U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Advanced Rectal Squamous Cell Carcinoma

MedGen UID:
1739737
•Concept ID:
C5418789
•
Neoplastic Process

Definition

Rectal squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Rectal Squamous Cell Carcinoma

Professional guidelines

PubMed

Presentation, treatment, and prognosis of colorectal adenosquamous carcinoma: A contemporary analysis of the surveillance, epidemiology, and end results database.
Khan AH, Gao X, Goffredo P, Kahl AR, Utria AF, Charlton ME, Ahad S, Hassan I
Am J Surg 2022 May;223(5):957-962. Epub 2021 Sep 11 doi: 10.1016/j.amjsurg.2021.09.004. PMID: 34530984
Anal Adenocarcinoma: A Rare Malignancy in Need of Multidisciplinary Management.
Lukovic J, Kim JJ, Krzyzanowska M, Chadi SA, Taniguchi CM, Hosni A
JCO Oncol Pract 2020 Oct;16(10):635-640. doi: 10.1200/OP.20.00363. PMID: 33049179
Update on treatment advances in combined-modality therapy for anal and rectal carcinomas.
Meyer J, Balch G, Willett C, Czito B
Curr Oncol Rep 2011 Jun;13(3):177-85. doi: 10.1007/s11912-011-0166-z. PMID: 21465120

Recent clinical studies

Etiology

Comprehensive look at rectal squamous cell carcinoma.
Liz-Pimenta J, Ferreira C, Araújo A, Sousa M
BMJ Case Rep 2024 Jan 24;17(1) doi: 10.1136/bcr-2023-255284. PMID: 38272508Free PMC Article
Adenocarcinoma arising from a chronic perianal fistula in a Crohn's disease patient: case report and review of the literature.
Gosse J, Simonelli V, Dessily M
Acta Chir Belg 2024 Apr;124(2):143-146. Epub 2023 Sep 5 doi: 10.1080/00015458.2023.2205722. PMID: 37668063
Anal Cancer: Emerging Standards in a Rare Disease.
Eng C, Ciombor KK, Cho M, Dorth JA, Rajdev LN, Horowitz DP, Gollub MJ, Jácome AA, Lockney NA, Muldoon RL, Washington MK, O'Brian BA, Benny A, Lebeck Lee CM, Benson AB 3rd, Goodman KA, Morris VK
J Clin Oncol 2022 Aug 20;40(24):2774-2788. Epub 2022 Jun 1 doi: 10.1200/JCO.21.02566. PMID: 35649196
Endoscopic submucosal dissection for superficial gastrointestinal lesions: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2022.
Pimentel-Nunes P, Libânio D, Bastiaansen BAJ, Bhandari P, Bisschops R, Bourke MJ, Esposito G, Lemmers A, Maselli R, Messmann H, Pech O, Pioche M, Vieth M, Weusten BLAM, van Hooft JE, Deprez PH, Dinis-Ribeiro M
Endoscopy 2022 Jun;54(6):591-622. Epub 2022 May 6 doi: 10.1055/a-1811-7025. PMID: 35523224
Neoadjuvant Chemotherapy Followed by Radical Surgery Versus Concomitant Chemotherapy and Radiotherapy in Patients With Stage IB2, IIA, or IIB Squamous Cervical Cancer: A Randomized Controlled Trial.
Gupta S, Maheshwari A, Parab P, Mahantshetty U, Hawaldar R, Sastri Chopra S, Kerkar R, Engineer R, Tongaonkar H, Ghosh J, Gulia S, Kumar N, Shylasree TS, Gawade R, Kembhavi Y, Gaikar M, Menon S, Thakur M, Shrivastava S, Badwe R
J Clin Oncol 2018 Jun 1;36(16):1548-1555. Epub 2018 Feb 12 doi: 10.1200/JCO.2017.75.9985. PMID: 29432076

Diagnosis

An Updated Review on Imaging and Staging of Anal Cancer-Not Just Rectal Cancer.
Congedo A, Mallardi D, Danti G, De Muzio F, Granata V, Miele V
Tomography 2023 Sep 4;9(5):1694-1710. doi: 10.3390/tomography9050135. PMID: 37736988Free PMC Article
Anal Cancer: Emerging Standards in a Rare Disease.
Eng C, Ciombor KK, Cho M, Dorth JA, Rajdev LN, Horowitz DP, Gollub MJ, Jácome AA, Lockney NA, Muldoon RL, Washington MK, O'Brian BA, Benny A, Lebeck Lee CM, Benson AB 3rd, Goodman KA, Morris VK
J Clin Oncol 2022 Aug 20;40(24):2774-2788. Epub 2022 Jun 1 doi: 10.1200/JCO.21.02566. PMID: 35649196
Endoscopic submucosal dissection for superficial gastrointestinal lesions: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2022.
Pimentel-Nunes P, Libânio D, Bastiaansen BAJ, Bhandari P, Bisschops R, Bourke MJ, Esposito G, Lemmers A, Maselli R, Messmann H, Pech O, Pioche M, Vieth M, Weusten BLAM, van Hooft JE, Deprez PH, Dinis-Ribeiro M
Endoscopy 2022 Jun;54(6):591-622. Epub 2022 May 6 doi: 10.1055/a-1811-7025. PMID: 35523224
Squamous cell carcinoma of the rectum: Practice trends and patient survival.
Dutta SW, Alonso CE, Waddle MR, Khandelwal SR, Janowski EM, Trifiletti DM
Cancer Med 2018 Dec;7(12):6093-6103. Epub 2018 Nov 20 doi: 10.1002/cam4.1893. PMID: 30457223Free PMC Article
Squamous cell cancer of the rectum.
Dyson T, Draganov PV
World J Gastroenterol 2009 Sep 21;15(35):4380-6. doi: 10.3748/wjg.15.4380. PMID: 19764088Free PMC Article

Therapy

Practice changing data and emerging concepts from recent radiation therapy randomised clinical trials.
Espenel S, Chargari C, Blanchard P, Bockel S, Morel D, Rivera S, Levy A, Deutsch E
Eur J Cancer 2022 Aug;171:242-258. Epub 2022 Jun 29 doi: 10.1016/j.ejca.2022.04.038. PMID: 35779346
Anal Adenocarcinoma: A Rare Malignancy in Need of Multidisciplinary Management.
Lukovic J, Kim JJ, Krzyzanowska M, Chadi SA, Taniguchi CM, Hosni A
JCO Oncol Pract 2020 Oct;16(10):635-640. doi: 10.1200/OP.20.00363. PMID: 33049179
Neoadjuvant Chemotherapy Followed by Radical Surgery Versus Concomitant Chemotherapy and Radiotherapy in Patients With Stage IB2, IIA, or IIB Squamous Cervical Cancer: A Randomized Controlled Trial.
Gupta S, Maheshwari A, Parab P, Mahantshetty U, Hawaldar R, Sastri Chopra S, Kerkar R, Engineer R, Tongaonkar H, Ghosh J, Gulia S, Kumar N, Shylasree TS, Gawade R, Kembhavi Y, Gaikar M, Menon S, Thakur M, Shrivastava S, Badwe R
J Clin Oncol 2018 Jun 1;36(16):1548-1555. Epub 2018 Feb 12 doi: 10.1200/JCO.2017.75.9985. PMID: 29432076
Esophageal cancer.
Coia LR, Sauter ER
Curr Probl Cancer 1994 Jul-Aug;18(4):189-247. doi: 10.1016/0147-0272(94)90007-8. PMID: 7533069
Clinical evidence of feasibility and efficacy of simultaneous irradiation and chemotherapy in advanced squamous cell carcinoma.
John M, Flam M, Wittlinger P, Podolsky W, Padmanabhan A, Mowry PA
Prog Clin Biol Res 1986;216:287-301. PMID: 3088598

Prognosis

Comprehensive look at rectal squamous cell carcinoma.
Liz-Pimenta J, Ferreira C, Araújo A, Sousa M
BMJ Case Rep 2024 Jan 24;17(1) doi: 10.1136/bcr-2023-255284. PMID: 38272508Free PMC Article
Presentation, treatment, and prognosis of colorectal adenosquamous carcinoma: A contemporary analysis of the surveillance, epidemiology, and end results database.
Khan AH, Gao X, Goffredo P, Kahl AR, Utria AF, Charlton ME, Ahad S, Hassan I
Am J Surg 2022 May;223(5):957-962. Epub 2021 Sep 11 doi: 10.1016/j.amjsurg.2021.09.004. PMID: 34530984
Neoadjuvant Chemotherapy Followed by Radical Surgery Versus Concomitant Chemotherapy and Radiotherapy in Patients With Stage IB2, IIA, or IIB Squamous Cervical Cancer: A Randomized Controlled Trial.
Gupta S, Maheshwari A, Parab P, Mahantshetty U, Hawaldar R, Sastri Chopra S, Kerkar R, Engineer R, Tongaonkar H, Ghosh J, Gulia S, Kumar N, Shylasree TS, Gawade R, Kembhavi Y, Gaikar M, Menon S, Thakur M, Shrivastava S, Badwe R
J Clin Oncol 2018 Jun 1;36(16):1548-1555. Epub 2018 Feb 12 doi: 10.1200/JCO.2017.75.9985. PMID: 29432076
Esophageal cancer.
Coia LR, Sauter ER
Curr Probl Cancer 1994 Jul-Aug;18(4):189-247. doi: 10.1016/0147-0272(94)90007-8. PMID: 7533069
Clinical evidence of feasibility and efficacy of simultaneous irradiation and chemotherapy in advanced squamous cell carcinoma.
John M, Flam M, Wittlinger P, Podolsky W, Padmanabhan A, Mowry PA
Prog Clin Biol Res 1986;216:287-301. PMID: 3088598

Clinical prediction guides

Prognostic Value of Tumor Regression Grade Based on Ryan Score in Squamous Cell Carcinoma and Adenocarcinoma of Esophagus.
Takeda FR, Tustumi F, de Almeida Obregon C, Yogolare GG, Navarro YP, Segatelli V, Sallum RAA, Junior UR, Cecconello I
Ann Surg Oncol 2020 Apr;27(4):1241-1247. Epub 2019 Oct 29 doi: 10.1245/s10434-019-07967-8. PMID: 31664618
Radiological prediction of positive circumferential resection margin in oesophageal cancer.
Foley KG, Christian A, Patel N, Lewis WG, Roberts SA
Eur J Radiol 2018 Oct;107:119-124. Epub 2018 Aug 30 doi: 10.1016/j.ejrad.2018.08.027. PMID: 30292255
Reconstruction following abdominoperineal resection (APR): Indications and complications from a single institution experience.
Sheckter CC, Shakir A, Vo H, Tsai J, Nazerali R, Lee GK
J Plast Reconstr Aesthet Surg 2016 Nov;69(11):1506-1512. Epub 2016 Jul 2 doi: 10.1016/j.bjps.2016.06.024. PMID: 27538340
Presenting symptoms predict local staging of anal cancer: a retrospective analysis of 86 patients.
Sauter M, Keilholz G, Kranzbühler H, Lombriser N, Prakash M, Vavricka SR, Misselwitz B
BMC Gastroenterol 2016 Apr 6;16:46. doi: 10.1186/s12876-016-0461-0. PMID: 27048435Free PMC Article
Advanced anal squamous cell carcinoma -- radiotherapy or surgery?
Smigielski J, Rychter A, Fijuth J, Brocki M
Chirurgia (Bucur) 2012 Sep-Oct;107(5):626-30. PMID: 23116837

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...