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Digestive System Inflammatory Myofibroblastic Tumor

MedGen UID:
1755929
•Concept ID:
C5419898
•
Neoplastic Process

Definition

A multinodular intermediate fibroblastic neoplasm arising from the digestive system. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes and plasma cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDigestive System Inflammatory Myofibroblastic Tumor

Professional guidelines

PubMed

Hepatic inflammatory pseudotumor mimicking malignancy: the value of differential diagnosis on contrast enhanced ultrasound.
Kong WT, Wang WP, Shen HY, Xue HY, Liu CR, Huang DQ, Wu M
Med Ultrason 2021 Feb 18;23(1):15-21. Epub 2020 Aug 18 doi: 10.11152/mu-2542. PMID: 32905565
Endoscopic ultrasound and fine needle aspiration in chronic pancreatitis: differential diagnosis between pseudotumoral masses and pancreatic cancer.
Ardengh JC, Lopes CV, Campos AD, Pereira de Lima LF, Venco F, Módena JL
JOP 2007 Jul 9;8(4):413-21. PMID: 17625292
Intestinal invagination in adults: preoperative diagnosis and management.
Martín-Lorenzo JG, Torralba-Martinez A, Lirón-Ruiz R, Flores-Pastor B, Miguel-Perelló J, Aguilar-Jimenez J, Aguayo-Albasini JL
Int J Colorectal Dis 2004 Jan;19(1):68-72. Epub 2003 Jun 28 doi: 10.1007/s00384-003-0514-z. PMID: 12838363

Recent clinical studies

Etiology

Paediatric Gastrointestinal, Hepatic and Pancreatic Inflammatory Myofibroblastic Tumours, A Single Centre Experience.
Couper MR, Eldredge JA, Kirby M, Kirby C, Moore D, Hammond P, Manton N, Glynn A, Couper RT
J Pediatr Gastroenterol Nutr 2022 Feb 1;74(2):253-257. doi: 10.1097/MPG.0000000000003311. PMID: 34596604
Differentiation between inflammatory myofibroblastic tumor and cholangiocarcinoma manifesting as target appearance on gadoxetic acid-enhanced MRI.
Chang AI, Kim YK, Min JH, Lee J, Kim H, Lee SJ
Abdom Radiol (NY) 2019 Apr;44(4):1395-1406. doi: 10.1007/s00261-018-1847-y. PMID: 30515535
Computed Tomography and Magnetic Resonance Imaging Findings of Inflammatory Pseudotumors in the Abdomen and Pelvis: Current Concepts and Pictorial Review.
Torres US, Matsumoto C, Maia DR, de Souza LRMF, D'Ippolito G
Semin Ultrasound CT MR 2018 Apr;39(2):220-229. Epub 2017 Sep 21 doi: 10.1053/j.sult.2017.09.005. PMID: 29571557
Inflammatory myofibroblastic tumor of the hepatobiliary system: report of MR imaging appearance in four patients.
Venkataraman S, Semelka RC, Braga L, Danet IM, Woosley JT
Radiology 2003 Jun;227(3):758-63. Epub 2003 May 1 doi: 10.1148/radiol.2273020572. PMID: 12728186
Benign hepatic tumours.
Biecker E, Fischer HP, Strunk H, Sauerbruch T
Z Gastroenterol 2003 Feb;41(2):191-200. doi: 10.1055/s-2003-37316. PMID: 12650132

Diagnosis

Rectal inflammatory myofibroblastic tumor: Case report and literature review.
Oh HH, Joo YE
Medicine (Baltimore) 2021 Aug 20;100(33):e27008. doi: 10.1097/MD.0000000000027008. PMID: 34414993Free PMC Article
Immunoglobulin G4-related hepatobiliary disease.
Lee HE, Zhang L
Semin Diagn Pathol 2019 Nov;36(6):423-433. Epub 2019 Jul 24 doi: 10.1053/j.semdp.2019.07.007. PMID: 31358425
Inflammatory myofibroblastic tumor of the gallbladder: a case report and literature review.
Yamada T, Hisa T, Shiozawa S, Kudo A, Furukawa R
J Med Ultrason (2001) 2018 Jan;45(1):175-180. Epub 2017 Jun 21 doi: 10.1007/s10396-017-0798-1. PMID: 28639154
Intra-abdominal inflammatory myofibroblastic tumor: spontaneous regression.
Zhao JJ, Ling JQ, Fang Y, Gao XD, Shu P, Shen KT, Qin J, Sun YH, Qin XY
World J Gastroenterol 2014 Oct 7;20(37):13625-31. doi: 10.3748/wjg.v20.i37.13625. PMID: 25309095Free PMC Article
Benign hepatic tumours.
Biecker E, Fischer HP, Strunk H, Sauerbruch T
Z Gastroenterol 2003 Feb;41(2):191-200. doi: 10.1055/s-2003-37316. PMID: 12650132

Therapy

Fibrohistiocytic Variant of Hepatic Pseudotumor: An Antibiotic Responsive Tumefactive Lesion.
Arora KS, Anderson MA, Neyaz A, Yilmaz O, Pankaj A, Ferrone CR, Zen Y, England J, Deshpande V
Am J Surg Pathol 2021 Oct 1;45(10):1314-1323. doi: 10.1097/PAS.0000000000001767. PMID: 34334689
Posttransplant epithelioid inflammatory myofibroblastic sarcoma: A case report.
Garg R, Kaul S, Arora D, Kashyap V
Indian J Pathol Microbiol 2019 Apr-Jun;62(2):303-305. doi: 10.4103/IJPM.IJPM_284_17. PMID: 30971562
Sevelamer-Induced Colitis Presenting as a Pseudotumor.
Okwara C, Choi C, Park JY
Clin Gastroenterol Hepatol 2015 Jul;13(7):A39-40. Epub 2015 Feb 18 doi: 10.1016/j.cgh.2015.02.015. PMID: 25701702
IgG4-related tubulointerstitial nephritis and hepatic inflammatory pseudotumor without hypocomplementemia.
Kim F, Yamada K, Inoue D, Nakajima K, Mizushima I, Kakuchi Y, Fujii H, Narumi K, Matsumura M, Umehara H, Yamagishi M, Kawano M
Intern Med 2011;50(11):1239-44. Epub 2011 Jun 1 doi: 10.2169/internalmedicine.50.5102. PMID: 21628942
Benign focal lesions of the liver.
Trotter JF, Everson GT
Clin Liver Dis 2001 Feb;5(1):17-42, v. doi: 10.1016/s1089-3261(05)70152-5. PMID: 11218914

Prognosis

ROS1-positive Inflammatory Myofibroblastic Tumor of the Small Bowel Causing Obstruction: A Case Report.
Budylev A, Solar I, Kessner R, Aizic A
J Radiol Case Rep 2022 Jan;16(1):14-21. Epub 2022 Jan 1 doi: 10.3941/jrcr.v16i1.3928. PMID: 35586084Free PMC Article
Paediatric Gastrointestinal, Hepatic and Pancreatic Inflammatory Myofibroblastic Tumours, A Single Centre Experience.
Couper MR, Eldredge JA, Kirby M, Kirby C, Moore D, Hammond P, Manton N, Glynn A, Couper RT
J Pediatr Gastroenterol Nutr 2022 Feb 1;74(2):253-257. doi: 10.1097/MPG.0000000000003311. PMID: 34596604
Inflammatory myofibroblastic tumor of the small intestine mimicking acute appendicitis: a case report and review of the literature.
Oeconomopoulou A, de Verney Y, Kanavaki K, Stefanaki K, Pavlakis K, Salakos C
J Med Case Rep 2016 Apr 19;10:100. doi: 10.1186/s13256-016-0880-0. PMID: 27094797Free PMC Article
Intra-abdominal inflammatory myofibroblastic tumor: spontaneous regression.
Zhao JJ, Ling JQ, Fang Y, Gao XD, Shu P, Shen KT, Qin J, Sun YH, Qin XY
World J Gastroenterol 2014 Oct 7;20(37):13625-31. doi: 10.3748/wjg.v20.i37.13625. PMID: 25309095Free PMC Article
Immunoglobulin G4-related gastrointestinal diseases, are they immunoglobulin G4-related diseases?
Koizumi S, Kamisawa T, Kuruma S, Tabata T, Chiba K, Iwasaki S, Endo Y, Kuwata G, Koizumi K, Shimosegawa T, Okazaki K, Chiba T
World J Gastroenterol 2013 Sep 21;19(35):5769-74. doi: 10.3748/wjg.v19.i35.5769. PMID: 24124321Free PMC Article

Clinical prediction guides

Clinical and Pathological Features of Immune Checkpoint Inhibitor-induced Liver Injury in Comparison with Drug-induced Liver Injury and Autoimmune Hepatitis.
Sunago K, Abe M, Yoshida O, Watanabe T, Nakamura Y, Imai Y, Koizumi Y, Hirooka M, Tokumoto Y, Hiasa Y
J Gastrointestin Liver Dis 2023 Dec 22;32(4):488-496. doi: 10.15403/jgld-5045. PMID: 38147620
Intra-abdominal inflammatory myofibroblastic tumor: spontaneous regression.
Zhao JJ, Ling JQ, Fang Y, Gao XD, Shu P, Shen KT, Qin J, Sun YH, Qin XY
World J Gastroenterol 2014 Oct 7;20(37):13625-31. doi: 10.3748/wjg.v20.i37.13625. PMID: 25309095Free PMC Article
Immunoglobulin G4-related gastrointestinal diseases, are they immunoglobulin G4-related diseases?
Koizumi S, Kamisawa T, Kuruma S, Tabata T, Chiba K, Iwasaki S, Endo Y, Kuwata G, Koizumi K, Shimosegawa T, Okazaki K, Chiba T
World J Gastroenterol 2013 Sep 21;19(35):5769-74. doi: 10.3748/wjg.v19.i35.5769. PMID: 24124321Free PMC Article
Abdominal inflammatory myofibroblastic tumor a clinicopathologic study with reappraisal of biologic behavior.
Fragoso AC, Eloy C, Estevão-Costa J, Campos M, Farinha N, Lopes JM
J Pediatr Surg 2011 Nov;46(11):2076-82. doi: 10.1016/j.jpedsurg.2011.07.009. PMID: 22075336
Inflammatory myofibroblastic tumor of the hepatobiliary system: report of MR imaging appearance in four patients.
Venkataraman S, Semelka RC, Braga L, Danet IM, Woosley JT
Radiology 2003 Jun;227(3):758-63. Epub 2003 May 1 doi: 10.1148/radiol.2273020572. PMID: 12728186

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