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Metastatic Endometrial Serous Adenocarcinoma

MedGen UID:
1732879
•Concept ID:
C5418808
•
Neoplastic Process

Definition

An endometrial serous adenocarcinoma that has spread to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Endometrial Serous Adenocarcinoma

Professional guidelines

PubMed

International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Uterine papillary serous carcinoma: epidemiology, pathogenesis and management.
Fader AN, Boruta D, Olawaiye AB, Gehrig PA
Curr Opin Obstet Gynecol 2010 Feb;22(1):21-9. doi: 10.1097/GCO.0b013e328334d8a3. PMID: 19952744
Clear-cell and papillary serous cancer: treatment options.
Tropé C, Kristensen GB, Abeler VM
Best Pract Res Clin Obstet Gynaecol 2001 Jun;15(3):433-46. doi: 10.1053/beog.2000.0187. PMID: 11476564

Recent clinical studies

Etiology

Randomized Phase II Trial of Carboplatin-Paclitaxel Compared with Carboplatin-Paclitaxel-Trastuzumab in Advanced (Stage III-IV) or Recurrent Uterine Serous Carcinomas that Overexpress Her2/Neu (NCT01367002): Updated Overall Survival Analysis.
Fader AN, Roque DM, Siegel E, Buza N, Hui P, Abdelghany O, Chambers S, Secord AA, Havrilesky L, O'Malley DM, Backes FJ, Nevadunsky N, Edraki B, Pikaart D, Lowery W, ElSahwi K, Celano P, Bellone S, Azodi M, Litkouhi B, Ratner E, Silasi DA, Schwartz PE, Santin AD
Clin Cancer Res 2020 Aug 1;26(15):3928-3935. Epub 2020 Jun 29 doi: 10.1158/1078-0432.CCR-20-0953. PMID: 32601075Free PMC Article
Extended Pelvic Resections as Part of Secondary Cytoreduction for Relapsed Ovarian Adenocarcinoma.
Bacalbasa N, Balescu I, Dima S, Vilcu M, Brezean I
In Vivo 2020 Jan-Feb;34(1):397-400. doi: 10.21873/invivo.11787. PMID: 31882505Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465
Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer.
Hamanishi J, Mandai M, Ikeda T, Minami M, Kawaguchi A, Murayama T, Kanai M, Mori Y, Matsumoto S, Chikuma S, Matsumura N, Abiko K, Baba T, Yamaguchi K, Ueda A, Hosoe Y, Morita S, Yokode M, Shimizu A, Honjo T, Konishi I
J Clin Oncol 2015 Dec 1;33(34):4015-22. Epub 2015 Sep 8 doi: 10.1200/JCO.2015.62.3397. PMID: 26351349

Diagnosis

Patterns of spread and genetic alterations of primary endometrioid carcinomas of the ovary.
Mazina V, Devins K, Philp L, Bercow AS, James K, Bregar A, Sisodia RC, Oliva E, Del Carmen M
Int J Gynecol Cancer 2023 Sep 4;33(9):1434-1439. doi: 10.1136/ijgc-2023-004627. PMID: 37567599
Randomized Phase II Trial of Carboplatin-Paclitaxel Compared with Carboplatin-Paclitaxel-Trastuzumab in Advanced (Stage III-IV) or Recurrent Uterine Serous Carcinomas that Overexpress Her2/Neu (NCT01367002): Updated Overall Survival Analysis.
Fader AN, Roque DM, Siegel E, Buza N, Hui P, Abdelghany O, Chambers S, Secord AA, Havrilesky L, O'Malley DM, Backes FJ, Nevadunsky N, Edraki B, Pikaart D, Lowery W, ElSahwi K, Celano P, Bellone S, Azodi M, Litkouhi B, Ratner E, Silasi DA, Schwartz PE, Santin AD
Clin Cancer Res 2020 Aug 1;26(15):3928-3935. Epub 2020 Jun 29 doi: 10.1158/1078-0432.CCR-20-0953. PMID: 32601075Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Cervical Adenocarcinoma: Diagnosis of Human Papillomavirus-Positive and Human Papillomavirus-Negative Tumors.
Pirog EC
Arch Pathol Lab Med 2017 Dec;141(12):1653-1667. Epub 2017 Jun 23 doi: 10.5858/arpa.2016-0356-RA. PMID: 28644686
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465

Therapy

Endoscopic Surgery Using Ultrasonic Energy Device for Tracheal Metastatic Tumor.
Iwasaki M, Ishihara S, Shimomura M, Inoue M
Ann Thorac Surg 2022 Sep;114(3):e189-e191. Epub 2021 Dec 29 doi: 10.1016/j.athoracsur.2021.11.061. PMID: 34973186
Randomized Phase II Trial of Carboplatin-Paclitaxel Compared with Carboplatin-Paclitaxel-Trastuzumab in Advanced (Stage III-IV) or Recurrent Uterine Serous Carcinomas that Overexpress Her2/Neu (NCT01367002): Updated Overall Survival Analysis.
Fader AN, Roque DM, Siegel E, Buza N, Hui P, Abdelghany O, Chambers S, Secord AA, Havrilesky L, O'Malley DM, Backes FJ, Nevadunsky N, Edraki B, Pikaart D, Lowery W, ElSahwi K, Celano P, Bellone S, Azodi M, Litkouhi B, Ratner E, Silasi DA, Schwartz PE, Santin AD
Clin Cancer Res 2020 Aug 1;26(15):3928-3935. Epub 2020 Jun 29 doi: 10.1158/1078-0432.CCR-20-0953. PMID: 32601075Free PMC Article
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465
Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer.
Hamanishi J, Mandai M, Ikeda T, Minami M, Kawaguchi A, Murayama T, Kanai M, Mori Y, Matsumoto S, Chikuma S, Matsumura N, Abiko K, Baba T, Yamaguchi K, Ueda A, Hosoe Y, Morita S, Yokode M, Shimizu A, Honjo T, Konishi I
J Clin Oncol 2015 Dec 1;33(34):4015-22. Epub 2015 Sep 8 doi: 10.1200/JCO.2015.62.3397. PMID: 26351349
Phase II study of liposomal cisplatin (SPI-77) in platinum-sensitive recurrences of ovarian cancer.
Seetharamu N, Kim E, Hochster H, Martin F, Muggia F
Anticancer Res 2010 Feb;30(2):541-5. PMID: 20332467

Prognosis

Randomized Phase II Trial of Carboplatin-Paclitaxel Compared with Carboplatin-Paclitaxel-Trastuzumab in Advanced (Stage III-IV) or Recurrent Uterine Serous Carcinomas that Overexpress Her2/Neu (NCT01367002): Updated Overall Survival Analysis.
Fader AN, Roque DM, Siegel E, Buza N, Hui P, Abdelghany O, Chambers S, Secord AA, Havrilesky L, O'Malley DM, Backes FJ, Nevadunsky N, Edraki B, Pikaart D, Lowery W, ElSahwi K, Celano P, Bellone S, Azodi M, Litkouhi B, Ratner E, Silasi DA, Schwartz PE, Santin AD
Clin Cancer Res 2020 Aug 1;26(15):3928-3935. Epub 2020 Jun 29 doi: 10.1158/1078-0432.CCR-20-0953. PMID: 32601075Free PMC Article
p53 immunohistochemistry is an accurate surrogate for TP53 mutational analysis in endometrial carcinoma biopsies.
Singh N, Piskorz AM, Bosse T, Jimenez-Linan M, Rous B, Brenton JD, Gilks CB, Köbel M
J Pathol 2020 Mar;250(3):336-345. Epub 2020 Jan 29 doi: 10.1002/path.5375. PMID: 31829441
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465
Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer.
Hamanishi J, Mandai M, Ikeda T, Minami M, Kawaguchi A, Murayama T, Kanai M, Mori Y, Matsumoto S, Chikuma S, Matsumura N, Abiko K, Baba T, Yamaguchi K, Ueda A, Hosoe Y, Morita S, Yokode M, Shimizu A, Honjo T, Konishi I
J Clin Oncol 2015 Dec 1;33(34):4015-22. Epub 2015 Sep 8 doi: 10.1200/JCO.2015.62.3397. PMID: 26351349

Clinical prediction guides

p53 immunohistochemistry is an accurate surrogate for TP53 mutational analysis in endometrial carcinoma biopsies.
Singh N, Piskorz AM, Bosse T, Jimenez-Linan M, Rous B, Brenton JD, Gilks CB, Köbel M
J Pathol 2020 Mar;250(3):336-345. Epub 2020 Jan 29 doi: 10.1002/path.5375. PMID: 31829441
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465
The predictors of response to neoadjuvant chemotherapy in advanced epithelial ovarian cancer.
Yildirim Y, Ertas IE, Dogan A, Gultekin OE, Gultekin E
J Surg Oncol 2012 Feb;105(2):200-5. Epub 2011 Aug 3 doi: 10.1002/jso.22053. PMID: 21815151
Secondary cytoreductive surgery in patients with platinum-sensitive recurrent ovarian cancer.
Benedetti Panici P, De Vivo A, Bellati F, Manci N, Perniola G, Basile S, Muzii L, Angioli R
Ann Surg Oncol 2007 Mar;14(3):1136-42. Epub 2006 Dec 31 doi: 10.1245/s10434-006-9273-8. PMID: 17195909

Recent systematic reviews

Incidence of omental metastasis in uterine serous carcinoma: a systematic review and meta-analysis.
Xu H, Cui SS, Ran L, Liu Y, Hu C, Xu Y, Tian Y
J Gynecol Obstet Hum Reprod 2022 Jun;51(6):102395. Epub 2022 Apr 28 doi: 10.1016/j.jogoh.2022.102395. PMID: 35489712

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