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Advanced Endometrial Adenocarcinoma

MedGen UID:
1737281
•Concept ID:
C5418809
•
Neoplastic Process

Definition

Endometrial adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Endometrial Adenocarcinoma

Professional guidelines

PubMed

Effectiveness of aromatase inhibitors in the treatment of advanced endometrial adenocarcinoma.
Bogliolo S, Gardella B, Dominoni M, Musacchi V, Cassani C, Zanellini F, De Silvestri A, Gaggero CR, Babilonti L, Spinillo A
Arch Gynecol Obstet 2016 Apr;293(4):701-8. Epub 2015 Dec 15 doi: 10.1007/s00404-015-3974-9. PMID: 26671487
Treatment of advanced endometrial adenocarcinoma with cis-dichlorodiammine platinum (II) after intensive prior therapy.
Deppe G, Cohen CJ, Bruckner HW
Gynecol Oncol 1980 Aug;10(1):51-4. doi: 10.1016/0090-8258(80)90062-1. PMID: 7190531
MANAGEMENT OF ADVANCED ENDOMETRIAL ADENOCARCINOMA WITH MEDROXYPROGESTERONE ACETATE.
ANDERSON DG
Am J Obstet Gynecol 1965 May 1;92:87-99. doi: 10.1016/0002-9378(65)90108-0. PMID: 14280914

Recent clinical studies

Etiology

Advanced endometrial cancer following the insertion of the levonorgestrel-releasing intrauterine system in a 34-year-old woman: A case report.
Jiang J, Du H, Peng H
Contraception 2020 Dec;102(6):428-429. Epub 2020 Aug 27 doi: 10.1016/j.contraception.2020.08.010. PMID: 32860769
Paclitaxel/carboplatin versus cyclophosphamide/adriamycin/cisplatin as postoperative adjuvant chemotherapy for advanced endometrial adenocarcinoma.
Hidaka T, Nakamura T, Shima T, Yuki H, Saito S
J Obstet Gynaecol Res 2006 Jun;32(3):330-7. doi: 10.1111/j.1447-0756.2006.00405.x. PMID: 16764625
Phase II clinical study of tamoxifen in advanced endometrial adenocarcinoma: a Gynecologic Oncology Group study.
Slavik M, Petty WM, Blessing JA, Creasman WT, Homesley HD
Cancer Treat Rep 1984 May;68(5):809-11. PMID: 6722836
Tamoxifen and medroxyprogesterone therapy for advanced endometrial carcinoma.
Rendina GM, Donadio C, Fabri M, Mazzoni P, Nazzicone P
Eur J Obstet Gynecol Reprod Biol 1984 Jun;17(4):285-91. doi: 10.1016/0028-2243(84)90071-6. PMID: 6235140
Phase II evaluation of dianhydrogalactitol in the treatment of advanced endometrial adenocarcinoma: a Gynecologic Oncology Group Study.
Stehman FB, Blessing JA, Delgado G, Louka M
Cancer Treat Rep 1983 Jul-Aug;67(7-8):737-8. PMID: 6871892

Diagnosis

Advanced endometrial cancer following the insertion of the levonorgestrel-releasing intrauterine system in a 34-year-old woman: A case report.
Jiang J, Du H, Peng H
Contraception 2020 Dec;102(6):428-429. Epub 2020 Aug 27 doi: 10.1016/j.contraception.2020.08.010. PMID: 32860769
Splenic metastases in gynaecologic cancer: clinical considerations, US, and CT diagnostic results.
La Fianza A, Madonia L
Radiol Med 2003 Jul-Aug;106(1-2):36-43. PMID: 12951549

Therapy

Effectiveness of aromatase inhibitors in the treatment of advanced endometrial adenocarcinoma.
Bogliolo S, Gardella B, Dominoni M, Musacchi V, Cassani C, Zanellini F, De Silvestri A, Gaggero CR, Babilonti L, Spinillo A
Arch Gynecol Obstet 2016 Apr;293(4):701-8. Epub 2015 Dec 15 doi: 10.1007/s00404-015-3974-9. PMID: 26671487
Intraperitoneal and systemic chemotherapy for advanced endometrial adenocarcinoma: a case report.
Vaughn CB, Chapman JL, Herschman BR, Bonczak MJ, Treisman EJ, Groshko GA, Nirenberg PL
Med Pediatr Oncol 1990;18(1):68-71. doi: 10.1002/mpo.2950180115. PMID: 2294393
Treatment of advanced endometrial adenocarcinoma with cyclic sequential ethinyl estradiol and medroxyprogesterone acetate.
Tatman JL, Freedman RS, Scott W, Atkinson EN
Eur J Cancer Clin Oncol 1989 Nov;25(11):1619-21. doi: 10.1016/0277-5379(89)90307-6. PMID: 2531671
Treatment of advanced endometrial adenocarcinoma with cis-dichlorodiammine platinum (II) after intensive prior therapy.
Deppe G, Cohen CJ, Bruckner HW
Gynecol Oncol 1980 Aug;10(1):51-4. doi: 10.1016/0090-8258(80)90062-1. PMID: 7190531
Medrogestone therapy in advanced endometrial adenocarcinoma.
Waterman EA, Benson RC
Obstet Gynecol 1967 Nov;30(5):626-34. PMID: 4167865

Prognosis

Chemotherapy for advanced, recurrent or metastatic endometrial carcinoma.
Humber C, Tierney J, Symonds P, Collingwood M, Kirwan J, Williams C, Green J
Cochrane Database Syst Rev 2005 Oct 19;(4):CD003915. doi: 10.1002/14651858.CD003915.pub3. PMID: 16235346
Chemotherapy for advanced, recurrent or metastatic endometrial carcinoma.
Humber C, Tierney J, Symonds P, Collingwood M, Kirwan J, Williams C, Green J
Cochrane Database Syst Rev 2005 Jul 20;(3):CD003915. doi: 10.1002/14651858.CD003915.pub2. PMID: 16034916
Tamoxifen and medroxyprogesterone therapy for advanced endometrial carcinoma.
Rendina GM, Donadio C, Fabri M, Mazzoni P, Nazzicone P
Eur J Obstet Gynecol Reprod Biol 1984 Jun;17(4):285-91. doi: 10.1016/0028-2243(84)90071-6. PMID: 6235140
Treatment of advanced endometrial adenocarcinoma with a combined cytotoxic therapy. Predictive value of cytosol estrogen and progestin receptor levels.
Kauppila A, Jänne O, Kujansuu E, Vihko R
Cancer 1980 Nov 15;46(10):2162-7. doi: 10.1002/1097-0142(19801115)46:10<2162::aid-cncr2820461010>3.0.co;2-v. PMID: 6253041
Doxorubicin-cyclophosphamide: effective chemotherapy for advanced endometrial adenocarcinoma.
Muggia FM, Chia G, Reed LJ, Romney SL
Am J Obstet Gynecol 1977 Jun 1;128(3):314-9. doi: 10.1016/0002-9378(77)90629-9. PMID: 860739

Clinical prediction guides

A feasibility study of sequential doublet chemotherapy comprising carboplatin-doxorubicin and carboplatin-paclitaxel for advanced endometrial adenocarcinoma and carcinosarcoma.
Ang JE, Shah RN, Everard M, Keyzor C, Coombes I, Jenkins A, Thomas K, A'Hern R, Jones RL, Blake P, Gabra H, Hall G, Gore ME, Kaye SB
Ann Oncol 2009 Nov;20(11):1787-93. Epub 2009 Jun 19 doi: 10.1093/annonc/mdp193. PMID: 19542250
Paclitaxel/carboplatin versus cyclophosphamide/adriamycin/cisplatin as postoperative adjuvant chemotherapy for advanced endometrial adenocarcinoma.
Hidaka T, Nakamura T, Shima T, Yuki H, Saito S
J Obstet Gynaecol Res 2006 Jun;32(3):330-7. doi: 10.1111/j.1447-0756.2006.00405.x. PMID: 16764625
Splenic metastases in gynaecologic cancer: clinical considerations, US, and CT diagnostic results.
La Fianza A, Madonia L
Radiol Med 2003 Jul-Aug;106(1-2):36-43. PMID: 12951549
Epirubicin in advanced endometrial adenocarcinoma: a phase II study of the Grupo Ginecologico Español para el Tratamiento Oncologico (GGETO).
Calero F, Asins-Codoñer E, Jimeno J, Rodriguez Escudero F, Mendaña J, Iglesias J, Matía F, Armas A, Díaz-Castellanos R, Garzón J
Eur J Cancer 1991;27(7):864-6. doi: 10.1016/0277-5379(91)90135-z. PMID: 1834118
Treatment of advanced endometrial adenocarcinoma with a combined cytotoxic therapy. Predictive value of cytosol estrogen and progestin receptor levels.
Kauppila A, Jänne O, Kujansuu E, Vihko R
Cancer 1980 Nov 15;46(10):2162-7. doi: 10.1002/1097-0142(19801115)46:10<2162::aid-cncr2820461010>3.0.co;2-v. PMID: 6253041

Recent systematic reviews

Effectiveness of aromatase inhibitors in the treatment of advanced endometrial adenocarcinoma.
Bogliolo S, Gardella B, Dominoni M, Musacchi V, Cassani C, Zanellini F, De Silvestri A, Gaggero CR, Babilonti L, Spinillo A
Arch Gynecol Obstet 2016 Apr;293(4):701-8. Epub 2015 Dec 15 doi: 10.1007/s00404-015-3974-9. PMID: 26671487
Chemotherapy for advanced, recurrent or metastatic endometrial carcinoma.
Humber C, Tierney J, Symonds P, Collingwood M, Kirwan J, Williams C, Green J
Cochrane Database Syst Rev 2005 Oct 19;(4):CD003915. doi: 10.1002/14651858.CD003915.pub3. PMID: 16235346
Chemotherapy for advanced, recurrent or metastatic endometrial carcinoma.
Humber C, Tierney J, Symonds P, Collingwood M, Kirwan J, Williams C, Green J
Cochrane Database Syst Rev 2005 Jul 20;(3):CD003915. doi: 10.1002/14651858.CD003915.pub2. PMID: 16034916

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