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Pyloric gland adenoma

MedGen UID:
1771507
•Concept ID:
C5421225
•
Neoplastic Process
Synonym: Gastric Pyloric Gland Adenoma
 
Monarch Initiative: MONDO:0006391

Definition

A rare neoplastic polyp that arises from the stomach. It is characterized by the presence of gastric epithelial differentiation and pyloric gland-type tubular structures, which are closely packed. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPyloric gland adenoma

Professional guidelines

PubMed

Surveillance for pathology associated with cancer on endoscopy (SPACE): criteria to identify high-risk gastric polyps in familial adenomatous polyposis.
Mankaney GN, Cruise M, Sarvepalli S, Bhatt A, Arora Z, Baggot B, Laguardia L, O'Malley M, Church J, Kalady M, Burke CA
Gastrointest Endosc 2020 Sep;92(3):755-762. Epub 2020 May 4 doi: 10.1016/j.gie.2020.04.065. PMID: 32380015

Recent clinical studies

Etiology

Large duodenal pyloric gland adenoma successfully resected by endoscopic submucosal dissection.
Takayanagi S, Sakai E, Muramoto T, Hashimoto H, Ohata K
Clin J Gastroenterol 2021 Apr;14(2):538-541. Epub 2021 Mar 4 doi: 10.1007/s12328-021-01367-w. PMID: 33661443
An LCM-based genomic analysis of SPEM, Gastric Cancer and Pyloric Gland Adenoma in an Asian cohort.
Srivastava S, Huang KK, Rebbani K, Das K, Fazreen Z, Yeoh KG, Tan P, Teh M
Mod Pathol 2020 Oct;33(10):2075-2086. Epub 2020 Apr 8 doi: 10.1038/s41379-020-0520-5. PMID: 32269290
Next-generation sequencing identifies 2 genomically distinct groups among pyloric gland adenomas.
Setia N, Wanjari P, Yassan L, Niu N, Kadri S, Ritterhouse L, Misdraji J, Brown I, Segal J, Hart J
Hum Pathol 2020 Mar;97:103-111. Epub 2019 Nov 27 doi: 10.1016/j.humpath.2019.11.004. PMID: 31783043
Gastric pyloric gland adenoma: a multicentre clinicopathological study of 67 cases.
Choi WT, Brown I, Ushiku T, Yozu M, Setia N, Srivastava A, Johncilla M, Pai RK, Gill RM, Fukayama M, Misdraji J, Lauwers GY
Histopathology 2018 May;72(6):1007-1014. Epub 2018 Mar 5 doi: 10.1111/his.13460. PMID: 29278427
Upper gastrointestinal tract polyps: what do we know about them?
Buyukasik K, Sevinc MM, Gunduz UR, Ari A, Gurbulak B, Toros AB, Bektas H
Asian Pac J Cancer Prev 2015;16(7):2999-3001. doi: 10.7314/apjcp.2015.16.7.2999. PMID: 25854396

Diagnosis

Pachydermoperiostosis combined with pyloric gland adenoma with foveolar-type adenoma.
Long B, Jiang C, Zheng Q, Wan P
United European Gastroenterol J 2024 Feb;12(1):152-154. Epub 2023 Nov 22 doi: 10.1002/ueg2.12484. PMID: 37991153Free PMC Article
Gastric Pyloric Gland Adenoma in MUTYH-Associated Polyposis.
Liu C, Matsukuma K, Tejaswi S
Clin Gastroenterol Hepatol 2022 Feb;20(2):A25-A26. Epub 2020 Oct 10 doi: 10.1016/j.cgh.2020.10.005. PMID: 33049409
The curious case of Gαs gain-of-function in neoplasia.
Innamorati G, Wilkie TM, Kantheti HS, Valenti MT, Dalle Carbonare L, Giacomello L, Parenti M, Melisi D, Bassi C
BMC Cancer 2018 Mar 15;18(1):293. doi: 10.1186/s12885-018-4133-z. PMID: 29544460Free PMC Article
Adenocarcinoma at the gastroesophageal junction.
Al-Haddad S, Chang AC, De Hertogh G, Grin A, Langer R, Sagaert X, Salemme M, Streutker CJ, Soucy G, Tripathi M, Upton MP, Vieth M, Villanacci V
Ann N Y Acad Sci 2014 Sep;1325:211-25. doi: 10.1111/nyas.12535. PMID: 25266027
Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264

Prognosis

Pyloric gland adenoma with low-grade intraepithelial neoplasia: A case report and literature review.
Li HL, Wang Y, Ren YB, Yang XS, Wang L, Zhang L, Lin XC
Medicine (Baltimore) 2021 Jun 25;100(25):e26378. doi: 10.1097/MD.0000000000026378. PMID: 34160413Free PMC Article
Reduced αGlcNAc glycosylation on gastric gland mucin is a biomarker of malignant potential for gastric cancer, Barrett's adenocarcinoma, and pancreatic cancer.
Yamanoi K, Nakayama J
Histochem Cell Biol 2018 Jun;149(6):569-575. Epub 2018 Apr 16 doi: 10.1007/s00418-018-1667-8. PMID: 29658052
Pyloric gland adenoma in Lynch syndrome.
Lee SE, Kang SY, Cho J, Lee B, Chang DK, Woo H, Kim JW, Park HY, Do IG, Kim YE, Kushima R, Lauwers GY, Park CK, Kim KM
Am J Surg Pathol 2014 Jun;38(6):784-92. doi: 10.1097/PAS.0000000000000185. PMID: 24518125Free PMC Article
Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264
Pyloric gland adenoma-- how to diagnose?
Vieth M, Vogel C, Kushima R, Borchard F, Stolte M
Cesk Patol 2006 Jan;42(1):4-7. PMID: 16506593

Clinical prediction guides

Decreased expression of TFF2 and decreased αGlcNAc glycosylation are malignant biomarkers of pyloric gland adenoma of the duodenum.
Yamanoi K, Fujii C, Nakayama A, Matsuura N, Takatori Y, Kato M, Yahagi N, Nakayama J
Sci Rep 2023 Dec 8;13(1):21641. doi: 10.1038/s41598-023-49040-1. PMID: 38062108Free PMC Article
Some observations on pyloric gland adenoma: an uncommon and long ignored entity!
Vieth M, Montgomery EA
J Clin Pathol 2014 Oct;67(10):883-90. doi: 10.1136/jclinpath-2014-202553. PMID: 25092673
Pyloric gland adenoma in Lynch syndrome.
Lee SE, Kang SY, Cho J, Lee B, Chang DK, Woo H, Kim JW, Park HY, Do IG, Kim YE, Kushima R, Lauwers GY, Park CK, Kim KM
Am J Surg Pathol 2014 Jun;38(6):784-92. doi: 10.1097/PAS.0000000000000185. PMID: 24518125Free PMC Article
Frequent GNAS and KRAS mutations in pyloric gland adenoma of the stomach and duodenum.
Matsubara A, Sekine S, Kushima R, Ogawa R, Taniguchi H, Tsuda H, Kanai Y
J Pathol 2013 Mar;229(4):579-87. Epub 2013 Feb 4 doi: 10.1002/path.4153. PMID: 23208952
Pyloric gland adenoma-- how to diagnose?
Vieth M, Vogel C, Kushima R, Borchard F, Stolte M
Cesk Patol 2006 Jan;42(1):4-7. PMID: 16506593

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