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Metastatic Salivary Gland Squamous Cell Carcinoma

MedGen UID:
1762905
•Concept ID:
C5419762
•
Neoplastic Process

Definition

Salivary gland squamous cell carcinoma that has spread from the original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Salivary Gland Squamous Cell Carcinoma

Professional guidelines

PubMed

Metastatic cutaneous squamous cell carcinoma to the parotid: Adjuvant radiotherapy and treatment outcomes.
Hu M, Kim ANH, Emeto TI, Collins M, Chopping A, Lin C
J Med Radiat Sci 2023 Jun;70(2):161-170. Epub 2023 Feb 15 doi: 10.1002/jmrs.650. PMID: 36790039Free PMC Article
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
Management of the neck in metastatic cutaneous squamous cell carcinoma of the head and neck.
D'Souza J, Clark J
Curr Opin Otolaryngol Head Neck Surg 2011 Apr;19(2):99-105. doi: 10.1097/MOO.0b013e328343e811. PMID: 21297477

Recent clinical studies

Etiology

Pitfalls in Salivary Gland Cytology.
Saoud C, Bailey GE, Graham A, Bonilla LM, Sanchez SI, Maleki Z
Acta Cytol 2024;68(3):194-205. Epub 2024 Feb 28 doi: 10.1159/000538069. PMID: 38417405
Salivary gland tumours: an epidemiological review of non-neoplastic and neoplastic pathology.
Mckenzie J, Lockyer J, Singh T, Nguyen E
Br J Oral Maxillofac Surg 2023 Jan;61(1):12-18. Epub 2022 Dec 9 doi: 10.1016/j.bjoms.2022.11.281. PMID: 36623970
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406

Diagnosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article
Hyalinizing clear cell carcinoma of salivary gland: a review and update.
Weinreb I
Head Neck Pathol 2013 Jul;7 Suppl 1(Suppl 1):S20-9. Epub 2013 Jul 3 doi: 10.1007/s12105-013-0466-8. PMID: 23821218Free PMC Article
Perineural tumor spread.
Maroldi R, Farina D, Borghesi A, Marconi A, Gatti E
Neuroimaging Clin N Am 2008 May;18(2):413-29, xi. doi: 10.1016/j.nic.2008.01.001. PMID: 18466839

Therapy

Anlotinib reversed resistance to PD-1 inhibitors in recurrent and metastatic head and neck cancers: a real-world retrospective study.
Jiang J, Wu B, Sun Y, Xiang J, Shen C, He X, Ying H, Xia Z
Cancer Immunol Immunother 2024 Aug 6;73(10):199. doi: 10.1007/s00262-024-03784-5. PMID: 39105897Free PMC Article
Real-world time on treatment with immuno-oncology therapy in recurrent/metastatic head and neck squamous cell carcinoma.
Ramakrishnan K, Liu Z, Baxi S, Chandwani S, Joo S, Chirovsky D
Future Oncol 2021 Aug;17(23):3037-3050. Epub 2021 May 28 doi: 10.2217/fon-2021-0360. PMID: 34044594
Mutational Patterns in Metastatic Cutaneous Squamous Cell Carcinoma.
Mueller SA, Gauthier MA, Ashford B, Gupta R, Gayevskiy V, Ch'ng S, Palme CE, Shannon K, Clark JR, Ranson M, Cowley MJ
J Invest Dermatol 2019 Jul;139(7):1449-1458.e1. Epub 2019 Jan 23 doi: 10.1016/j.jid.2019.01.008. PMID: 30684551
Oral cavity squamous cell carcinoma metastasis to the submandibular gland.
Naidu TK, Naidoo SK, Ramdial PK
J Laryngol Otol 2012 Mar;126(3):279-84. Epub 2011 Oct 13 doi: 10.1017/S0022215111002660. PMID: 22017858
Cutaneous head and neck squamous cell carcinoma metastatic to parotid and cervical lymph nodes.
Veness MJ, Porceddu S, Palme CE, Morgan GJ
Head Neck 2007 Jul;29(7):621-31. doi: 10.1002/hed.20576. PMID: 17230560

Prognosis

Lymphoepithelial carcinoma of the parotid gland: Clinicopathological analysis of 146 cases from a single institute.
Zhang C, Gu T, Tian Z, Wang L, Han J, Hu Y, Xia R, Li J
Head Neck 2022 Sep;44(9):2055-2062. doi: 10.1002/hed.27083. PMID: 35915861
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article

Clinical prediction guides

Pitfalls in Salivary Gland Cytology.
Saoud C, Bailey GE, Graham A, Bonilla LM, Sanchez SI, Maleki Z
Acta Cytol 2024;68(3):194-205. Epub 2024 Feb 28 doi: 10.1159/000538069. PMID: 38417405
Involvement of submandibular gland in oral squamous cell carcinoma.
Yamagata K, Bukawa M, Uchida F, Fukuzawa S, Takaoka S, Ishibashi-Kanno N, Bukawa H
J Stomatol Oral Maxillofac Surg 2024 Apr;125(2):101662. Epub 2023 Oct 21 doi: 10.1016/j.jormas.2023.101662. PMID: 37871650
Metastatic cutaneous squamous cell carcinoma to the parotid: Adjuvant radiotherapy and treatment outcomes.
Hu M, Kim ANH, Emeto TI, Collins M, Chopping A, Lin C
J Med Radiat Sci 2023 Jun;70(2):161-170. Epub 2023 Feb 15 doi: 10.1002/jmrs.650. PMID: 36790039Free PMC Article
Parotidectomy for Parotid Cancer.
Cracchiolo JR, Shaha AR
Otolaryngol Clin North Am 2016 Apr;49(2):415-24. Epub 2016 Feb 17 doi: 10.1016/j.otc.2015.10.007. PMID: 26895698Free PMC Article
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article

Recent systematic reviews

Superficial versus total parotidectomy for metastatic cutaneous squamous cell carcinoma and melanoma of the head and neck: a systematic review.
Leong WS, Gowda S, Jackson R, Chabrillac E, Edafe O
J Laryngol Otol 2023 Jun;137(6):592-598. Epub 2022 Aug 1 doi: 10.1017/S0022215122001724. PMID: 35912693
A systematic review of the primary squamous cell carcinoma of the external auditory canal: survival outcome based on T-staging and proposal of a new classification.
George M, Borsotti F, Gereige R, Kolethekkat AA, Das A, Messerer M, Mahasampath G, Simon C
J Laryngol Otol 2021 Feb;135(2):96-103. Epub 2021 Feb 11 doi: 10.1017/S0022215121000323. PMID: 33568243
Salivary gland transfer to prevent radiation-induced xerostomia: a systematic review and meta-analysis.
Sood AJ, Fox NF, O'Connell BP, Lovelace TL, Nguyen SA, Sharma AK, Hornig JD, Day TA
Oral Oncol 2014 Feb;50(2):77-83. Epub 2013 Nov 1 doi: 10.1016/j.oraloncology.2013.10.010. PMID: 24189058
Paraneoplastic syndromes in patients with primary oral cancers: a systematic review.
Chapireau D, Adlam D, Cameron M, Thompson M
Br J Oral Maxillofac Surg 2010 Jul;48(5):338-44. Epub 2009 Oct 14 doi: 10.1016/j.bjoms.2009.08.025. PMID: 19833419

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