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Locally Advanced Lung Adenosquamous Carcinoma

MedGen UID:
1771112
•Concept ID:
C5421211
•
Neoplastic Process

Definition

Lung adenosquamous carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Lung Adenosquamous Carcinoma

Professional guidelines

PubMed

ABO blood groups are not associated with treatment response and prognosis in patients with local advanced non- small cell lung cancer.
Unal D, Eroglu C, Kurtul N, Oguz A, Tasdemir A, Kaplan B
Asian Pac J Cancer Prev 2013;14(6):3945-8. doi: 10.7314/apjcp.2013.14.6.3945. PMID: 23886212
Predictive and prognostic factors in second- and third-line erlotinib treatment in NSCLC patients with known status of the EGFR gene.
Krawczyk P, Kowalski DM, Krawczyk KW, Szczyrek M, Mlak R, Rolski A, Szudy A, Kieszko R, Winiarczyk K, Milanowski J, Krzakowski M
Oncol Rep 2013 Sep;30(3):1463-72. Epub 2013 Jun 19 doi: 10.3892/or.2013.2553. PMID: 23783797
Multidisciplinary approach to the treatment of locally and regionally advanced non-small cell lung cancer: University of Miami experience.
Sridhar KS, Thurer RJ, Markoe AM, Chatoor HT, Fountzilas G, Raub WJ, Savaraj N, Beattie EJ
Semin Surg Oncol 1993 Mar-Apr;9(2):114-9. doi: 10.1002/ssu.2980090209. PMID: 8387688

Recent clinical studies

Etiology

Ensartinib in the treatment of anaplastic lymphoma kinase-positive locally advanced or metastatic patients with lung squamous or adenosquamous carcinoma: A real-world, retrospective study.
Ding L, Yuan X, Wang Y, Yang M, Wu P, Chen H, Yun Y, Shen Z, Ji D, Ma Y
Asia Pac J Clin Oncol 2024 Dec;20(6):700-706. Epub 2024 Jun 19 doi: 10.1111/ajco.14091. PMID: 38898784
Neoadjuvant PD-1 Inhibitors and Chemotherapy for Locally Advanced NSCLC: A Retrospective Study.
Chen T, Ning J, Campisi A, Dell'Amore A, Ciarrocchi AP, Li Z, Song L, Huang J, Yang Y, Stella F, Luo Q
Ann Thorac Surg 2022 Mar;113(3):993-999. Epub 2021 Mar 26 doi: 10.1016/j.athoracsur.2021.03.041. PMID: 33781737
A Pilot Trial of Cisplatin/Etoposide/Radiotherapy Followed by Consolidation Docetaxel and the Combination of Bevacizumab (NSC-704865) in Patients With Inoperable Locally Advanced Stage III Non-Small-Cell Lung Cancer: SWOG S0533.
Wozniak AJ, Moon J, Thomas CR Jr, Kelly K, Mack PC, Gaspar LE, Raben D, Fitzgerald TJ, Pandya KJ, Gandara DR
Clin Lung Cancer 2015 Sep;16(5):340-7. Epub 2015 Jan 9 doi: 10.1016/j.cllc.2014.12.014. PMID: 25703100Free PMC Article
Extended pneumonectomy with partial resection of the left atrium, without cardiopulmonary bypass, for lung cancer.
Spaggiari L, D' Aiuto M, Veronesi G, Pelosi G, de Pas T, Catalano G, de Braud F
Ann Thorac Surg 2005 Jan;79(1):234-40. doi: 10.1016/j.athoracsur.2004.06.100. PMID: 15620949
Lung carcinoma in 1,336 patients.
Sridhar KS, Raub W Jr, Duncan RC, Hilsenbeck S, Richman SP
Am J Clin Oncol 1991 Dec;14(6):496-508. doi: 10.1097/00000421-199112000-00008. PMID: 1957838

Diagnosis

Neoadjuvant ceritinib treatment in ALK-rearranged locally advanced adenosquamous carcinoma: A case report.
Mai S, Wang Y, Wang X, Yang W, Gao H, Xu Z, Xu L, Xu L, Ou Q, Chen H, Wang Z
Thorac Cancer 2022 Aug;13(15):2275-2278. Epub 2022 Jul 12 doi: 10.1111/1759-7714.14558. PMID: 35818908Free PMC Article
Intestinal adenosquamous carcinoma with a synchronous skin metastasis: a immunohistochemical and molecular analysis.
Parente P, Covelli C, Parrella P, Latiano TP, Fiordelisi F, Pellico MT, Maiello E, Graziano P
Int J Colorectal Dis 2020 Feb;35(2):337-341. Epub 2019 Dec 10 doi: 10.1007/s00384-019-03464-2. PMID: 31823050
Pre-clinical imaging for establishment and comparison of orthotopic non-small cell lung carcinoma: in search for models reflecting clinical scenarios.
Aktar R, Dietrich A, Tillner F, Kotb S, Löck S, Willers H, Baumann M, Krause M, Bütof R
Br J Radiol 2019 Mar;92(1095):20180539. Epub 2018 Oct 11 doi: 10.1259/bjr.20180539. PMID: 30215546Free PMC Article
CXCL16 and CXCR6 are coexpressed in human lung cancer in vivo and mediate the invasion of lung cancer cell lines in vitro.
Hu W, Liu Y, Zhou W, Si L, Ren L
PLoS One 2014;9(6):e99056. Epub 2014 Jun 4 doi: 10.1371/journal.pone.0099056. PMID: 24897301Free PMC Article
Targeted therapies for locally advanced or metastatic squamous cell carcinoma of the lung.
Stinchcombe TE
Curr Treat Options Oncol 2013 Dec;14(4):568-79. doi: 10.1007/s11864-013-0256-2. PMID: 23996521

Therapy

Efficacy and Safety of 8 spheres Plus Cisplatin Versus Vinorelbine Plus Cisplatin in Locally Advanced Non-small Cell Lung Cancer.
Wang X, Zhang H, Zhou L, Ou H, Liu H
Cancer Biother Radiopharm 2023 Jun;38(5):313-321. Epub 2020 Dec 17 doi: 10.1089/cbr.2020.4301. PMID: 33332223
Neoadjuvant ceritinib treatment in ALK-rearranged locally advanced adenosquamous carcinoma: A case report.
Mai S, Wang Y, Wang X, Yang W, Gao H, Xu Z, Xu L, Xu L, Ou Q, Chen H, Wang Z
Thorac Cancer 2022 Aug;13(15):2275-2278. Epub 2022 Jul 12 doi: 10.1111/1759-7714.14558. PMID: 35818908Free PMC Article
Neoadjuvant PD-1 Inhibitors and Chemotherapy for Locally Advanced NSCLC: A Retrospective Study.
Chen T, Ning J, Campisi A, Dell'Amore A, Ciarrocchi AP, Li Z, Song L, Huang J, Yang Y, Stella F, Luo Q
Ann Thorac Surg 2022 Mar;113(3):993-999. Epub 2021 Mar 26 doi: 10.1016/j.athoracsur.2021.03.041. PMID: 33781737
Surgical outcomes and complications of pneumonectomy after induction therapy for non-small cell lung cancer.
Kayawake H, Okumura N, Yamanashi K, Otsuki Y, Takahashi A, Itasaka S, Yoshioka H, Nakashima T, Matsuoka T
Gen Thorac Cardiovasc Surg 2018 Nov;66(11):658-663. Epub 2018 Aug 6 doi: 10.1007/s11748-018-0980-4. PMID: 30083866
Targeted therapies for locally advanced or metastatic squamous cell carcinoma of the lung.
Stinchcombe TE
Curr Treat Options Oncol 2013 Dec;14(4):568-79. doi: 10.1007/s11864-013-0256-2. PMID: 23996521

Prognosis

Early-stage multi-differentiated gastric carcinosarcoma and post-resection local recurrence: a case report.
Shioya A, Kurose N, Mizutani K, Kumagai M, Kawaura K, Nakamura N, Kosaka T, Motono N, Uramoto H, Yamada S
Diagn Pathol 2020 Sep 24;15(1):118. doi: 10.1186/s13000-020-01037-4. PMID: 32972454Free PMC Article
Intestinal adenosquamous carcinoma with a synchronous skin metastasis: a immunohistochemical and molecular analysis.
Parente P, Covelli C, Parrella P, Latiano TP, Fiordelisi F, Pellico MT, Maiello E, Graziano P
Int J Colorectal Dis 2020 Feb;35(2):337-341. Epub 2019 Dec 10 doi: 10.1007/s00384-019-03464-2. PMID: 31823050
10-year long-term survival (LTS) of induction chemotherapy with three cycles cisplatin/paclitaxel followed by concurrent chemoradiation cisplatin/etoposide/45 Gy (1.5 Gy bid) plus surgery in locally advanced non-small-cell lung cancer (NSCLC)-a multicenter phase-II trial (CISTAXOL).
Eberhardt WE, Gauler TC, Lepechoux C, Stamatis G, Bildat S, Krbek T, Welter S, Grunenwald D, Fischer B, Rodrigo Hde L, Theegarten D, Le Chevalier T, Seeber S, Stuschke M, Poettgen C
Lung Cancer 2013 Oct;82(1):83-9. Epub 2013 Aug 16 doi: 10.1016/j.lungcan.2013.06.007. PMID: 23957964
ABO blood groups are not associated with treatment response and prognosis in patients with local advanced non- small cell lung cancer.
Unal D, Eroglu C, Kurtul N, Oguz A, Tasdemir A, Kaplan B
Asian Pac J Cancer Prev 2013;14(6):3945-8. doi: 10.7314/apjcp.2013.14.6.3945. PMID: 23886212
Lung carcinoma in 1,336 patients.
Sridhar KS, Raub W Jr, Duncan RC, Hilsenbeck S, Richman SP
Am J Clin Oncol 1991 Dec;14(6):496-508. doi: 10.1097/00000421-199112000-00008. PMID: 1957838

Clinical prediction guides

Efficacy and Safety of 8 spheres Plus Cisplatin Versus Vinorelbine Plus Cisplatin in Locally Advanced Non-small Cell Lung Cancer.
Wang X, Zhang H, Zhou L, Ou H, Liu H
Cancer Biother Radiopharm 2023 Jun;38(5):313-321. Epub 2020 Dec 17 doi: 10.1089/cbr.2020.4301. PMID: 33332223
Early-stage multi-differentiated gastric carcinosarcoma and post-resection local recurrence: a case report.
Shioya A, Kurose N, Mizutani K, Kumagai M, Kawaura K, Nakamura N, Kosaka T, Motono N, Uramoto H, Yamada S
Diagn Pathol 2020 Sep 24;15(1):118. doi: 10.1186/s13000-020-01037-4. PMID: 32972454Free PMC Article
Intestinal adenosquamous carcinoma with a synchronous skin metastasis: a immunohistochemical and molecular analysis.
Parente P, Covelli C, Parrella P, Latiano TP, Fiordelisi F, Pellico MT, Maiello E, Graziano P
Int J Colorectal Dis 2020 Feb;35(2):337-341. Epub 2019 Dec 10 doi: 10.1007/s00384-019-03464-2. PMID: 31823050
Irinotecan, cisplatin, and radiation in esophageal cancer.
Ilson DH, Minsky B, Kelsen D
Oncology (Williston Park) 2002 May;16(5 Suppl 5):11-5. PMID: 12109799
Lung carcinoma in 1,336 patients.
Sridhar KS, Raub W Jr, Duncan RC, Hilsenbeck S, Richman SP
Am J Clin Oncol 1991 Dec;14(6):496-508. doi: 10.1097/00000421-199112000-00008. PMID: 1957838

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