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Advanced Sarcomatoid Renal Cell Carcinoma

MedGen UID:
1735882
•Concept ID:
C5419190
•
Neoplastic Process

Definition

Sarcomatoid renal cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Sarcomatoid Renal Cell Carcinoma

Professional guidelines

PubMed

Efficacy and Safety of Nivolumab Plus Ipilimumab versus Sunitinib in First-line Treatment of Patients with Advanced Sarcomatoid Renal Cell Carcinoma.
Tannir NM, Signoretti S, Choueiri TK, McDermott DF, Motzer RJ, Flaifel A, Pignon JC, Ficial M, Frontera OA, George S, Powles T, Donskov F, Harrison MR, Barthélémy P, Tykodi SS, Kocsis J, Ravaud A, Rodriguez-Cid JR, Pal SK, Murad AM, Ishii Y, Saggi SS, McHenry MB, Rini BI
Clin Cancer Res 2021 Jan 1;27(1):78-86. Epub 2020 Sep 1 doi: 10.1158/1078-0432.CCR-20-2063. PMID: 32873572Free PMC Article
Re: Nizar M. Tannir, Sabina Signoretti, Toni K. Choueiri, et al. Efficacy and Safety of Nivolumab Plus Ipilimumab versus Sunitinib in First-line Treatment of Patients with Advanced Sarcomatoid Renal Cell Carcinoma. Clin Cancer Res. In press. https://doi.org/10.1158/1078-0432.ccr-20-2063.
Rizzo A, Mollica V, Massari F
Eur Urol Oncol 2020 Dec;3(6):804-805. Epub 2020 Oct 26 doi: 10.1016/j.euo.2020.10.005. PMID: 33121939
Sarcomatoid renal cell carcinoma: clinical outcome and survival after treatment with sunitinib.
Kunene V, Miscoria M, Pirrie S, Islam MR, Afshar M, Porfiri E
Clin Genitourin Cancer 2014 Aug;12(4):251-5. Epub 2013 Dec 27 doi: 10.1016/j.clgc.2013.12.001. PMID: 24560086

Recent clinical studies

Etiology

Long-term outcomes with nivolumab plus ipilimumab versus sunitinib in first-line treatment of patients with advanced sarcomatoid renal cell carcinoma.
Rini BI, Signoretti S, Choueiri TK, McDermott DF, Motzer RJ, George S, Powles T, Donskov F, Tykodi SS, Pal SK, Gupta S, Lee CW, Jiang R, Tannir NM
J Immunother Cancer 2022 Dec;10(12) doi: 10.1136/jitc-2022-005445. PMID: 36549781Free PMC Article
Sarcomatoid renal cell carcinoma: clinical outcome and survival after treatment with sunitinib.
Kunene V, Miscoria M, Pirrie S, Islam MR, Afshar M, Porfiri E
Clin Genitourin Cancer 2014 Aug;12(4):251-5. Epub 2013 Dec 27 doi: 10.1016/j.clgc.2013.12.001. PMID: 24560086

Diagnosis

Remarkable shrinkage of sarcomatoid renal cell carcinoma with single-agent gemcitabine.
Fujiwara Y, Kiura K, Tabata M, Takigawa N, Hotta K, Umemura S, Omori M, Gemba K, Ueoka H, Tanimoto M
Anticancer Drugs 2008 Apr;19(4):431-3. doi: 10.1097/CAD.0b013e3282f5d336. PMID: 18454054

Therapy

Long-term outcomes with nivolumab plus ipilimumab versus sunitinib in first-line treatment of patients with advanced sarcomatoid renal cell carcinoma.
Rini BI, Signoretti S, Choueiri TK, McDermott DF, Motzer RJ, George S, Powles T, Donskov F, Tykodi SS, Pal SK, Gupta S, Lee CW, Jiang R, Tannir NM
J Immunother Cancer 2022 Dec;10(12) doi: 10.1136/jitc-2022-005445. PMID: 36549781Free PMC Article
Sarcomatoid renal cell carcinoma: clinical outcome and survival after treatment with sunitinib.
Kunene V, Miscoria M, Pirrie S, Islam MR, Afshar M, Porfiri E
Clin Genitourin Cancer 2014 Aug;12(4):251-5. Epub 2013 Dec 27 doi: 10.1016/j.clgc.2013.12.001. PMID: 24560086
Remarkable shrinkage of sarcomatoid renal cell carcinoma with single-agent gemcitabine.
Fujiwara Y, Kiura K, Tabata M, Takigawa N, Hotta K, Umemura S, Omori M, Gemba K, Ueoka H, Tanimoto M
Anticancer Drugs 2008 Apr;19(4):431-3. doi: 10.1097/CAD.0b013e3282f5d336. PMID: 18454054

Prognosis

Long-term outcomes with nivolumab plus ipilimumab versus sunitinib in first-line treatment of patients with advanced sarcomatoid renal cell carcinoma.
Rini BI, Signoretti S, Choueiri TK, McDermott DF, Motzer RJ, George S, Powles T, Donskov F, Tykodi SS, Pal SK, Gupta S, Lee CW, Jiang R, Tannir NM
J Immunother Cancer 2022 Dec;10(12) doi: 10.1136/jitc-2022-005445. PMID: 36549781Free PMC Article
Sarcomatoid renal cell carcinoma: clinical outcome and survival after treatment with sunitinib.
Kunene V, Miscoria M, Pirrie S, Islam MR, Afshar M, Porfiri E
Clin Genitourin Cancer 2014 Aug;12(4):251-5. Epub 2013 Dec 27 doi: 10.1016/j.clgc.2013.12.001. PMID: 24560086

Clinical prediction guides

Sarcomatoid renal cell carcinoma: clinical outcome and survival after treatment with sunitinib.
Kunene V, Miscoria M, Pirrie S, Islam MR, Afshar M, Porfiri E
Clin Genitourin Cancer 2014 Aug;12(4):251-5. Epub 2013 Dec 27 doi: 10.1016/j.clgc.2013.12.001. PMID: 24560086

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