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Digestive System Inflammatory Myofibroblastic Tumor

MedGen UID:
1755929
•Concept ID:
C5419898
•
Neoplastic Process

Definition

A multinodular intermediate fibroblastic neoplasm arising from the digestive system. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes and plasma cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDigestive System Inflammatory Myofibroblastic Tumor

Professional guidelines

PubMed

Hepatic inflammatory pseudotumor mimicking malignancy: the value of differential diagnosis on contrast enhanced ultrasound.
Kong WT, Wang WP, Shen HY, Xue HY, Liu CR, Huang DQ, Wu M
Med Ultrason 2021 Feb 18;23(1):15-21. Epub 2020 Aug 18 doi: 10.11152/mu-2542. PMID: 32905565
Endoscopic ultrasound and fine needle aspiration in chronic pancreatitis: differential diagnosis between pseudotumoral masses and pancreatic cancer.
Ardengh JC, Lopes CV, Campos AD, Pereira de Lima LF, Venco F, Módena JL
JOP 2007 Jul 9;8(4):413-21. PMID: 17625292
Intestinal invagination in adults: preoperative diagnosis and management.
Martín-Lorenzo JG, Torralba-Martinez A, Lirón-Ruiz R, Flores-Pastor B, Miguel-Perelló J, Aguilar-Jimenez J, Aguayo-Albasini JL
Int J Colorectal Dis 2004 Jan;19(1):68-72. Epub 2003 Jun 28 doi: 10.1007/s00384-003-0514-z. PMID: 12838363

Recent clinical studies

Etiology

Cytohistological and immunohistochemical characteristics of spindle-shaped mesenchymal neoplasms occurring in the gastrointestinal tract.
Ieni A, Barresi V, Reggiani Bonetti L, Branca G, Caruso RA, Tuccari G
Scand J Gastroenterol 2017 Mar;52(3):291-299. Epub 2016 Nov 6 doi: 10.1080/00365521.2016.1251607. PMID: 27817254
Inflammatory myofibroblastic tumor of gall bladder.
Muduly D, Deo SV, Shukla NK, Manjunath NM, Durgapal P, Kallianpur A
Trop Gastroenterol 2012 Oct-Dec;33(4):297-9. doi: 10.7869/tg.2012.79. PMID: 23923363
Pulmonary inflammatory myofibroblastic tumor invading the gastroesophageal junction.
Chow SC, Nahal A, Mayrand S, Ferri LE
Ann Thorac Surg 2010 May;89(5):1659-61. doi: 10.1016/j.athoracsur.2009.09.082. PMID: 20417808
Benign hepatic tumours.
Biecker E, Fischer HP, Strunk H, Sauerbruch T
Z Gastroenterol 2003 Feb;41(2):191-200. doi: 10.1055/s-2003-37316. PMID: 12650132
Inflammatory myofibroblastic tumor of small bowel wall in childhood: Report of a case and a review of the literature.
Demirkan NC, Akalin T, Yilmaz F, Ozgenc F, Ozcan C, Alkanat MB, Aydogdu S
Pathol Int 2001 Jan;51(1):47-9. doi: 10.1046/j.1440-1827.2001.01158.x. PMID: 11148464

Diagnosis

An unusual mass in the colon: Inflammatory myofibroblastic tumor.
Hong SK, Ding Y, Li H, Zhang JY, Huang WF
Clin Res Hepatol Gastroenterol 2022 Oct;46(8):101988. Epub 2022 Jun 28 doi: 10.1016/j.clinre.2022.101988. PMID: 35777729
Follicular pancreatitis: A rare pancreatic inflammatory pseudotumor.
Tom WJ, Xu X, Vahdat N, Cassidy F, Aganovic L
Clin Imaging 2020 Jan;59(1):39-44. Epub 2019 Oct 25 doi: 10.1016/j.clinimag.2019.08.006. PMID: 31756593Free PMC Article
Inflammatory myofibroblastic tumor of the colon.
Gurzu S, Bara T, Jung I
J Clin Oncol 2013 Apr 1;31(10):e155-8. Epub 2013 Jan 28 doi: 10.1200/JCO.2012.42.8961. PMID: 23358988
Inflammatory myofibroblastic tumor of gall bladder.
Muduly D, Deo SV, Shukla NK, Manjunath NM, Durgapal P, Kallianpur A
Trop Gastroenterol 2012 Oct-Dec;33(4):297-9. doi: 10.7869/tg.2012.79. PMID: 23923363
Benign tumors of the liver.
Brunt EM
Clin Liver Dis 2001 Feb;5(1):1-15, v. doi: 10.1016/s1089-3261(05)70151-3. PMID: 11218909

Therapy

IgG4-related inflammatory pseudotumour mimicking a hepatic abscess impending rupture.
Mulki R, Garg S, Manatsathit W, Miick R
BMJ Case Rep 2015 Sep 21;2015 doi: 10.1136/bcr-2015-211893. PMID: 26392451Free PMC Article
Sevelamer-Induced Colitis Presenting as a Pseudotumor.
Okwara C, Choi C, Park JY
Clin Gastroenterol Hepatol 2015 Jul;13(7):A39-40. Epub 2015 Feb 18 doi: 10.1016/j.cgh.2015.02.015. PMID: 25701702
Eosinophilic pseudotumour of the liver.
Charatcharoenwitthaya P, Apisarnthanarak P, Pongpaibul A, Boonyaarunnate T
Liver Int 2012 Feb;32(2):311. Epub 2011 Nov 30 doi: 10.1111/j.1478-3231.2011.02691.x. PMID: 22128767
Gastrointestinal histoplasmosis presenting as colonic pseudotumour.
Sehgal S, Chawla R, Loomba PS, Mishra B
Indian J Med Microbiol 2008 Apr-Jun;26(2):187-9. doi: 10.4103/0255-0857.40541. PMID: 18445963
Benign focal lesions of the liver.
Trotter JF, Everson GT
Clin Liver Dis 2001 Feb;5(1):17-42, v. doi: 10.1016/s1089-3261(05)70152-5. PMID: 11218914

Prognosis

Immunoglobulin G4-related gastrointestinal diseases, are they immunoglobulin G4-related diseases?
Koizumi S, Kamisawa T, Kuruma S, Tabata T, Chiba K, Iwasaki S, Endo Y, Kuwata G, Koizumi K, Shimosegawa T, Okazaki K, Chiba T
World J Gastroenterol 2013 Sep 21;19(35):5769-74. doi: 10.3748/wjg.v19.i35.5769. PMID: 24124321Free PMC Article
Inflammatory myofibroblastic tumor of gall bladder.
Muduly D, Deo SV, Shukla NK, Manjunath NM, Durgapal P, Kallianpur A
Trop Gastroenterol 2012 Oct-Dec;33(4):297-9. doi: 10.7869/tg.2012.79. PMID: 23923363
Pulmonary inflammatory myofibroblastic tumor invading the gastroesophageal junction.
Chow SC, Nahal A, Mayrand S, Ferri LE
Ann Thorac Surg 2010 May;89(5):1659-61. doi: 10.1016/j.athoracsur.2009.09.082. PMID: 20417808
Gastrointestinal histoplasmosis presenting as colonic pseudotumour.
Sehgal S, Chawla R, Loomba PS, Mishra B
Indian J Med Microbiol 2008 Apr-Jun;26(2):187-9. doi: 10.4103/0255-0857.40541. PMID: 18445963
Multiple inflammatory pseudotumors mimicking liver metastasis from colon cancer: report of a case.
Ishida H, Tatsuta M, Furukawa H, Ohta H, Hashimoto K, Hayashi N, Morimoto O, Ikeda M, Miya A, Masutani S, Kawasaki T, Satomi T, Yoshioka H, Hanai J
Surg Today 2000;30(6):530-3. doi: 10.1007/s005950070121. PMID: 10883465

Clinical prediction guides

Clinical and Pathological Features of Immune Checkpoint Inhibitor-induced Liver Injury in Comparison with Drug-induced Liver Injury and Autoimmune Hepatitis.
Sunago K, Abe M, Yoshida O, Watanabe T, Nakamura Y, Imai Y, Koizumi Y, Hirooka M, Tokumoto Y, Hiasa Y
J Gastrointestin Liver Dis 2023 Dec 22;32(4):488-496. doi: 10.15403/jgld-5045. PMID: 38147620
An ulcerated gastric ulcer and pseudotumour with pancreatic affectation associated with immunoglobulin G4-related disease: a case report and literature review.
Ortuño Moreno MI, Ferri Ñíguez B, Martínez Barba E, Fernández Hernández JÁ
Rev Esp Enferm Dig 2017 Dec;109(12):870-874. doi: 10.17235/reed.2017.4996/2017. PMID: 29082738
Intra-abdominal inflammatory myofibroblastic tumor: spontaneous regression.
Zhao JJ, Ling JQ, Fang Y, Gao XD, Shu P, Shen KT, Qin J, Sun YH, Qin XY
World J Gastroenterol 2014 Oct 7;20(37):13625-31. doi: 10.3748/wjg.v20.i37.13625. PMID: 25309095Free PMC Article
IgG4 positive lymphoplasmacytic inflammatory pseudotumour mimicking hepatocellular carcinoma.
Hastir D, Verset L, Lucidi V, Demetter P
Liver Int 2014 Jul;34(6):961. Epub 2013 Oct 1 doi: 10.1111/liv.12319. PMID: 24118880
Immunoglobulin G4-related gastrointestinal diseases, are they immunoglobulin G4-related diseases?
Koizumi S, Kamisawa T, Kuruma S, Tabata T, Chiba K, Iwasaki S, Endo Y, Kuwata G, Koizumi K, Shimosegawa T, Okazaki K, Chiba T
World J Gastroenterol 2013 Sep 21;19(35):5769-74. doi: 10.3748/wjg.v19.i35.5769. PMID: 24124321Free PMC Article

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