):1157-62. doi: 10.5858/arpa.2015-0102-RS. PMID: 27684986
Gravante G, Markiewicz D, Madeddu F, Giordano P
Can J Surg 2009 Jun;52(3):E49-51. PMID: 19503644Free PMC Article
Spigel DR, Hainsworth JD, Greco FA
Semin Oncol 2009 Feb;36(1):52-9. doi: 10.1053/j.seminoncol.2008.10.003. PMID: 19179188

Therapy

Zimmer V, Eltze E
Am J Med 2021 Sep;134(9):e494-e495. Epub 2021 May 11 doi: 10.1016/j.amjmed.2021.04.014. PMID: 33989607
Dijkstra KK, van den Berg JG, Weeber F, van de Haar J, Velds A, Kaing S, Peters DDGC, Eskens FALM, de Groot DA, Tesselaar MET, Voest EE
Front Endocrinol (Lausanne) 2021;12:627819. Epub 2021 Mar 11 doi: 10.3389/fendo.2021.627819. PMID: 33776923Free PMC Article
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Chen X, Wang X, Abadi M, Kumar A
Clin Colorectal Cancer 2020 Mar;19(1):61-64. Epub 2019 Oct 31 doi: 10.1016/j.clcc.2019.10.005. PMID: 31761668
Stoner P, Ghaffaripour T, Cohen D
BMJ Case Rep 2017 Aug 7;2017 doi: 10.1136/bcr-2017-220093. PMID: 28790093Free PMC Article

Prognosis

Kasajima A, Klöppel G
Pathol Int 2022 Oct;72(10):488-495. Epub 2022 Aug 19 doi: 10.1111/pin.13266. PMID: 35983917
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Acosta AM, Wiley EL
Arch Pathol Lab Med 2016 Oct;140(10):1157-62. doi: 10.5858/arpa.2015-0102-RS. PMID: 27684986
Lin J, Goldblum JR, Bennett AE, Bronner MP, Liu X
Am J Surg Pathol 2012 Feb;36(2):292-5. doi: 10.1097/PAS.0b013e318236e4d2. PMID: 22082602
Gravante G, Markiewicz D, Madeddu F, Giordano P
Can J Surg 2009 Jun;52(3):E49-51. PMID: 19503644Free PMC Article

Clinical prediction guides

Sorbye H, Hjortland GO, Vestermark LW, Sundlov A, Assmus J, Couvelard A, Perren A, Langer SW
J Neuroendocrinol 2024 Nov;36(11):e13428. Epub 2024 Jun 27 doi: 10.1111/jne.13428. PMID: 38937137
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Gock M, Mullins CS, Harnack C, Prall F, Ramer R, Göder A, Krämer OH, Klar E, Linnebacher M
World J Gastroenterol 2018 Sep 7;24(33):3749-3759. doi: 10.3748/wjg.v24.i33.3749. PMID: 30197480Free PMC Article
Jaeger E, Leedham S, Lewis A, Segditsas S, Becker M, Cuadrado PR, Davis H, Kaur K, Heinimann K, Howarth K; HMPS Collaboration, East J, Taylor J, Thomas H, Tomlinson I
Nat Genet 2012 May 6;44(6):699-703. doi: 10.1038/ng.2263. PMID: 22561515Free PMC Article
Spigel DR, Hainsworth JD, Greco FA
Semin Oncol 2009 Feb;36(1):52-9. doi: 10.1053/j.seminoncol.2008.10.003. PMID: 19179188

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