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Recurrent viral upper respiratory tract infections

MedGen UID:
1739717
Concept ID:
C5421654
Finding
HPO: HP:0033166

Definition

An increased susceptibility to viral upper respiratory tract infections as manifested by a history of recurrent viral upper respiratory tract infections (otitis, sinusitis, pharyngitis, tonsillitis). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent viral upper respiratory tract infections

Conditions with this feature

Immunodeficiency, common variable, 10
MedGen UID:
816321
Concept ID:
C3809991
Disease or Syndrome
Common variable immunodeficiency-10 (CVID10) is an autosomal dominant primary immunodeficiency characterized by childhood-onset of recurrent infections, hypogammaglobulinemia, and decreased numbers of memory and marginal zone B cells. Some patients may develop autoimmune features and have circulating autoantibodies. An unusual feature is central adrenal insufficiency (summary by Chen et al., 2013). For a general description and a discussion of genetic heterogeneity of common variable immunodeficiency, see CVID1 (607594).
Autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity
MedGen UID:
816672
Concept ID:
C3810342
Disease or Syndrome
Immunodeficiency-20 is a rare autosomal recessive primary immunodeficiency characterized by functional deficiency of NK cells. Patient NK cells are defective in spontaneous cell cytotoxicity, but retain antibody-dependent cellular cytotoxicity. Patients typically present early in childhood with severe herpes viral infections, particularly Epstein Barr virus (EBV), and human papillomavirus (HPV) (summary by Grier et al., 2012).
15q14 microdeletion syndrome
MedGen UID:
930899
Concept ID:
C4305230
Disease or Syndrome
A recently described syndrome with characteristics of developmental delay, short stature and facial dysmorphism. Dysmorphic features include bi-temporal narrowing, smooth philtrum, pointed chin and dysmorphic ears. All reported patients had a cleft palate, whereas congenital heart defects or epilepsy are observed in patients with large deletions. Deletions are located within chromosome band 15q14, distal to the Prader-Willi/Angelman region. They have a variable size with the smallest deletion being 1.6 Mb in length.
Immunodeficiency 95
MedGen UID:
1802205
Concept ID:
C5676929
Disease or Syndrome
Immunodeficiency-95 (IMD95) is an autosomal recessive disorder characterized predominantly by the onset of recurrent and severe viral respiratory infections in infancy or early childhood. Affected individuals often require hospitalization or respiratory support for these infections, which include human rhinovirus (HRV) and RSV. Immunologic workup is usually normal, although some mild abnormalities may be observed. The disorder results from a loss of ability of the innate immune system to sense viral genetic information, which causes a lack of interferon (IFN) production, poor response to viral and immunologic stimulation, and failure to control viral replication (summary by Lamborn et al., 2017, Asgari et al., 2017, Cananzi et al., 2021).

Professional guidelines

PubMed

Smith KL, Hughes R, Myrex P
Am Fam Physician 2023 Jan;107(1):35-41. PMID: 36689967
Stokes JR, Bacharier LB
Ann Allergy Asthma Immunol 2020 Aug;125(2):156-162. Epub 2020 May 23 doi: 10.1016/j.anai.2020.05.018. PMID: 32454096
Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Ashok Kumar K, Kramper M, Orlandi RR, Palmer JN, Patel ZM, Peters A, Walsh SA, Corrigan MD
Otolaryngol Head Neck Surg 2015 Apr;152(2 Suppl):S1-S39. doi: 10.1177/0194599815572097. PMID: 25832968

Recent clinical studies

Etiology

Zar HJ, Cacho F, Kootbodien T, Mejias A, Ortiz JR, Stein RT, Hartert TV
Lancet Respir Med 2024 Oct;12(10):810-821. Epub 2024 Sep 9 doi: 10.1016/S2213-2600(24)00246-7. PMID: 39265601
Dable C, Nicolli E
Med Clin North Am 2021 Sep;105(5):849-858. doi: 10.1016/j.mcna.2021.05.007. PMID: 34391538
Stokes JR, Bacharier LB
Ann Allergy Asthma Immunol 2020 Aug;125(2):156-162. Epub 2020 May 23 doi: 10.1016/j.anai.2020.05.018. PMID: 32454096
Garcia-Garcia ML, Calvo Rey C, Del Rosal Rabes T
Arch Bronconeumol 2016 May;52(5):269-73. Epub 2016 Jan 4 doi: 10.1016/j.arbres.2015.11.008. PMID: 26766408Free PMC Article
Jain N, Lodha R, Kabra SK
Indian J Pediatr 2001 Dec;68(12):1135-8. doi: 10.1007/BF02722930. PMID: 11838568Free PMC Article

Diagnosis

Quraishi H, Lee DJ
Pediatr Clin North Am 2022 Apr;69(2):319-328. doi: 10.1016/j.pcl.2021.12.004. PMID: 35337542
Padem N, Saltoun C
Allergy Asthma Proc 2019 Nov 1;40(6):385-388. doi: 10.2500/aap.2019.40.4253. PMID: 31690376
Frazier AA
Radiographics 2018 Nov-Dec;38(7):2150. doi: 10.1148/rg.2018184010. PMID: 30422770
Jain N, Lodha R, Kabra SK
Indian J Pediatr 2001 Dec;68(12):1135-8. doi: 10.1007/BF02722930. PMID: 11838568Free PMC Article
Hall CB
N Engl J Med 2001 Jun 21;344(25):1917-28. doi: 10.1056/NEJM200106213442507. PMID: 11419430

Therapy

Romera I, Núñez K, Calizaya M, Baeza I, Molina R, Morillas J
Med Intensiva (Engl Ed) 2021 Aug-Sep;45(6):375-376. Epub 2021 May 2 doi: 10.1016/j.medine.2021.04.009. PMID: 34294235Free PMC Article
Vandini S, Biagi C, Fischer M, Lanari M
Viruses 2019 Jun 5;11(6) doi: 10.3390/v11060521. PMID: 31195744Free PMC Article
Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Ashok Kumar K, Kramper M, Orlandi RR, Palmer JN, Patel ZM, Peters A, Walsh SA, Corrigan MD
Otolaryngol Head Neck Surg 2015 Apr;152(2 Suppl):S1-S39. doi: 10.1177/0194599815572097. PMID: 25832968
Venkatesan NN, Pine HS, Underbrink MP
Otolaryngol Clin North Am 2012 Jun;45(3):671-94, viii-ix. doi: 10.1016/j.otc.2012.03.006. PMID: 22588043Free PMC Article
Jain N, Lodha R, Kabra SK
Indian J Pediatr 2001 Dec;68(12):1135-8. doi: 10.1007/BF02722930. PMID: 11838568Free PMC Article

Prognosis

Gracci S, Novelli T, D'Elios S, Bernardini R, Peroni D
Curr Pediatr Rev 2024;20(3):253-264. doi: 10.2174/1573396320666230912103124. PMID: 37702167
Qin N, Wang J, Peng X, Wang L
Expert Rev Neurother 2023 Jul-Dec;23(7):641-650. Epub 2023 Jun 13 doi: 10.1080/14737175.2023.2224503. PMID: 37309119
Blanchard AC, Waters VJ
Semin Respir Crit Care Med 2019 Dec;40(6):727-736. Epub 2019 Dec 30 doi: 10.1055/s-0039-1698464. PMID: 31887768Free PMC Article
Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E
Respir Med 2017 May;126:116-121. Epub 2017 Apr 1 doi: 10.1016/j.rmed.2017.03.030. PMID: 28427542
Venkatesan NN, Pine HS, Underbrink MP
Otolaryngol Clin North Am 2012 Jun;45(3):671-94, viii-ix. doi: 10.1016/j.otc.2012.03.006. PMID: 22588043Free PMC Article

Clinical prediction guides

Gracci S, Novelli T, D'Elios S, Bernardini R, Peroni D
Curr Pediatr Rev 2024;20(3):253-264. doi: 10.2174/1573396320666230912103124. PMID: 37702167
Smith KL, Hughes R, Myrex P
Am Fam Physician 2023 Jan;107(1):35-41. PMID: 36689967
Abrokwa SK, Müller SA, Méndez-Brito A, Hanefeld J, El Bcheraoui C
PLoS One 2021;16(12):e0261221. Epub 2021 Dec 9 doi: 10.1371/journal.pone.0261221. PMID: 34882750Free PMC Article
Massachi J, Donohue KC, Kelly JD
Am J Trop Med Hyg 2021 Aug 9;105(4):884-889. doi: 10.4269/ajtmh.21-0365. PMID: 34370705Free PMC Article
Fernandes RM, Wingert A, Vandermeer B, Featherstone R, Ali S, Plint AC, Stang AS, Rowe BH, Johnson DW, Allain D, Klassen TP, Hartling L
BMJ Open 2019 Aug 1;9(8):e028511. doi: 10.1136/bmjopen-2018-028511. PMID: 31375615Free PMC Article

Recent systematic reviews

Focosi D, Maggi F, Franchini M, McConnell S, Casadevall A
Int J Mol Sci 2021 Dec 21;23(1) doi: 10.3390/ijms23010029. PMID: 35008446Free PMC Article
Abrokwa SK, Müller SA, Méndez-Brito A, Hanefeld J, El Bcheraoui C
PLoS One 2021;16(12):e0261221. Epub 2021 Dec 9 doi: 10.1371/journal.pone.0261221. PMID: 34882750Free PMC Article
Massachi J, Donohue KC, Kelly JD
Am J Trop Med Hyg 2021 Aug 9;105(4):884-889. doi: 10.4269/ajtmh.21-0365. PMID: 34370705Free PMC Article
Fernandes RM, Wingert A, Vandermeer B, Featherstone R, Ali S, Plint AC, Stang AS, Rowe BH, Johnson DW, Allain D, Klassen TP, Hartling L
BMJ Open 2019 Aug 1;9(8):e028511. doi: 10.1136/bmjopen-2018-028511. PMID: 31375615Free PMC Article
Georgalas CC, Tolley NS, Narula PA
BMJ Clin Evid 2014 Jul 22;2014 PMID: 25051184Free PMC Article

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