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Small Progressed Hepatocellular Carcinoma

MedGen UID:
1749508
Concept ID:
C5419809
Neoplastic Process
Synonym: Small pHCC

Definition

A well to moderately differentiated small hepatocellular carcinoma. It is characterized by the presence of obvious stromal invasion and increase atypia compared with early hepatocellular carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Progressed Hepatocellular Carcinoma

Professional guidelines

PubMed

Harris PE, Zhernosekov K
Front Endocrinol (Lausanne) 2022;13:941832. Epub 2022 Oct 31 doi: 10.3389/fendo.2022.941832. PMID: 36387893Free PMC Article
De Mattia E, Cecchin E, Guardascione M, Foltran L, Di Raimo T, Angelini F, D'Andrea M, Toffoli G
World J Gastroenterol 2019 Aug 7;25(29):3870-3896. doi: 10.3748/wjg.v25.i29.3870. PMID: 31413525Free PMC Article
Singh S, Osna NA, Kharbanda KK
World J Gastroenterol 2017 Sep 28;23(36):6549-6570. doi: 10.3748/wjg.v23.i36.6549. PMID: 29085205Free PMC Article

Recent clinical studies

Etiology

Sun B, Ding P, Song Y, Zhou J, Chen X, Peng C, Liu S
Redox Biol 2024 Sep;75:103302. Epub 2024 Aug 5 doi: 10.1016/j.redox.2024.103302. PMID: 39128228Free PMC Article
Liang J, Li PY, Norman J, Lauzon M, Yeo YH, Trivedi H, Ayoub WS, Kuo A, Friedman ML, Sankar K, Gong J, Osipov A, Hendifar A, Todo T, Kim I, Voidonikolas G, Brennan TV, Wisel SA, Steggarda J, Kosari K, Saouaf R, Nissen N, Yao F, Mehta N, Yang JD
Hepatol Commun 2024 Jul 1;8(7) Epub 2024 Jun 19 doi: 10.1097/HC9.0000000000000466. PMID: 38896084Free PMC Article
Gudan A, Kozłowska-Petriczko K, Wunsch E, Bodnarczuk T, Stachowska E
Nutrients 2023 Mar 8;15(6) doi: 10.3390/nu15061323. PMID: 36986052Free PMC Article
Forner A, Llovet JM, Bruix J
Lancet 2012 Mar 31;379(9822):1245-55. Epub 2012 Feb 20 doi: 10.1016/S0140-6736(11)61347-0. PMID: 22353262
Effendi K, Sakamoto M
Oncology 2010;78(2):157-60. Epub 2010 Apr 13 doi: 10.1159/000312658. PMID: 20389138

Diagnosis

Takahashi Y, Dungubat E, Kusano H, Ganbat D, Tomita Y, Odgerel S, Fukusato T
Int J Mol Sci 2021 May 28;22(11) doi: 10.3390/ijms22115780. PMID: 34071338Free PMC Article
Ye Q, Ling S, Zheng S, Xu X
Mol Cancer 2019 Jul 3;18(1):114. doi: 10.1186/s12943-019-1043-x. PMID: 31269959Free PMC Article
Forner A, Llovet JM, Bruix J
Lancet 2012 Mar 31;379(9822):1245-55. Epub 2012 Feb 20 doi: 10.1016/S0140-6736(11)61347-0. PMID: 22353262
Lohse AW, Mieli-Vergani G
J Hepatol 2011 Jul;55(1):171-82. Epub 2010 Dec 15 doi: 10.1016/j.jhep.2010.12.012. PMID: 21167232
Liang TJ
Hepatology 2009 May;49(5 Suppl):S13-21. doi: 10.1002/hep.22881. PMID: 19399811Free PMC Article

Therapy

Pfister D, Núñez NG, Pinyol R, Govaere O, Pinter M, Szydlowska M, Gupta R, Qiu M, Deczkowska A, Weiner A, Müller F, Sinha A, Friebel E, Engleitner T, Lenggenhager D, Moncsek A, Heide D, Stirm K, Kosla J, Kotsiliti E, Leone V, Dudek M, Yousuf S, Inverso D, Singh I, Teijeiro A, Castet F, Montironi C, Haber PK, Tiniakos D, Bedossa P, Cockell S, Younes R, Vacca M, Marra F, Schattenberg JM, Allison M, Bugianesi E, Ratziu V, Pressiani T, D'Alessio A, Personeni N, Rimassa L, Daly AK, Scheiner B, Pomej K, Kirstein MM, Vogel A, Peck-Radosavljevic M, Hucke F, Finkelmeier F, Waidmann O, Trojan J, Schulze K, Wege H, Koch S, Weinmann A, Bueter M, Rössler F, Siebenhüner A, De Dosso S, Mallm JP, Umansky V, Jugold M, Luedde T, Schietinger A, Schirmacher P, Emu B, Augustin HG, Billeter A, Müller-Stich B, Kikuchi H, Duda DG, Kütting F, Waldschmidt DT, Ebert MP, Rahbari N, Mei HE, Schulz AR, Ringelhan M, Malek N, Spahn S, Bitzer M, Ruiz de Galarreta M, Lujambio A, Dufour JF, Marron TU, Kaseb A, Kudo M, Huang YH, Djouder N, Wolter K, Zender L, Marche PN, Decaens T, Pinato DJ, Rad R, Mertens JC, Weber A, Unger K, Meissner F, Roth S, Jilkova ZM, Claassen M, Anstee QM, Amit I, Knolle P, Becher B, Llovet JM, Heikenwalder M
Nature 2021 Apr;592(7854):450-456. Epub 2021 Mar 24 doi: 10.1038/s41586-021-03362-0. PMID: 33762733Free PMC Article
Al-Salama ZT, Syed YY, Scott LJ
Drugs 2019 Apr;79(6):665-674. doi: 10.1007/s40265-019-01116-x. PMID: 30993651
Cullis PR, Hope MJ
Mol Ther 2017 Jul 5;25(7):1467-1475. Epub 2017 Apr 13 doi: 10.1016/j.ymthe.2017.03.013. PMID: 28412170Free PMC Article
Forner A, Llovet JM, Bruix J
Lancet 2012 Mar 31;379(9822):1245-55. Epub 2012 Feb 20 doi: 10.1016/S0140-6736(11)61347-0. PMID: 22353262
Lohse AW, Mieli-Vergani G
J Hepatol 2011 Jul;55(1):171-82. Epub 2010 Dec 15 doi: 10.1016/j.jhep.2010.12.012. PMID: 21167232

Prognosis

Sun B, Ding P, Song Y, Zhou J, Chen X, Peng C, Liu S
Redox Biol 2024 Sep;75:103302. Epub 2024 Aug 5 doi: 10.1016/j.redox.2024.103302. PMID: 39128228Free PMC Article
Guo W, Li S, Qian Y, Li L, Wang F, Tong Y, Li Q, Zhu Z, Gao WQ, Liu Y
Clin Transl Med 2023 Oct;13(10):e1452. doi: 10.1002/ctm2.1452. PMID: 37846441Free PMC Article
Xing R, Gao J, Cui Q, Wang Q
Front Immunol 2021;12:783236. Epub 2021 Nov 26 doi: 10.3389/fimmu.2021.783236. PMID: 34899747Free PMC Article
Ye Q, Ling S, Zheng S, Xu X
Mol Cancer 2019 Jul 3;18(1):114. doi: 10.1186/s12943-019-1043-x. PMID: 31269959Free PMC Article
Forner A, Llovet JM, Bruix J
Lancet 2012 Mar 31;379(9822):1245-55. Epub 2012 Feb 20 doi: 10.1016/S0140-6736(11)61347-0. PMID: 22353262

Clinical prediction guides

Liang J, Li PY, Norman J, Lauzon M, Yeo YH, Trivedi H, Ayoub WS, Kuo A, Friedman ML, Sankar K, Gong J, Osipov A, Hendifar A, Todo T, Kim I, Voidonikolas G, Brennan TV, Wisel SA, Steggarda J, Kosari K, Saouaf R, Nissen N, Yao F, Mehta N, Yang JD
Hepatol Commun 2024 Jul 1;8(7) Epub 2024 Jun 19 doi: 10.1097/HC9.0000000000000466. PMID: 38896084Free PMC Article
Limousin W, Laurent-Puig P, Ziol M, Ganne-Carrié N, Nahon P, Ait-Omar A, Seror O, Sidali S, Campani C, Blanc P, Lermine A, Marisa L, Zucman-Rossi J, Nault JC
J Hepatol 2023 Dec;79(6):1450-1458. Epub 2023 Aug 28 doi: 10.1016/j.jhep.2023.08.017. PMID: 37647991
Liao Y, Liu Y, Yu C, Lei Q, Cheng J, Kong W, Yu Y, Zhuang X, Sun W, Yin S, Cai G, Huang H
Adv Sci (Weinh) 2023 Sep;10(27):e2302025. Epub 2023 Jul 28 doi: 10.1002/advs.202302025. PMID: 37515378Free PMC Article
Liu L, Zhang R, Deng J, Dai X, Zhu X, Fu Q, Zhang H, Tong Z, Zhao P, Fang W, Zheng Y, Bao X
Cancer Immunol Immunother 2022 Jan;71(1):121-136. Epub 2021 May 24 doi: 10.1007/s00262-021-02967-8. PMID: 34028567Free PMC Article
Muntané J
Anticancer Agents Med Chem 2011 Jul;11(6):576-84. doi: 10.2174/187152011796011082. PMID: 21554206

Recent systematic reviews

Wade R, South E, Anwer S, Sharif-Hurst S, Harden M, Fulbright H, Hodgson R, Dias S, Simmonds M, Rowe I, Thornton P, Eastwood A
Health Technol Assess 2023 Dec;27(29):1-172. doi: 10.3310/GK5221. PMID: 38149643Free PMC Article
Du F, Zhang L, Zhang Y, Fan H, Ren L
Clin Res Hepatol Gastroenterol 2023 Jan;47(1):102069. Epub 2022 Dec 10 doi: 10.1016/j.clinre.2022.102069. PMID: 36513251
Nathani P, Gopal P, Rich N, Yopp A, Yokoo T, John B, Marrero J, Parikh N, Singal AG
Gut 2021 Feb;70(2):401-407. Epub 2020 May 12 doi: 10.1136/gutjnl-2020-321040. PMID: 32398224Free PMC Article
Shuai Y, Ma Z, Lu J, Feng J
Cell Prolif 2020 Jan;53(1):e12716. Epub 2019 Nov 27 doi: 10.1111/cpr.12716. PMID: 31774607Free PMC Article
Chen C, Ma YH, Zhang YT, Zhang F, Zhou N, Wang X, Liu T, Li YM
Cytotherapy 2018 Aug;20(8):975-989. Epub 2018 Jul 30 doi: 10.1016/j.jcyt.2018.06.002. PMID: 30072299

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