U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Liver Small Cell Neuroendocrine Carcinoma

MedGen UID:
1742185
Concept ID:
C5419814
Neoplastic Process
Synonyms: Hepatic Small Cell Carcinoma; Hepatic Small Cell Neuroendocrine Carcinoma; Liver Small Cell Carcinoma

Definition

An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the liver. It is characterized by the presence of malignant small cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver Small Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Shyam Sunder S, Sharma UC, Pokharel S
Signal Transduct Target Ther 2023 Jul 7;8(1):262. doi: 10.1038/s41392-023-01469-6. PMID: 37414756Free PMC Article
Hsu WH, Yang JC, Mok TS, Loong HH
Ann Oncol 2018 Jan 1;29(suppl_1):i3-i9. doi: 10.1093/annonc/mdx702. PMID: 29462253
Singh S, Osna NA, Kharbanda KK
World J Gastroenterol 2017 Sep 28;23(36):6549-6570. doi: 10.3748/wjg.v23.i36.6549. PMID: 29085205Free PMC Article

Recent clinical studies

Etiology

Katoh M, Loriot Y, Brandi G, Tavolari S, Wainberg ZA, Katoh M
Nat Rev Clin Oncol 2024 Apr;21(4):312-329. Epub 2024 Feb 29 doi: 10.1038/s41571-024-00869-z. PMID: 38424198
Conteduca V, Oromendia C, Eng KW, Bareja R, Sigouros M, Molina A, Faltas BM, Sboner A, Mosquera JM, Elemento O, Nanus DM, Tagawa ST, Ballman KV, Beltran H
Eur J Cancer 2019 Nov;121:7-18. Epub 2019 Sep 13 doi: 10.1016/j.ejca.2019.08.011. PMID: 31525487Free PMC Article
Singh S, Osna NA, Kharbanda KK
World J Gastroenterol 2017 Sep 28;23(36):6549-6570. doi: 10.3748/wjg.v23.i36.6549. PMID: 29085205Free PMC Article
Misra S, Bihari C
APMIS 2016 Apr;124(4):245-51. Epub 2016 Jan 14 doi: 10.1111/apm.12502. PMID: 26994733
von Pawel J, Schiller JH, Shepherd FA, Fields SZ, Kleisbauer JP, Chrysson NG, Stewart DJ, Clark PI, Palmer MC, Depierre A, Carmichael J, Krebs JB, Ross G, Lane SR, Gralla R
J Clin Oncol 1999 Feb;17(2):658-67. doi: 10.1200/JCO.1999.17.2.658. PMID: 10080612

Diagnosis

Karachaliou GS, Shi C, Abdelmalek MF
Gastroenterology 2022 Jul;163(1):e10-e12. Epub 2022 Jan 5 doi: 10.1053/j.gastro.2021.12.283. PMID: 34995531
Ling D, Chirchir M, Alzahrani N, Morris DL
ANZ J Surg 2022 Mar;92(3):608-610. Epub 2021 Jul 28 doi: 10.1111/ans.17105. PMID: 34319648
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Conteduca V, Oromendia C, Eng KW, Bareja R, Sigouros M, Molina A, Faltas BM, Sboner A, Mosquera JM, Elemento O, Nanus DM, Tagawa ST, Ballman KV, Beltran H
Eur J Cancer 2019 Nov;121:7-18. Epub 2019 Sep 13 doi: 10.1016/j.ejca.2019.08.011. PMID: 31525487Free PMC Article
Pinsky SM, Henkin RE
Semin Nucl Med 1976 Oct;6(4):397-409. doi: 10.1016/s0001-2998(76)80017-7. PMID: 185721

Therapy

Katoh M, Loriot Y, Brandi G, Tavolari S, Wainberg ZA, Katoh M
Nat Rev Clin Oncol 2024 Apr;21(4):312-329. Epub 2024 Feb 29 doi: 10.1038/s41571-024-00869-z. PMID: 38424198
Lau HC, Zhang X, Ji F, Lin Y, Liang W, Li Q, Chen D, Fong W, Kang X, Liu W, Chu ES, Ng QW, Yu J
EBioMedicine 2024 Feb;100:104952. Epub 2024 Jan 4 doi: 10.1016/j.ebiom.2023.104952. PMID: 38176203Free PMC Article
Pfister D, Núñez NG, Pinyol R, Govaere O, Pinter M, Szydlowska M, Gupta R, Qiu M, Deczkowska A, Weiner A, Müller F, Sinha A, Friebel E, Engleitner T, Lenggenhager D, Moncsek A, Heide D, Stirm K, Kosla J, Kotsiliti E, Leone V, Dudek M, Yousuf S, Inverso D, Singh I, Teijeiro A, Castet F, Montironi C, Haber PK, Tiniakos D, Bedossa P, Cockell S, Younes R, Vacca M, Marra F, Schattenberg JM, Allison M, Bugianesi E, Ratziu V, Pressiani T, D'Alessio A, Personeni N, Rimassa L, Daly AK, Scheiner B, Pomej K, Kirstein MM, Vogel A, Peck-Radosavljevic M, Hucke F, Finkelmeier F, Waidmann O, Trojan J, Schulze K, Wege H, Koch S, Weinmann A, Bueter M, Rössler F, Siebenhüner A, De Dosso S, Mallm JP, Umansky V, Jugold M, Luedde T, Schietinger A, Schirmacher P, Emu B, Augustin HG, Billeter A, Müller-Stich B, Kikuchi H, Duda DG, Kütting F, Waldschmidt DT, Ebert MP, Rahbari N, Mei HE, Schulz AR, Ringelhan M, Malek N, Spahn S, Bitzer M, Ruiz de Galarreta M, Lujambio A, Dufour JF, Marron TU, Kaseb A, Kudo M, Huang YH, Djouder N, Wolter K, Zender L, Marche PN, Decaens T, Pinato DJ, Rad R, Mertens JC, Weber A, Unger K, Meissner F, Roth S, Jilkova ZM, Claassen M, Anstee QM, Amit I, Knolle P, Becher B, Llovet JM, Heikenwalder M
Nature 2021 Apr;592(7854):450-456. Epub 2021 Mar 24 doi: 10.1038/s41586-021-03362-0. PMID: 33762733Free PMC Article
Xu F, Jin T, Zhu Y, Dai C
J Exp Clin Cancer Res 2018 May 29;37(1):110. doi: 10.1186/s13046-018-0777-4. PMID: 29843754Free PMC Article
Singh S, Osna NA, Kharbanda KK
World J Gastroenterol 2017 Sep 28;23(36):6549-6570. doi: 10.3748/wjg.v23.i36.6549. PMID: 29085205Free PMC Article

Prognosis

Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Conteduca V, Oromendia C, Eng KW, Bareja R, Sigouros M, Molina A, Faltas BM, Sboner A, Mosquera JM, Elemento O, Nanus DM, Tagawa ST, Ballman KV, Beltran H
Eur J Cancer 2019 Nov;121:7-18. Epub 2019 Sep 13 doi: 10.1016/j.ejca.2019.08.011. PMID: 31525487Free PMC Article
Rudin CM, Pietanza MC, Bauer TM, Ready N, Morgensztern D, Glisson BS, Byers LA, Johnson ML, Burris HA 3rd, Robert F, Han TH, Bheddah S, Theiss N, Watson S, Mathur D, Vennapusa B, Zayed H, Lally S, Strickland DK, Govindan R, Dylla SJ, Peng SL, Spigel DR; SCRX16-001 investigators
Lancet Oncol 2017 Jan;18(1):42-51. Epub 2016 Dec 5 doi: 10.1016/S1470-2045(16)30565-4. PMID: 27932068Free PMC Article
von Pawel J, Schiller JH, Shepherd FA, Fields SZ, Kleisbauer JP, Chrysson NG, Stewart DJ, Clark PI, Palmer MC, Depierre A, Carmichael J, Krebs JB, Ross G, Lane SR, Gralla R
J Clin Oncol 1999 Feb;17(2):658-67. doi: 10.1200/JCO.1999.17.2.658. PMID: 10080612
Jones SE, Salmon SE
Semin Nucl Med 1976 Oct;6(4):331-46. doi: 10.1016/s0001-2998(76)80012-8. PMID: 62399

Clinical prediction guides

Zen Y
Hum Pathol 2023 Feb;132:197-207. Epub 2022 Jun 11 doi: 10.1016/j.humpath.2022.06.001. PMID: 35697170
Lee JC, Green MD, Huppert LA, Chow C, Pierce RH, Daud AI
Clin Cancer Res 2022 Jan 1;28(1):5-12. Epub 2021 Jul 20 doi: 10.1158/1078-0432.CCR-21-1193. PMID: 34285059Free PMC Article
Liu L, Zhang R, Deng J, Dai X, Zhu X, Fu Q, Zhang H, Tong Z, Zhao P, Fang W, Zheng Y, Bao X
Cancer Immunol Immunother 2022 Jan;71(1):121-136. Epub 2021 May 24 doi: 10.1007/s00262-021-02967-8. PMID: 34028567Free PMC Article
Paver EC, Cooper WA, Colebatch AJ, Ferguson PM, Hill SK, Lum T, Shin JS, O'Toole S, Anderson L, Scolyer RA, Gupta R
Pathology 2021 Feb;53(2):141-156. Epub 2020 Dec 30 doi: 10.1016/j.pathol.2020.10.007. PMID: 33388161
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article

Recent systematic reviews

Cozma A, Sporis ND, Lazar AL, Buruiana A, Ganea AM, Malinescu TV, Berechet BM, Fodor A, Sitar-Taut AV, Vlad VC, Negrean V, Orasan OH
Int J Mol Sci 2022 Sep 19;23(18) doi: 10.3390/ijms231810948. PMID: 36142866Free PMC Article
Siciliano MA, Caridà G, Ciliberto D, d'Apolito M, Pelaia C, Caracciolo D, Riillo C, Correale P, Galvano A, Russo A, Barbieri V, Tassone P, Tagliaferri P
ESMO Open 2022 Jun;7(3):100465. Epub 2022 Apr 12 doi: 10.1016/j.esmoop.2022.100465. PMID: 35427835Free PMC Article
Liu J, Sauer MA, Hussein SG, Yang J, Tenen DG, Chai L
Genes (Basel) 2021 Aug 24;12(9) doi: 10.3390/genes12091301. PMID: 34573282Free PMC Article
Dafni U, Tsourti Z, Vervita K, Peters S
Lung Cancer 2019 Aug;134:127-140. Epub 2019 May 30 doi: 10.1016/j.lungcan.2019.05.029. PMID: 31319971
Yang Z, Hackshaw A, Feng Q, Fu X, Zhang Y, Mao C, Tang J
Int J Cancer 2017 Jun 15;140(12):2805-2819. Epub 2017 Mar 27 doi: 10.1002/ijc.30691. PMID: 28295308

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...